Contribution and safety of the side‐to‐end hypoglossal‐to‐facial transfer in multidisciplinary facial reanimation

alexandrossfakianakis shared this article with you from Inoreader Contribution and safety of the side‐to‐end hypoglossal‐to‐facial transfer in multidisciplinary facial reanimation Via Head & Neck Abstract Background This study evaluates facial and tongue function in patients undergoing side-to-end hypoglossal-to-facial transfer (HFT) with additional techniques. Methods Thirty-seven patients underwent a side-to-end HFT. Twelve had additional cross-face grafts, and 9 had an additional masseter-to-facial transfer. Facial was assessed with House–Brackmann (HB), Sunnybrook Facial Grading Scale (SFGS), and eFACE. Martins scale and the Oral-Pharyngeal Disability Index (OPDI) were used to assess tongue function. Results Ninety-four percent of cases reached HB grades III–IV. Mean total SFGS score improved from 16 ± 15 to 59 ± 11, while total eFACE score from 52 ± 13 to 80 ± 5. Dual nerve transfers were a predictor for a better eFACE total score p = 0.034, β = 2.350 [95% CI, 0.184–4.516]), as well as for a higher SFGS total score (p = 0.036, β = 5.412 [95% CI, 0.375–10.449]). All patients had Martin's grade I. Mean postoperative OPDI scores were 84 ± 17 (local physical), 69 ± 16 (simple and sensory motor components), 82 ± 14 (complex functions), and 73 ± 22 (psychosocial). Conclusions The side-to-end HFT offers predictable facial function outcome and preserves tongue function in nearly all cases. Dual nerve transfers appear to improve the final outcome. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Bad, mad, or glad? Exploring the relationship between leaders’ appraisals or attributions of their use of abusive supervision and emotional reactions

alexandrossfakianakis shared this article with you from Inoreader Bad, mad, or glad? Exploring the relationship between leaders' appraisals or attributions of their use of abusive supervision and emotional reactions Via Applied Psychology Abstract A large body of research has documented the ill effects of abusive supervision. However, this begs the question of why these behaviors continue to occur. To address this question, we contend that scholars need to understand how leaders – the perpetrators of these actions – make sense of abusive supervision. Specifically, drawing upon theories of appraisal and attribution, this paper examines leaders' cognitions of who is accountable for incidents of abusive supervision (i.e., the leader or the subordinate) and their future expectations (i.e., are individuals likely to engage in the same behaviors subsequently or capable of change) and how these appraisals interact to shape emotional reactions. We conducted three complementary studies: a pilot study to identify relevant emotions, an event-based experience sampling study (Study 1), and a retrospective recall study (Study 2). Accountability appraisals were associated with emotions, such that appraisals that oneself (vs. one's subordinate) was more responsible for the incident were linked to higher levels of guilt and shame. Although growth mindset moderated associations between accountability appraisals and emotions, it did so for different emotions across the two studies (i.e., hostility in Study 1 and shame in Study 2). Implications for theory and practice are discussed. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Assessing the risks associated with the emergence of Florona and possible preventive measures

