Journal of Cosmetic Dermatology, EarlyView.
Παρασκευή 31 Αυγούστου 2018
Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis
Sweet's syndrome associated with Talaromyces marneffei and Mycobacterium abscessus infection due to anti-interferon-gamma autoantibodies
Hongyan Xu, Donghua Liu, Xiaoyue He, Dongyan Zheng, Yan Deng
Indian Journal of Dermatology 2018 63(5):428-430
Indian Journal of Dermatology 2018 63(5):428-430
Three sequential lymphomatous tumors in a patient
Ellie Choi, Sam Yang, Kong Bing Tan, Derrick Aw, Nisha Suyien Chandran
Indian Journal of Dermatology 2018 63(5):443-444
Indian Journal of Dermatology 2018 63(5):443-444
Estimation of zinc and iron levels in the serum and hair of women with androgenetic alopecia: Case–control study
Samer A Dhaher, Abdulla A Yacoub, Ausama Ayob Jacob
Indian Journal of Dermatology 2018 63(5):369-374
Background: Although female androgenetic alopecia (FAGA) occurs in genetically susceptible women, some trace elements may play an important role. Aim of the Study: This study aimed to evaluate serum and hair zinc and iron levels in patients with FAGA and to compare the findings with normal controls. Patients and Methods: A case–control study that was conducted at Dermatology Clinic in Basra General Hospital, Basra, Iraq. The participants were divided into two groups: The first group consisted of 27 women with FAGA and the second was age-matched 28 healthy women control group. The serum and hair zinc and iron assays were done for all participants. Results: Both hair and serum zinc levels in FAGA group were significantly lower than that in the control (103.4±25.5 ppm vs. 143.5±33.1 ppm for hair and 65.6±14.2 μg/dl vs. 128.4±41.4 μg/dl for serum). Hair iron level in FAGA was significantly lower than in control (17.9±3.8 ppm vs. 26.9±7.4 ppm, P>0.05). Serum iron level in FAGA group was lower than in the control, but it was not significant statistically (88.9±22.3 μg/dl vs. 100.9±18.9 μg/dl). Except for the hair iron, there was no significant correlation between zinc and iron concentrations in hair and serum with severity of alopecia. Conclusions: Zinc and iron levels in serum and hair were lower in FAGA compared to that of normal individuals indicating that trace elements might play an important role in the etiopathogenesis of FAGA.
Indian Journal of Dermatology 2018 63(5):369-374
Background: Although female androgenetic alopecia (FAGA) occurs in genetically susceptible women, some trace elements may play an important role. Aim of the Study: This study aimed to evaluate serum and hair zinc and iron levels in patients with FAGA and to compare the findings with normal controls. Patients and Methods: A case–control study that was conducted at Dermatology Clinic in Basra General Hospital, Basra, Iraq. The participants were divided into two groups: The first group consisted of 27 women with FAGA and the second was age-matched 28 healthy women control group. The serum and hair zinc and iron assays were done for all participants. Results: Both hair and serum zinc levels in FAGA group were significantly lower than that in the control (103.4±25.5 ppm vs. 143.5±33.1 ppm for hair and 65.6±14.2 μg/dl vs. 128.4±41.4 μg/dl for serum). Hair iron level in FAGA was significantly lower than in control (17.9±3.8 ppm vs. 26.9±7.4 ppm, P>0.05). Serum iron level in FAGA group was lower than in the control, but it was not significant statistically (88.9±22.3 μg/dl vs. 100.9±18.9 μg/dl). Except for the hair iron, there was no significant correlation between zinc and iron concentrations in hair and serum with severity of alopecia. Conclusions: Zinc and iron levels in serum and hair were lower in FAGA compared to that of normal individuals indicating that trace elements might play an important role in the etiopathogenesis of FAGA.
Use of an anal retractor device for excision in patients with perianal extramammary paget's disease
Yuichi Yoshida, Hiroyuki Goto, Reiko Tsutsumi, Osamu Yamamoto
Indian Journal of Dermatology 2018 63(5):435-437
Indian Journal of Dermatology 2018 63(5):435-437
Topical steroid damaged/dependent face (TSDF): A study from a tertiary care hospital in Eastern India
Dayamay Pal, Projna Biswas, Sudip Das, Abhishek De, Nidhi Sharma, Asad Ansari
Indian Journal of Dermatology 2018 63(5):375-379
Background: Awareness against abuse of topical corticosteroids (TC), especially over the face, has been going on for last 5 years in India. In spite of that we are getting lots of cases in our hospitals. Aims: The aims of this study were to ascertain the demographics, magnitude and clinical features of TC misuse on the face among the dermatology outpatient department (OPD) attendees and to analyze its causes. Methods: This study was conducted in a tertiary care medical center of eastern India. Patients with relevant facial dermatoses were asked about their current use of topical formulations and confirmed to be TSDF were included in the study. Results: A total of 748 patients with facial dermatoses were screened, of which 271 (36.22%) were using TC. Of them mostly young adults between 20 and 29 years (37.10%) were using TC. Average duration between starting of use of medication and the onset of symptoms was 5 months. Ninety-eight (36.16%) patients were using topical corticosteroid for the treatment of acne and 74 (27.30%) were using as depigmenting cream. About 108 (39.85%) patients bought medicine over the counter being recommended by pharmacist/shop owner. Rosacea like features with photosensitivity was the most common adverse effect found in 79 (29.15%) patients whereas comedonal acne/acne exacerbation were found in 68 (25.09%) patients. Most of them (227, 83.76%) were unaware about the side effects of steroids. Conclusions: TC misuse in patients with facial dermatoses is still quite common even after efforts to grow the awareness among population.
