Related ArticlesNovel agent DMAMCL suppresses osteosarcoma growth and decreases the stemness of osteosarcoma stem cell. Cell Cycle. 2020 May 13;:1-15 Authors: Ba G, Hua Z, Xu N, Zhang S, Liu Z, Thiele CJ, Li Z Abstract Osteosarcoma (OS) is the most common primary malignancy of bone that mostly affects children, adolescents, and young people. Despite advances have been made in multimodal therapy of OS, the long-term survival rate has reached a plateau,...
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Related ArticlesEffective inhibitory activity against MCF-7, A549 and HepG2 cancer cells by a phosphomolybdate based hybrid solid. Dalton Trans. 2020 May 13;: Authors: Joshi A, Gupta R, Singh B, Sharma D, Singh M Abstract A novel Strandberg type polyoxomolybdate based organic-inorganic hybrid solid, [{4,4'-H2bpy}{4,4'-Hbpy}2{H2P2Mo5O23}]·5H2O (1) has been synthesized and structurally characterized by the single crystal X-ray diffraction technique....
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Related ArticlesGedunin isolated from the mangrove plant Xylocarpus granatum exerts its anti-proliferative activity in ovarian cancer cells through G2/M-phase arrest and oxidative stress-mediated intrinsic apoptosis. Apoptosis. 2020 May 13;: Authors: Sahai R, Bhattacharjee A, Shukla VN, Yadav P, Hasanain M, Sarkar J, Narender T, Mitra K Abstract Gedunin is a natural tetranorterpenoid secondary metabolite found in plants of the Meliaceae family, which...
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Related ArticlesA new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells. Int J Biol Sci. 2020;16(11):1901-1916 Authors: Tae IH, Son JY, Lee SH, Ahn MY, Yoon K, Yoon S, Moon HR, Kim HS Abstract Ovarian cancer is a common gynecological cancer that is found worldwide. Class III histone deacetylase (HDAC) inhibitors, a new class of anticancer agents, induce autophagy in various...
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Related ArticlesNaked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. Nat Commun. 2020 May 12;11(1):2376 Authors: Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V Abstract Naked mole-rat (NMR), the longest-living rodent, produces very-high-molecular-mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is unclear if exceptional polymer length of vHMM-HA...
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Related ArticlesHypermethylation and decreased expression of TMEM240 are potential early-onset biomarkers for colorectal cancer detection, poor prognosis, and early recurrence prediction. Clin Epigenetics. 2020 May 12;12(1):67 Authors: Chang SC, Liew PL, Ansar M, Lin SY, Wang SC, Hung CS, Chen JY, Jain S, Lin RK Abstract BACKGROUND: Gene silencing by aberrant DNA methylation of promoter regions remains the most dominant phenomenon occurring during...
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Related ArticlesInvolvement of heme oxygenase-1 in suppression of T cell activation by quercetin. Immunopharmacol Immunotoxicol. 2020 May 12;:1-11 Authors: Sugiyama T, Matsushima M, Ohdachi T, Hashimoto N, Hasegawa Y, Yokoi K, Kawabe T Abstract Aim: Acute rejection is still a major problem in transplantation and one of the most important causes of late graft loss. Cyclosporine and tacrolimus are widely used for suppression of T cell function to avoid...
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Related ArticlesA Prognostic Immunoscore for Relapse-Free Survival Prediction in Colorectal Cancer. DNA Cell Biol. 2020 May 12;: Authors: Wang H, Xu F, Zhang M, Liu J, Wang F, Zhao Q Abstract We aimed to establish a novel immunoscore (IS) model based on the transcriptomes of tumor tissues to improve the relapse-free survival (RFS) prediction of colorectal cancer (CRC). CIBERSORT was used to estimate the immune cell fractions based on the Gene Expression...
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Related ArticlesTFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response. Cells. 2020 May 10;9(5): Authors: Pisonero-Vaquero S, Soldati C, Cesana M, Ballabio A, Medina DL Abstract The MiT/TFE family of transcription factors (MITF, TFE3, and TFEB), which control transcriptional programs for autophagy and lysosome biogenesis have emerged as regulators of energy metabolism in cancer. Thus, their activation increases lysosomal catabolic function to...
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Related ArticlesGold Nanocomplex Strongly Modulates the PI3K/Akt Pathway and Other Pathways in MCF-7 Breast Cancer Cell Line. Int J Mol Sci. 2020 May 08;21(9): Authors: Mahmoud NN, Abuarqoub D, Zaza R, Sabbah DA, Khalil EA, Abu-Dahab R Abstract Conjugating drugs with gold nanoparticles (GNP) is a key strategy in cancer therapy. Herein, the potential inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, and other pathways of the MCF-7...