alexandrossfakianakis shared this article with you from Inoreader Message: Κορωνοϊός: Τι είναι η Delmicron και η Florona REUTERS / MAY JAMES Το στέλεχος Όμικρον του SARS-CoV-2 κυριαρχεί πλέον στην Ευρώπη και οδηγεί σε κατακόρυφη αύξηση των νέων κρουσμάτων COVID-19. Πρόσφατα, δύο νέοι όροι έχουν έρθει στο προσκήνιο. Ο λόγος για τους όρους Delmicron και Florona. Οι Ιατροί της Θεραπευτικής Κλινικής της Ιατρικής Σχολής του Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών Θεοδώρα Ψαλτοπούλου, Γιάννης Ντάνασης, Πάνος Μαλανδράκης και Θάνος Δημόπουλος (Πρύτανης ΕΚΠΑ) συνοψίζουν τα νεότερα σχετικά με τα Delmicron και Florona. Αρχικά πρέπει να σημειωθεί ότι και οι δύο όροι δεν αναφέρονται σε κάποιο νέο στέλεχος του SARS-CoV-2, αλλά σε συνύπαρξη του στελέχους Όμικρον είτε με το στέλεχος Δέλτα (Delmicron) είτε με την εποχική γρίπη (Florona). Σύμφωνα με τον Παγκόσμιο Οργανισμό Υγείας (ΠΟΥ), η επικράτηση του στελέχους Όμικρον δεν θα πρέπει να μας κάνει να λησμονήσουμε άλλες πολύ συχνές ιογενείς λοιμώξεις που συνυπάρχουν στην κοινότητα και μπορεί να εμφανιστούν παράλληλα σε ευάλωτα άτομα. Γι' αυτό το λόγο, τονίζεται η ανάγκη πλήρους εμβολιασμού με όλες τις απαραίτητες αναμνηστικές δόσεις τόσο έναντι του SARS-CoV-2 όσο και έναντι της εποχικής γρίπης, παράλληλα με την τήρηση των κανόνων σωματικής απομάκρυνσης για την πρόληψη της μετάδοσης και των δύο λοιμώξεων. Τι είναι η Delmicron: Ποια τα συμπτώματα Τα άτομα με εξασθενημένο ανοσοποιητικό σύστημα, τα άτομα μεγαλύτερης ηλικίας και με συνυπάρχουσες παθήσεις παρουσιάζουν αυξημένο κίνδυνο COVID-19 και μάλιστα είναι πιθανό να νοσήσουν ταυτόχρονα και από δύο επικρατούντα στελέχη του SARS-CoV-2, δηλαδή το Όμικρον και το Δέλτα. Η συλλοίμωξη με τα δύο στελέχη (Delmicron) μπορεί επίσης να παρατηρηθεί σε περιοχές με χαμηλή εμβολιαστική κάλυψη του πληθυσμού. Και αυτό ισχύει γιατί μπορεί το στέλεχος Όμικρον να είναι το κυρίαρχο, ωστόσο το στέλεχος Δέλτα δεν έχει εκλείψει. Στο γενικό πληθυσμό η πιθανότητα της ταυτόχρονης λοίμωξης με δύο στελέχη SARS-CoV-2 είναι χαμηλή, ωστόσο σε περιπτώσεις συνωστισμού μπορεί να συνυπάρχουν κρούσματα τόσο Δέλτα όσο και Όμικρον. Εάν τα άτομα που έχουν εξασθενημένο ανοσοποιητικό βρεθούν στο πλήθος, θα εκτεθούν πιθανότατα και στα δύο στελέχη και μπορεί να εμφανίσουν κλινική νόσο και από τα δύο στελέχη. Τα συμπτώματα είναι ουσιαστικά ο συνδυασμός των συμπτωμάτων από τα δύο στελέχη και περιλαμβάνουν εμπύρετο, βήχα, ανοσμία, αγευσία, πονοκέφαλο, καταρροή και πονόλαιμο. Τι είναι η Florona: Τα συμπτώματα και οι επιπλοκές Πολύ πρόσφατα αναφέρθηκε στο Ισραήλ η περίπτωση μιας εγκύου που προσήλθε στο νοσοκομείο για τοκετό και διαγνώσθηκε με παράλληλη λοίμωξη COVID-19 και γρίπης (Florona). Η ασθενής δεν είχε εμβολιαστεί για κανέναν από τους δύο ιούς. Παρόλο που ο όρος Florona μπορεί να προέκυψε πρόσφατα, η συλλοίμωξη δεν αποτελεί κάτι καινούργιο για την ιατρική κοινότητα. Ο ιός SARS-CoV-2 και ο ιός της γρίπης μεταδίδονται με παρόμοιο τρόπο, δηλαδή με την κοντινή επαφή σε απόσταση μικρότερη των 2 μέτρων μέσω αναπνευστικών σταγονιδίων ή/και αερολύματος κατά τη διάρκεια της ομιλίας, του βήχα και του πτερνίσματος. Οι δύο λοιμώξεις έχουν κοινά συμπτώματα όπως βήχας, πυρετό και καταρροή. Διαφορετικές δοκιμασίες PCR για τον ιό της γρίπης και για τον SARS-CoV-2 μπορεί να αποσαφηνίσουν σε κάθε περίπτωση την αιτιολογία των συμπτωμάτων. Και οι δύο λοιμώξεις μπορεί να έχουν σοβαρές επιπλοκές όπως πνευμονία, οξεία αναπνευστική ανεπάρκεια, πολυ-οργανική ανεπάρκεια, καρδιακά συμβάματα, εγκεφαλίτιδα, μυοκαρδίτιδα, ισχαιμικό εγκεφαλικό επεισόδιο και θάνατο. Unlike some of the claims made by fake news posts of social media, Florona is not a new Covid-19 variant. The last Covid-19 variant that was detected was Omicron and no further variants have since been identified by the World Health Organisation. The WHO does, however, confirm that co-infection with both Covid-19 (any variant) and the flu virus is indeed possible and added that the best way to avoid such a condition is to get vaccinated against both Covid-19 and Influenza. What are the symptoms of Florona? While both Covid-19 and influenza affect the respiratory system, there are some differences between the way flu and Covid-19 impacts health and manifests themselves. Symptoms of "Florona" include high fever, consistent chest pain or constriction, shortness of breath and loss of appetite. It can also lead to states of confusion and anxiety. According to the WHO, mild symptoms of a double Covid-19 and flu infection can be treated at home itself without requiring any hospitalisation. In severe cases, symptoms of Florona may also include pneumonia, myocarditis and inflammation in heart muscles. Is Florona a matter of concern? Both Covid-19 and flu are viruses that affect the respiratory tract and can cause severe illness and even death. While the symptoms and means of transmission for both viruses are the same, both have different treatments and different vaccines. Double infection with both viruses can cause complications the body and stress out the immune system. While "Florona" is not a new variant, the occurrence might be indicative of a weakened immune system under attack from two virus infections, Dr Nahla Abdel Wahab, Cairo University Hospital doctor, was quoted by Israeli media following the emergence of the disease. Amid the ongoing winter months, otherwise known as "flu season", season influenza breakouts are not uncommon in several countries. With Covid-19 cases also peaking across the world following the emergence of Omicron, fear of "Florona" cases spiking may not be unfounded. (Credit: Pixabay) How to prevent Florona? Following social distancing protocols, wearing masks and getting vaccinated against both Covid-19 and influenza is the only way to prevent Florona. Flu vaccines have been used since 1949, especially among vulnerable groups such as senior citizens. Meanwhile, a majority of countries have rolled out vaccination plans for their adult populations. Assessing the risks associated with the emergence of Florona and possible preventive measures Via Journal of Medical Virology Abstract The emergence of novel variants of SARS-CoV-2, especially the VOCs (variants of concern), has been considered a severe threat amid the mighty efforts of various nations to contain the negative repercussions of the COVID-19 pandemic caused by SARS-CoV-2. This article is protected by copyright. All rights reserved. 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Two conserved amino acids differentiate the biology of high‐risk and low‐risk HPV E5 proteins.

