Bacterial vaginosis affects 15 to 50% of women of reproductive age worldwide. After treatment with an antibiotic agent, 20 to 75% of women have recurrent bacterial vaginosis within 3 months. Bacterial vaginosis has been associated with an increased risk of sexually transmitted infections (STIs),…
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To the Editor: Lymphatic filariasis is a neglected tropical disease, caused by the nematode parasites Wuchereria bancrofti and brugia species, that is targeted for elimination by mass drug administration. In 2018, we published results from a clinical trial in Papua New Guinea that showed that a…
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In Racism without Racists, Eduardo Bonilla-Silva articulates why "color blindness," an ethos based on the belief that race is no longer relevant, is contradictory and harmful. Color-blind policies, such as race-neutral mortgage practices and Medicare and Medicaid rules, have resulted in…
Wed May 13, 2020 03:00
Presentation of Case. Dr. Meridale V. Baggett: A 68-year-old man was admitted to this hospital with fever, shortness of breath, and acute kidney injury during the pandemic of coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The…
Wed May 13, 2020 03:00
The Covid-19 pandemic, which had killed more than 60,000 Americans by May 1, has been compared with Pearl Harbor and September 11 — cataclysmic events that left indelible imprints on the U.S. national psyche. Like the volunteers who flooded into Manhattan after the World Trade Center attacks, the…
Wed May 13, 2020 03:00
Streamlining Definitive Care for Occult Scaphoid Fractures: A Retrospective Review of the Workup of Scaphoid Nonunions and Applying Lessons Learned. Mil Med. 2020 May 13;: Authors: Liu Peterson S, Scott Donoughe J, O'Neal D, Mombell K, GomezLeonardelli D Abstract INTRODUCTION: The process for working up scaphoid fractures from frontline providers to the specialty care clinic is variable. Initial imaging can often be negative and the management algorithm...
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A Systems Perspective of DoD Global Health Engagement. Mil Med. 2020 May 13;: Authors: Lebeda FJ, Scheerer JB, Dembek ZF Abstract INTRODUCTION: A systems perspective was used to describe U.S. Department of Defense (DoD) Global Health Engagement (GHE). This description was based on DoD instructions and higher-level documents related to DoD GHE. A complex system of systems such as health care can benefit from using modeling approaches to help understand...
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Related ArticlesAnaphylaxis to MMR Vaccine Mediated by IgE Sensitivity to Gelatin. Mil Med. 2020 May 12;: Authors: Miller CK, Mendoza JC, Coop CA Abstract The measles-mumps-rubella (MMR) vaccine is generally well tolerated, and reports of anaphylaxis to the vaccine are rare. IgE-mediated reactions to vaccines are often caused by additives or residual vaccine components. An inability to obtain proper immunizations can be a disqualifying component to military...
Wed May 13, 2020 15:04
Related ArticlesArmy Sanitary School 1917-1918. Mil Med. 2020 May 12;: Authors: Nieves JE PMID: 32395757 [PubMed - as supplied by publisher]
Wed May 13, 2020 15:04
Related ArticlesNo Bioterror Battle Plan Survives First Outbreak. Mil Med. 2020 May 12;: Authors: Lane HC, Schoomaker EB PMID: 32395747 [PubMed - as supplied by publisher]
Wed May 13, 2020 15:04
Related ArticlesHNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer. Cell Rep. 2020 May 12;31(6):107625 Authors: Brunton H, Caligiuri G, Cunningham R, Upstill-Goddard R, Bailey UM, Garner IM, Nourse C, Dreyer S, Jones M, Moran-Jones K, Wright DW, Paulus-Hock V, Nixon C, Thomson G, Jamieson NB, McGregor GA, Evers L, McKay CJ, Gulati A, Brough R, Bajrami I, Pettitt SJ, Dziubinski ML, Barry ST, Grützmann R, Brown R, Curry E, Glasgow Precision...
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Related ArticlesEarly budget impact analysis on magnetic seed localization for non-palpable breast cancer surgery. PLoS One. 2020;15(5):e0232690 Authors: Lindenberg M, van Beek A, Retèl V, van Duijnhoven F, van Harten W Abstract INTRODUCTION: Current localization techniques used in breast conserving surgery for non-palpable tumors show several disadvantages. Magnetic Seed Localization (MSL) is an innovative localization technique aiming to overcome these...
