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Δευτέρα 4 Απριλίου 2022

Improvement of osseointegration of Ti–6Al–4V ELI alloy orthodontic mini-screws through anodization, cyclic pre-calcification, and heat treatments

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Mini-screws are widely used as temporary anchorages in orthodontic treatment, but have the disadvantage of showing a high failure rate of about 10%. Therefore, orthodontic mini-screws should have high biocompa...
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Vorstellung und Evaluation des haptisch-visuellen, ohrchirurgischen Trainingssystems „HaptiVisT“

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Laryngorhinootologie
DOI: 10.1055/a-1802-4887

Hintergrund Operationen am Felsenbein stellen eine besondere Herausforderung für HNO-Chirurgen dar. Ziel des BMBF-geförderten Projektes war die Entwicklung eines realitätsnahen Trainingssystems für Ohroperationen in Form eines „Serious Game". Methodik Der vorgestellte Prototyp des HaptiVisT-Systems fungiert als ohrchirurgisches Trainingssystem mit visueller Rückkopplung durch einen brillenlosen 3D-Monitor und haptischer Rückkopplung durch einen den Bohrer simulierenden Haptik-Arm. Eine Vielfalt von Trainingsmöglichkeiten wird durch 3 verfügbare chirurgische Prozeduren (Antrotromie, Mastoidektomie, posteriore Tympanotomie) gewährleistet. Ein gewichtetes Punktesystem ermöglicht die Messbarkeit des Trainingserfolgs. Im Zuge der technischen Entwicklung des Prototyps erfolgte eine prospektive Evaluation durch 8 HNO-Ärzte und 4 Studierende u.a. hinsichtlich der Lerninhalte und Benutzerfreundlichkeit. Zur Anwendung kam ein standardisierter Fragebogen (Ordinalskala: 1=sehr gut bis 5=sehr schlecht). Ergebnisse Hinsichtlich der Lerninhalte ergaben die Aspekte „Festigung Anatomie (Mittelwert=1,58)", „Training Hand-Augen-Koordination (1,67)", „Übertragbarkeit in die Praxis (1,83)" und „Nützlichkeit für die Praxis (1,33)" gute bis sehr gute Werte. Die Benutzerfreundlichkeit zeigte für die Aspekte „Realitätsnähe (2,29)", „Zusammenspiel Haptik und Optik (2,33)" sowie „Immersion in das Trainingssystem (1,89)" ebenfalls gute Werte. Der „Motivationsfaktor" war bei allen Testpersonen sehr hoch (1,2). Schlussfolgerung Das ohrchirurgische Trainingssystem HaptiVisT bietet die Möglichkeit des immersiven Trainings von Ohroperationen. Eine Integration in den klinischen Alltag und insbesondere in die ärztliche Weiterbildung zum HNO-Facharzt erscheint daher sinnvoll.
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Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Sociomedical and oral factors affecting masticatory performance in an older population

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Abstract

Objectives

To assess the sociomedical and oral factors affecting masticatory performance in a community-dwelling older population.

Materials and methods

Community-dwelling persons over 60 years were investigated using medical and dental oral interviews, oral and denture examination (natural teeth, tooth mobility, number of occluding tooth pairs, and removable dentures' prevalence and quality), and evaluation of masticatory performance using a mixing ability test.

Results

A total of 130 participants with a mean age of 73.9±8.5 years were recorded. Fifty-eight (44.6%) used various types of removable prostheses. Twenty were edentulous and used a pair of complete dentures. Univariate analyses revealed statistically significant associations (p≤0.05) between masticatory performance and aging, marital status, subjective chewing ability, use of removable dentures, use of various combinations of complete dentures, pain caused by maxillary denture, number of teeth, tooth mobility, posterior chewing pairs, all chewing contacts natural or prosthetic, retention of mandibular partial dentures, and dentures' occlusion. The multivariable quantile regression analysis revealed that fewer natural teeth (95% CI: −0.02–0.01, p<0.001), being edentulous and using a pair of complete dentures (95% CI: 0.09–0.35, p=0.001), and larger percentage of severely mobile teeth (95% CI: 0.07–0.82, p=0.020) we re associated with lower masticatory performance.

Conclusions

Poor masticatory performance in older adults was associated with fewer teeth, being edentulous and using a pair of complete dentures, and increased prevalence of severe tooth mobility.