Indian Journal of Dermatology 2018 63(5):375-379
Background: Awareness against abuse of topical corticosteroids (TC), especially over the face, has been going on for last 5 years in India. In spite of that we are getting lots of cases in our hospitals. Aims: The aims of this study were to ascertain the demographics, magnitude and clinical features of TC misuse on the face among the dermatology outpatient department (OPD) attendees and to analyze its causes. Methods: This study was conducted in a tertiary care medical center of eastern India. Patients with relevant facial dermatoses were asked about their current use of topical formulations and confirmed to be TSDF were included in the study. Results: A total of 748 patients with facial dermatoses were screened, of which 271 (36.22%) were using TC. Of them mostly young adults between 20 and 29 years (37.10%) were using TC. Average duration between starting of use of medication and the onset of symptoms was 5 months. Ninety-eight (36.16%) patients were using topical corticosteroid for the treatment of acne and 74 (27.30%) were using as depigmenting cream. About 108 (39.85%) patients bought medicine over the counter being recommended by pharmacist/shop owner. Rosacea like features with photosensitivity was the most common adverse effect found in 79 (29.15%) patients whereas comedonal acne/acne exacerbation were found in 68 (25.09%) patients. Most of them (227, 83.76%) were unaware about the side effects of steroids. Conclusions: TC misuse in patients with facial dermatoses is still quite common even after efforts to grow the awareness among population.
Metastatic dermatosis in breast carcinoma on adjuvant trastuzumab: Is skin a sanctuary site in human epidermal growth factor receptor-2-amplified disease?
Amit Sehrawat, Sumedha A Kotwal, KM Parthasarathy
Indian Journal of Dermatology 2018 63(5):424-426
Cutaneous metastasis (CM) from internal malignancies is commonly seen. Sometimes, skin metastases can be the first sign of advanced cancer or an indicator of cancer recurrence. Cases of breast cancer with cutaneous progression after or during trastuzumab therapy have been described in the past, frequently associated with systemic disease progression. However, CM during adjuvant trastuzumab therapy is very rare. It has been hypothesized that cancer cells located in the skin survive and take proliferative advantage by virtue of an immune-tolerance mechanism that hampers trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity. We describe a case of human epidermal growth factor receptor-2-overexpressing breast cancer presenting with diffuse CM during adjuvant trastuzumab therapy.
Indian Journal of Dermatology 2018 63(5):424-426
Cutaneous metastasis (CM) from internal malignancies is commonly seen. Sometimes, skin metastases can be the first sign of advanced cancer or an indicator of cancer recurrence. Cases of breast cancer with cutaneous progression after or during trastuzumab therapy have been described in the past, frequently associated with systemic disease progression. However, CM during adjuvant trastuzumab therapy is very rare. It has been hypothesized that cancer cells located in the skin survive and take proliferative advantage by virtue of an immune-tolerance mechanism that hampers trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity. We describe a case of human epidermal growth factor receptor-2-overexpressing breast cancer presenting with diffuse CM during adjuvant trastuzumab therapy.
Comparison of efficacy of doxycycline and isotretinoin on cutaneous human beta-defensin-1 and -2 levels in acne vulgaris
Gulhan Aksoy, Esra Adisen, Ozlem Erdem, Ahmet Burhan Aksakal
Indian Journal of Dermatology 2018 63(5):380-385
Background: Recent studies have shown that human beta-defensin-1 (hBD-1) and (human beta-defensin-2 hBD-2), which are antimicrobial peptides produced by the skin, play a role in the pathogenesis of acne vulgaris (AV). Objective: The aim of this study was to determine the role of antimicrobial peptides in the pathogenesis of AV and enlighten the effects of doxycycline and isotretinoin in the expression of these defensins in AV. Materials and Methods: A total of 44 patients (22 patients in each group) with Grade 6 and 8 AV who were indicated doxycycline or isotretinoin for their treatment, and 20 healthy volunteers were included in this study. Pretreatment cutaneous samples were obtained from pustular lesions and uninvolved skin of AV patients and were repeated after the treatment. Only one biopsy was obtained from controls. Results: Cutaneous levels of hBD-1 and hBD-2 were significantly increased in AV patients when compared with healthy controls (P<0.05). Doxycycline therapy achieved a decrease in hBD-1 levels (P<0.05), whereas isotretinoin therapy achieved a reduction in hBD-2 levels when compared with pretreatment levels (P<0.05). Posttreatment hBD-1 and hBD-2 levels were not different between doxycycline and isotretinoin groups (P>0.05). Conclusion: In the light of these results, it was reasonable to assume the role of hBD-1 and hBD-2 in the pathogenesis of AV. Our results showing a significant reduction in hBD-1 staining with doxycycline treatment and in hBD-2 with isotretinoin suggested that some part of their anti-acne effect worked through these mechanisms.
