New approaches for patients with advanced radioiodine-refractory thyroid cancer

xlomafota13 shared this article with you from Inoreader New approaches for patients with advanced radioiodine-refractory thyroid cancer Via radioactive iodine World J Clin Oncol. 2022 Jan 24;13(1):9-27. doi: 10.5306/wjco.v13.i1.9. ABSTRACT The cumulative evidence over the past decades has shown that the incidence of differentiated thyroid carcinoma (DTC) has exponentially increased. Approximately 10% of patients with DTC exhibit recurrent or metastatic disease, and about two-thirds of the latter will be defined as refractory to radioactive iodine (RAIR) treatment. Since this condition implies 10-year survival rates less than 10% after de tection, using available treatments, such as systemic and targeted therapies, have become increasingly relevant. The initiation of these treatments aims to reach stabilization, tumor volume reduction, and/or symptom improvement and it should be decided by highly specialized endocrinologists/oncologists on the basis of patient's features. Considering that despite enlarged progression-free survival was proven, multikinase inhibitors remain non-curative, their benefits last for a limited time and the side effects potentially cause harm and quality of life reduction. In this context, molecular testing of cancer cells provides a promising spectrum of targeted therapies that offer increased compatibility with individual patient needs by improving efficacy, progression free survival, overall survival and adverse events profile. This review article aims to provide a summary of the current therapeutic strategies in advanced RAIR-DTC, including approved target therapies as well as those for < i>off-label use, RAI resensitization agents, and immunotherapy. PMID:35116229 | PMC:PMC8790300 | DOI:10.5306/wjco.v13.i1.9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Updates in hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in 2021

xlomafota13 shared this article with you from Inoreader Updates in hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in 2021 Via Association française pour l'étude du cancer Bull Cancer. 2022 Jan 31:S0007-4551(22)00001-7. doi: 10.1016/j.bulcan.2021.12.009. Online ahead of print. ABSTRACT Overall, 2021 was marked by the confirmation of the major interest of cell cycle inhibitors for hormone receptor (HR) positive/human epidermal growth factor receptor 2 (HER2) negative advanced breast cancers with very high overall survival data exceeding five years for hormone-sensitive disease. Studies have also confirmed the efficacy and safety of this therapeutic class in the elderly population. New cell cycle inhibitors are under development (SHR6390). New combinations are also being evaluated, notably palbociclib with SAR439859 (a new selective estrogen receptor degrader: SERD). Targeting of the Phosphoinositide 3-kinases (PI3K) pathway by taselisib, in hormone-resistant disease with a Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) mutation, modestly improves progression-free survival but with a non-negligible toxicity of the treatment. PMID:35115114 | DOI:10.1016/j.bulcan.2021.12.009 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Bilateral persistent primitive olfactory arteries associated with an accessory anterior cerebral artery

