Palmoplantar keratoderma Bothnia type with acrokeratoelastoidosis‐like features due to AQP5 mutations

Clinical and Experimental Dermatology, EarlyView.

How to do things with metaphors: engineering life as hodgepodge

Abstract

This paper presents a collaboration between social scientists and a chemist exploring the promises for new therapy development at the intersection between synthetic biology and nanotechnology. Drawing from ethnographic studies of laboratories and a recorded discussion between the three authors, we interrogate the metaphors that underpin what Mackenzie (Futures 48:5-12 2013) has identified as a recursive relationship in the iconography of the life sciences and its infrastructure. Focusing specifically on the use of gene editing techniques in synthetic biology and bio-nanotechnology, we focus our analysis on the key metaphors of 'evolutionary life as hodge-podge' within which 'cutting' of DNA and the 'sticking' and 'binding' of engineered particles to proteins can be performed by researchers in laboratory settings. Taken together, we argue that these metaphors are consequential for understanding metaphors of life-as-machine and the prevalence of notions of 'engineering life'. Exploring the ways in which notions of cutting, targeting and life as an evolutionary hodgepodge prefigure a more contingent notion of engineering and synthesis we close by considering the interpretive implications for ethnomethodological approaches to contemporary life science research.

Sex Differences in the Olfactory System: a Functional MRI Study

Abstract

Introduction

Olfactory dysfunction is an early marker of neurological disease and a common symptom in psychotic disorders. Previous anatomical and functional research suggests that sex effects may be crucial in the assessment of the olfactory system. Nonetheless, the neural mechanisms through which the factor sex impacts olfactory perception are still not well understood. In this context, we use fMRI to investigate sex differences in the passive processing of chemical stimuli, in order to obtain new neuroscientific data that may help improve the assessment of odor perception.

Methods

Thirty healthy subjects (17 women) were stimulated with mint and butanol (event-related design) in a 3.0-T MRI scanner. A one-sample t test analysis was performed in order to observe olfactory-related activations. Intergroup differences (women vs. men) and the influence of each aroma were analyzed using a 2 × 2 ANOVA and post hoc contrasts.

Results

Men and women showed differential activity (males > females) in right superior/middle temporal areas, the right inferior frontal cortex, and the hypothalamus. Both groups showed a predominance of the right hemisphere for the processing of odors.

Conclusion

Functional differences between women and men in olfaction are not restricted to specific sensory areas and reflect a more general sex-dependent effect in multisensory integration processes.

Implications

Considering sex differences is essential in order to develop more specific and efficient strategies for the assessment and rehabilitation of the olfactory system and for the interpretation of the olfactory loss as an early biomarker of neurological and psychiatric diseases.

Tea waste derived activated carbon for the adsorption of sodium diclofenac from wastewater: adsorbent characteristics, adsorption isotherms, kinetics, and thermodynamics

Abstract

The present experimental study reports the performance of tea waste (TW) derived adsorbent for the adsorption of sodium diclofenac (SD) from aqueous solution (SD concentration = 10–50 mg/L). The waste-derived activated carbon was prepared by chemical activation process of raw waste using H₂SO₄, KOH, ZnCl₂, and K₂CO₃ as activating agents (TW: activating agent = 1:1 by weight). Subsequently, the oven-dried material was carbonized at 600-°C temperature for 2 h. The synthesized adsorbents were porous and their Brunauer-Emmett-Teller (BET) surface area was ranged 115–865 m²/g. Among all synthesized adsorbents, the adsorbent activated by ZnCl₂ exhibited the highest adsorption capacity (= 62 mg/g), though it was much lower compared to 91 mg/g obtained with commercial activated carbon (CAC) (SD concentration = 30 mg/L, adsorbent dose = 300 mg/L and initial wastewater pH = 6.47). SD equilibrium data could be described by Langmuir isotherm adequately, while pseudo-second-order rate model showed better fit to the time based adsorption data. Low activation energy of the adsorption process suggests the reaction to be temperature independent. Thermodynamic parameters showed the spontaneous and endothermic nature of adsorption process conducted in the presence of waste derived adsorbent.