Indian Journal of Dermatology 2018 63(5):380-385
Background: Recent studies have shown that human beta-defensin-1 (hBD-1) and (human beta-defensin-2 hBD-2), which are antimicrobial peptides produced by the skin, play a role in the pathogenesis of acne vulgaris (AV). Objective: The aim of this study was to determine the role of antimicrobial peptides in the pathogenesis of AV and enlighten the effects of doxycycline and isotretinoin in the expression of these defensins in AV. Materials and Methods: A total of 44 patients (22 patients in each group) with Grade 6 and 8 AV who were indicated doxycycline or isotretinoin for their treatment, and 20 healthy volunteers were included in this study. Pretreatment cutaneous samples were obtained from pustular lesions and uninvolved skin of AV patients and were repeated after the treatment. Only one biopsy was obtained from controls. Results: Cutaneous levels of hBD-1 and hBD-2 were significantly increased in AV patients when compared with healthy controls (P<0.05). Doxycycline therapy achieved a decrease in hBD-1 levels (P<0.05), whereas isotretinoin therapy achieved a reduction in hBD-2 levels when compared with pretreatment levels (P<0.05). Posttreatment hBD-1 and hBD-2 levels were not different between doxycycline and isotretinoin groups (P>0.05). Conclusion: In the light of these results, it was reasonable to assume the role of hBD-1 and hBD-2 in the pathogenesis of AV. Our results showing a significant reduction in hBD-1 staining with doxycycline treatment and in hBD-2 with isotretinoin suggested that some part of their anti-acne effect worked through these mechanisms.
Cyclosporine in generalized bullous-fixed drug eruption
Ranjana Beniwal, Lalit Kumar Gupta, Ashok Kumar Khare, Asit Mittal, Sharad Mehta, Manisha Balai
Indian Journal of Dermatology 2018 63(5):432-433
Indian Journal of Dermatology 2018 63(5):432-433
Pathogenic yeasts recovered from acne vulgaris: Molecular characterization and antifungal susceptibility pattern
Ayatollah Nasrollahi Omran, Alinaghi Ghiasi Mansori
Indian Journal of Dermatology 2018 63(5):386-390
Context: Acne vulgaris is a disorder showing persistent inflammation in the pilosebaceous follicles. It is one of the most prevalent dermatoses that millions of people suffer from globally. Aim: The aim of this study was to identify Candida species from patients with acne and to determine their drugs susceptibility. Subjects and Methods: A total of 70 cutaneous samples from acne vulgaris patients suspected to have Candida infections were collected. Macroscopic and microscopic morphology were recorded followed by polymerase chain reaction-sequencing of ITS regions, using universal primers. In vitro antifungal susceptibility was performed using Clinical and Laboratory Standards Institute method. Results: Overall, 11 Candida species including Candida parapsilosis 8 (72.73%), Candida krusei 1 (12.5%), Candida lusitaniae 1 (12.5%), Candida kefyr 1 (12.5%), and a Trichosporon asahi out of the collected clinical materials were isolated and identified. C. parapsilosis isolates susceptibility to diverse concentrations of the antifungal agents to isolate Cp1 study indicated that the isolated Cp8 and Cp5 with minimal inhibitory concentration (MIC) 50 = 32, 0.5, 0.25 and MIC 90 of <64, <1, <0.5 μg/ml fluconazole, itraconazole, and ketoconazole were resistant, respectively. Some of the isolates having relative strength, almost all other species of C. parapsilosis isolates were susceptible to these drugs. Conclusion: C. parapsilosis was the most prevalent Candida species in acne vulgaris samples which had higher in vitro susceptibility for antifungals.
Indian Journal of Dermatology 2018 63(5):386-390
Context: Acne vulgaris is a disorder showing persistent inflammation in the pilosebaceous follicles. It is one of the most prevalent dermatoses that millions of people suffer from globally. Aim: The aim of this study was to identify Candida species from patients with acne and to determine their drugs susceptibility. Subjects and Methods: A total of 70 cutaneous samples from acne vulgaris patients suspected to have Candida infections were collected. Macroscopic and microscopic morphology were recorded followed by polymerase chain reaction-sequencing of ITS regions, using universal primers. In vitro antifungal susceptibility was performed using Clinical and Laboratory Standards Institute method. Results: Overall, 11 Candida species including Candida parapsilosis 8 (72.73%), Candida krusei 1 (12.5%), Candida lusitaniae 1 (12.5%), Candida kefyr 1 (12.5%), and a Trichosporon asahi out of the collected clinical materials were isolated and identified. C. parapsilosis isolates susceptibility to diverse concentrations of the antifungal agents to isolate Cp1 study indicated that the isolated Cp8 and Cp5 with minimal inhibitory concentration (MIC) 50 = 32, 0.5, 0.25 and MIC 90 of <64, <1, <0.5 μg/ml fluconazole, itraconazole, and ketoconazole were resistant, respectively. Some of the isolates having relative strength, almost all other species of C. parapsilosis isolates were susceptible to these drugs. Conclusion: C. parapsilosis was the most prevalent Candida species in acne vulgaris samples which had higher in vitro susceptibility for antifungals.