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Related ArticlesThe BiTE (Bispecific T-Cell engager) platform: development and future potential of a targeted immuno-oncology therapy across Tumor Types. Cancer. 2020 May 13;: Authors: Einsele H, Borghaei H, Orlowski RZ, Subklewe M, Roboz GJ, Zugmaier G, Kufer P, Iskander K, Kantarjian HM Abstract Immuno-oncology therapies engage the immune system to treat cancer. BiTE (bispecific T-cell engager) technology is a targeted immuno-oncology platform that...
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Related ArticlesNovel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing. Elife. 2020 May 13;9: Authors: Baslan T, Kendall J, Volyanskyy K, McNamara K, Cox H, D'Italia S, Ambrosio F, Riggs M, Rodgers L, Leotta A, Song J, Mao Y, Wu J, Shah R, Gularte-Mérida R, Chadalavada K, Nanjangud G, Varadan V, Gordon A, Curtis C, Krasnitz A, Dimitrova N, Harris L, Wigler M, Hicks J Abstract Copy number alterations...
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Related ArticlesMorphology tunable and acid-sensitive dextran-doxorubicin conjugate assemblies for targeted cancer therapy. J Mater Chem B. 2020 May 13;: Authors: Zhang Q, He S, Kuang G, Liu S, Lu H, Li X, Zhou D, Huang Y Abstract Stimuli-responsive and targetable nanomedicine systems have been widely applied as effective modalities for drug delivery and tumor therapeutics. Particle shape is also important for the biodistribution and cellular uptake...
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Related ArticlesNatural history of incidentally diagnosed brainstem cavernous malformations in a prospective observational cohort. Neurosurg Rev. 2020 May 12;: Authors: Zheng JJ, Liu PP, Wang L, Zhang LW, Zhang JT, Li D, Wu Z, Wu YM Abstract There was a lack of natural history of incidental brainstem cavernous malformations (CMs), hemorrhage of which would lead to severe neuropathies. The study aimed to evaluate the prospective hemorrhage rate and neurological...
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Related ArticlesUtilization of Physiologically Based Pharmacokinetic Modeling in Clinical Pharmacology and Therapeutics: an Overview. Curr Pharmacol Rep. 2020 May 12;:1-14 Authors: Perry C, Davis G, Conner TM, Zhang T Abstract The purpose of this review was to assess the advancement of applications for physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We conducted a PubMed search, and 166 articles published between 2012...
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Related ArticlesLymph Node Ratio as a Prognostic Marker in Rectal Cancer Survival: A Systematic Review and Meta-Analysis. Cureus. 2020 May 10;12(5):e8047 Authors: Karjol U, Jonnada P, Chandranath A, Cherukuru S Abstract Introduction The lymph node ratio (LNR) is defined as the ratio of the number of positive lymph nodes to the total number of nodes retrieved. LNR has recently emerged as a prognostic factor in rectal cancer. The objective of our study...
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Related ArticlesEvaluating treatment protocols for rectal squamous cell carcinomas: the Duke experience and literature. J Gastrointest Oncol. 2020 Apr;11(2):242-249 Authors: Song EJ, Jacobs CD, Palta M, Willett CG, Wu Y, Czito BG Abstract Background: Colorectal cancer is the third most common cancer in the United States and associated with significant morbidity and mortality. Within colorectal cancer histologies, squamous cell carcinomas (SCC) are rare...
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Related ArticlesInsights of stem cell-based endogenous repair of intervertebral disc degeneration. World J Stem Cells. 2020 Apr 26;12(4):266-276 Authors: Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Feng XM, Liu H, Zhang L Abstract Low back pain has become more prevalent in recent years, causing enormous economic burden for society and government. Common therapies used in clinics including conservative treatment and surgery can only relieve pain. Subsequent...
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Related ArticlesMultimodality treatment for localized gastric cancer: state of the art and new insights. Curr Opin Oncol. 2020 May 07;: Authors: Petrillo A, Smyth EC Abstract PURPOSE OF REVIEW: Surgery represents the only curative approach for resectable gastric cancer. However, rates of recurrence remain high. This review summarizes the state of the art and future perspectives regarding perioperative, neoadjuvant and adjuvant chemotherapy for localized...
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Related ArticlesMoving Beyond the Friend-Foe Myth: A Scoping Review of the Use of Social Media in Adolescent and Young Adult Oncology. J Adolesc Young Adult Oncol. 2020 May 12;: Authors: De Clercq E, Rost M, Gumy-Pause F, Diesch T, Espelli V, Elger BS Abstract Purpose: Adolescents and young adults (AYA) with cancer present a unique challenge to health care institutions. Their cancer diagnosis and treatment have a profound impact upon their health and...