Open Access Medical Journals: Benefits and challenges

Publication date: Available online 15 September 2018

Source: Clinics in Dermatology

Author(s): Jenny Z. Wang, Aunna Pourang, Barbara Burrall

Abstract

The world of medical science literature is ever increasingly accessible via the internet. Open access online medical journals, in particular, offer access to a wide variety of useful information at no cost. In addition, they provide avenues for publishing that are available to healthcare providers of all levels of training and practice. Whereas costs are less with the publishing of online open access journals, fewer resources for funding and technical support also exist. A recent rise in predatory journals, which solicit authors but charge high fees-per-paper published and provide low oversight, also pose other challenges to ensuring the credibility of accessible scientific literature. Recognizing the value and efforts of legitimate open access online medical journals can help the reader navigate the over 11,000 open access journals that are available to date.

COMMENTARY

Publication date: Available online 15 September 2018

Source: Clinics in Dermatology

Author(s): Mauricio Goihman-Yahr, Lawrence Charles Parish

IMAGING THE UNIMAGINABLE: Me Imaging in the Realm of Photography

Publication date: Available online 15 September 2018

Source: Clinics in Dermatology

Author(s): Fabian Michelangeli

Abstract

There is an almost innate urge in human beings to represent reality in a visual form. From rock art in the Paleolithic to images of galaxies, the quotidian and the extraordinary have been visually represented through the ages. Medical and scientific disciplines are no exception. Accurate representation of the human body structures and anatomy based on cadaver dissections was almost not possible up to the Renaissance due to ethical social and religious beliefs and objections. The works of Leonardo da Vinci (1452–1519) and others and, later, Andreas Vesalius (1514–1564), who produced De Humanis Corporis Fabrica, are considered landmarks in the history of medicine. During the following centuries medical and scientific illustration relied upon the expertise of physician-artists and scientist-artists until a new paradigm appeared in the realm of scientific (medical) illustration: the invention of photography in the 19th century. Two of the medical disciplines most rapidly impacted by photography were dermatology and pathology, both macro- and microscopic. Physicians rapidly started to use photographs as a tool for consultation, documentation and education and large collections of images were amassed by individuals and institutions for these purposes. Photographic images are produced by visible light impressing a light sensitive material like a silver halide plate, and nowadays a silicon chip. But photons are reflected by non transparent objects including the human skin. Developments in science and technology allowed the use of other types of radiation to reveal internal structures in the human body and, most interestingly, non-invasively. Thus, today much of the medical diagnosis and treatment is guided by the so called medical imaging with the use of these techniques, i.e.: medical photography, endoscopy, X-ray radiography, computer-aided tomography, magnetic resonance imaging, ultrasonography, thermography, and nuclear medicine functional imaging techniques as positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Some of these techniques are being applied at the microscopic level to study cell structure and even functional changes in real-time. All these advancements in science and technology applied to medicine and other disciplines pose the question as to what extent physicians are trading their capabilities as clinicians. Ethical issues add to the complexity of this new era governed by constant changes in scientific paradigms.

Conceptual Issues in Dermatology and Medicine: Where Do Non-Physician Practitioners Rightfully Belong: A Dermatologist's Perspective

Publication date: Available online 15 September 2018

Source: Clinics in Dermatology

Author(s): William Abramovits

Abstract

The invasion of the turf of medicine by non-physician practitioners (NPPs) has not spared dermatology. The reasons behind this phenomenon are complex, as so many political issues are; some of them may be reasonable, other concerning. An undeniable fact is that patients are being cared for by medical providers with significantly lower levels of education than physicians. The proper practice of dermatology, a "visual specialty," is unquestionably dependent on experience complemented by scientific information; for this, years of post-graduate education are required. My purpose is to expose, as I was invited to do and with limitations, my opinions about the concept of having "midlevels," providing inadequately supervised medical care to patients afflicted by skin disease.

Nodal Staging of High Risk Cutaneous Squamous Cell Carcinoma

Publication date: Available online 15 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Matthew Fox, Marc Brown, Nicholas Golda, Dori Goldberg, Christopher Miller, Melissa Pugliano-Mauro, Chrysalyne Schmults, Thuzar Shin, Thomas Stasko, Yaohui G. Xu, Kishwer Nehal

Abstract

Background

While progress has been made in defining the clinical and histopathologic features of high-risk cutaneous squamous cell carcinoma (HRcSCC), optimal staging guidelines remain elusive.

Objective

We seek to guide clinical practice regarding nodal staging options for patients with HRcSCC via review of evolving definitions of HRcSCC, nodal staging options and how nodal staging may impact treatment and affect outcomes.

