Introduction: The aim of this study was to assess the biocompatibility of several intra-tympanic (IT) drug delivery vehicles and to compare hearing outcomes. Materials and Methods: After acute acoustic trauma, rats were treated with IT 10 mg/mL dexamethasone phosphate (D) and divided into the following groups for drug delivery: saline + D (n = 15), hyaluronic acid (HA) + D (n = 17), and methoxy polyethylene glycol-b-polycaprolactone block copolymer (MP) + D (n = 24). Results: No inflammation was...
Wed May 13, 2020 14:27
Background: Most of the evidence explaining the language-literacy link is derived from children learning to read and write alphabetic orthography. Aim: This study investigated the literacy deficits in children learning to read Kannada, a Dravidian language that employs an alphasyllabary. Methods: A group of 15 children with language impairment (CwLI) was compared with two groups of control (age- and language-matched) participants on a range of literacy measures. Results: The results showed that,...
Wed May 13, 2020 14:33
Abstract In everyday contexts, children must respond to both self-related constraints (their own skills and abilities) and environmental constraints (external obstacles and goals). How do young children simultaneously accommodate these to support skilled and flexible behaviour? We used walking in a complex environment as a testbed for two hypotheses. Hypothesis 1: children will accommodate the self-related constraint of high foot placement variability via dynamic scaling. Hypothesis...
Wed May 13, 2020 03:00
Publication date: Available online 13 May 2020Source: NeoplasiaAuthor(s): Suzie K. Hight, Allison Mootz, Rahul K. Kollipara, Elizabeth McMillan, Paul Yenerall, Yoichi Otaki, Long-Shan Li, Kimberley Avila, Michael Peyton, Jaime Rodriguez, Barbara Mino, Pamela Villalobos, Luc Girard, Patrick Dospoy, Jill Larsen, Michael A. White, John V. Heymach, Ignacio I. Wistuba, Ralf Kittler, John D. Minna
Wed May 13, 2020 14:59
Related ArticlesCD200 and CD200R1 are differentially expressed and have differential prognostic roles in non-small cell lung cancer. Oncoimmunology. 2020;9(1):1746554 Authors: Yoshimura K, Suzuki Y, Inoue Y, Tsuchiya K, Karayama M, Iwashita Y, Kahyo T, Kawase A, Tanahashi M, Ogawa H, Inui N, Funai K, Shinmura K, Niwa H, Sugimura H, Suda T Abstract CD200, a member of the immunoglobulin superfamily, interacts with its receptor CD200R1 to modulate cancer...
Wed May 13, 2020 14:52
Related ArticlesPerspectives on Spinal Dysraphism : Past, Present, and Future. J Korean Neurosurg Soc. 2020 May;63(3):366-372 Authors: Pang D Abstract This article recounts the author's personal views and recollections of the history, conception of embryogenetic theories, application of intraoperative electrophysiology, and development of prospective treatment recommendations of several important spinal dysraphic malformations, including limited dorsal...
Wed May 13, 2020 14:51
Related ArticlesUrological Evaluation of Tethered Cord Syndrome. J Korean Neurosurg Soc. 2020 May;63(3):358-365 Authors: Park K Abstract To describe how to perform urological evaluation in children with tethered cord syndrome (TCS). Although a common manifestation of TCS is the development of neurogenic bladder in developing children, neurosurgeons often face difficulty in detecting urological problems in patients with TCS. From a urological perspective,...
Wed May 13, 2020 14:51
Related ArticlesSurgical Management of Complex Spinal Cord Lipomas : A New Perspective. J Korean Neurosurg Soc. 2020 May;63(3):279-313 Authors: Pang D Abstract This review summarises the classification, anatomy and embryogenesis of complex spinal cord lipomas, and describes in some detail the new technique of total lipoma resection and radical reconstruction of the affected neural placode. Its specific mission is to tackle two main issues surrounding...