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Related ArticlesPaxillin regulated genomic networks in prostate cancer. Steroids. 2019 11;151:108463 Authors: Ma X, Biswas A, Hammes SR Abstract Paxillin is extensively involved in focal adhesion signaling and kinase signaling throughout the plasma membrane and cytoplasm. However, recent studies in prostate cancer suggest that paxillin also plays a critical role in regulating gene expression within the nucleus, serving as a liaison between cytoplasmic...
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Related ArticlesComplexes of lanthanides(iii) with mixed 2,2'-bipyridyl and 5,7-dibromo-8-quinolinoline chelating ligands as a new class of promising anti-cancer agents. Metallomics. 2019 05 22;11(5):1005-1015 Authors: Qin QP, Wang ZF, Tan MX, Huang XL, Zou HH, Zou BQ, Shi BB, Zhang SH Abstract Five novel lanthanides(iii) complexes, [Lu(Me)(MBrQ)2NO3] (MeMBrQ-Lu), [Ho(MeO)(MBrQ)2NO3] (MeOMBrQ-Ho), [Ho(Me)(MBrQ)2NO3] (MeMBrQ-Ho), [La(Me)2(BrQ)2NO3] (MeBrQ-La)...
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Targeted Gold Nanorods Combined with Low-intensity nsPEFs enhance antimelanoma efficacy in vitro. Nanotechnology. 2020 May 12;: Authors: Mi Y, Liu Q, Li P, Xu J, Yang Q, Tang J Abstract High-intensity nanosecond pulsed electric fields (nsPEFs) are a novel treatment with promising applications for cell stimulation and tissue ablation, and many research studies have shown that gold nanorods (GNRs) are high-conductivity nanomaterials that can enhance...
Wed May 13, 2020 13:09
Chondrocyte Suppression is Mediated by miR-129-5p via GDF11/SMAD3 signaling in Developmental Dysplasia of the Hip. J Orthop Res. 2020 May 12;: Authors: Liu X, Deng X, Ding R, Cheng X, Jia J Abstract Recent studies have shown that developmental dysplasia of the hip (DDH) during childhood and in animal models is associated with impaired endochondral ossification of the roof of the acetabulum, yet the molecular mechanism of this pathology remains unknown....
Wed May 13, 2020 13:09
ATG5 knockout promotes paclitaxel sensitivity in drug-resistant cells via induction of necrotic cell death. Korean J Physiol Pharmacol. 2020 May 01;24(3):233-240 Authors: Hwang SH, Yeom H, Lee M Abstract Autophagy regulators are often effective as potential cancer therapeutic agents. Here, we investigated paclitaxel sensitivity in cells with knockout (KO) of ATG5 gene. The ATG5 KO in multidrug resistant v-Ha-ras-transformed NIH 3T3 cells (Ras-NIH...
Wed May 13, 2020 13:09
Sesamin induces A549 cell mitophagy and mitochondrial apoptosis via a reactive oxygen species-mediated reduction in mitochondrial membrane potential. Korean J Physiol Pharmacol. 2020 May 01;24(3):223-232 Authors: Yang S, Li X, Dou H, Hu Y, Che C, Xu D Abstract Sesamin, a lipid-soluble lignin originally isolated from sesame seeds, which induces cancer cell apoptosis and autophagy. In the present study, has been reported that sesamin induces apoptosis...
Wed May 13, 2020 13:09
Cytotoxic Heptaketides from the Endolichenic Fungus Ulospora bilgramii. J Nat Prod. 2020 May 12;: Authors: Xie F, Luan XY, Gao Y, Xu K, Lou HX Abstract Eleven new metabolites including nine heptaketides, ulosporin A-G (1a-7b), one diphenyl compound, ulophenol (8), and one spirobisnaphthalene, palmarumycin P5 (9), were isolated from the endolichenic fungus Ulospora bilgramii, which inhabits the lichen Umbilicaria sp. The structures of these compounds...
Wed May 13, 2020 13:09
Novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor DDHCB inhibits proliferation of BRCA mutant breast cancer cell in vitro and in vivo through a synthetic lethal mechanism. Chem Res Toxicol. 2020 May 12;: Authors: Wang L, Zhang S, Yu X, Guo C Abstract Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors are drugs that are effectively used to treat breast cancer. We synthesized a novel bromophenol derivative ethyl (E)-4-(2-(2,3-dibromo-4,5-dimethoxybenzylidene)hydrazine-1-carbothioamido)benzoate...