Dermatofibrosarcoma protuberans secondary to a decorative tattoo: An Isotattootopic Response?
Irene Lastrucci, Susanna Gunnella, Alessandro Pileri, Vincenza Maio, Vieri Grandi
Indian Journal of Dermatology 2018 63(5):439-440
Indian Journal of Dermatology 2018 63(5):439-440
Sensitization to fungi in atopic dermatitis patients 14 year and older – Association with other atopic diseases and parameters
Jarmila Celakovska, Bukac Josef, Karel Ettler, Jaroslava Vaneckova, Kvetuse Ettlerova, Krejsek Jan
Indian Journal of Dermatology 2018 63(5):391-398
Background: Fungi as a source of allergen are still largely neglected in basic research as well as in clinical practice. This study aimed to highlight the impact of fungal allergens in a group of patients suffering from atopic dermatitis (AD). Aims and Objectives: The evaluation of the sensitization to fungi in AD patients aged 14 year and older and the evaluation of the relation of fungal sensitization to the occurrence of other atopic diseases and parameters. Materials and Methods: All patients satisfying inclusion criteria attending our hospital between 2008 and 2017 were included in the study. The complete dermatological and allergological examinations were performed in all included patients including examination of specific immunoglobulin E, skin prick test to mixture of fungi and inhalant allergens, evaluation of asthma bronchiale, rhinitis, onset of AD, family history about atopy, duration of eczematous lesions, severity of AD. Pairs of these categories were entered in the contingency tables and the Chi-square test for relationship of these variables was performed with the level of significance set below 5%. Results: Three hundred and thirty-one patients were included in the study; the average age was 26.8 years. The sensitization to fungi was recorded in 100 patients (30%). In these patients, the occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher than in patients without sensitization to fungi. We did not find any significant relation between the sensitization to fungi and the severity of AD, no relation was also found between the sensitization to fungi and sensitization to mites, animal dander, bird feather, and dust. Conclusion: The occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher in AD patients with sensitization to fungi. No relation was found between the severity of AD and the sensitization to fungi.
Indian Journal of Dermatology 2018 63(5):391-398
Background: Fungi as a source of allergen are still largely neglected in basic research as well as in clinical practice. This study aimed to highlight the impact of fungal allergens in a group of patients suffering from atopic dermatitis (AD). Aims and Objectives: The evaluation of the sensitization to fungi in AD patients aged 14 year and older and the evaluation of the relation of fungal sensitization to the occurrence of other atopic diseases and parameters. Materials and Methods: All patients satisfying inclusion criteria attending our hospital between 2008 and 2017 were included in the study. The complete dermatological and allergological examinations were performed in all included patients including examination of specific immunoglobulin E, skin prick test to mixture of fungi and inhalant allergens, evaluation of asthma bronchiale, rhinitis, onset of AD, family history about atopy, duration of eczematous lesions, severity of AD. Pairs of these categories were entered in the contingency tables and the Chi-square test for relationship of these variables was performed with the level of significance set below 5%. Results: Three hundred and thirty-one patients were included in the study; the average age was 26.8 years. The sensitization to fungi was recorded in 100 patients (30%). In these patients, the occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher than in patients without sensitization to fungi. We did not find any significant relation between the sensitization to fungi and the severity of AD, no relation was also found between the sensitization to fungi and sensitization to mites, animal dander, bird feather, and dust. Conclusion: The occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher in AD patients with sensitization to fungi. No relation was found between the severity of AD and the sensitization to fungi.
Antifungal resistance in dermatology
Varadraj Pai, Ajantha Ganavalli, Naveen Narayanshetty Kikkeri
Indian Journal of Dermatology 2018 63(5):361-368
Cutaneous fungal infections affect more than one-fourth of world's population. The pathogenesis and severity of fungal infection depend on various immunological and nonimmunological factors. The rampant use of antifungal therapy in immunocompromised individuals marked the onset of antifungal drug resistance. Fungal resistance can be microbiological or clinical. Microbiological resistance depends on various fungal factors which have established due to genetic alteration in the fungi. Clinical resistance is due to host- or drug-related factors. All these factors may cause fungal resistance individually or in tandem. In addition to standardized susceptibility testing and appropriate drug dosing, one of the ways to avoid resistance is the use of combinational antifungal therapy. Combination therapy also offers advantages in increased synergistic action with enhanced spectrum activity. Newer insights into mechanisms of drug resistance will help in the development of appropriate antifungal therapy.
Indian Journal of Dermatology 2018 63(5):361-368
Cutaneous fungal infections affect more than one-fourth of world's population. The pathogenesis and severity of fungal infection depend on various immunological and nonimmunological factors. The rampant use of antifungal therapy in immunocompromised individuals marked the onset of antifungal drug resistance. Fungal resistance can be microbiological or clinical. Microbiological resistance depends on various fungal factors which have established due to genetic alteration in the fungi. Clinical resistance is due to host- or drug-related factors. All these factors may cause fungal resistance individually or in tandem. In addition to standardized susceptibility testing and appropriate drug dosing, one of the ways to avoid resistance is the use of combinational antifungal therapy. Combination therapy also offers advantages in increased synergistic action with enhanced spectrum activity. Newer insights into mechanisms of drug resistance will help in the development of appropriate antifungal therapy.