alexandrossfakianakis shared this article with you from Inoreader Two conserved amino acids differentiate the biology of high‐risk and low‐risk HPV E5 proteins. Via Journal of Medical Virology Abstract The high-risk alpha human papillomaviruses (HPVs) are responsible for 99% of cervical cancers. While the biological functions of the HPV E6 and E7 oncoproteins are well-characterized, the function of E5 has remained elusive. Here, we examined gene expression changes induced by E5 proteins from high-risk HPV-16 and low-risk HPV-6b in multiple pools of primary human keratinocytes. Surprisingly, microarray analysis revealed that over 700 genes were significantly regulated by HPV-6b E5, while only 25 genes were consistently and significantly regulated by HPV-16 E5 in three biological replicates. However, we observed that more than thousand genes were altered in individual sample compared to vector. The gene expression profile induced by 16E5 in primary genital keratinocytes was very different from what has been previously published using immortalized HaCaT cells. Genes altered by HPV-16 E5 were unaffected by HPV-6b E5. Our data demonstrate that E5 proteins from the high- and low-risk HPVs have different functions in the HPV-host cell. Interestingly, conversion of two amino acids in HPV-16 E5 to the low-risk HPV-6b sequence eliminated the induction of high-risk related cellular genes. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

In Silico Finite Element Analysis of Implant‐Supported CAD‐CAM Resin Composite Crowns

alexandrossfakianakis shared this article with you from Inoreader In Silico Finite Element Analysis of Implant‐Supported CAD‐CAM Resin Composite Crowns Via Journal of Prosthodontics Abstract Purpose The aim of this study was to evaluate the mechanical behavior of an implant-supported crown made using computer-aided design and computer aided manufacturing (CAD-CAM) resin composite (RC) blocks in the posterior region. Material and methods Four commercially available CAD-CAM RC blocks were used in this study: Cerasmart 300 (CS300; GC, Tokyo, Japan), Katana Avencia P Block (KAP; Kuraray Noritake Dental, Niigata, Japan); KZR HR3 Gamma Theta (HR3; Yamakin, Osaka, Japan), and Estelite P block (ESP; Tokuyama Dental, Tokyo, Japan). Katana Zirconia STML (ST; Kuraray Noritake Dental) was used as the control group. The elastic moduli of each material were determined by a three-point bending test. After the CAD models were designed, two different loading scenarios (oblique, vertical) were created. 3D finite element analysis was conducted with the prepared models. Results The elastic modulus of the material utilized for the implant restorations did not cause any change in the stresses transmitted to the implant or peripheral bone. An important difference was detected in the abutment–crown junction area. The minimum von Mises value at the abutment-crown interface was obtained in ST, which has the closest elastic modulus to the titanium abutment. Conclusions The 3D finite element model designed in this study was used to demonstrate that implant-supported crowns fabricated with four different CAD-CAM RCs showed no critical stress concentrations in the bone or implant under all loading conditions. These results suggest that CAD-CAM RC blocks could be used as an alternative material for implant-supported restorations in the posterior region in terms of stress distribution. This article is protected by copyright. All rights reserved View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Feasibility of face mask spirometry during decannulation in head and neck surgery: prospective cohort study

