In April 2018, Ms. K. an active 84-year-old, was diagnosed with metastatic lung cancer that had spread to her brain. She received whole-brain radiation and was started on gefitinib, directed at the EGFR mutation that her tumor cells luckily carried. Her tumor responded beautifully, and she did well…
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More than a decade ago, sorafenib became the first systemic therapy that conferred a meaningful survival benefit in the treatment of advanced hepatocellular carcinoma. Since then, no treatment had surpassed the effect of sorafenib in the first line until the regimen of atezolizumab and bevacizumab…
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Hepatocellular carcinoma is a common cancer worldwide and a leading cause of cancer-related death. Although early-stage disease may be curable by resection, liver transplantation, or ablation, most patients present with unresectable disease and have a poor prognosis. The multikinase inhibitors…
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Aim. We wish to investigate the therapeutic potential of a single-session high-energy extracorporeal shock wave therapy (ESWT) on the rotator cuff lesions with shoulder stiffness. Patients and Methods. Thirty-seven patients afflicted with rotator cuff lesions with shoulder stiffness were randomized to receive either shockwave or sham treatment based on statistical randomization. In the shockwave group, we used Orthospec™ Extracorporeal Shock Wave Therapy 3000 impulse 24 kV (0.32 mJ/mm2) focused at...
Wed May 13, 2020 10:35
Background. This study explored the relationship between thyroid-associated antibodies, immune cells, and hypothyroidism to establish a predictive model for the incidence of hypothyroidism in patients with nasopharyngeal carcinoma (NPC) after radiotherapy. Methods. A total of 170 patients with NPC treated at the Cancer Hospital of University of Chinese Academy of Sciences between January 2015 and August 2018 were included. The complete blood count, biochemical, coagulation function, immune cells,...
Wed May 13, 2020 10:35
The AT-hook transcription factor, AKNA, is a nuclear protein that affects a few physiological and pathological processes including cancer. Here, we investigated the role of AKNA in gastric cancer (GC). By using quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot assays, AKNA was found deregulated in both GC cell lines and 32 paired GC tissues. Subsequently, Kaplan-Meier analysis and clinicopathological analysis were conducted using both 32 GC cases’ data above and RNA-Seq...
Wed May 13, 2020 09:20
The histone demethylase JMJD family is involved in various physiological and pathological functions. However, the roles of JMJD1A in the cardiovascular system remain unknown. Here, we studied the function of JMJD1A in cardiac hypertrophy. The mRNA and protein levels of JMJD1A were significantly downregulated in the hearts of human patients with hypertrophic cardiomyopathy and the hearts of C57BL/6 mice underwent cardiac hypertrophy induced by transverse aortic constriction (TAC) surgery or isoproterenol...
Wed May 13, 2020 09:05
Background. Adrenaline quickly inhibits the release of histamine from mast cells. Besides β2-adrenergic receptors, several in vitro studies also indicate the involvement of α-adrenergic receptors in the process of exocytosis. Since exocytosis in mast cells can be detected electrophysiologically by the changes in the membrane capacitance (Cm), its continuous monitoring in the presence of drugs would determine their mast cell-stabilizing properties. Methods. Employing the whole-cell patch-clamp technique...
Wed May 13, 2020 08:35
Colorectal cancer is the third most common cancer in men and the second most common in women, [1]. Radiation therapy is an indispensable part of adjuvant therapy for rectal cancer, because it improves local control, overall survival, and the opportunity for good quality of life [2]. Intensity-modulated radiation therapy (IMRT) is the most commonly used technique [3,4], with the advantages of high target dose coverage and organs-at-risk (OAR) dose sparing because IMRT has strong dose modulation ability...
Wed May 13, 2020 03:00
Pancreatic cancer is one of the most lethal cancer entities with estimated 45.750 deaths in the United States in 2019[1]. Despite decades of research, the overall survival rate at five years is still at 5-10%[2]. The only curative therapy option is tumor resection, but only 20% of all patients present with resectable disease at time of diagnosis[3]. Even after resection the postoperative 5-year overall survival rate remains poor[4] since metachronous metastasis and local recurrence occur commonly.
Wed May 13, 2020 03:00
Stereotactic radiosurgery (SRS) has become a standard-of-care option for patients with limited numbers of brain metastases as SRS alone results in similar overall survival outcomes but better neurocognitive outcomes than whole-brain radiotherapy (WBRT) or WBRT plus SRS boost [1,2]. Especially with improved systemic options and prolonged OS, SRS provides the possibility for repeated treatments of sequentially diagnosed brain metastases [3].Table 1.Table 2.