Impact on quality of life in vitiligo patients treated with narrowband ultraviolet B phototherapy
Yatendra S Chahar, Pramod Kumar Singh, Vijay Kumar Sonkar, Inder Rajani, Mohammad Adil
Indian Journal of Dermatology 2018 63(5):399-402
Context: Vitiligo is a psychosocial problem which significantly affects quality of life in Indian scenario. Aims: The purpose of this study was to compare the changes in quality of life in patients of vitiligo before and after treatment with narrowband ultraviolet B (NBUVB) phototherapy. Subjects and Methods: A total of 54 patients had completed the study. The age ranged between 16 and 70 years with a mean age of 26.77±14.2 years. The initial dose of NBUVB was 300 mJ/cm2 in adults and 150 mJ/cm2 in children twice weekly with 20% dose increment on subsequent visits. It was given for a maximum period of 6 months and was followed up for another 6 months to determine stability of repigmentation. Results: The average number of exposure given to the patients was 45.63±12.74 while the mean irradiation cumulative dose was 39.8 J/cm2. Mean Dermatology Life Quality Index (DLQI) of the vitiligo patients was 8.64±4.32 while those patients with acrofacial vitiligo had a mean DLQI of 11.78±5.61. After treatment with NBUVB, mean DLQI of all vitiligo patients was significantly reduced to 5.86±2.15 (P<0.01). Conclusions: This study showed that phototherapy had a positive therapeutic outcome in vitiligo, especially in younger patients. Even a small, depigmented lesion in a child could be psychosocially devastating.
Indian Journal of Dermatology 2018 63(5):399-402
Context: Vitiligo is a psychosocial problem which significantly affects quality of life in Indian scenario. Aims: The purpose of this study was to compare the changes in quality of life in patients of vitiligo before and after treatment with narrowband ultraviolet B (NBUVB) phototherapy. Subjects and Methods: A total of 54 patients had completed the study. The age ranged between 16 and 70 years with a mean age of 26.77±14.2 years. The initial dose of NBUVB was 300 mJ/cm2 in adults and 150 mJ/cm2 in children twice weekly with 20% dose increment on subsequent visits. It was given for a maximum period of 6 months and was followed up for another 6 months to determine stability of repigmentation. Results: The average number of exposure given to the patients was 45.63±12.74 while the mean irradiation cumulative dose was 39.8 J/cm2. Mean Dermatology Life Quality Index (DLQI) of the vitiligo patients was 8.64±4.32 while those patients with acrofacial vitiligo had a mean DLQI of 11.78±5.61. After treatment with NBUVB, mean DLQI of all vitiligo patients was significantly reduced to 5.86±2.15 (P<0.01). Conclusions: This study showed that phototherapy had a positive therapeutic outcome in vitiligo, especially in younger patients. Even a small, depigmented lesion in a child could be psychosocially devastating.
A case of bullous pemphigoid associated with lichen sclerosus et atrophicus
Asuka Yoshifuku, Aoi Okubo, Nozomi Jimura, Kazuyasu Fujii, Yuko Higashi, Takuro Kanekura
Indian Journal of Dermatology 2018 63(5):427-428
Indian Journal of Dermatology 2018 63(5):427-428
A comparative study of combined dermaroller and platelet-rich plasma versus dermaroller alone in acne scars and assessment of quality of life before and after treatment
Shefali Porwal, Yatendra Singh Chahar, Pramod Kumar Singh
Indian Journal of Dermatology 2018 63(5):403-408
Background: Scarring due to acne is a frequently encountered problem in dermatological outpatient department. Microneedling has been a well-accepted modality for the treatment of atrophic acne scars. Platelet-rich plasma (PRP) is a newer option to investigate. Aims: The aims of this study were (1) to compare the efficacy of combined dermaroller and PRP therapy with dermaroller alone in facial acne scars and (2) to assess the psychosocial impact due to acne scars and its treatment. Methods: A total of 55 patients were included in the study and randomly divided into two groups, Group A: 28 and Group B: 27. Proper counseling was done, and detailed clinical findings were recorded. Patients in Group A were treated with dermaroller alone while Group B patients underwent treatment with a combination of dermaroller and intradermal PRP injections. A total of three sitting were done at monthly interval. Final response was assessed at 1 month after the last sitting. Criteria of evaluation included Goodman and Baron's quantitative scale, visual analog score, and dermatology life quality index scores. Side effects were noted. Results were analyzed using Chi-square test and t-test. Results: Significant percentage improvement was noted in both the groups. However, Group B treated with both modalities had better results when compared with that in the Group A. Conclusion: A combination approach using dermaroller and PRP was a safe and better option than using dermaroller alone in atrophic acne scars for clinical improvement as well as for improvement in dermatology life quality index score.
