Wed May 13, 2020 03:00
Nature Communications, Published online: 13 May 2020; doi:10.1038/s41467-020-16223-7Trefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same disaccharide.
Wed May 13, 2020 03:00
Nature Communications, Published online: 13 May 2020; doi:10.1038/s41467-020-15827-3Designing efficient nonlinear dynamic resonances for weak signal amplification remains a challenge. Here, the authors demonstrate a resonance manipulation strategy able to enhance weak signals in a nonlinear oscillator consisting of an optically-probed driven nano-electromechanical resonator.
Wed May 13, 2020 03:00
Nature Communications, Published online: 13 May 2020; doi:10.1038/s41467-020-16046-6Deep brain stimulation (DBS) is a symptomatic treatment of Parkinson’s disease (PD) that benefits only a minority of patients. Here, the authors show that activation of cortical somatostatin interneurons alleviates motor symptoms in a mouse model of PD and may constitute a less invasive alternative than DBS.
Wed May 13, 2020 03:00
Nature Communications, Published online: 13 May 2020; doi:10.1038/s41467-020-16182-zThe TATA-box binding protein (TBP) is required for transcription initiation in archaea and eukaryotes. Here the authors delineate how TBP’s function has evolved new functional features through context-dependent interactions with various protein partners.
Wed May 13, 2020 03:00
Nature Communications, Published online: 13 May 2020; doi:10.1038/s41467-020-16169-wThe type III secretion system (T3SS) of bacteria can be used to inject cargo into eukaryotic cells but its lack of target specificity is a disadvantage. Here the authors place the T3SS under the regulation of light by engineering optogenetic switches into the dynamic cytosolic T3SS component SctQ.
Wed May 13, 2020 03:00
Nature Communications, Published online: 13 May 2020; doi:10.1038/s41467-020-16011-3Metagenome approaches can unravel relationships between environment, community composition, and ecological functions. Here, the authors show that bacterial communities sampled from rainwater pools can be clustered into few classes with distinct functional capacities and genetic repertoires, the assembly of which is likely driven by local conditions.
Wed May 13, 2020 03:00
Nature Communications, Published online: 13 May 2020; doi:10.1038/s41467-020-16148-1The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldinduced browning of inguinal fat.
Wed May 13, 2020 03:00
Nature Communications, Published online: 13 May 2020; doi:10.1038/s41467-020-16181-0It is generally thought many microbes, owing to their ubiquity and dispersal capability, lack biogeographic structuring and clear speciation patterns compared to macroorganisms. However, Pinseel et al. demonstrate multiple cycles of colonization and diversification in Pinnularia borealis, a rare biosphere soil diatom.
Wed May 13, 2020 03:00
Related ArticlesHiring Young Doctors: What Otolaryngologists Should Know About Changes in the Medical School Curriculum. Ear Nose Throat J. 2020 Jun;99(5):290-291 Authors: Sataloff RT PMID: 32397825 [PubMed - in process]
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Related ArticlesPatterns of Bone Damage in Patients With Chronic Middle Ear Inflammation. Ear Nose Throat J. 2020 May 13;:145561320924144 Authors: Wiatr A, Strek P, Wiatr M Abstract BACKGROUND: Despite different etiologies, chronic otitis media involves the damaging and restructuring of bone tissue. The inflammatory process destroys elements of the ossicular chain, and bone lesions may appear that allow the development of otogenous complications....
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Related ArticlesSecondary Cleft Lip Induced by Congenital Hemangioma: Report of a Rare Case. Ear Nose Throat J. 2020 May 13;:145561320925937 Authors: Yan F, Cao J, Lu YY Abstract Infant hemangioma is a relatively rare congenital disease. Ulcer and infection may occur in some cases. A few cases may develop into deformity and defect. Herein, we present a case of secondary cleft lip induced by congenital hemangioma and also our sequential treatment.PMID:...
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Related ArticlesDiagnosis of the Patulous Eustachian Tube. Ear Nose Throat J. 2020 May 13;:145561320925938 Authors: Ikeda R, Kikuchi T, Oshima H, Kobayashi T Abstract OBJECTIVES: To review the diagnosis of patulous Eustachian tube (PET) based on the diagnostic criteria for the PET proposed by Japan Otological Society (JOS). METHODS: We reviewed typical aural symptoms of PET, Eustachian tube (ET) obstruction procedure to confirm diagnosis...
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Related ArticlesThe First Descriptions of Dorsal Preservation Rhinoplasty in the 19th and Early- to Mid-20th Centuries and Relevance Today. Ear Nose Throat J. 2020 May 13;:145561320925572 Authors: Lee J, Abdul-Hamed S, Kazei D, Toriumi D, Lin SJ Abstract INTRODUCTION: The basis of dorsal preservation rhinoplasty goes back to the late 19th and the early 20th centuries. In that era, pioneers such as Drs. Goodale, Lothrop, and Cottle were prominent...