Wed May 13, 2020 13:09
Related ArticlesAnti-Proliferative Activity of Nodosin, a Diterpenoid from Isodon serra, via Regulation of Wnt/β-Catenin Signaling Pathways in Human Colon Cancer Cells. Biomol Ther (Seoul). 2020 May 12;: Authors: Bae ES, Kim YM, Kim DH, Byun WS, Park HJ, Chin YW, Lee SK Abstract Colorectal cancer (CRC) is one of the most malignant type of cancers and its incidence is steadily increasing, due to life style factors that include western diet. Abnormal...
Wed May 13, 2020 13:09
Related ArticlesNeferine inhibits proliferation and migration of human prostate cancer stem cells through p38 MAPK/JNK activation. J Food Biochem. 2020 May 11;:e13253 Authors: Erdogan S, Turkekul K Abstract Cancer stem cells (CSCs) are one of the significant causes of cancer treatment failure and metastasis, as they have significant chemo-and radio-resistance leading to tumor recurrence. Here we investigated the possible anticancer properties of...
Wed May 13, 2020 13:09
Related ArticlesDifferent p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells. J Exp Clin Cancer Res. 2020 May 11;39(1):83 Authors: Liu K, Zheng M, Zhao Q, Zhang K, Li Z, Fu F, Zhang H, Du J, Li Y, Zhang S Abstract BACKGROUND: Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells...
Wed May 13, 2020 13:09
Related ArticlesATG5 knockout promotes paclitaxel sensitivity in drug-resistant cells via induction of necrotic cell death. Korean J Physiol Pharmacol. 2020 May 01;24(3):233-240 Authors: Hwang SH, Yeom H, Lee M Abstract Autophagy regulators are often effective as potential cancer therapeutic agents. Here, we investigated paclitaxel sensitivity in cells with knockout (KO) of ATG5 gene. The ATG5 KO in multidrug resistant v-Ha-ras-transformed NIH 3T3...
Wed May 13, 2020 13:09
Related ArticlesSesamin induces A549 cell mitophagy and mitochondrial apoptosis via a reactive oxygen species-mediated reduction in mitochondrial membrane potential. Korean J Physiol Pharmacol. 2020 May 01;24(3):223-232 Authors: Yang S, Li X, Dou H, Hu Y, Che C, Xu D Abstract Sesamin, a lipid-soluble lignin originally isolated from sesame seeds, which induces cancer cell apoptosis and autophagy. In the present study, has been reported that sesamin...
Wed May 13, 2020 13:09
Related ArticlesCytotoxic 4-Hydroxyprorocentrolide and Prorocentrolide C from Cultured Dinoflagellate Prorocentrum lima Induce Human Cancer Cell Death through Apoptosis and Cell Cycle Arrest. Toxins (Basel). 2020 May 07;12(5): Authors: Lee SM, Kim NH, Jeong EJ, Rho JR Abstract Prorocentrolide and its analogs, the novel naturally derived antitumor agents, have recently been identified in the dinoflagellate Prorocentrum lima. In the current study,...
Wed May 13, 2020 13:09
Related ArticlesThe Effect of 4'-hydroxy-3,4,5-trimetoxystilbene, the Metabolite of Resveratrol Analogue DMU-212, on Growth, Cell Cycle and Apoptosis in DLD-1 and LOVO Colon Cancer Cell Lines. Nutrients. 2020 May 07;12(5): Authors: Jozkowiak M, Skupin-Mrugalska P, Nowicki A, Borys-Wojcik S, Wierzchowski M, Kaczmarek M, Ramlau P, Jodynis-Liebert J, Piotrowska-Kempisty H Abstract Resveratrol is a phytoalexin that naturally occurs in grapes, blueberries,...
Wed May 13, 2020 13:09
Related ArticlesThe molecular architecture of the meiotic spindle is remodeled during metaphase arrest in oocytes. J Cell Biol. 2019 09 02;218(9):2854-2864 Authors: Costa MFA, Ohkura H Abstract Before fertilization, oocytes of most species undergo a long, natural arrest in metaphase. Before this, prometaphase I is also prolonged, due to late stable kinetochore-microtubule attachment. How oocytes stably maintain the dynamic spindle for hours during...
Wed May 13, 2020 13:09
Related ArticlesDifferential expression of cyclin-dependent kinases in the adult human retina in relation to CDK inhibitor retinotoxicity. Arch Toxicol. 2019 03;93(3):659-671 Authors: Wright P, Kelsall J, Healing G, Sanderson J Abstract Cyclin-dependent kinases (CDKs) are a family of kinases associated predominantly with cell cycle control, making CDK inhibitors interesting candidates for anti-cancer therapeutics. However, retinal toxicity (loss of...
Wed May 13, 2020 13:09
Background Decreasing costs make RNA sequencing technologies increasingly affordable for biologists. However, many researchers who can now afford sequencing lack access to resources necessary for downstream analysis. This means that even as algorithms to process RNA-Seq data improve, many biologists still struggle to manage the sheer volume of data produced by next generation sequencing (NGS) technologies. Scalable bioinformatics tools that exploit multiple platforms are needed to democratize bioinformatics...