Clinical relevance

Retaining the natural dentition and preventing and treating periodontal disease are important measures to maintain masticatory performance in older adults.

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Metabolic Syndrome and Periodontitis among Adults

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Abstract

Aim

This study aimed to examine the association between metabolic syndrome (MetS), its components, and periodontitis among Indonesian adults.

Materials and Methods

Cross-sectional data from the 2018 Indonesia National Health Survey (Riskesdas) was analysed. The sample included dentate individuals aged 35 years or older for whom complete information was available on components of MetS and periodontitis, including bleeding on probing (BOP) (N=13,356), pocket depth (PD) (N=13,273), and clinical attachment loss (CAL) (N=13,000). Rate ratios (RRs) and 95% confidence intervals (CIs) were estimated with negative binomial regression models.

Results

The prevalence of MetS was 41.0%. The prevalences of individuals having at least one tooth with BOP, one tooth with PD ≥4 mm, or one sextant with CAL ≥4 mm were 74.9%, 40.7%, and 40.6%, respectively. No associations were observed between MetS and BOP, PD, or CAL, but hyperglycaemia was constantly positively associated with BOP (RR=1.06; 95% CI 1.01-1.11), PD (RR=1.13; 95% CI 1.03-1.23), and CAL (RR=1.15; 95% CI 1.08-1.23).

Conclusions

Our findings support the potential influence of hyperglycaemia on periodontitis. Incorporating oral disease prevention strategies into the management of systemic diseases could be beneficial for reducing the burden of these diseases in Indonesia.

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Sclerostin in Periodontal Ligament: Homeostatic Regulator in Biophysical Force‐Induced Tooth Movement

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Abstract

Aim

This study elucidates the role of sclerostin in periodontal ligament (PDL) as a homeostatic regulator in biophysical force-induced tooth movement (BFTM).

Materials and Methods

BFTM was performed in rats, followed by microarray, immunofluorescence, in situ hybridization, and real-time PCR for detection and identification of the molecules. The periodontal space was analyzed via micro-computed tomography. Effects on osteoclastogenesis and bone resorption were evaluated in mouse bone marrow-derived cells. In vitro human PDL cells were subjected to biophysical forces.

Results

In the absence of BFTM, sclerostin was hardly detected in the periodontium except the PDL and alveolar bone in the furcation region and apex of the molar roots. However, sclerostin was upregulated in the PDL in vivo by adaptable force, which induced typical transfiguration without changes in periodontal space as well as in vitro PDL cells under compression and tension. In contrast, the sclerostin level was unaffected by heavy force, which caused severe degeneration of the PDL and narrowed periodontal space. Sclerostin inhibited osteoclastogenesis and bone resorption, which corroborates the accelerated tooth movement by the heavy force.

Conclusions

Sclerostin in PDL may be a key homeostatic molecule in the periodontium and a biological target for the therapeutic modulation of BFTM.

This article is protected by copyright. All rights reserved.

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Does social support predict increased use of dental services in older men?

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Abstract

Background

Past research on social support and dental visits in older people has been limited by cross-sectional design, limited social support dimensions, and non-representative samples.

Methods

Data came from men with natural teeth completing Waves 3 and 4 of the Concord Health and Ageing in Men Project (CHAMP) in Sydney, Australia. The relationship between social support at Wave 3 (2011-2012) and at least one dental visit per year at Wave 4 (2014-2016) was examined by Poisson regression. Social support was measured by structural (marital status, living arrangements, family support, social interaction) and functional (social support satisfaction) domains.

Results

There were 673 men analysed. Structural and functional social support were not associated with the pattern of usual dental visits five years later in univariable or multivariable analyses. The only consistent significant factor was income source, with older men who had other sources of income more likely to regularly visit the dentist than older men solely reliant on the pension for income (PR: 1.31, 95% CI: 1.13 – 1.52).