Methods

Retrospective review of published peer-reviewed literature regarding risk stratification, nodal staging and treatment and outcomes for patients with HRcSCC via PubMed search.

Results

For patients without clinical lymphadenopathy, based on literature from head and neck SCC, pre-operative nodal staging with US may be more useful than CT or MRI. Since early nodal disease is usually curable, sentinel lymph node biopsy (SLNB) may be considered in those with negative imaging while we await studies of nodal staging outcomes.

Limitations

More data is needed to validate the relationships between primary tumor stage and SLNB status and to determine if early detection of nodal disease impacts survival for patients with HRcSCC.

Conclusion

It is reasonable to consider nodal staging for patients with HRcSCC (BWH stage T2b and T3) in the absence of clinically palpable lymphadenopathy via radiographic imaging and, if negative, SLNB.

Assessment of Clinician Accuracy for Diagnosing Melanoma Based on Electrical Impedance Spectroscopy Score Plus Morphology Versus Lesion Morphology Alone

Publication date: Available online 15 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Ryan M. Svoboda, Giselle Prado, Rachel S. Mirsky, Darrell S. Rigel

Long-term outcomes of laser treatment for congenital melanocytic nevus

Publication date: Available online 15 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Yeongjoo Oh, Si-Hyung Lee, Jung Min Lim, Kee Yang Chung, Mi Ryung Roh

Abstract

Background

Although various laser treatments have been tried for CMNs, only small retrospective studies with short-term follow-up had been done to assess outcomes.

Objective

We analyzed the long-term outcomes of laser treatment for CMN and compared the outcomes with the combination treatment of partial excisions and lasers.

Methods

Patients with CMN treated with lasers were retrospectively reviewed and patients with more than 3-year follow-up were grouped as the long-term follow-up group.

Results

A total of 67 cases of CMN were reviewed. Among 20 patients (20/52, 38.5%) with nearly total clearance during laser-only treatment, 11 patients were in long-term follow-up group and 5 of them showed repigmentation. 15 patients showed repigmentation regardless of clearance, and the mean period until repigmentation was 3.93 years from the initial treatment. Patients with combination treatment of partial excision and lasers showed higher Investigator's Global Assessment (IGA) scores, less number of laser treatments and shorter treatment period compared to patients with laser-only treatment.

Limitations

This is a retrospective study and various laser devices were used.

Conclusion

More than 4 years of follow-up is required to evaluate the efficacy of lasers in CMN and combination treatment of partial excision and lasers can be an effective treatment option.

Long-term safety results from a Phase 3 open-label study of a fixed combination halobetasol propionate 0.01% and tazarotene 0.045% (HP/TAZ) lotion in moderate-to-severe plaque psoriasis

Publication date: Available online 15 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Mark G. Lebwohl, Jeffrey L. Sugarman, Linda Stein Gold, David M. Pariser, Tina Lin, Radhakrishnan Pillai, Gina Martin, Susan Harris, Robert Israel

Analysis of Dermatologic Procedures Billed Independently by Non-Physician Practitioners in the United States

Publication date: Available online 15 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Qiaochu Qi, Brian P. Hibler, Brett Coldiron, Anthony M. Rossi

Abstract

Background

Non-physician practitioners (NPPS), including nurse practitioners (NPs) and physician assistants (PAs) are expanding their scope of practice outside of primary care and performing more procedures in dermatology.

Objective

To understand the scope and geographic pattern of practice by NPs and PAs in dermatology in the US.

Methods

Cross-sectional retrospective cohort analysis of dermatology practices in the 2014 Medicare Physician/Supplier Procedure Summary Master File, which reflects Part B carrier and durable medical equipment fee-for-service claims in the US.

Results

Over 4 million procedures were billed independently by NPs and PAs, which accounts for 11.51% of all. Injection, simple repair, and biopsy were the most commonly billed by non-physician practitioners, but complex procedures were also increasingly billed independently by NPs and PAs. Proportions of their claims are higher in the East Coast, Midwest, and Mountain states.

Limitations

Data is at the state level, limited to Medicare beneficiaries, and doesn't include billing incident-to physicians.

Conclusions

This study demonstrated the increasing scope of practice of NPs and PAs in dermatology, despite limited training and lack of uniform regulations. To ensure quality and safety of care, it is prudent to set benchmarks for proper supervision and utilization of procedures in dermatology.

