Protective Effect of Baicalin Against TLR4‐mediated UVA‐induced Skin Inflammation

Photochemistry and Photobiology, Volume 0, Issue ja, -Not available-.

Cutaneous leishmaniasis in Sri Lanka: effect on quality of life

International Journal of Dermatology, EarlyView.

Moral enhancement and the good life

Abstract

One approach to defining enhancement is in the form of bodily or mental changes that tend to improve a person's well-being. Such a "welfarist account", however, seems to conflict with moral enhancement: consider an intervention that improves someone's moral motives but which ultimately diminishes their well-being. According to the welfarist account, this would not be an instance of enhancement—in fact, as I argue, it would count as a disability. This seems to pose a serious limitation for the account. Here, I elaborate on this limitation and argue that, despite it, there is a crucial role for such a welfarist account to play in our practical deliberations about moral enhancement. I do this by exploring four scenarios where a person's motives are improved at the cost of their well-being. A framework emerges from these scenarios which can clarify disagreements about moral enhancement and help sharpen arguments for and against it.

Primary Cutaneous Non‐Pigmented Mycotic Cyst Contained in an Epidermal Inclusion Cyst: Case Report and Review of the Literature

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.

A Bibliography of Aśvaghoṣa

Abstract

Though quite extensive in its coverage, the present bibliography does not claim to be exhaustive. Among the many works traditionally (but incorrectly) ascribed to Aśvaghoṣa, some, such as the *Mahāyānaśraddhotpādaśāstra (Taishō no. 1666, 1667) or, to a lesser degree, the Kalpanāmaṇḍitikā alias Sūtrālaṅkāra, have lived their own lives in modern scholarship and received virtually as much attention as Aśvaghoṣa himself. An attempt has been made to list all the contributions that have proved decisive in questioning and finally rejecting the poet's authorship of them. In much the same way, most of what has been written about the Chinese and Japanese elaborations of the figure of Aśvaghoṣa (as a patriarch, as a god of sericulture, etc.) has been disregarded. Collecting in a systematic way all Indian editions and translations in modern-day Indian languages (Bengali, Hindi, etc.) has proved practically impossible. Finally, this bibliography does not include all the entries on Aśvaghoṣa in dictionaries, encyclopedias, histories of Indian literature, etc. Only the earliest and the historically or scholarly most significant ones (e.g., those of Winternitz and Keith, and, very recently, Salomon) have found their way into the list. This bibliography would have been even more limited in its coverage had Nobuyoshi Yamabe not generously agreed to include the most important Japanese titles on the subject. In carrying out this task he acknowledges his indebtedness to Kiyoshi Okano's online bibliography (http://gdgdgd.g.dgdg.jp/asvaghosa-index.html). This bibliography is meant as a work in progress. We would like to invite all those who are writing on Aśvaghoṣa to send us their publications or at least detailed references to them so that the bibliography (an online version of which should be available soon) can be regularly updated (vincent.eltschinger@ephe.psl.eu; yamabe@waseda.jp). The sign "†" signals references that were not/could not be accessed directly.

CRYAB protects cardiomyocytes against heat stress by preventing caspase-mediated apoptosis and reducing F-actin aggregation

Abstract

CRYAB is a small heat shock protein (sHSP) that has previously been shown to protect the heart against various cellular stresses; however, its precise function in myocardial cell injury caused by heat stress remains unclear. This study aimed to investigate the molecular mechanism by which CRYAB protects cardiomyocytes against heat stress. We constructed two H9C2 cell lines that stably express CRYAB protein to differing degrees: CRYAB-5 and CRYAB-7. Both CRYAB-5 and CRYAB-7 showed significantly reduced granular degeneration and vacuolar degeneration following heat stress compared to control cells. In addition, CRYAB overexpression in H9C2 cells relieved cell cycle proportion at the G0/G1 phase following heat stress compared to control cells. These protective effects were associated with the level of CRYAB protein expression. Our immunofluorescence analysis showed CRYAB could translocate from the cytoplasm to the nucleus under heat stress conditions, but that CRYAB co-localized with F-actin (which accumulates under stress conditions). Indeed, overexpression of CRYAB significantly reduced the aggregation of F-actin in H9C2 cells caused by heat stress. Furthermore, overexpressing CRYAB protein significantly reduced the apoptosis of cardiomyocytes induced by heat stress, likely by reducing the expression of cleaved-caspase 3. Collectively, our results show overexpression of CRYAB significantly increases the heat resistance of H9C2 cardiomyocytes, likely by reducing F-actin aggregation (thus stabilizing the cytoskeleton), regulating the cell cycle, and preventing caspase-mediated apoptosis.

