A 72-year-old woman presented to the emergency department with a 3-month history of a rash on both legs and an additional 6 months of gingival bleeding. The patient’s medical history was notable for esophageal strictures leading to poor oral intake for at least 2 years. Physical examination of the…
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A 61-year-old man with a history of stage IIIB squamous-cell carcinoma of the lung began to have seizurelike activity while he was undergoing restaging computed tomography (CT) in the hospital. He had a known primary cavitary lesion in the right lower lobe and had previously received three cycles…
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Abstract Introduction High-resolution peripheral quantitative computed tomography (HR-pQCT) has enabled us to observe the changes in bone microarchitecture over time in vivo. In this study, the process of fracture healing was analyzed using HR-pQCT in patients with distal radius fracture who underwent osteosynthesis. Materials and methods A total of...
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Abstract The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS‐Co‐V‐2) has resulted in a critical need to rapidly develop new pharmacologic interventions and disseminate information. This has led to confusing and conflicting information on drug efficacy. Remdesivir has emerged as a promising treatment for SARS‐Co‐V‐2 infection yet published clinical pharmacology and drug interaction studies are limited. Additional studies of the disposition of remdesivir, its active metabolite...
Wed May 13, 2020 19:36
Background The Centers for Medicare and Medicaid Services (CMS) has released quality measures regarding potentially avoidable hospitalizations visits in the 30 days after receipt of outpatient chemotherapy. This study evaluated the proportions of patients treated by Medicare‐reimbursed clinicians and Veterans Health Administration (VA) clinicians who experienced avoidable acute care in order to evaluate differences in health system performance. Methods This retrospective evaluation of Medicare...
Wed May 13, 2020 16:26
Immuno‐oncology therapies engage the immune system to treat cancer. BiTE (bispecific T‐cell engager) technology is a targeted immuno‐oncology platform that connects patients' own T cells to malignant cells. The modular nature of BiTE technology facilitates the generation of molecules against tumor‐specific antigens, allowing off‐the‐shelf immuno‐oncotherapy. Blinatumomab was the first approved canonical BiTE molecule and targets CD19 surface antigens on B cells, making blinatumomab largely independent...
Wed May 13, 2020 16:24
Tue May 12, 2020 19:11
Tue May 12, 2020 19:11
Background The purpose of this study was to estimate the proportion of Chinese cancer survivors experiencing financial hardship and then examine the relationship between material and behavioral financial hardship. Methods This study surveyed 964 cancer survivors who were 30 to 64 years old and 644 survivors who were 65 years old or older during 2015‐2016 (1608 survivors in all). Material financial hardship was measured by whether they had borrowed money because of cancer, its treatment, or...
Tue May 12, 2020 17:58
Abstract Background Patients with atopic dermatitis (AD) often show the infiltration of basophils in the affected skin. Because basophils represent only a minor fraction among cellular infiltrates in the skin lesion, the functional significance of skin‐infiltrating basophils in AD pathogenesis remains ill‐defined. In this study, we aimed to clarify the role of basophils and their effector molecules triggering skin inflammation in oxazolone (OX)‐induced murine model of AD. Methods A panel...
Wed May 13, 2020 20:15
ABSTRACT This spring, the majority of allergic patients are confined to their homes due to COVID‐19 pandemic restrictions. In the following weeks, these restrictions will be reduced andpeople will be allowed to take walks, go jogging, and return to work.Spring is the time for ocular allergy (OA) to emerge with signs and symptoms consequent to increasing pollen counts. Even when wearing a mask, the eyes may remain unprotectedleading to an increase in ocular symptoms and patients seeking treatment...
Wed May 13, 2020 18:59
ABSTRACT The outbreak of coronavirus disease 2019 (COVID‐19) caused by the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses a global health emergency and became a worldwide pandemic. We summarize the recent findings with respect to the function, structure and immunogenicity of the spike (S) protein, arising mutations, and implications on vaccine development and therapeutics.
Wed May 13, 2020 18:53
ABSTRACT Background Peanut allergy (PA) is a common, potentially life‐threatening, and typically lifelong condition with a significant burden of illness. However, information is lacking on how persons with PA (PwPA) and their caregivers perceive the psychosocial impact of living with PA. The Allergy to Peanuts imPacting Emotions And Life study 1 (APPEAL‐1) survey, conducted across Europe, investigated the experience and impact of living with PA. Here, we report data evaluating the psychosocial...