alexandrossfakianakis shared this article with you from Inoreader Feasibility of face mask spirometry during decannulation in head and neck surgery: prospective cohort study Via Clinical Otolaryngology Abstract Objectives To analyze the relationship between spirometric parameters measured with a face mask versus a mouthpiece, as well as the feasibility of face mask spirometric evaluation in a head and neck surgery (HNS) decannulation context. Furthermore, we examine peak inspiratory flow (PIF) cut-off values before and after decannulation. Design Prospective cohort study. Setting Otolaryngology HNS Department of a University teaching hospital. Participants Twenty-four patients were selected. A maximal flow-volume loop was conducted before (with mouthpiece) and after (with mouthpiece and face mask) decannulation. Main outcome measures Recorded outcomes were forced vital capacity (FVC), forced expiratory volume in the first second, peak expiratory flow, PIF, forced expiratory flow at 50% of FVC and forced inspiratory flow at 50% of FVC. Spearman correlation coefficients between spirometric parameters measured with a face mask versus a mouthpiece were calculated. Wilcoxon test was used to check differences between mouthpiece and face mask values. Results Correlation between mouthpiece and face mask spirometric values was moderate to high (r = 0.46 to 0.95). All parameters measured by spirometry were significantly lower with a face mask than those obtained with a mouthpiece (p < 0.05). Before decannulation, the lowest PIF value (tested with mouthpiece) that allowed successful decannulation was 1 L/s. After decannulation, the lowest PIF value tested with mouthpiece and face mask for successful completion of the decannulation process were 0.77 and 0.56 L/s, respectively. Conclusion Face mask is a feasible option to perform a spirometry when face diseases hinder spirometric evaluation through a mouthpiece in an HNC surgery context. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tooth as graft material: Histologic study

alexandrossfakianakis shared this article with you from Inoreader Tooth as graft material: Histologic study Via Clinical Implant Dentistry and Related Research Abstract Background An effective regenerative protocol is key to reestablish and maintain the hard and soft tissue dimensions over time. The choice of the graft material and its properties also could have an impact on the results. To prevent alveolar ridge dimensional changes, since numerous graft materials have been suggested and in the past years, a growing interest in teeth material has been observed as a valuable alternative to synthetic biomaterials. Aim The aim of the study was to explore the histomorphometric outcomes of tooth derivative materials as used as bone substitute material in socket preservation procedure. Methods After alveolar socket preservation (ASP) procedures using autologous demineralized tooth as graft material prepared by means of an innovative device, was evaluated. A total of 101 histological samples, from 96 subjects, were analyzed by evaluating the total amount of bone (BV), residual tooth material (residual graft, TT), and vital bone (VB). The section from each sample was then split in nine subsections, resulting in 909 subsections, to allow statistical comparison between the different areas. Results It was not noticed a statistically significant difference between maxillary and mandibular sites, being the amount of VB in upper jaw sites 37.9 ± 21.9% and 38.0 ± 22.0% in lower jaw sites and the amount of TT was 7.7 ± 12.2% in maxilla and 7.0 ± 11.1% in mandibles. None of the other considered parameters, including defect type and section position, were statistically correlated to the results of the histomorphometric analysis. Conclusions ASP procedure using demineralized autologous tooth-derived biomaterial may be a predictable procedure to produce new vital bone potentially capable to support dental implant rehabilitation. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clinical evaluation of the buccal aspect around immediate implant using dual zone therapeutic concept versus buccal gap fill to bone level: A randomized controlled clinical trial