Subcutaneous nodules at progesterone injection sites after fertility treatment

Australasian Journal of Dermatology, EarlyView.

IgG/IgA pemphigus: Report of a rare subtype of pemphigus

Australasian Journal of Dermatology, EarlyView.

Clinical and dermoscopic features of pleomorphic dermal sarcoma

Australasian Journal of Dermatology, EarlyView.

Use of a lumbar puncture needle to reduce the number of needle insertions in infiltration local anaesthesia of large areas in dermatologic surgery

Australasian Journal of Dermatology, EarlyView.

Tanning, selfies and social media

Australasian Journal of Dermatology, EarlyView.

Facial trauma reconstruction with polymethyl methacrylate—A case report

Journal of Cosmetic Dermatology, EarlyView.

Assessment of practice efficacy by retrospective analysis of long‐term patient outcomes: A proposed method

Journal of Cosmetic Dermatology, EarlyView.

Appearance‐based vs health‐based sun protective messages: A randomized, double‐blind controlled study

Journal of Cosmetic Dermatology, EarlyView.

Effects of contrast cryolipolysis on flank region adiposity: Case study

Journal of Cosmetic Dermatology, EarlyView.

Three‐dimensional nail imaging by optical coherence tomography: a novel biomarker of response to therapy for nail disease in psoriasis and psoriatic arthritis

Clinical and Experimental Dermatology, EarlyView.

The meshed biological matrix in immediate, definitive breast reconstruction

The aim of this study is to verify the advantages of using a meshed biological matrix (U.I.B.M.-Italian Patent N° 283625) compared to the intact one. A prospective double blind randomized clinical trial with 46 cases of immediate breast reconstruction was performed. The utilization of a meshed biological matrix results in less drainage, reduced need for drains after a few days and a very small percentage rate of seromas and complications, if compared with the utilization of an intact biological matrix.

An Alternative Approach to the Intraoperative Indocyanine Green Angiography (ICGA) in reconstructive surgery

Indocyanine Green (ICG) is a nontoxic, near- infrared fluorescent dye that has been used for imaging since the 1950s to evaluate liver perfusion and in cardiology.1 It has more recently gained traction in other key areas of reconstructive surgery such as sentinel node biopsy in breast and melanoma skin cancers, lymphangiography in the surgical management of lymphedema and in assessing flap viability in free tissue transfers.1,2

Evaluation of Paeonia emodi and its gold nanoparticles for cardioprotective and antihyperlipidemic potentials