Wed May 13, 2020 14:51
The Journal of Antibiotics, Published online: 13 May 2020; doi:10.1038/s41429-020-0315-4Diterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth
Wed May 13, 2020 03:00
Wed May 13, 2020 03:00
The Journal of Antibiotics, Published online: 13 May 2020; doi:10.1038/s41429-020-0309-22-Epi-anthracimycin, a new cytotoxic agent from the marine-derived actinomycete Streptomyces sp. OPMA00631
Wed May 13, 2020 03:00
Wed May 13, 2020 03:00
Related ArticlesAntibiotic usage in hospitalized patients: a one-day point prevalence study. J Chemother. 2020 May 12;:1-5 Authors: Karabay O, Ince N, Aypak A, Guclu E, Bodur H, Group EKMUD Antibiotic Study Abstract Measurements are one of the most important means of evaluating the quality of antibiotic consumption. This study has evaluated the antibiotic consumption using one-day point prevalence study data collected from different hospitals in Turkey....
Wed May 13, 2020 14:47
Related ArticlesMethicillin-resistant Staphylococcus aureus replication in the presence of high (≥32 µg/ml) drug concentration of vancomycin as seen by electron microscopy. J Chemother. 2020 May 12;:1-9 Authors: Alsaeed A, Wright G, Deneer H, Rubin JE, Sanche SE, Blondeau JM Abstract Methicillin-resistant Staphylococcus aureus (MRSA) has unfortunately become a common pathogen in many healthcare facilities. In many institutions, vancomycin remains the...
Wed May 13, 2020 14:47
Abstract Purpose This work aims at describing a technique “The ALblation technique” for treating migraine headache. This technique describes radiofrequency ablation for supraorbital, supratrochlear, lesser occipital and greater occipital nerves bilaterally for treating migraine headache. This is a novel procedure that was not described before. Recent findings...
Wed May 13, 2020 03:00
Related ArticlesIn vivo near-infrared fluorescent optical imaging for CNS drug discovery. Expert Opin Drug Discov. 2020 May 12;:1-13 Authors: Moreno MJ, Ling B, Stanimirovic DB Abstract Introduction: In vivo imaging technologies have become integral and essential component of drug discovery, development, and clinical assessment for central nervous system (CNS) diseases. Near-infrared (NIR) fluorescence imaging in the range of 650-950 nm is widely used...
Wed May 13, 2020 14:41
Related ArticlesCurrent models of pulmonary fibrosis for future drug discovery efforts. Expert Opin Drug Discov. 2020 May 12;:1-11 Authors: Yanagihara T, Chong SG, Vierhout M, Hirota JA, Ask K, Kolb M Abstract Introduction: Pulmonary fibrosis includes several lung disorders characterized by progressive fibrosis, of which idiopathic pulmonary fibrosis (IPF) is a particularly severe form with a median survival time of 3-5 years after diagnosis. Although...
Wed May 13, 2020 14:41
Related ArticlesSCeQTL: an R package for identifying eQTL from single-cell parallel sequencing data. BMC Bioinformatics. 2020 May 11;21(1):184 Authors: Hu Y, Xi X, Yang Q, Zhang X Abstract BACKGROUND: With the rapid development of single-cell genomics, technologies for parallel sequencing of the transcriptome and genome in each single cell is being explored in several labs and is becoming available. This brings us the opportunity to uncover association...
Wed May 13, 2020 14:37
Related ArticlesMulti-task learning sparse group lasso: a method for quantifying antigenicity of influenza A(H1N1) virus using mutations and variations in glycosylation of Hemagglutinin. BMC Bioinformatics. 2020 May 11;21(1):182 Authors: Li L, Chang D, Han L, Zhang X, Zaia J, Wan XF Abstract BACKGROUND: In addition to causing the pandemic influenza outbreaks of 1918 and 2009, subtype H1N1 influenza A viruses (IAVs) have caused seasonal epidemics since...
Wed May 13, 2020 14:37
Related ArticlesmethCancer-gen: a DNA methylome dataset generator for user-specified cancer type based on conditional variational autoencoder. BMC Bioinformatics. 2020 May 11;21(1):181 Authors: Choi J, Chae H Abstract BACKGROUND: Recently, DNA methylation has drawn great attention due to its strong correlation with abnormal gene activities and informative representation of the cancer status. As a number of studies focus on DNA methylation signatures...
Wed May 13, 2020 14:37
Related ArticlesMEPHAS: an interactive graphical user interface for medical and pharmaceutical statistical analysis with R and Shiny. BMC Bioinformatics. 2020 May 11;21(1):183 Authors: Zhou Y, Leung SW, Mizutani S, Takagi T, Tian YS Abstract BACKGROUND: Even though R is one of the most commonly used statistical computing environments, it lacks a graphical user interface (GUI) that appeals to students, researchers, lecturers, and practitioners in medicine...