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Related ArticlesRNA Sequencing in Comparison to Immunohistochemistry for Measuring Cancer Biomarkers in Breast Cancer and Lung Cancer Specimens. Biomedicines. 2020 May 09;8(5): Authors: Sorokin M, Ignatev K, Poddubskaya E, Vladimirova U, Gaifullin N, Lantsov D, Garazha A, Allina D, Suntsova M, Barbara V, Buzdin A Abstract RNA sequencing is considered the gold standard for high-throughput profiling of gene expression at the transcriptional level. Its...
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Related ArticlesToxicological Profile of Nanostructured Bone Substitute Based on Hydroxyapatite and Poly(lactide-co-glycolide) after Subchronic Oral Exposure of Rats. Nanomaterials (Basel). 2020 May 09;10(5): Authors: Paraš S, Trišić D, Mitrović Ajtić O, Prokić B, Drobne D, Živković S, Jokanović V Abstract Novel three-dimensional (3D) nanohydroxyapatite-PLGA scaffolds with high porosity was developed to better mimic mineral component and microstructure...
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Related ArticlesThe Influence of Chronic Liver Diseases on Hepatic Vasculature: A Liver-on-a-chip Review. Micromachines (Basel). 2020 May 09;11(5): Authors: Özkan A, Stolley D, Cressman ENK, McMillin M, DeMorrow S, Yankeelov TE, Rylander MN Abstract In chronic liver diseases and hepatocellular carcinoma, the cells and extracellular matrix of the liver undergo significant alteration in response to chronic injury. Recent literature has highlighted the...
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Related ArticlesOncogene-Addicted Non-Small-Cell Lung Cancer: Treatment Opportunities and Future Perspectives. Cancers (Basel). 2020 May 08;12(5): Authors: Ferrara MG, Di Noia V, D'Argento E, Vita E, Damiano P, Cannella A, Ribelli M, Pilotto S, Milella M, Tortora G, Bria E Abstract Before the introduction of tyrosine kinase inhibitors (TKIs) for a particular subgroup of patients, despite platinum-based combination chemotherapy, the majority of patients...
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Related ArticlesResults From the ASCO 2019 Survey of Oncology Practice Operations. JCO Oncol Pract. 2020 May;16(5):253-262 Authors: Bourbeau B, Harter D, Towle E Abstract The Survey of Oncology Practice Operations is an annual survey conducted by ASCO since 2016. This is the first year in which results have been published publicly for use by practice leaders to compare the performance of their practice. The scope of the 125-question survey instrument...
Wed May 13, 2020 14:26
Related ArticlesClues for genetic anticipation in Multiple Endocrine Neoplasia type 1. J Clin Endocrinol Metab. 2020 May 12;: Authors: van den Broek MFM, van Nesselrooij BPM, Pieterman CCR, Verrijn Stuart AA, van de Ven AC, de Herder WW, Dekkers OM, Drent ML, Havekes B, Kerstens MN, Bisschop PH, Valk GD Abstract CONTEXT: Multiple Endocrine Neoplasia type 1 (MEN1) is a rare autosomal dominant hereditary disease caused by loss-of-function of the MEN1 gene,...
Wed May 13, 2020 14:26
Related ArticlesImmune-gene signature: a new tool for patient selection for checkpoint inhibitors? Future Oncol. 2020 May 12;: Authors: Sobhani N, Corona SP, Roviello G, Bagby S, D'Angelo A, Iezzi G, Generali D PMID: 32396404 [PubMed - as supplied by publisher]
Wed May 13, 2020 14:26
Related ArticlesPatients' Experiences and Attitudes of Using a Secure Mobile Phone App for Medical Photography: Qualitative Survey Study. J Med Internet Res. 2020 May 12;22(5):e14412 Authors: Wyatt KD, Finley A, Uribe R, Pallagi P, Willaert B, Ommen S, Yiannias J, Hellmich T Abstract BACKGROUND: Point-of-care clinical photography using mobile devices is coming of age as a new standard of care for clinical documentation. High-quality cameras in modern...
Wed May 13, 2020 14:26
Related ArticlesThe potentiality of immunotherapy for sarcomas: a summary of potential predictive biomarkers. Future Oncol. 2020 May 12;: Authors: Liang J, Chen D, Chen L, She X, Zhang H, Xiao Y Abstract Sarcomas are rare and heterogeneous malignant tumors of mesenchymal origin. A total of 25-50% of patients treated with initial curative intent will develop as recurrent and metastatic disease. In the recurrent and metastatic setting, effect of chemotherapy...