Publication date: Available online 22 September 2018

Source: Journal of Photochemistry and Photobiology B: Biology

Author(s): Muhammad Ibrar, Mir Azam Khan, Abdullah, Muhammad Imran

Abstract

Paeonia emodi Wall. ex Royle is an important member of family Paeoniaceae and folklorically used for constipation, hysteria, respiratory diseases, epilepsy and cardiac diseases like hypertension, palpitations, congestive heart failure and atherosclerosis. In the present study, ethyl acetate fraction of P. emodi (Pe.EA) was subjected to column chromatography to obtain sub- fractions. These sub-fractions were screened for their cardioprotective activity in isoproterenol hydrochloride (ISO) induced myocardial infarction (MI) in mice. The most active fraction Pe. EA 40 was used for its gold nanoparticles synthesis (Pe.EA 40-AuNPs). Pe.EA 40 and Pe.EA 40-AuNPs were investigated for their cardioprotective, antihyperlipidemic, DNA fragmentation assay and histopathological study. Pe.EA 40 (80 mg/kg body weight) significantly reduced the serum levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Lactate Dehydrogenase (LDH), Creatine Phosphokinase (CPK) to 66.07 ± 1.54, 77.08 ± 1.79, 84.86 ± 1.34 and 265.34 ± 4.34 IU/L respectively as compared to ISO treated group. Pe.EA 40-AuNPs (40 mg/kg) reduced the levels of ALT, AST, CPK and LDH to 60.74 ± 2.79, 75.47 ± 1.67, 80.48 ± 2.64 and 247.54. ± 5.57 IU/L respectively. A significant reduction was observed in lipid profile, protection in DNA damage and restoration of histopathological changes as compared to ISO treated group. Based on the results, it can be suggested that preparation of Pe.EA 40-AuNPs enhances the therapeutic potential of plant extract for the treatment of atherosclerosis and MI.

Graphical Abstract

Monitoring of topoisomerase (I) inhibitor camptothecin release from endogenous redox-stimulated GO-polymer hybrid carrier

Publication date: Available online 22 September 2018

Source: Journal of Photochemistry and Photobiology B: Biology

Author(s): Richa Rashmi, Divya Nedungadi, Arup Podder, Nandita Mishra, Sankarprasad Bhuniya

Abstract

We have developed endogenous redox-responsive polymer conjugated GO-based hybrid nanomaterials (GO-PEGssFol-CPT) for delivery of anticancer drug camptothecin (CPT) to the cancer cells. The synthesized intermediate (PEG_SSFol) and CPT loaded GO- PEG_SSFol were characterized using Fourier transform infrared spectroscopy (FTIR) and ¹H NMR. The morphological feature changes of TEM and AFM images have confirmed the loading of CPT on the nanocarrier and its release from the nanocarrier. The amount of CPT was loaded was found to be 14.2%. The extent of camptothecin (CPT) release from GO-BiotinPVA-CPT in the presence of different concentrations of glutathione (GSH) was monitored with the increase in the fluorescence intensity at λ_max 438 nm and UV–Vis absorbance at 366 nm. The time-dependent camptothecin (CPT) release was monitored in the presence of GSH. It was noticed that CPT was completely released from GO-PEGssFol-CPT within 45 min. This release process is free from interference by other ubiquitous analytes in the living system. The constant fluorescence intensity of GO-PEGssFol-CPT against acidic pH indicated that CPT would not be released in the extracellular region of cancer cells. Therefore, such delivery system could be used to prevent unwanted cytotoxicity to the healthy cells. The GO-PEGssFol-CPT showed higher antiproliferative activity against cervical cancer cells compared to the CPT. Thus, GO-PEGssFol-CPT can be a new material to deliver the anticancer drug to the target tumor region.

Graphical abstract

Differential surface contact killing of pristine and low EPS Pseudomonas aeruginosa with Aloe vera capped hematite (α-Fe2O3) nanoparticles