Wed May 13, 2020 14:37
Related ArticlesCluster correlation based method for lncRNA-disease association prediction. BMC Bioinformatics. 2020 May 11;21(1):180 Authors: Yuan Q, Guo X, Ren Y, Wen X, Gao L Abstract BACKGROUND: In recent years, increasing evidences have indicated that long non-coding RNAs (lncRNAs) are deeply involved in a wide range of human biological pathways. The mutations and disorders of lncRNAs are closely associated with many human diseases. Therefore, it...
Wed May 13, 2020 14:37
Related ArticlesSpatiotemporal photosynthetic physiology responses of remnant Myricaria laxiflora populations to regulated water level fluctuations. Conserv Physiol. 2020;8(1):coaa020 Authors: Guan SP, Chen FQ, Zhou JM, Xie ZQ, Huang YW Abstract The construction of the Three Gorges-Gezhouba Dam cascade hydropower station has changed the water level fluctuation pattern of the habitats for remnant rare and endangered Myricaria laxiflora populations downstream...
Wed May 13, 2020 14:32
Publication date: Available online 12 May 2020Source: Journal of Bodywork and Movement TherapiesAuthor(s): Cíntia Domingues de Freitas, Deborah Araujo Costa, Nelson Carvas Junior, Vinicius Tassoni Civile
Wed May 13, 2020 14:29
Related ArticlesEffect of lumbar medial branch blocks on extension-related axial chronic low back pain in a pediatric population: a retrospective chart review and prospective follow-up. Reg Anesth Pain Med. 2020 May 10;: Authors: Donado C, Spagnuolo GM, Lobo K, Berde C, Dinakar P PMID: 32393524 [PubMed - as supplied by publisher]
Wed May 13, 2020 14:27
Related ArticlesChanges in Pharyngeal Baseline Impedance in Patients With Laryngopharyngeal Reflux. Otolaryngol Head Neck Surg. 2020 May 12;:194599820918820 Authors: Doo JG, Kim SI, Park JM, Kwon OE, Lee YC, Eun YG Abstract OBJECTIVE: Few studies have investigated pharyngeal intraluminal baseline impedance (BI) levels in patients with laryngopharyngeal reflux (LPR). The aim of this study was to compare intraluminal BI levels between patients with...
Wed May 13, 2020 14:18
Related ArticlesElective Tracheostomy During Mechanical Ventilation in Patients Affected by COVID-19: Preliminary Case Series From Lombardy, Italy. Otolaryngol Head Neck Surg. 2020 May 12;:194599820928963 Authors: Turri-Zanoni M, Battaglia P, Czaczkes C, Pelosi P, Castelnuovo P, Cabrini L Abstract The COVID-19 outbreak poses continued struggles due to the unprecedented number of patients admitted to intensive care units and the overwhelming need...
Wed May 13, 2020 14:18
Related ArticlesHigh-Risk Aerosol-Generating Procedures in COVID-19: Respiratory Protective Equipment Considerations. Otolaryngol Head Neck Surg. 2020 May 12;:194599820927335 Authors: Howard BE Abstract The correct selection and utilization of respiratory personal protective equipment is of the utmost importance in the current COVID-19 pandemic. This is especially true for health care workers exposed to high-risk aerosol-generating procedures, including...
Wed May 13, 2020 14:18
Related ArticlesOtologic and Audiologic Considerations for COVID-19. Otolaryngol Head Neck Surg. 2020 May 12;:194599820928989 Authors: Eby TL, Arteaga AA, Spankovich C Abstract The COVID-19 pandemic has created a number of considerations for otolaryngology; anosmia and ageusia in particular have gained significant attention. Here we present considerations in regard to treatment with quinine-derived drugs and the influence of masks on communication.PMID:...
Wed May 13, 2020 14:18
Related ArticlesApproaching Otolaryngology Patients During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 May 12;:194599820926144 Authors: Cui C, Yao Q, Zhang D, Zhao Y, Zhang K, Nisenbaum E, Cao P, Zhao K, Huang X, Leng D, Liu C, Li N, Luo Y, Chen B, Casiano R, Weed D, Sargi Z, Telischi F, Lu H, Denneny JC, Shu Y, Liu X Abstract Objective. To describe coronavirus disease 2019 (COVID-19) patient presentations requiring otolaryngology consultation...