Wed May 13, 2020 03:00
Stereotactic body radiation therapy (SBRT) has been recognized as an appropriate treatment option for both primary and metastatic tumors in different anatomical sites such as the lungs [1], liver [2], prostate [3] and spine [4]. Furthermore, international recommendations on SBRT delivery are being cited in literature [3,5,6]. An important feature of SBRT is that it delivers high radiation doses to small lesions with short fractionation schemes [7]. Single or few fractions (up to 8) with dose for...
Wed May 13, 2020 03:00
Oncogenesis, Published online: 13 May 2020; doi:10.1038/s41389-020-0236-xCarbidopa suppresses prostate cancer via aryl hydrocarbon receptor-mediated ubiquitination and degradation of androgen receptor
Wed May 13, 2020 03:00
Oncogenesis, Published online: 13 May 2020; doi:10.1038/s41389-020-0234-zUSP38 regulates the stemness and chemoresistance of human colorectal cancer via regulation of HDAC3
Wed May 13, 2020 03:00
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Although recently published randomised controlled trials did not confirm significant positive effect of ART-123 or polymyxin B‑immobilised haemoperfusion (PMX-HP) on survival outcome, previous studies using a ...
Wed May 13, 2020 03:00
The number of intensive care patients aged ≥ 80 years (Very old Intensive Care Patients; VIPs) is growing. VIPs have high mortality and morbidity and the benefits of ICU admission are frequently questioned. Se...
Wed May 13, 2020 03:00
Multiple myeloma (MM) is a hematologic cancer that disrupts normal bone marrow function with multiple lines of therapeutic options but is incurable, as patients ultimately relapse. We developed a novel antibody-drug conjugate targeting CS-1, a protein that is highly expressed on MM tumor cells. The anti-CS-1 monoclonal antibody specifically bound to cells expressing CS-1 and, when conjugated to a cytotoxic pyrrolobenzodiazepine payload, reduced the viability of MM cell lines in vitro. In mouse models...
Wed May 13, 2020 16:42
HER2-positive breast cancer is currently managed with chemotherapy in combination with specific anti-HER2 therapies, including trastuzumab. However, a high percentage of patients with HER2-positive tumors do not respond to trastuzumab (primary resistance) or either recur (acquired resistance), mostly due to molecular alterations in the tumor that are either unknown or undetermined in clinical practice. Those alterations may cause the tumor to be refractory to treatment with trastuzumab, promoting...
Wed May 13, 2020 16:42
Focal adhesion kinase (FAK) promotes cancer cell growth and metastasis. We previously reported that FAK inhibition by the selective inhibitor VS-4718 exerted anti-leukemia activities in AML. The mechanisms involved, and whether VS-4718 potentiates efficacy of other therapeutic agents, have not been investigated. Resistance to apoptosis inducted by the BCL-2 inhibitor ABT-199 (venetoclax) in AML is mediated by pre-existing and ABT-199-induced overexpression of MCL-1 and BCL-XL. We observed that VS-4718...
Wed May 13, 2020 16:42
Surgical resection is currently the only potentially curative option for patients with pancreatic cancer. However, the five-year survival rate after resection is only 25%, due in part to high rates of R1 resections, in which cells are left behind at the surgical margin, resulting in disease recurrence. Fluorescence-guided surgery (FGS) has emerged as a method to reduce incomplete resections and improve intraoperative assessment of cancer. Mucin-16 (MUC16), a protein biomarker highly overexpressed...
Wed May 13, 2020 16:42
Background: COVID-19 has become a global pandemic with a dramatic impact on healthcare systems. Concern for viral transmission necessitates the investigation of otologic procedures that use high-speed drilling instruments, including mastoidectomy, which we hypothesized to be an aerosol generating procedure. Methods: Mastoidectomy with a high-speed drill was simulated using fresh-frozen cadaveric heads with fluorescein solution injected into the mastoid air cells. Specimens were drilled for...
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Analytical ChemistryDOI: 10.1021/acs.analchem.0c00645
Wed May 13, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00903
Wed May 13, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c01153
Wed May 13, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b05744
Wed May 13, 2020 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00573
Wed May 13, 2020 07:00
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