Publication date: Available online 22 September 2018

Source: Journal of Photochemistry and Photobiology B: Biology

Author(s): Khursheed Ali, Bilal Ahmed, Mohammad Saghir Khan, Javed Musarrat

Abstract

Biogenic hematite (α-Fe₂O₃) nanoparticles (NPs) of average size <10 nm were synthesized using green approach with Aloe vera extract (ALE). The aim of the study was to assess the protective effect of extracellular polymeric substances (EPS) against antibacterial and antibiofilm activities of ALE-α-Fe₂O₃NPs in normal EPS producers (pristine) and experimentally modified (low-EPS) Pseudomonas aeruginosa (P. aeruginosa) cells and the mechanism of cell killing. Formation of ALE-α-Fe₂O₃NPs has been validated by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier-transformed infrared spectroscopy (FTIR) analysis. The FTIR data suggested the possible role OH group bearing organic compounds of ALE in metal reduction and nucleation of NPs. Gas Chromatography-Mass spectroscopy (GC–MS) analysis revealed the presence of oxime-methoxy-phenyl, ethanone 1-phenyl, hexadecanoic acid, cyclohexanol 2,6-dimethyl, tetracontane, stigmast-5-en-3-ol, cyclohexanol 2,6-dimethyl, and cyclohexasiloxane dodecamethyl on the surface of ALE-α-Fe₂O₃NPs. Cell viability assay and SEM imaging revealed significantly greater bacteriostatic and/or bactericidal effect of ALE-α-Fe₂O₃NPs in low EPS cells compared to pristine cells or bare-α-Fe₂O₃NPs. This is attributed to thinner protective layer of EPS around the low EPS cells, and higher dispersibility and stability of ALE-α-Fe₂O₃NPs. Absorption of ALE-α-Fe₂O₃NPs and bare-α-Fe₂O₃NPs on EPS surface and within EPS matrix was ascertained by atomic absorption spectroscopy (AAS). The results suggest differential internalization of ALE-α-Fe₂O₃NPs and bare-α-Fe₂O₃NPs in P. aeruginosa cells. The flow cytometry (FCM) results exhibited increased intracellular granularity in low EPS (18.94%) as compared with pristine (10.94%) cells, which signifies the greater internalization of ALE-α-Fe₂O₃NPs. Moreover, the proportionate increase in intracellular ROS generation in low EPS (20.47%) via-a-vis pristine (7.56%) cells was observed. Overall, the results elucidate that ALE-α-Fe₂O₃NPs-bacterial interaction leads to attachment of NPs to EPS surface, migration within the EPS matrix and penetration into cell, which eventually results in growth inhibition due to intracellular ROS activity. Owing to significant antibacterial and antibiofilm activities, ALE-α-Fe₂O₃NPs may serve as a good candidate for clinical management of extended spectrum beta lactamases (ESBL) positive P. aeruginosa.

Graphical Abstract

ESPD Photodermatology Day, Program and Abstracts

Photodermatology, Photoimmunology &Photomedicine, Volume 34, Issue 5, Page 354-357, September 2018.

Issue Information

Photodermatology, Photoimmunology &Photomedicine, Volume 34, Issue 5, Page 285-286, September 2018.

Photodermatology and Photomedicine: Meeting Calendar

Photodermatology, Photoimmunology &Photomedicine, Volume 34, Issue 5, Page 287-287, September 2018.

Local Recurrence and Quality of Life After Adjuvant Radiation Therapy in High‐Risk Squamous Cell Carcinoma

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

Low resolution rates of seafood allergy

Publication date: Available online 22 September 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Victoria N. Zotova, Ann Elaine Clarke, Edmond S. Chan, Yuka Asai, Ricky Chin, Chynace Van Lambalgen, Laurie Harada, Moshe Ben-Shoshan

Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti‐programmed cell death (PD)‐1 therapy

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

An Alternative Approach to the Intraoperative Indocyanine Green Angiography (ICGA) in reconstructive surgery

Publication date: Available online 23 September 2018

Source: Journal of Plastic, Reconstructive & Aesthetic Surgery

Author(s): Angelos Mantelakis, Stamatis Sapountzis

The meshed biological matrix in immediate, definitive breast reconstruction

Publication date: Available online 23 September 2018

Source: Journal of Plastic, Reconstructive & Aesthetic Surgery

Author(s): Tommaso Fabrizio, Salvatore Serio, Domenico Massariello, Michelangelo Vestita, Vittorio Simeon

Abstract

The aim of this study is to verify the advantages of using a meshed biological matrix (U.I.B.M.-Italian Patent N° 283625) compared to the intact one. A prospective double blind randomized clinical trial with 46 cases of immediate breast reconstruction was performed. The utilization of a meshed biological matrix results in less drainage, reduced need for drains after a few days and a very small percentage rate of seromas and complications, if compared with the utilization of an intact biological matrix.