Wed May 13, 2020 14:18
Related ArticlesManagement Patterns in Pediatric Complicated Sinusitis. Otolaryngol Head Neck Surg. 2020 May 12;:194599820918832 Authors: McDermott SM, Onwuka A, Elmaraghy C, Walz PC Abstract OBJECTIVES: Sinusitis is a common pediatric illness that can be complicated by periorbital or intracranial extension. Patients can be managed with antimicrobials alone or in conjunction with surgical intervention. This article examines management patterns and...
Wed May 13, 2020 14:18
Related ArticlesErratum to "Appropriateness of Otic Quinolone Use among Privately Insured US Patients". Otolaryngol Head Neck Surg. 2020 May 12;:194599820924651 Authors: PMID: 32396033 [PubMed - as supplied by publisher]
Wed May 13, 2020 14:18
Related ArticlesOtolaryngology Community Operating With Collaboration and Productive Resolve During the COVID-19 Pandemic. Otolaryngol Head Neck Surg. 2020 May 12;:194599820927710 Authors: Denneny JC Abstract In the wake of the tremendous fallout from the COVID-19 pandemic that was mostly negative, I find great optimism and encouragement from the ability of society at all levels to focus on a common problem with a collaborative and productive resolve...
Wed May 13, 2020 14:18
Related ArticlesMedial Sural Artery Musculocutaneous Perforator (MSAP) Flap for Reconstruction of Pharyngoesophageal Defects. Otolaryngol Head Neck Surg. 2020 May 12;:194599820920829 Authors: Taufique ZM, Daar DA, Levine JP, Jacobson AS Abstract We describe the use of the medial sural artery musculocutaneous perforator (MSAP) flap at our institution. It is a relatively new flap, originally described in 2001 for lower extremity defects, that has become...
Wed May 13, 2020 14:18
Related ArticlesAirway Management for Endoscopic Laryngotracheal Stenosis Surgery During COVID-19. Otolaryngol Head Neck Surg. 2020 May 12;:194599820927002 Authors: Prince ADP, Cloyd BH, Hogikyan ND, Schechtman SA, Kupfer RA Abstract The novel coronavirus disease 2019 (COVID-19) pandemic presents unique challenges for surgical management of laryngotracheal stenosis. High viral concentrations in the upper aerodigestive tract, the ability of the virus...
Wed May 13, 2020 14:18
Related ArticlesSubglottic Stenosis: Development of a Clinically Relevant Endoscopic Animal Model. Otolaryngol Head Neck Surg. 2020 May 12;:194599820921404 Authors: Mady LJ, Criado M, Park J, Baddour K, Aral AM, Roy A, Rigatti LH, Kumta PN, Chi DH Abstract OBJECTIVE: Develop a clinically relevant and reproducible endoscopic animal model for subglottic stenosis amenable to testing of minimally invasive therapeutic modalities. STUDY DESIGN:...
Wed May 13, 2020 14:18
Related ArticlesOutpatient Otolaryngology in the Era of COVID-19: A Data-Driven Analysis of Practice Patterns. Otolaryngol Head Neck Surg. 2020 May 12;:194599820928987 Authors: Kasle DA, Torabi SJ, Savoca EL, Judson BL, Manes RP Abstract INTRODUCTION: Coronavirus disease 2019 (COVID-19) has induced a prioritization of acute care and telehealth, affecting the quantity of patients seen and the modality of their care. STUDY DESIGN: Retrospective...
Wed May 13, 2020 14:18
Related ArticlesBudesonide vs Saline Nasal Irrigation in Allergic Rhinitis: A Randomized Placebo-Controlled Trial. Otolaryngol Head Neck Surg. 2020 May 12;:194599820919363 Authors: Periasamy N, Pujary K, Bhandarkar AM, Bhandarkar ND, Ramaswamy B Abstract OBJECTIVES: Budesonide nasal irrigation is currently widely used in the treatment of chronic sinusitis typically following endoscopic sinus surgery to improve inflammatory control. Its application...
Wed May 13, 2020 14:18
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