xlomafota13 shared this article with you from Inoreader Bilateral persistent primitive olfactory arteries associated with an accessory anterior cerebral artery Via radiol anat Surg Radiol Anat. 2022 Feb 4. doi: 10.1007/s00276-022-02893-z. Online ahead of print. ABSTRACT Persistent primitive olfactory artery (PPOA) is a relatively rare variation of the proximal anterior cerebral artery (ACA) that generally follows an extreme anteroinferior course and takes a hairpin turn before continuing to the A2 segment of the ACA. This variation is usually seen unilaterally, and the anterior communicating artery (ACoA) is usually long or absent. We herein repor t a case of bilateral persistent PPOAs associated with an accessory ACA. The length of the bilateral A1 segments was normal and the length of the ACoA was normally short. Thus, hypoplasia of the distal A1 segment is important but not necessary for the formation of the PPOA. To our knowledge, no similar cases have been reported in the relevant English language literature. PMID:35122111 | DOI:10.1007/s00276-022-02893-z View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A comprehensive analysis of intratumor microbiome in head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader A comprehensive analysis of intratumor microbiome in head and neck squamous cell carcinoma Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Feb 5. doi: 10.1007/s00405-022-07284-z. Online ahead of print. ABSTRACT PURPOSE: Human microbiome has been considered as the second genome of our body. The intratissue/intratumor microbiome analysis is a relatively new field and deserves more attention. In this study, we conducted a comprehensive analysis of microbiome signatures of head and neck squamous cell carcinoma (HNSC). METHODS: The intratumor microbiome profiling and clinicopathological information about a total of 177 HNSC samples, including 155 tumors and 22 adjacent normal tissues, were obtained from The Cancer Microbiome Atlas (TCMA) and The Cancer Genome Atlas (TCGA) databases. We identified the microbes that differed between tumors and normal tissues, and assessed their utility values as diagnostic biomarkers. The microbiome signatures under different conditions of clinicopathological parameters were also analyzed. RESULTS: The intratissue microbiome profiles differed between tumor and normal samples of HNSC. The composition of four, six, and six microbes changed in tumors compared to normal tissues at the phylum, order, and genus levels, respectively (P < 0.05). Eight of the differential microbes performed well in distinguishing tumors from normal tissues (AUC > 0.7, P ≤ 0.001). The microbiome signature was found to be associated with tumor clinicopathological characteristics such as host-gender, host-age, tumor stage, and neoplasm histologic grade. CONCLUSION: Overall, our results revealed an intratissue microbiome signature of HNSC. We concluded that the intratumor microbiome signature may also reflect human biology in both healthy and disease status, and provide novel perspective for microbiota research about their roles in tumors. PMID:35122129 | DOI:10.1007/s00405-022-07284-z View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Consensus on Triple Endoscopy Data Elements Preparatory to Development of an Aerodigestive Registry

xlomafota13 shared this article with you from Inoreader Consensus on Triple Endoscopy Data Elements Preparatory to Development of an Aerodigestive Registry Via The Laryngoscope Objectives/Hypothesis This study defines essential data elements to be recorded during an aerodigestive "triple endoscopy" to form the foundation of a standardized multicenter registry and to clearly define measurement of each consensus item. Study Design Modified Delphi process. Methods Modified Delphi consensus with six survey rounds. Twenty-four expert pediatric otolaryngology, pulmonology, and gastroenterology aerodigestive clinicians from eight large academic pediatric aerodigestive programs formed the Delphi panel. After achieving consensus through the Delphi process, outside validation was performed at 2019 national Aerodigestive Society conference. Consensus, near-consensus, or exclusion was obtained for each proposed data element. Concordance was then measured between expert panel conclusions and validation group conclusions. Results Overall response rate was 94.4%. 73/167 proposed items reached consensus in six domains (flexible bronchoscopy, bronchoalveolar lavage, microdirect laryngoscopy and bronchoscopy, esophagogastroduodenoscopy with biopsies, and esophageal impedance and pH probe). Measurement of all items was defined; classification/grading systems were selected for 11 items. Validation group endorsed importance of 82/167 data items; compared to expert consensus, overall, inclusion, and exclusion concordance rates were 94.5%, 98.7%, and 90.9%. Conclusion Triple endoscopy is a central component of aerodigestive care. This study identifies and defines data elements to be recorded for all triple endoscopy procedures. The list is of usable length, and clear definitions were created for all items, with explicit classification/grading systems selected for 11 items. Face validity was confirmed with an independent multispecialty sample of aerodigestive providers. This consensus provides the foundation for a triple endoscopy registry but also is immediately applicable to standardize clinical documentation in aerodigestive care. Level of Evidence 5 Laryngoscope, 2022 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Mutations within the putative protease domain of the human FAM111B gene may predict disease severity and poor prognosis: A review of POIKTMP cases