Wed May 13, 2020 14:26
Related ArticlesFeasibility study of nivolumab as neoadjuvant chemotherapy for locally esophageal carcinoma: FRONTiER (JCOG1804E). Future Oncol. 2020 May 12;: Authors: Yamamoto S, Kato K, Daiko H, Kojima T, Hara H, Abe T, Tsubosa Y, Nagashima K, Aoki K, Mizoguchi Y, Kitano S, Yachida S, Shiba S, Kitagawa Y Abstract One of the standard treatments of resectable esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemotherapy followed by surgery. Nivolumab...
Wed May 13, 2020 14:26
Related ArticlesAnti-epidermal growth factor receptor therapy for glioblastoma in adults. Cochrane Database Syst Rev. 2020 May 12;5:CD013238 Authors: Lee A, Arasaratnam M, Chan DLH, Khasraw M, Howell VM, Wheeler H Abstract BACKGROUND: Glioblastoma is an uncommon but highly aggressive type of brain tumour. Significant gains have been achieved in the molecular understanding and the pathogenesis of glioblastomas, however clinical improvements are difficult...
Wed May 13, 2020 14:26
Related ArticlesMicroRNA-18a induces epithelial-mesenchymal transition like cancer stem cell phenotype via regulating RKIP pathway in pancreatic cancer. Ann Transl Med. 2020 Apr;8(7):433 Authors: Kang H, Ma D, Zhang J, Zhao J, Yang M Abstract Background: Pancreatic cancer is a devastating invasive disease. Understanding the molecular mechanism of metastasis of this cancer is basis for its treatment and prevention. Methods: Pancreatic cancer...
Wed May 13, 2020 14:26
Related ArticlesSjögren-Larsson syndrome: The mild end of the phenotypic spectrum. JIMD Rep. 2020 May;53(1):61-70 Authors: Staps P, van Gaalen J, van Domburg P, Steijlen PM, Ferdinandusse S, den Heijer T, Seyger MMB, Theelen T, Willemsen MAAP Abstract Sjögren-Larsson syndrome (SLS) is a rare inborn error of lipid metabolism. The syndrome is caused by mutations in the ALDH3A2 gene, resulting in a deficiency of fatty aldehyde dehydrogenase. Most patients...
Wed May 13, 2020 14:26
Related ArticlesPast, present, and future of palliative care in emergency medicine in the USA. Acute Med Surg. 2020 Jan-Dec;7(1):e497 Authors: George N, Bowman J, Aaronson E, Ouchi K Abstract The emergency department (ED) provides immediate access to medical care for patients and families in times of need. Increasingly, older patients with serious illness seek care in the ED, hoping for relief from symptoms and suffering associated with advanced disease....
Wed May 13, 2020 14:26
Related ArticlesVisual Pathway Degeneration in Chemotherapy-Related Neurotoxicity: A Review and Directions for Future Research. Neuroophthalmology. 2020 Jun;44(3):139-147 Authors: Anderson DE, Holstein SA, Kedar S Abstract Chemotherapy-related neurotoxicity (CRNT) is an emerging public health concern. Visual pathway degeneration may be a symptom of CRNT. We surveyed the current literature for evidence of visual pathway degeneration in cancer patients...
Wed May 13, 2020 14:26
Related ArticlesSKIN-COBRA (Consortium for Brachytherapy data Analysis) ontology: The first step towards interdisciplinary standardized data collection for personalized oncology in skin cancer. J Contemp Brachytherapy. 2020 Apr;12(2):105-110 Authors: Lancellotta V, Guinot JL, Fionda B, Rembielak A, Di Stefani A, Gentileschi S, Federico F, Rossi E, Guix B, Chyrek AJ, Meritxell A, Villalba SR, Colloca GF, Dinapoli N, Masciocchi C, Lenkowicz J, Capocchiano ND, Damiani A,...
Wed May 13, 2020 14:26
Related ArticlesNovel Strategies in Immune Checkpoint Inhibitor Drug Development: How Far Are We From the Paradigm Shift? Br J Clin Pharmacol. 2020 May 11;: Authors: Watson GA, Doi J, Hansen AR, Spreafico A Abstract The development of immune checkpoint inhibitors (ICI) represents a major milestone in immune-oncology. Over the years these agents have demonstrated efficacy in an increasing array of malignancies. Despite this success however, significant...
Wed May 13, 2020 13:35
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