Rouleaux: a microscopic clue that helps distinguish psoriasis from dermatitis

Publication date: Available online 15 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Ying Luo, Brett Keeling, Jessica A. Forcucci, Dirk M. Elston

Safe and efficacious treatment of purpura with Nd:YAG laser in Skin Types IV-VI

Publication date: Available online 15 September 2018

Source: Journal of the American Academy of Dermatology

Author(s): Dana S. Saade, Neelam A. Vashi

LED-enhanced biosynthesis of biologically active ingredients in callus cultures of Ocimum basilicum

Publication date: Available online 15 September 2018

Source: Journal of Photochemistry and Photobiology B: Biology

Author(s): Muhammad Nadeem, Bilal Haider Abbasi, Muhammad Younas, Waqar Ahmad, Adnan Zahir, Christophe Hano

Abstract

Ocimum basilicum is a medicinal plant with multiple health benefits including cardiovascular, cancer and diabetics. In the present study, the influence of light emitting diodes (LEDs) was investigated on the accumulation of biologically active ingredients in callus cultures of Ocimum basilicum. Among the various tested treatments optimum levels of Total phenolic content (TPC) was noted in callus culture grown under blue lights as compared to control, while maximum accumulation of Total flavonoid content (TFC) was noted in callus culture grown under red light as compared to control. HPLC analyses showed that highest concentrations of Rosmarinic acid (96.0 mg/g DW) and Eugenol (0.273 mg/g DW) were accumulated in blue light which was 2.46 and 2.25 times greater than control (39.0 mg/g DW, 0.171 mg/g DW), respectively. Chicoric acid (81.40 mg/g DW) optimum accumulation was noted in callus grown under the continuous white light, which was almost 4.52 times greater than control. Anthocyanins content were also analyzed, the highest amount of Peonidin (0.127 mg/g DW) and cyanidin (0.1216 mg/g DW) were found in callus culture grown under red light. These findings suggest that application of LED's is a promising strategy for enhancing production of biologically active ingredients in callus cultures Ocimum basilicum.

55PTP53 mutations as predictor of response and longer survival under immune checkpoint inhibitors in advanced non-small cell lung cancer

Background: Tumor mutational burden (TMB) correlates with response to immune checkpoint inhibitors (ICI) in advanced non-small-cell lung cancer (aNSCLC). We hypothesized that TP53 mutations could reflect TMB and predict ICI benefit.

101PInvolvement of miR-99a in resistance to chemotherapy in triple-negative breast cancer

Background: Breast cancer is the most prevalent type of cancer among women worldwide, and also the leading cause of women death in developed countries. Among the different breast cancer subtypes, triple-negative breast cancer is the most aggressive one. Those patients can be treated with cytotoxic therapies, but the most of them develop resistance against those drugs. Due to this reason, it is important to study new therapeutic approaches to increase the efficacy of chemotherapy. Herein, microRNAs have a major role in tumoral cell regulation as well as in drug resistance. Our aim was to determine which microRNAs are differentially expressed by MDA-MB-231 cells and MDA-MB-231 cells with acquired resistance to doxorubicin.

85PThe role of topoisomerase II-α (TOPO IIA) as a predictive factor for response to neoadjuvant anthracycline-based chemotherapy in locally advanced breast cancer

Background: Topoisomerase II-α is a molecular target of anthracyclines; several studies have suggested that topoisomerase II-α expression is related to response to anthracycline treatment. The objective of this study was to evaluate whether topoisomerase II-α overexpression predicts response to anthracycline treatment in locally advanced breast cancer patients.

102PMuscleblind-like 1 regulates epithelial to mesenchymal transition markers in triple-negative breast cancer

Background: Muscleblind-like 1 (MBNL1) has been deeply investigated because its implication in myotonic dystrophy. However, the role of RNA-binding proteins in breast cancer remains unknown. Recent findings suggest the role of MBNL1 as a suppressor of metastasis by stabilization of other genes in triple-negative breast cancer cell lines.

6PNGS cfDNA data as a basis for the development of qPCR diagnostic systems

Background: Circulating cell-free DNA (cfDNA) analysis can serve as a powerful diagnostic tool. However, most of the modern techniques used in oncology nowadays are based on expensive NGS procedures on the nuclear DNA. Here we propose a new approach for the development of cheap diagnostic tests based on cfDNA fragmentation profiles.