Indian Journal of Dermatology 2018 63(5):403-408
Background: Scarring due to acne is a frequently encountered problem in dermatological outpatient department. Microneedling has been a well-accepted modality for the treatment of atrophic acne scars. Platelet-rich plasma (PRP) is a newer option to investigate. Aims: The aims of this study were (1) to compare the efficacy of combined dermaroller and PRP therapy with dermaroller alone in facial acne scars and (2) to assess the psychosocial impact due to acne scars and its treatment. Methods: A total of 55 patients were included in the study and randomly divided into two groups, Group A: 28 and Group B: 27. Proper counseling was done, and detailed clinical findings were recorded. Patients in Group A were treated with dermaroller alone while Group B patients underwent treatment with a combination of dermaroller and intradermal PRP injections. A total of three sitting were done at monthly interval. Final response was assessed at 1 month after the last sitting. Criteria of evaluation included Goodman and Baron's quantitative scale, visual analog score, and dermatology life quality index scores. Side effects were noted. Results were analyzed using Chi-square test and t-test. Results: Significant percentage improvement was noted in both the groups. However, Group B treated with both modalities had better results when compared with that in the Group A. Conclusion: A combination approach using dermaroller and PRP was a safe and better option than using dermaroller alone in atrophic acne scars for clinical improvement as well as for improvement in dermatology life quality index score.
Familiar manifestations of unfamiliar selenium toxicity
Banashree Majumdar, Nirmala Saini, Shweta Agrawal, Chiatra Prakash
Indian Journal of Dermatology 2018 63(5):430-431
Indian Journal of Dermatology 2018 63(5):430-431
Idiopathic eruptive macular pigmentation - uncommon presentation of an uncommon condition
Resham Jayvant Vasani
Indian Journal of Dermatology 2018 63(5):409-411
Idiopathic eruptive macular pigmentation (IEMP) is an asymptomatic condition with dark brown, nonconfluent lesions chiefly occurring in children and adolescents. The usual sites involved are face, trunk, extremities, and the lesions resolve over few months to years. We report an unusual presentation of this uncommon condition. A 22-year-old male presented with multiple dark-colored asymptomatic lesions on the scalp and forehead for the past 3 years. There was no history of preceding symptoms, drug, or applications, past or family history of such lesions. Examination revealed multiple hyperpigmented macules and barely elevated nonscaly plaques with a velvety feel akin to acanthosis nigricans (AN). Dermoscopy was similar to AN. Blood sugar, thyroid, and lipid profiles were normal. Histology showed "pigmented papillomatosis" concluding the final diagnosis of IEMP. Confluence of lesions is a rarely described phenomenon, with the scalp being a hitherto unreported site. The velvety feel of lesions, the dermoscopic, and histopathological findings further substantiate the hypothesis of this entity being an eruptive variant of AN.
Indian Journal of Dermatology 2018 63(5):409-411
Idiopathic eruptive macular pigmentation (IEMP) is an asymptomatic condition with dark brown, nonconfluent lesions chiefly occurring in children and adolescents. The usual sites involved are face, trunk, extremities, and the lesions resolve over few months to years. We report an unusual presentation of this uncommon condition. A 22-year-old male presented with multiple dark-colored asymptomatic lesions on the scalp and forehead for the past 3 years. There was no history of preceding symptoms, drug, or applications, past or family history of such lesions. Examination revealed multiple hyperpigmented macules and barely elevated nonscaly plaques with a velvety feel akin to acanthosis nigricans (AN). Dermoscopy was similar to AN. Blood sugar, thyroid, and lipid profiles were normal. Histology showed "pigmented papillomatosis" concluding the final diagnosis of IEMP. Confluence of lesions is a rarely described phenomenon, with the scalp being a hitherto unreported site. The velvety feel of lesions, the dermoscopic, and histopathological findings further substantiate the hypothesis of this entity being an eruptive variant of AN.
Kaposi's varicelliform eruption in a patient with darier's disease
Irene Garcia-Morales, Sandra Case-Mérida, Jerónimo Escudero
Indian Journal of Dermatology 2018 63(5):434-435
Indian Journal of Dermatology 2018 63(5):434-435
A distinct clinicopathological presentation of cutaneous dermatophytosis mimicking autoimmune blistering disorder
Jignaben Krunal Padhiyar, Nayankumar Harshadkumar Patel, Trusha Gajjar, Bhagirath Patel, Aseem Chhibber, Mansi Buch
Indian Journal of Dermatology 2018 63(5):412-414
Infectious diseases can clinically present as vesiculobullous disorders. Direct immunofluorescence (DIF) study of skin biopsy helps distinguish true autoimmune blistering disorders from other conditions. In many situations, even DIF findings in infections disorders imitate autoimmune process. Here, we describe a case of 29-year-old female with extensive dermatophytosis having presentation mimicking bullous pemphigoid both clinically and histopathologically including DIF findings.
Indian Journal of Dermatology 2018 63(5):412-414
Infectious diseases can clinically present as vesiculobullous disorders. Direct immunofluorescence (DIF) study of skin biopsy helps distinguish true autoimmune blistering disorders from other conditions. In many situations, even DIF findings in infections disorders imitate autoimmune process. Here, we describe a case of 29-year-old female with extensive dermatophytosis having presentation mimicking bullous pemphigoid both clinically and histopathologically including DIF findings.