The Helsinki Approach to Face Transplantation

Publication date: Available online 22 September 2018

Source: Journal of Plastic, Reconstructive & Aesthetic Surgery

Author(s): Andrew J Lindford, Heikki Mäkisalo, Hannu Jalanko, Jouni Lauronen, Veli-Jukka Anttila, Susanna Juteau, Antti-Jussi Ämmälä, Anna Eskola, Samuli Saarni, Helena Isoniemi, Antti Mäkitie, Patrik Lassus

Abstract

Aim

We herein describe the establishment of the Helsinki Vascularized Composite Allotransplantation (VCA) program and its execution in the first two face transplant cases.

Methods & Patients

The Helsinki VCA program initially required the fulfillment of legal, hospital, financial, and ethical requirements. Thereafter, the assembling of a multidisciplinary team commenced. A team of Plastic, maxillofacial and ENT surgeons comprise the facial VCA team. The protocol involves collaboration with the Solid Organ Transplant (SOT) team, transplant immunology, immunosuppression, microbiology, psychiatric evaluation, well-defined VCA indications and informed consent. Between 2011-2017 two patients were selected for transplantation. Both patients had a severe composite facial deformity involving the maxilla and mandible following earlier ballistic injury.

Results

Patient 1 was a 35 year-old male who underwent successful near total face transplantation in February 2016 and at 30 months he has a good aesthetic outcome with symmetrical restoration of the central face and good sensory and symmetrical motor functional outcomes. Patient 2 was a 58 year-old male who underwent full face transplantation in March 2018 and at 5 months he has recovered without major problems.

Conclusion

A successful facial VCA program requires a well-prepared research protocol, experts from multiple specialties and careful patient selection. The establishment of the Helsinki VCA program required long and thorough planning and resulted in the first two Nordic face transplantation cases. This protocol now forms the platform (as a proof of concept) for other types of vascularized composite allotransplantations.

Comment on “How to assess the volume of a DIEP flap using a free online calculator: the DIEP V (volume) method”

Publication date: Available online 22 September 2018

Source: Journal of Plastic, Reconstructive & Aesthetic Surgery

Author(s): Kyong-Je Woo, Goo-Hyun Mun

Gingko flap: The development of a novel flap technique to reduce dog ear formation

Publication date: Available online 22 September 2018

Source: Journal of Plastic, Reconstructive & Aesthetic Surgery

Author(s): Hiroyuki Hashimoto, Rui Suzuki, Sekinori Munemoto, Manami Kusatsu, Kaho Matsuda, Seiichi Sato, Osamu Okamoto

Anatomic Location of a Sensory Nerve to the Transverse Upper Gracilis (TUG) Flap: A Novel Option for Sensate Autologous Tissue Reconstruction

Publication date: Available online 22 September 2018

Source: Journal of Plastic, Reconstructive & Aesthetic Surgery

Author(s): James Gatherwright, Rebecca Knackstedt, David Kurlander, Risal Djohan

When should we use the terms “aponeurotic blepharoptosis” and “reinsertion of the levator aponeurosis”?

Publication date: Available online 22 September 2018

Source: Journal of Plastic, Reconstructive & Aesthetic Surgery

Author(s): Stephanie Lemaitre, Miguel González-Candial

Accuracy of tele‐consultation on management decisions of lesions suspect for melanoma using reflectance confocal microscopy as a stand‐alone diagnostic tool

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Certolizumab Pegol for the Treatment of Patients with Moderate‐to‐Severe Chronic Plaque Psoriasis: Pooled Analysis of Week 16 Data from 3 Randomized Controlled Trials

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Pregnancy complications, treatment characteristics and birth outcomes in women with atopic dermatitis in Denmark

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Treatment use and satisfaction among patients with psoriasis and psoriatic arthritis: results from the NORdic PAtient survey of Psoriasis and Psoriatic arthritis (NORPAPP)

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Association of vitiligo with hospitalization for mental health disorders in US adults

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Erosive lichen planus: beyond the nails

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.