104PStudy of toxicity of the conventional treatments in myeloproliferative neoplasms, based on the functional status of the RUNX1/CBF-BETA/P300/HIPK2 complex

Background: Myeloproliferative neoplasms (MPNs) are clonal hematological malignancies with an inherent tendency to progress to acute leukemia, after a variable period of time. Although the mechanisms involved in the disease transformation are still unclear, it´s known that transcription factor RUNX1 (AML1) is frequently deregulated in human leukemia, and recently, it has been described that the activity of RUNX1 together with CBF-β cofactor is regulated by the proteins p300 and HIPK2. In fact, HIPK2 phosphorylates both RUNX1 and p300, activating the whole transcriptional complex. Therefore, the study of the status of this complex seems to be interesting in order to understand the mechanisms involved in the leukemic transformation.

Drug Index

Abiraterone: 29P, 57TiP

105PGlycolytic enzymes lactate dehydrogenase A (LDHA) and phosphofructokinase P (PFKP) are good biomarkers of survival and potential therapeutic targets in cervical cancer

Background: Cervical Cancer (CC) is the fourth most common cancer in women worldwide. Potential biomarkers in cancer can be identified by considering the changes in tumoral glycolysis. In this work, we investigated whether the expression of some glycolytic enzymes is associated with the overall and disease-free survival of patients with CC.

62PIdentification of resistance mechanisms for EGFR-targeted therapy in head and neck squamous cell carcinoma: Combining whole-exome sequencing and tumour kinase profiling

Background: The epidermal growth factor receptor (EGFR) is a therapeutic target in head and neck squamous cell carcinoma (HNSCC). Resistance to EGFR-targeted therapies such as cetuximab is a major clinical problem. This study aims to unravel resistance mechanisms by combining whole-exome sequencing (WES) and tumour kinase profiling. Based on the genetic and tumour kinase profile, new combination treatments can be designed to overcome therapy resistance.

106PExperience of 22 patients with ROS mutated lung adenocarcinoma treated with crizotinib at a tertiary care center in India

Background: ROS1 hence became recognized as a distinct molecular target in NSCLC.Like ALK rearrangements ROS1 fusions are also found more in never smokers but define a distinct molecular subgroup with both rarely occurring together in same patient Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the treatment of patients with advanced ROS1-positive NSCLC .We report our experience in a tertiary cancer care centre in ROS-1 positive patients.

77PThe reduction of the expression of B-catenin and c-Myc is related to a better outcome in patients with AML

Background: Acute myeloid leukemia (AML) is a malignant clonal disorder characterized by mutations affecting myeloid differentiation, gene expression, and epigenetic profiles. Although treatment strategy depends on a genetic profile-based risk, the accuracy of this stratification system is highly variable. Changes in gene expression profiles of signaling pathways involved in hematopoietic development, such as Wnt/B-catenin, may contribute to the transformation, development, and maintenance of leukemic cells, and could be related to the clinical outcome.

107PComputational integrative analysis of identification of potential therapeutic genes and networks in breast cancer

Background: Cancer genomics research aims at investigation of biological pathways affected by mutations of these genes will help us to understand the determinants of cancer initiation, progression, and other biological functions. The sophisticated computational methods have been developed to facilitate the detection of cancer driver mutations and pathways. We made an attempt in this study to identify the potential candidate genes in the breast cancer carcinogenesis by computational integrative analysis. This approach is appropriated for identifying potentially useful diagnostic and prognostic biomarkers for therapeutic intervention of breast cancer.

93PDecreasing telomerase activity of adenocarcinoma cancer cell line (AGS) is associated with different concentrations of sodium selenite and cadmium chloride and selenium l methionine

Background: Selenium (Se) has been recognized as an essential element for animals and humans. In the late 1960s, it was first suggested that selenium might have anti-cancer properties. Selenium controls apoptosis in cell cycle. Cadmium (Cd) is a widely used heavy metal that affects human health through occupational and environmental exposure and has been reported as a cause of cancers such as lung, prostate and kidney. The previous studies on Ovarian and breast cancer have shown that cadmium increases telomerase activity and expression level of hTERT. In the present study, we find out the effect of sodium selenite and selenium l methionine and cadmium chloride on telomerase activity in adenocarcinoma cancer cell line (AGS).