Conclusions

We found no differences in the pattern of usual dental visits between older men with different levels and types of social support. For older Australian men, income source seems to be the most important determinant of regular dental visits. © 2022 Australian Dental Association

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Use of transoral carbon dioxide laser for supraglottic web from caustic ingestion in a 13 year old

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A 13 year old male was referred to the Department of Otorhinolaryngology due to unsuccessful decannulation. At 2 years of age, patient accidentally ingested a caustic liquid alkali and underwent emergency tracheostomy, exploratory laparotomy, and tube gastrectomy. 11 years after, patient was seen at the outpatient department for decannulation. On nasopharyngolaryngoscopy, a supraglottic stenosis with a central 1-mm opening was visualized. Patient underwent transoral carbon dioxide laser excision of supraglottic stenosis.
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Differential Activation of Canal and Otolith Afferents by Acoustic Tone Bursts in Rats

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Abstract

Vestibular evoked myogenic potentials (VEMPs) are routinely used to test otolith function, but which specific vestibular afferent neurons and central circuits are activated by auditory frequency VEMP stimuli remains unclear. To examine this question, we analyzed the sensitivity of individual vestibular afferents in adult Sprague–Dawley rats to tone bursts delivered at 9 frequencies (125–4000 Hz) and 3 intensity levels (60, 70, 80 dB SL re: acoustic brainstem response (ABR) threshold). Afferent neuron tone sensitivity was quantified by the cumulative probability of evoking a spike (CPE). Based on a threshold CPE of 0.1, acoustic stimuli in the present study evoked responses in 78.2 % (390/499) of otolith afferent neurons vs. 48.4 % (431/891) of canal afferent neurons. Organ-specific vestibular inputs to the central nervous system in response to tone bursts differ based on intensity and frequency content of the stimulus. At frequencies below 500  Hz, tone bursts primarily activated both otolith afferents, even at the highest intensity tested (80 dB SL re ABR threshold). At 1500 Hz, however, tone bursts activated the canal and otolith afferents at the moderate and high intensities tested (70, 80 dB SL), but activated only otolith afferents at the low intensity tested (60 dB SL). Within an end organ, diversity of sensitivity between individual afferent neurons correlated with spontaneous discharge rate and regularity. Examination of inner ear fluid mechanics in silico suggests that the frequency response and preferential activation of the otolith organs likely arise from inner ear fluid motion trapped near the oval and round windows. These results provide insight into understanding the mechanisms of sound activation of the vestibular system and developing novel discriminative VEMP testing protocols and interpretative guidelines in humans.

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Effect of Selective Carboplatin-Induced Inner Hair Cell Loss on Temporal Integration in Chinchillas

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Abstract

Integration of acoustic information over time is essential for processing complex stimuli, such as speech, due to its continuous variability along the time domain. In both humans and animals, perception of acoustic stimuli is a function of both stimulus intensity and duration. For brief acoustic stimuli, as duration increases, thresholds decrease by approximately 3 dB for every doubling in duration until stimulus duration reaches 500 ms, a phenomenon known as temporal integration. Although hearing loss and damage to outer hair cells (OHC) have been shown to alter temporal integration in some studies, the role of cochlear inner hair cells (IHC) on temporal integration is unknown. Because IHC transmit nearly all acoustic information to the central auditory system and are believed to code both intensity and timing information, these sensory cells likely play a critical role in temporal integration. To test the hypothesis that selective IHC loss degrades th e temporal integration function, behaviorally trained chinchillas were treated with carboplatin, a drug known to selectively destroy IHC with little to no effect on OHC in this species. Pure-tone thresholds were assessed across frequencies (1, 2, 4, 8, 12 kHz) as a function of signal duration (500, 100, 50, 10, and 5 ms). Baseline testing showed a significant effect of duration on thresholds. Threshold decreased as a function of increasing duration, as expected. Carboplatin treatment (75 mg/kg) produced a moderate to severe loss of IHC (45–85%) with little-to-no loss of OHC. Contrary to our hypothesis, post-carboplatin temporal integration thresholds showed no significant differences from baseline regardless of stimulus duration or frequency. These data suggest that few IHC are necessary for temporal integration of simple stimuli. Temporal integration may be sensitive to loss of OHC and loss of cochlear non-linearities but does not appear to be sensitive to selectiv e IHC loss.

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Modification of an extended total temporomandibular joint replacement (eTMJR) classification system

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The aims of this paper were to validate a modification of an extended total temporomandibular joint replacement (eTMJR) classification system and develop a classification schematic for ease of reference. High volume TMJ surgeons were asked to score 20 separate eTMJR devices using the updated classification system and inter-rater variability was calculated. Using the modified classification system developed, a Conger's kappa (k) coefficient of 0.53 was returned, suggesting moderate to good levels of agreement.
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