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Related ArticlesEndoscopic Repair of Choanal Atresia: 33 Years Later. Ear Nose Throat J. 2020 May 13;:145561320925194 Authors: Stankiewicz JA PMID: 32397809 [PubMed - as supplied by publisher]
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Related ArticlesResponse to Letter to the Editor Titled Remote Fiberoptic Nasopharyngolaryngoscopy in the Pediatric Population: Methodological Issues on Reliability and Accuracy. Ear Nose Throat J. 2020 May 13;:145561320926096 Authors: Miller LE, Buzi A, Rogers RS, Elden LM PMID: 32397808 [PubMed - as supplied by publisher]
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Related ArticlesThe Whole Lateral Type of the Sphenoethmoidal Cell and Its Relevance to Endoscopic Sinus Surgery. Ear Nose Throat J. 2020 May 12;:145561320922119 Authors: Liu J, Yuan J, Dai J, Wang N Abstract BACKGROUND: The sphenoethmoidal cell and the sphenoid sinus (SS) show great similarity in endoscopy and imaging. Hence, it is important to accurately identify the sphenoethmoidal cell preoperatively to prevent injury of the nerve and artery...
Wed May 13, 2020 14:35
Related ArticlesSystemic Immune Inflammatory Index of Patients With Idiopathic Sudden Sensorineural Hearing Loss: Comparison of NLR and PRL Values. Ear Nose Throat J. 2020 May 12;:145561320924312 Authors: Ulu Ş, Kınar A, Bucak A, Özdemir M PMID: 32396031 [PubMed - as supplied by publisher]
Wed May 13, 2020 14:35
Related Articles5-HT7 receptorsare over-expressed in patients with nasal polyps. Ear Nose Throat J. 2020 May 12;:145561320919603 Authors: Yayla M, Halici Z, Kose D, Tatar A, SitkiGozeler M Abstract Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent...
Wed May 13, 2020 14:35
Related ArticlesManagement of Foreign Bodies in the Ear: A Retrospective Review of 123 Cases in Nigeria. Ear Nose Throat J. 2020 May 12;:145561320920510 Authors: Olajide TG, Ologe FE, Arigbede OO Abstract Foreign bodies in the ear are relatively common in emergency medicine. However, attempts at removal made outside the healthcare setting by untrained persons can result in complications of varying degrees. We conducted a 3-year retrospective review...
Wed May 13, 2020 14:35
Publication date: Available online 14 May 2020Source: Revue des Maladies RespiratoiresAuthor(s): Cl Andrejak, F-X Blanc, F. Costes, B. Crestani, Th Perez, B. Philippe, L. Plantier, F. Schlemmer, L. Sese, B. Stach, Y. Uzunhan, C. Zanetti, M. Zysman, C. Raherison, B. Maitre
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Publication date: Available online 13 May 2020Source: Revue des Maladies RespiratoiresAuthor(s):
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Publication date: Available online 13 May 2020Source: Revue des Maladies RespiratoiresAuthor(s): N. Lhommeau, A. Huchet, P. Castera
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Related ArticlesPresbylarynx: Does Body Muscle Mass Correlate With Vocal Atrophy? A Prospective Case Control Study. Laryngoscope. 2020 May 13;: Authors: Santos M, Freitas SV, Dias D, Costa J, Coutinho M, Sousa CA, da Silva ÁM Abstract OBJECTIVE: To analyze the potential association between body muscle mass and presbylarynx. METHODS: Study performed on subjects referred to the otorhinolaryngology department in a tertiary center between January...
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Related ArticlesSurgical Considerations for an Awake Tracheotomy During the COVID-19 Pandemic. J Laparoendosc Adv Surg Tech A. 2020 May;30(5):477-480 Authors: Crossley J, Clark C, Brody F, Maxwell JH Abstract Background: The current global COVID-19 pandemic is caused by the novel coronavirus Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). Given that SARS-CoV-2 is highly transmissible, surgical societies have recommended that procedures...
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Related ArticlesUpper airway visualization in pediatric obstructive sleep apnea. Paediatr Respir Rev. 2019 Nov;32:48-54 Authors: Quinlan CM, Otero H, Tapia IE Abstract Pediatric Obstructive Sleep Apnea (OSA) is a condition that may lead to a variety of comorbidities in adolescence and adulthood. The gold standard of diagnosing OSA is polysomnography (PSG). Over the past fifteen years numerous publications have explored how to better visualize the upper...