108PThe effect of the seleno-L-methionin, sodium selenite and cadmium chloride on telomerase activity of chick embryo neural tube cells

Background: Telomerase is a ribonucleoprotein enzyme with reverse transcriptase activity, that more important in developmental processes including cell proliferation, differentiation, senescence and tumorigenesis. Selenium as a trace element for animals and human has been detected which can have anticancer properties, while cadmium (Cd) is a heavy metal in the natural environment and is very toxic. Purpose of this study was investigating the effects of Seleno-L-methionine, Sodium selenite and Cadmium chloride on the expression of telomerase activity in Chick embryo neural tube.

10PEGFR T790M mutation in treatment-naïve tumor samples: Low frequency, evidence for interaction with EGFR TKI-sensitizing mutations and lack of clear predictive value

Background: EGFR T790M mutation is associated with acquired resistance of lung cancer (LC) to first-generation TKIs. Several studies suggest that LCs often contain a small fraction of T790M-mutated cells even before the treatment, and the persistence of these mosaic clones renders poor tumor response to gefitinib or erlotinib.

51PDNA damage ATR/Chk1 checkpoint signalling increases PD-L1 immune checkpoint activation and its implication for personalised combination therapy

Background: DNA double-strand break (DSB) is the most critical type of genotoxic stress. Clinical studies have revealed a link between genomic instability and response to anti-PD-1/PD-L1 therapy in cancer management. We investigated role of DBS repair and ATR/Chk1 DNA damage checkpoint in regulating PD-L1 expression and their use in therapy selection and study design.

109PPARP inhibitor (PARPi) monotherapy treatment in non-BRCA and/or non-serous gynaecological cancers

Background: The vast majority of PARPi clinical trial experience in gynaecological cancer is for patients with platinum sensitive high grade serous ovarian carcinoma (HGSOC) and deleterious BRCA1/2 mutations. It is known that other homologous recombination deficiency (HRD) associated mutations exist eg RAD51, BRIP1 that can potentially sensitise to PARPi. Extremely limited clinical data exists on the use of PARPi in HGSOC with HRD mutations other than BRCA1/2; or in BRCA-mutated gynaecological cancers excluding HGSOC. We investigated the role of PARPi in a cohort of patients with non-BRCA and/or non-high grade serous (HGS) gynaecological cancer.

59OPreliminary results on mechanisms of resistance to ALK inhibitors: A prospective cohort from the MATCH-R study

Background: ALK tyrosine kinase inhibitors (TKIs) have shown to be effective in the treatment of patients with ALK rearranged NSCLC. The clinical benefit is eventually limited by the acquisition of resistance to ALK TKIs by tumor cells. The study of the biological mechanisms implied in tumor progression can provide the rational for therapeutic strategies to overcome resistance.

66PAdapting a prescreening program to match molecular alterations in over 5,000 patients’ tumors with targeted agents and immunotherapies in early clinical trials over the last 8 years

Background: Since 2010, when the Molecular Prescreening Program (MPP) was established at VHIO, we have adapted the techniques and procedures to improve the identification of genomic alterations in tumors from patients (pts) eligible to Early Clinical Trials (ECTs). Here we report the clinical utility of our program given the evolving molecular testing landscape and trends in drug development.

110TiPPREvalence of BRCA mutations and correlations with Demographic and clinical characteristICs in paTients with ovarian, fallopian tube or primary peritoneal cancer in Romania (PREDICT)

Background: The epidemiology of ovarian cancer in Romania is not well characterized and only few limited regional data are available. Moreover, the BRCA status in patients with homologous recombination-deficient tumorsis not known and no data about dominant founder mutations exist. BRCA1/2 are tumor suppression genes critical to DNA repair through homologous recombination in response to DNA damage. Around 13% of high-grade serous ovarian cancers is attributable to germline BRCA mutations.

Precision and reproducibility of automated computer‐guided PASI measurements in comparison to trained physicians

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

The vascular morphology of melanoma is related to Breslow index: an in vivo study with dynamic optical coherence tomography

Experimental Dermatology, Volume 0, Issue ja, -Not available-.

Mechanisms of Pathogenic Effects of Eosinophil Cationic Protein and Eosinophil Derived Neurotoxin on Human Keratinocytes

Experimental Dermatology, Volume 0, Issue ja, -Not available-.

A lentiviral vector‐based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma

Pigment Cell &Melanoma Research, Volume 0, Issue ja, -Not available-.