xlomafota13 shared this article with you from Inoreader Mutations within the putative protease domain of the human FAM111B gene may predict disease severity and poor prognosis: A review of POIKTMP cases Via Experimental Dermatology Abstract Mutations in the human FAM111B gene are associated with a rare, hereditary multi-systemic fibrosing disease, POIKTMP. To date, there are ten POIKTMP-associated FAM111B gene mutations reported in thirty-six patients from five families globally. To investigate the clinical significance of these mutations, we summarized individual cases by clinical features and position of the reported FAM111B gene mutations as those within and outside the putative protease domain (MWPPD and MOPPD, respectively). MWPPD cases had more clinical manifestations than MOPPD (25 versus 18). Although the most common clinical features of poikiloderma, alopecia, and hypohidrosis overall occurred in 94%, 86%, and 75% of all cases with no significant differences between the MOPPD and MWPPD group, less common features included life-threatening (pulmonary fibrosis 47 % vs. 13 %; liver abnormalities specifically cirrhosis 26 % vs. 7 %) and physically disabling conditions (myopathy 53% vs. 20%; tendon contracture 55% vs. 7%) were more common in MWPPD cases. Similarly, the only 2 cases of POIKTMP with fatal pancreatic cancers were both only in the MWPPD group. This review thus suggests that mutations within the putative protease domain of the FAM111B protein are associated with a broader range of clinical features and may predict increased POIKTMP severity and a poorer prognosis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of endoscopic and microscopic tympanoplasty in patients with chronic otitis media

xlomafota13 shared this article with you from Inoreader Comparison of endoscopic and microscopic tympanoplasty in patients with chronic otitis media Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2022 Feb 5. doi: 10.1007/s00405-022-07273-2. Online ahead of print. ABSTRACT BACKGROUND: To compare the results between type I tympanoplasty performed with transcanal endoscopic ear surgery (TEES) and microscopic ear surgery (MES) for treatment of chronic otitis media in a homogenous group of patients. METHODS: A retrospective study was performed in our department between January 2011 and January 2016 to review primary type I tympanoplasty cases with a subtotal perforation, an intact ossicular chain, a dry ear for at least 1 month, normal middle ear mucosa, and a follow-up period of at least 6 months post surgery. The adoption of TEES or MES was divided temporally (before and since 2013). TEES was undertaken in 224 patients (224 ears) and MES in 121 patients (121 ears). RESULTS: The successful graft take rate was 94.64% (212/224) in the TEES group and 90.91% (110/121) in the MES group (P = 0.239). The improvements in the air conduction levels between the 2 groups were not statistically different at 1, 3, or 6 (> 6) months (P > 0.05) after surgery. The improvements in the air-bone gaps were not significantly different between the 2 groups (P > 0.05). The average hearing gains in the TEES group 6 (and > 6) months post surgery were 11.85 ± 5.47 dB, which was better than 10.48 ± 5.18 dB in the MES group (P = 0.031). The use of medical resources was lower in the TEES group than in the MES group regarding the average operating time (49.22 ± 8.24 min vs 81.22 ± 14.73 min, respectively; P < 0.0001). Patients receiving MES had a significant higher incidence of the wound problems (ear pain, numbness around the ears, and wet ear; P < 0.05). CONCLUSION: TEES for type I tympanoplasty seems to achieve a shorter operative time and ideal tympanic membrane healing rate and hearing results in patients with chronic otitis media. PMID:35122510 | DOI:10.1007/s00405-022-07273-2 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Diffuse Large B-Cell Non-Hodgkin Lymphoma Involving Multiple Different Organs in a Young Adult with 18F-FDG PET/CT

xlomafota13 shared this article with you from Inoreader Diffuse Large B-Cell Non-Hodgkin Lymphoma Involving Multiple Different Organs in a Young Adult with <sup>18</sup>F-FDG PET/CT Via Mol Imaging Radionucl Ther Mol Imaging Radionucl Ther. 2022 Feb 2;31(1):72-74. doi: 10.4274/mirt.galenos.2021.28190. ABSTRACT Extranodal-multiorgan involvement is rarely presented in diffuse large B-cell non-Hodgkin lymphoma. 18Fluorine-fluorodeoxyglucose positron emission tomography/computed tomography findings of a 22-year-old female patient with supra/infra-diaphragmatic nodal and skeletal involvements and thyroid, pancreas, right breast, bilateral renal, and ovarian involvements were presented. PMID:35114758 | DOI:10.4274/mirt.galenos.2021.28190 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