alexandrossfakianakis shared this article with you from Inoreader Clinical evaluation of the buccal aspect around immediate implant using dual zone therapeutic concept versus buccal gap fill to bone level: A randomized controlled clinical trial Via Clinical Implant Dentistry and Related Research Abstract Objective Soft tissue esthetics for immediate implant is considered challenging when restoring a tooth in an esthetic zone. This study aimed to evaluate the buccal aspect after immediate implant using the dual-zone therapeutic concept compared to grafting the buccal gap to the bone crest. Materials and methods Twenty-four patients were randomly assigned into either immediate implant with the dual-zone therapeutic concept (DZ, test group) or with bone grafting till buccal bone crest with immediate temporization (BCG, control group). Pink esthetic score (PES), buccal bone loss (BBL), mid-facial recession (MFR), soft tissue thickness (STT), keratinized tissue width (KTW), post-operative swelling (POS), and patient satisfaction (PS) were evaluated for 1 year. Results At 12 months the PES in the test group was 11.36 ± 1.69, and 10.80 ± 1.55 in the control group, with no statistically significant difference (p = 0.45). MFR in the DZ and BCG groups was 0.27 ± 0.34 and 0.45 ± 0.44 after 12 months with no statistical significance difference (p = 0.195). The STT assessment showed a statistically significant increase in both groups, however the intergroup comparison was statistically not significant (p = 0.23). The mean KTW in the DZ and BCG groups was 4.55 ± 1.08 and 4.20 ± 0.82 mm, respectively with no statistical significance (p = 0.42). There was no statistical significant difference in patient satisfaction between the two groups except in question number 10 concerning the post-operative swelling which was higher in the DZ group (p = 0.009). Conclusions Both treatment modalities are considered reliable methods to achieve good soft tissue esthetics. However, both treatment modalities were not effective in preventing facial bone resorption despite the use of bone graft. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

International variations in central nervous system incidence in children and adolescents

alexandrossfakianakis shared this article with you from Inoreader International variations in central nervous system incidence in children and adolescents Via Japanese Journal of Clinical Oncology - current issue In order to compare the subtype distribution of central nervous system (CNS) and miscellaneous intracranial and intraspinal neoplasms in children and adolescents between Japan and other countries, we extracted information on cancer incidence in children and adolescents from the third volume of the International Incidence of Childhood Cancer series (IICC-3) (1). The IICC-3 reports the number or incidence rates of cancers occurring in childhood and adolescence, collected from cancer registries (regional or national) worldwide. We analyzed CNS and miscellaneous intracranial and intraspinal neoplasms incidence in four countries in Asia (Japan, China, the Republic of Korea and Thailand), two countries in Africa (Egypt and Uganda), four countries in the Americas (North: the USA and Canada, Latin and Caribbean: Brazil and Colombia), three countries in Europe (the UK, France and Germany) and two countries in Oceania (Australia and New Zealand). Information from the Republic of Korea, USA, UK, Australia and New Zealand was obtained at the national level, and those from the other countries were from one or multiple regional cancer registries. The years of incidence to be collected varied from country to country, but ranged from 1990 to 2014, with the shortest being 12 years (Egypt: 1999–2010, UK: 2000–2011) and the longest being 24 years (Japan and China: both 1990–2013). In this study, we compared the incidence and proportional distribution of subtype in children (0–14 years old) and adolescents (15–19 years old) between these countries. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Total Thyroidectomy vs Hemithyroidectomy for Treatment of Papillary Thyroid Microcarcinoma

alexandrossfakianakis shared this article with you from Inoreader Total Thyroidectomy vs Hemithyroidectomy for Treatment of Papillary Thyroid Microcarcinoma Via JAMA Otolaryngology–Head & Neck Surgery Online First This systematic review and meta-analysis compares surgical complication rates between total thyroidectomy and hemithyroidectomy in the treatment of papillary thyroid microcarcinomas. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thyroarytenoid botulinum toxin injection for refractory laryngeal contact granuloma

alexandrossfakianakis shared this article with you from Inoreader Thyroarytenoid botulinum toxin injection for refractory laryngeal contact granuloma Via ScienceDirect Publication: American Journal of Otolaryngology Publication date: Available online 4 May 2022 Source: American Journal of Otolaryngology Author(s): Yufei Pan, Jinrang Li, Jinhong Zhang, Xiaoyu Wang, Yuanyuan Jia View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Red meat consumption and risk factors for type 2 diabetes

alexandrossfakianakis shared this article with you from Inoreader Red meat consumption and risk factors for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials Via European Journal of Clinical Nutrition - Issue - nature.com science feeds European Journal of Clinical Nutrition, Published online: 05 May 2022; doi:10.1038/s41430-022-01150-1 Red meat consumption and risk factors for type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.