A bibliometric evaluation of global productivity of teledermatology publications between 1975 and 2017 with a 3-year update
Engin Senel, Emre Demir, Refika Ferda Artüz
Indian Journal of Dermatology 2018 63(5):437-439
Indian Journal of Dermatology 2018 63(5):437-439
BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation
B lymphocyte-induced maturation protein-1 (BLIMP1) encoded by the PRDM1 gene belongs to the PRDM family of transcription repressor. BLIMP1 lacks intrinsic histone methyltransferase activity and serves as a scaffold for numerous epigenetic regulators to modulate DNA binding, gene silencing and chromatin reorganization [1,2]. Beside the well-known master regulator of B lymphocyte differentiation, BLIMP1 controls the development of various immune cells [3–7]. Thus, BLIMP1 is critical in maintenance of immune homeostasis, and dysfunction of BLIMP1 may contribute to autoimmune disorders.
NEUTROPHILS CONTRIBUTE TO VASCULITIS BY INCREASED RELEASE OF NEUTROPHIL EXTRACELLULAR TRAPS IN BEHÇET’S DISEASE
Bechet's disease (BD) is an inflammatory multi-system disorder causing recurrent oral and genital ulcers, uveitis, and vasculitis, in addition to cutaneous, neurological, gastrointestinal, articular and pulmonary manifestations [1]. Mild cases are treated with Colchicine, an anti-inflammatory drug. Severe cases can be life threatening and require systemic steroids, anti-TNFα drugs and immunosuppressants. Its pathophysiology is poorly known. Genetic studies identified several susceptibility loci implicating MHC1 and innate immunity genes namely HLA-B51, ERAP1, IL10, IL23R-IL12RB2, and IL1 A-IL1B [2–4].
Low-dose UVB therapy is comparable with conventional UVB phototherapy for treatment of vitiligo: A pilot study
UVB phototherapy is currently considered as the treatment of choice for vitiligo [1]. UVB is also used for treating inflammatory conditions including psoriasis. Although the major goals for treating vitiligo and psoriasis are different: one aims to bio-stimulate while the other aims to immune modulate, respectively, the protocols of phototherapy are surprisingly similar. More specifically, for narrow-band UVB (NBUVB) treatment of vitiligo, lesion repigmentation is associated with melanocyte precursor cell activation [2].
Non‐healing herpes zoster ophthalmicus
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Dissecting folliculitis (dissecting cellulitis) of the scalp: a 66‐patient case series and proposal of classification
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Antibacterial Effectiveness of Rice Water (Starch) Capped Silver Nanoparticles Fabricated Rapidly in Presence of Sunlight
Photochemistry and Photobiology, Volume 0, Issue ja, -Not available-.
Assessment of endothelial function during the loading phase of infliximab in psoriasis: a potential predictor of its drug survival
International Journal of Dermatology, EarlyView.
Basal cell carcinoma treated with Mohs micrographic surgery in young Ibero‐American patients
International Journal of Dermatology, EarlyView.
Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review
International Journal of Dermatology, EarlyView.
Controversies in off‐label prescriptions in dermatology: the perspective of the patient, the physician, and the pharmaceutical companies
International Journal of Dermatology, EarlyView.
Specific foot health‐related quality‐of‐life impairment in patients with type II versus type I diabetes
International Wound Journal, EarlyView.
The first ever reported case of malignant fibrous histiocytoma of the scalp
International Wound Journal, EarlyView.
Secondary‐intention healing following Mohs micrographic surgery for squamous cell carcinoma of a finger
International Wound Journal, EarlyView.
Prevention of hypergranulation tissue after gastrostomy tube placement: A randomised controlled trial of hydrocolloid dressings
International Wound Journal, EarlyView.
Percutan nasal septal retraction technique for dorsal cartilagenous deviations
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
The Effect of Ventilation Tube Insertion to the Health‐Related Quality of Life in a Group of Children in Southeast Anatolia
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
Fluoroscopic Balloon Diameter Measurement at Different Pressures during Eustachian Balloon Dilation
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
Atopic Dermatitis and Cancer in Solid Organs: a Systematic Review and Meta‐Analysis
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Creation and pilot test results of the dermatology‐specific proxy instrument the Infants and Toddlers Dermatology Quality of Life
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Evaluation of a non‐ablative, fractional 1565 nm laser for the improvement of striae distensae albae
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Investigation of the Predisposing Factor of Pemphigus and its clinical subtype through a Genome‐wide association and next generation sequence analysis
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Chromoblastomycosis: an autochthonous case of a tropical disease
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Bier's spots
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
The impact of atopic dermatitis on sexual health
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Manipulating mindsets to improve patient outcomes: Is it ethical? Can it be avoided?
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Does the Dermatology Life Quality Index (DLQI) underestimate the disease‐specific burden of psoriasis patients?
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Terminal osseous dysplasia presenting with intracytoplasmic inclusion bodies in digital fibromas
Pediatric Dermatology, EarlyView.
Vancomycin‐induced red man syndrome presentation in a preterm infant
Pediatric Dermatology, EarlyView.
The value of full‐body skin examination: Poland syndrome diagnosed as an incidental finding
Pediatric Dermatology, EarlyView.
An atypical presentation of herpes simplex virus infection in Harlequin ichthyosis
Pediatric Dermatology, EarlyView.
Localized infantile hemangiomas of the face and scalp: Predilection for the midline and periorbital and perioral skin
Pediatric Dermatology, EarlyView.