18F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging Appearance of Gastrointestinal Behcet's Disease

xlomafota13 shared this article with you from Inoreader <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging Appearance of Gastrointestinal Behcet's Disease Via Mol Imaging Radionucl Ther Mol Imaging Radionucl Ther. 2022 Feb 2;31(1):57-59. doi: 10.4274/mirt.galenos.2021.27147. ABSTRACT Behcet's syndrome (BS) is a variable vessel vasculitis with multi-organ involvement. Recurrent episodes of oral and genital ulcers, papulopustular and erythema nodosum-like skin lesions, and arthritis are relatively more frequent, whereas uveitis, venous and arterial lesions, nervous system, and gastrointestinal involvement are less common, but are severe manifestations. The frequency of gastrointestinal involvement shows important variation between countries as more common in the Far East and the United States, and much less common in Turkey and the Middle East. The main clinical signs of gastrointestinal Behcet's disease include abdominal pain, diarrhea, blood in the stool, fever, and weight loss. Ulcers seen in the terminal ileum, cecum, and ascending colon are common endoscopic findings. Herein, we presented the positron emission tomo graphy/magnetic resonance imaging findings of gastrointestinal involvement in BS. PMID:35114753 | DOI:10.4274/mirt.galenos.2021.27147 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Investigation of Added Value of Imaging Performed in a Prone Position to Standard 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Staging in Patients with Breast Cancer

xlomafota13 shared this article with you from Inoreader Investigation of Added Value of Imaging Performed in a Prone Position to Standard <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Staging in Patients with Breast Cancer Via Mol Imaging Radionucl Ther Mol Imaging Radionucl Ther. 2022 Feb 2;31(1):23-32. doi: 10.4274/mirt.galenos.2021.48343. ABSTRACT OBJECTIVES: To investigate whether additional imaging in a prone position has any value to the supine whole-body 18fluorine-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) images by comparing the visual and quantitative data about a local disease in the breast and axilla for the initial staging of breast cancer (BC). METHODS: In this study, a total of 91 female patients with the BC were studied. Both the supine and prone images were examined based on the axial diameter, number and location of the primary tumor, local invasion signs of the tumor, the number of axillary lymph nodes with a suspected metastasis, metabolic parameters of the primary tumor and axillary lymph nodes, and registration artifacts of the PET and CT images were evaluated individually. These findings were compared with the h istopathological data obtained after a surgery. RESULTS: In the evaluation of a supine and prone imaging, tumor diameter and metabolic tumor volume (MTV) values of the breast lesions were greater in the supine position than in the prone position. However, there was no significant difference found between the other metabolic parameters of a primary tumor and axilla in both positions. In the supine and prone images, accuracy for skin involvement was 84% and 91.3%, respectively. CONCLUSION: In our study, we observed that, obtaining additional images in the prone position does not significantly benefit the evaluation of a local disease. The average values of the primary tumor diameter and MTV in the prone position appear to be smaller than the one in the supine position. However, the prone imaging in the patients with a newly diagnosed BC may be beneficial in selected patients and may contribute to preventing the false-positive results especially in patients with a suspected skin involvement. PMID:35114748 | DOI:10.4274/mirt.galenos.2021.48343 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Myocardial Ischemia on MPI SPECT in a Patient with Acute Myeloid Leukemia Without Significant Coronary Artery Disease

xlomafota13 shared this article with you from Inoreader Myocardial Ischemia on MPI SPECT in a Patient with Acute Myeloid Leukemia Without Significant Coronary Artery Disease Via Mol Imaging Radionucl Ther Mol Imaging Radionucl Ther. 2022 Feb 2;31(1):63-65. doi: 10.4274/mirt.galenos.2020.36035. ABSTRACT Herein, we report the case of a 56-year-old male patient with acute myeloid leukemia (AML) in remission who had asymptomatic myocardial ischemia on myocardial perfusion imaging and transthoracic echocardiography. Angiography did not reveal any significant coronary artery disease. Although the etiology is not entirely clear, this case suggested that myocardial perfusion imaging should be considered in patients with AML who received idarubicin to screen for possible myocardial dysfunction. PMID:35114755 | DOI:10.4274/mirt.galenos.2020.36035 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.