Wed May 13, 2020 13:00
Abstract As a zoonotic disease that has already spread globally to several million human beings and possibly to domestic and wild animals, eradication of coronavirus disease 2019 (COVID‐19) appears practically impossible. There is a pressing need to improve our understanding of the immunology of this disease to contain the pandemic by developing vaccines and medicines for the prevention and treatment of patients. In this review, we aim to improve our understanding on the immune response and immunopathological...
Tue May 12, 2020 12:26
Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 54-year-old…
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Presentation of Case. Dr. Joseph A. Rosenthal (Medicine): A 79-year-old man was admitted to this hospital because of hyponatremia and involuntary movements of the arm and face. The patient had been in his usual state of health and walking 3 miles per day until 5 weeks before the current admission,…
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Tissue transplantation in patients with Parkinson’s disease to replace the lost dopaminergic neurons of the substantia nigra pars compacta has been studied since the 1980s. Sources of these cells have included adrenal medulla and fetal midbrain tissues from allogeneic or xenogeneic sources.…
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Abstract Lung adenocarcinoma with micropapillary pattern (MPP) has an aggressive malignant behavior. Limited resection should be avoided because of its high recurrence rate. If adenocarcinoma with MPP is diagnosed preoperatively, the selection of proper treatment is possible. To explore a preoperative biomarker for diagnosing MPP, we here conducted RNA sequencing analysis of 25 clinical samples as the training set, including 6 MPP, 16 other adenocarcinoma subtypes and 3 normal lung tissues. Unsupervised...
Wed May 13, 2020 12:08
Summary The present study aimed to evaluate the efficacy of the real‐world use of axitinib and to develop a prognostic model for stratifying patients who could derive long‐term benefit from axitinib. This was a retrospective, descriptive study evaluating the efficacy of axitinib in patients with metastatic renal cell carcinoma that had been treated with one or two systemic anti‐angiogenic therapy regimens at one of 36 hospitals belonging to the Japan Urologic Oncology Group between January 2012...
Wed May 13, 2020 11:08
S ‐adenosyl‐l‐methionine (SAM)‐dependent methyltransfer ‐ases (MT) are an important class of enzymes, catalysing methylation of a vast array of small metabolites and biomacromolecules. Recently, rare carboxymethylation pathways have been discovered, including carboxymethyltransferase enzymes that utilise a carboxy‐SAM (cxSAM) cofactor, generated from SAM by a cxSAM synthase (CmoA). In this study we show how MT enzymes can utilise cxSAM, catalysing carboxymethylation of tetrahydroisoquinoline (THIQ)...
Wed May 13, 2020 19:50
The key descriptor that dominates the kinetics of alkaline hydrogen evolution reaction (HER) has not yet fully been identified so far. Herein, we isolate adsorption hydroxyl (OHad) transfer process (OHad + e– ↔ OH–) and reveal its crucial role in promoting the overall kinetics of alkaline HER based on Ni/Co modified MoSe2 model catalysts (Ni‐MoSe2 and Co‐MoSe2) that feature almost identical water dissociation and hydrogen adsorption energies, but evidently different activity trends in alkaline (Ni‐MoSe2...
Wed May 13, 2020 19:50
The Au‐S bond is the classic way to functionalize gold nanoparticles (AuNPs). However, cleavage of the bond by biothiols and other chemicals is a long‐standing problem hindering practical applications, especially in cells. Instead of replacing the thiol by a carbene or selenol for stronger adsorption, we herein communicate that Pt‐S bond is much more stable, fully avoiding cleavage by biothiols. AuNPs were deposited with a thin layer of platinum, and an AuNP@Pt‐S nanoflare was constructed to detect...
Wed May 13, 2020 16:51
Oxoborane carbamate and carboxylate analogues result from the in situ trapping of [BO 2 ] ‐ produced by elimination of 2,3‐dimethyl‐2‐butene from a pinacolatoboryl anion.
Wed May 13, 2020 16:50
We report the first trans phosphinoboration of internal alkynes. Employing an organophosphine catalyst, alkynoate esters and the phosphinoboronate Ph 2 P–Bpin are efficiently converted to the corresponding trans α‐phosphino‐β‐boryl acrylate products in moderate to good yield with high regio‐ and Z ‐selectivity. This reaction operates under mild conditions and demonstrates good atom economy, requiring only a modest excess of the phosphinoboronate. X‐ray crystallography experiments allowed...
Wed May 13, 2020 16:49
We constructed ordered mesoporous metal‐organic frameworks (mesoMOFs) with uniform pore size up to approximately 10 nm and thick microporous walls, opening up the possibility for the mass diffusion of large‐size molecules through crystalline MOFs. The synergistic effects based on triblock copolymer templates and the Hofmeister salting‐in anion promote the nucleation of stable MOFs in aqueous phase and the in‐situ crystallization of MOFs around templates, rendering the generation of a microcrystal...