Ulcerated congenital plexiform fibrohistiocytic tumor: Case report and literature review
Pediatric Dermatology, EarlyView.
Chronic urticaria in infants as the first manifestation of autoinflammatory disease
Pediatric Dermatology, EarlyView.
Pediatric ocular lichen planus and lichen planopilaris: One new case and a review of the literature
Pediatric Dermatology, EarlyView.
Prolonged migraine aura: new insights from a prospective diary-aided study
There is limited literature on prolonged aura (PA - defined as an aura including at least one symptom for > 1 h and
Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)
We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was unde...
New CACNA1A deletions are associated to migraine phenotypes
Familial hemiplegic migraine type 1 (FHM1) is a form of migraine with aura caused by heterozygous mutations in 4 genes: CACNA1A, ATP1A2, SNC1A and PRRT2, but further heterogeneity is expected. Here have been desc...
A Milroy case with FLT4/VEGFR3 mutation and an unusual skin biopsy
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Fatigue and the wear‐off effect in adult patients with common variable immunodeficiency
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
Perfused 3D angiogenic sprouting in a high-throughput in vitro platform
Abstract
Angiogenic sprouting, the growth of new blood vessels from pre-existing vessels, is orchestrated by cues from within the cellular microenvironment, such as biochemical gradients and perfusion. However, many of these cues are missing in current in vitro models of angiogenic sprouting. We here describe an in vitro platform that integrates both perfusion and the generation of stable biomolecular gradients and demonstrate its potential to study more physiologically relevant angiogenic sprouting and microvascular stabilization. The platform consists of an array of 40 individually addressable microfluidic units that enable the culture of perfused microvessels against a three-dimensional collagen-1 matrix. Upon the introduction of a gradient of pro-angiogenic factors, the endothelial cells differentiated into tip cells that invaded the matrix. Continuous exposure resulted in continuous migration and the formation of lumen by stalk cells. A combination of vascular endothelial growth factor-165 (VEGF-165), phorbol 12-myristate 13-acetate (PMA), and sphingosine-1-phosphate (S1P) was the most optimal cocktail to trigger robust, directional angiogenesis with S1P being crucial for guidance and repetitive sprout formation. Prolonged exposure forces the angiogenic sprouts to anastomose through the collagen to the other channel. This resulted in remodeling of the angiogenic sprouts within the collagen: angiogenic sprouts that anastomosed with the other perfusion channel remained stable, while those who did not retracted and degraded. Furthermore, perfusion with 150 kDa FITC-Dextran revealed that while the angiogenic sprouts were initially leaky, once they fully crossed the collagen lane they became leak tight. This demonstrates that once anastomosis occurred, the sprouts matured and suggests that perfusion can act as an important survival and stabilization factor for the angiogenic microvessels. The robustness of this platform in combination with the possibility to include a more physiological relevant three-dimensional microenvironment makes our platform uniquely suited to study angiogenesis in vitro.
Removal of hexavalent chromium from water by modified sponge iron particles and insights into mechanism
Abstract
Sponge iron particles modified with expanded graphite and Cu were used to purify solutions contaminated with aqueous Cr(VI). A removal mechanism that involved physical adsorption and a redox reaction is proposed. The reaction, which consisted of rapid adsorption, a desorption stage, and an adsorption–desorption equilibrium stage, corresponded to a first-order kinetic model. The properties of the adsorption materials before and after use were investigated by X-ray diffraction, scanning electron microscopy–energy-dispersive spectroscopy, Fourier-transform infrared spectroscopy, energy-dispersive X-ray fluorescence spectroscopy, and surface area measurements. Changes in the surface properties, e.g., attachment of material to the surface and filling of pores with Cr, were clearly observed. The Langmuir model best described Cr(VI) adsorption on the sponge iron and its modified particles. Removal efficiencies of 98.7, 98.8, and 100% were achieved in 7 h at a Cr(VI) dosage of 10 mg/L. Sponge iron particles are therefore potential adsorbents and after modification give good removal of Cr(VI) ions from contaminated water.
Familial acanthosis nigricans with the FGFR3 mutation: Differences of pigmentation between male and female patients
The Journal of Dermatology, EarlyView.
Efficiency of methylene blue mediated photodynamic therapy versus intense pulsed light in the treatment of onychomycosis in the toenails
Photodermatology, Photoimmunology &Photomedicine, Volume 0, Issue ja, -Not available-.
Diagnostic ultrasonography in a child with eosinophilic fasciitis
Clinical and Experimental Dermatology, EarlyView.
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Publication date: Available online 25 July 2018 Source: Journal of Photochemistry and Photobiology B: Biology Author(s): Marco Ballestr...
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Editorial AJR Reviewers: Heartfelt Thanks From the Editors and Staff Thomas H. Berquist 1 Share + Affiliation: Citation: American Journal...
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https://www.youtube.com/watch?v=DFOhpBjLqN4&t=1s , Η ΘΕΡΑΠΕΙΑ ΓΙΑ ΟΛΕΣ ΤΙΣ ΑΣΘΕΝΕΙΕΣ 1 Περιεχόμενα Σύντομο βιογραφικό Πρόλογος μεταφραστ...