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Related ArticlesOur experience of shorter stay and lower cost for local vs general anaesthetic placement of tracheoesophageal fistulae in twenty-seven patients. Clin Otolaryngol. 2019 05;44(3):423-426 Authors: Megow AK, Goggin RK, Padhye V, Krishnan S, Foreman A, Hodge JC PMID: 30672668 [PubMed - indexed for MEDLINE]
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Related ArticlesThe Difficult Secondary Tracheoesophageal Puncture: A Technique for Safe Insertion. ORL J Otorhinolaryngol Relat Spec. 2019;81(1):10-15 Authors: Abdul-Aziz D, Zenga J, Deschler DG Abstract BACKGROUND/AIMS: The tracheoesophageal prothesis (TEP) has become the primary modality for laryngeal communication after total laryngectomy due to high success rates, minimal morbidity, and more natural pulmonary driven speech. Fibrosis, kyphosis,...
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Related ArticlesA pilot investigation of twang quality using magnetic resonance imaging. Logoped Phoniatr Vocol. 2020 May 12;:1-9 Authors: Perta K, Bae Y, Obert K Abstract Background: Twang quality is a bright, piercing quality often produced in contemporary pop/rock/country music, musical theatre singing, and character voices. Despite its potential application to voice therapy and singing pedagogy, limited information is available regarding the exact...
Wed May 13, 2020 14:23
Related ArticlesBougie-assisted cricothyroidotomy: Delphi-derived essential steps for the novice learner. CJEM. 2019 03;21(2):283-290 Authors: Dharamsi A, Gray S, Hicks C, Sherbino J, McGowan M, Petrosoniak A Abstract OBJECTIVE: A cricothyroidotomy is a life-saving procedure, performed as a final option to emergency airway algorithms, and is essential for all clinicians who perform emergency airway management. The bougie-assisted cricothyroidotomy (BAC)...
Wed May 13, 2020 14:23
Background: The study aimed to investigate the prognostic factors for patients with brain metastases undergoing radiosurgical treatment and to introduce a simple and practical scoring system for the prediction of survival time. Methods: We retrospectively analyzed data for 311 patients treated with Gamma Knife radiosurgery at a single institute. The mean age at time of treatment was 60 years (range 23–86 years), and the median Karnofsky performance status (KPS) score was 90 (range 60–100). Using...
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Magnetic resonance image-guided high-intensity focused ultrasound (MRgFUS)-based thermal ablation of the ventral intermediate nucleus of the thalamus (VIM) is a minimally invasive treatment modality for essential tremor (ET). Dentato-rubro-thalamic tractography (DRTT) is becoming increasingly popular for direct targeting of the presumed VIM ablation focus. It is currently unclear if patients with implanted pulse generators (IPGs) can safely undergo MRgFUS ablation and reliably acquire DRTT suitable...
Wed May 13, 2020 14:32
Direct targeting methods for stereotactic neurosurgery in the treatment of essential tremor have been the subject of active research over the past decade but have not yet been systematically reviewed. We present a clinically oriented topic review based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses Group guidelines. Our focus is studies using advanced magnetic resonance imaging (MRI) techniques (ultrahigh-field structural MRI, diffusion-weighted imaging, diffusion-tensor tractography,...
Wed May 13, 2020 14:31
Related ArticlesThe association between jaw-opening strength, geniohyoid muscle thickness and echo intensity measured by ultrasound. Med Ultrason. 2020 Mar 27;: Authors: Miura Y, Nakagami G, Tohara H, Ogawa N, Sanada H Abstract AIM: Jaw-opening strength is an indicator of swallowing function including hyoid bone elevation. Geniohyoid muscles play an important role during hyoid bone elevation. This study aimed to investigate whether geniohyoid muscle...
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Related ArticlesAssociation of Sarcopenic Dysphagia with Underlying Sarcopenia Following Hip Fracture Surgery in Older Women. Nutrients. 2020 May 10;12(5): Authors: Nagano A, Maeda K, Shimizu A, Nagami S, Takigawa N, Ueshima J, Suenaga M Abstract This study aimed to investigate the association between the development of dysphagia in patients with underlying sarcopenia and the prevalence of sarcopenic dysphagia in older patients following surgical treatment...
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Related ArticlesDefinitive maxillary obturator prosthesis: Timelines for fabrication and follow-up. Spec Care Dentist. 2020 May 12;: Authors: Ahmed ZU, Flynn J, Riedel ER, Huryn JM, Rosen EB Abstract INTRODUCTION: A definitive maxillary obturator prosthesis can be used to rehabilitate a maxillary defect with the aim of improving speech, deglutition, and elimination of oronasal regurgitation. The aims of this study were (1) to determine the time required...
Wed May 13, 2020 15:02
Abstract Wrist injuries are common in paediatric trauma; however, only half of children evaluated with an x-ray for possible fractures will have one. Thermal imaging offers a possible non-ionising method of screening for fractures and thus reducing negative x-ray rates. One hundred five children attending the Emergency Department for wrist injuries were recruited. Two 30-s thermal videos were recorded from injured and uninjured wrists—in flat and 45° elevated positions. A region...
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