Wed May 13, 2020 15:19
The development of ultrastable carbon materials for potassium storage poses key limitations caused by the huge volume variation and sluggish kinetics. Nitrogen‐enriched porous carbons have recently emerged as promising candidates for this application, however, rational control over nitrogen doping is still challenging to further improve the long‐term capacity fading. Here we propose a pyridine‐coordinated polymer pyrolysis‐etching strategy for deliberate manipulation of edge‐nitrogen doping and specific...
Wed May 13, 2020 12:19
Prelithiation is of great interest to Li‐ion battery manufacturers to compensate for the inevitable loss of active Li during initial cycling of a battery that would otherwise degrade its available energy density. Nevertheless, none of the current strategies are suited for mass production due to lack of control, homogeneity, safety and scalability. Solution‐based chemical prelithiation using a reductive chemical promises unparalleled reaction homogeneity and simplicity. Thus far, however, the applied...
Wed May 13, 2020 13:10
In the present study, chiral Cu x Co y S nanoparticles (NPs) were developed to selectively induce apoptosis of senescent cells using both an alternating magnetic field (AMF) and near infrared (NIR) photon illumination. The chiral effects on living cells were investigated, and D ‐Cu x Co y S NPs showed about 2.5 times higher of internalized ability than L ‐NPs. By modifying beta 2 macroglobulin (MG), senescent cells were effectively eliminated by D ‐Cu x Co y S NPs without damaging...
Wed May 13, 2020 11:48
The cyclohexanol homodimer is a delicate test model of the role of dispersion forces in intermolecular association. While phenol produces a single dimer, suppression of π interactions and larger conformational flexibility in cyclohexanol results in multiple isomerism, as six competing dimers of the free molecule are observed in a supersonic jet expansion. Rotational spectroscopy reveals accurate structural data, specifically the formation of homo‐ and heterochiral diasteroisomers and the presence...
Tue May 12, 2020 22:51
The general principles guiding the design of molecular machines based on interlocked structures are well known. Nonetheless, the identification of suitable molecular components for a precise tuning of the energetic parameters that determine the mechanical link is still challenging. Indeed, what are the reasons of the “all‐or‐nothing” effect, which turns a molecular “speed‐bump” into a stopper in pseudorotaxane‐based architectures? Here we investigate the threading and dethreading processes for a...
Tue May 12, 2020 22:24
This communication describes the use of CuInS 2 /ZnS quantum dots (QDs) as photocatalysts for the reductive deprotection of aryl sulfonyl‐protected phenols. For a series of aryl sulfonates with electron‐withdrawing substituents, the rate of deprotection for the corresponding phenyl aryl sulfonates increases with decreasing electrochemical potential for the two electron transfers within the catalytic cycle. The rate of deprotection for a substrate that contains a carboxylic acid, a known QD‐binding...
Tue May 12, 2020 22:20
The iodine(III) reagents vinylbenziodoxolones (VBX) were employed to vinylate a series of aliphatic and aromatic thiols, providing E ‐alkenyl sulfides with complete chemo‐ and regioselectivity, as well as excellent stereoselectivity. The methodology displays high functional group tolerance and proceeds under mild and transition metal‐free conditions without the need for excess substrate or reagents. Mercaptothiazoles could be vinylated under modified conditions, resulting in opposite stereoselectivity...
Tue May 12, 2020 22:00
Rationally tailoring a robust artificial coating can enhance the life‐time of the fragile biomacromolecules. However, the shrouded coating also can restrain the activity of the guest because of the decreased substrate accessibility. Herein, we report a peptides‐directed strategy that enables to tailor the MOFs‐shrouded biohybrids into controllable nanoarchitectures in‐situ. The MOFs biohybrid is feasible to be shaped from different 3D microporous architectures to 2D mesoporous layer by a peptide...
Tue May 12, 2020 21:18
Rhenium tricarbonyl complexes have been recently investigated as novel anticancer agents. However, little is understood about their mechanisms of action, as well as the means by which cancer cells respond to chronic exposure to these compounds. To gain a deeper mechanistic insight into these rhenium anticancer agents, we developed and characterized an ovarian cancer cell line that is resistant to a previously studied compound [Re(CO) 3 (dmphen)(ptolICN)] + , where dmphen = 2,9‐dimethyl‐1,10‐phenanthroline...
Tue May 12, 2020 20:43
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