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Trypanosoma cruzi is a flagellated protozoan that causes Chagas disease; it presents a complex life cycle comprising four morphological stages: epimastigote (EP), metacyclic trypomastigote (MT), cell-derived trypomastigote (CDT) and amastigote (AM). Previous transcriptomic studies on three stages (EPs, CDTs and AMs) have demonstrated differences in gene expressions among them; however, to the best of our knowledge, no studies have reported on gene expressions in MTs. Therefore, the present study...
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Animals often show high consistency in their social organisation despite facing changing environmental conditions. Especially in shoaling fish, fission–fusion dynamics that describe for which periods individuals are solitary or social have been found to remain unaltered even when density changed. This compensatory ability is assumed to be an adaptation towards constant predation pressure, but the mechanism through which individuals can actively compensate for density changes is yet unknown. The aim...
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Malus sieversii is the wild progenitor for many cultivars of domesticated apple and an important germplasm resource for breeding. However, this valuable species faces a significant threat in the areas north of the Tianshan Mountains in China, by the invasion of Agrilus mali, a destructive pest of apple trees belonging to the family Buprestidae. Our preliminary study has has shown that there may be resistance to this insect in M. sieversii plants in the field, but the corresponding molecular mechanisms...
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‘Animal personality’ is considered to be developed through complex interactions of an individual with its surrounding environment. How can we quantify the ‘personality’ of an individual? Quantifying intra- and inter-individual variability of behavior, or individual behavioral type, appears to be a prerequisite in the study of animal personality. We propose a statistical method from a predictive point of view to measure the appropriateness of our assumption of ‘individual’ behavior in repeatedly measured...
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Xyloglucan (XyG) is the predominant hemicellulose in the primary cell walls of most dicotyledonous plants. Current models of these walls predict that XyG interacts with cellulose microfibrils to provide the wall with the rigidity and strength necessary to maintain cell integrity. Remodeling of this network is required to allow cell elongation and plant growth. In this study, homologs of Arabidopsis thaliana MURUS3 (MUR3), which encodes a XyG-specific galactosyltransferase, were obtained from Brassica...
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Background Teosinte branched1/Cycloidea/proliferating cell factors (TCPs) are plant-specific transcription factors widely involved in leaf development, flowering, shoot branching, the circadian rhythm, hormone signaling, and stress responses. However, the TCP function in Brassica juncea var. tumida, the tumorous stem mustard, has not yet been reported. This study identified and characterized the entire TCP family members in B. juncea var. tumida. ...
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Introduction Metabolomics has emerged as a valuable tool to discover novel biomarkers and study the pathophysiology of diabetic nephropathy (DN). However, the effect of postoperative acute kidney injury (AKI) on diabetes mellitus (DM) to chronic DN progression has not been evaluated from the perspective of metabolomics. Methods A group of type 2 diabetes mellitus (T2DM) inpatients, who underwent off-pump coronary artery bypass...
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Background The body of literature considering caffeine as an ergogenic aid has primarily considered typically aerobic based exercise, male participants and moderate-to large-caffeine doses. With this in mind the aim of this project was to explore the effects of a low-caffeine dose upon maximal voluntary contraction (MVC) and muscular endurance (time to task failure, TTF) at heavier-and lighter-loads. Methods Nineteen physically active, habitual caffeine consuming females randomly performed...
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Cow mastitis is a major problem frequently encountered by dairy farmers and it is manifested by the high number of somatic cells and the low quality of the milk. The conventional treatment for mastitis is use of antibiotics. In the current study, a new approach is applied to target this disorder: rumen bypass melatonin feeding (RBMF). The RBMF significantly reduced milk somatic cell count and improved milk nutritional values with the elevated protein, fat and dry matter levels. This approach also...
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Beta diversity, the compositional variation among communities, is often associated with environmental gradients. Other drivers of beta diversity include stochastic processes, priority effects, predation, or competitive exclusion. Temporal turnover may also explain differences in faunal composition between fossil assemblages. To assess the drivers of beta diversity in reef-associated soft-bottom environments, we investigate community patterns in a Middle to Late Triassic reef basin assemblage from...
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We point out complications inherent in biodiversity inventory metrics when applied to large-scale datasets. The number of units of inventory effort (e.g., days of inventory effort) in which a species is detected saturates, such that crucial numbers of detections of rare species approach zero. Any rare errors can then come to dominate species richness estimates, creating upward biases in estimates of species numbers. We document the problem via simulations of sampling from virtual biotas, illustrate...
Wed May 13, 2020 03:00
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