DNA methylation‐derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

xlomafota13 shared this article with you from Inoreader DNA methylation‐derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival Via Head & Neck Cannot fetch mobilized content. Please try again later. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Lidocaine represses the malignant behavior of lung carcinoma cells via the circ_PDZD8/miR-516b-5p/GOLT1A axis

xlomafota13 shared this article with you from Inoreader Lidocaine represses the malignant behavior of lung carcinoma cells via the circ_PDZD8/miR-516b-5p/GOLT1A axis Via Cellular and Molecular Biology Histol Histopathol. 2022 Jan 21:18423. doi: 10.14670/HH-18-423. Online ahead of print. ABSTRACT Lung carcinoma is the most prevalent malignancy in adults. Lidocaine (Lido) has been confirmed to exert an anti-tumor role in many human cancers. However, the role and underlying mechanism of Lido in lung carcinoma remain poorly understood. Cell proliferation ability, migration, invasion, and apoptosis were measured by Colony formation, 5-ethynyl-2'-deoxyuridine (EdU), Cell Counting Kit-8 (CCK-8), transwell, and flow cytometry assays. Circ_PDZD8, microRNA-516b-5p (miR-516b-5p), and Golgi transport 1A (GOLT1A) levels were detected by real-time quantitative polymerase chain reaction (RT-qPCR). Protein levels of proliferating cell nuclear antigen (PCNA) and GOLT1A were examined by western blot assay. The binding relationship between miR-516b-5p and circ_PDZD8 or GOLT1A was predicted by circular RNA Interactome or Starbase 3.0 and then verified by a dual-luciferase reporter assay. The biological roles of circ_PDZD8 and Lido on lung carcinoma cell growth were examined by the xenograft tumor model in vivo. Lido suppressed proliferation, migration, invasion, and induced apoptosis in lung carcinoma cells. Circ_PDZD8 and GOLT1A were increased, miR-516b-5p was decreased in lung carcinoma tissues and cell lines. Their expression presented the opposite trend in Lido-triggered lung carcinoma cells. Circ_PDZD8 might overturn the repression of Lido on cell growth ability and metastasis in this tumor. Mechanically, circ_PDZD8 might regulate GOLT1A expression by sponging miR-516b-5p. Circ_PDZD8 weakened the anti-lung carcinoma effect of Lido in vivo. Circ_PDZD8 might mitigate the inhibitory effect of Lido on tumor cell malignancy by modulating the miR-516b-5p/GOLT1A axis, providing a novel insight for lung carcinoma treatment. PMID:35060113 | DOI:10.14670/HH-18-423 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nodular mass-A case of auricular schwannoma

xlomafota13 shared this article with you from Inoreader Nodular mass-A case of auricular schwannoma Via ear nose throat Ear Nose Throat J. 2022 Jan 20:1455613211068001. doi: 10.1177/01455613211068001. Online ahead of print. ABSTRACT Schwannomas are benign tumors derived from the sheath of Schwann cells. Though it is common to see schwannomas in the head and neck region, auricular schwannomas are rare and only few cases have been reported. There are no distinguishing clinical findings or images; therefore, the histopathological diagnosis is mandatory. We describe a case of auricular schwannoma with clinical pictures and discuss the differential diagnoses according to histopathologic findings. PMID:35057654 | DOI:10.1177/01455613211068001 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Patient experience of diagnosis and management of spontaneous intracranial hypotension: a cross-sectional online survey

xlomafota13 shared this article with you from Inoreader Patient experience of diagnosis and management of spontaneous intracranial hypotension: a cross-sectional online survey Via leak of cerebrospinal fluid BMJ Open. 2022 Jan 20;12(1):e057438. doi: 10.1136/bmjopen-2021-057438. ABSTRACT OBJECTIVES: To present the results of a survey of patients with spontaneous intracranial hypotension (SIH) secondary to spinal cerebrospinal fluid (CSF) leak, documenting the patient experience of its diagnosis and management as well as quantifying its impact on quality of life. DESIGN: A cross-sectional anonymous online survey was designed in conjunction with the CSF Leak Association patient charity. The survey included questions on diagnosis, investigations and treatments received, as well as validated disability and quality of life questionnaires. PARTICIPANTS: Sixty-four patients with a confirmed diagnosis of SIH who were receiving treatment within the UK were included in the analysis. The mean age was 42.8 years, 94% were female and 43 had ongoing symptoms of SIH. RESULTS: Patients who presented to their general practitioner with symptoms of SIH were seen an average three times before being referred to a specialist, and in just under half of patients, the diagnosis was not made by the first specialist they saw. There was variability in which investigations were performed and how urgently they were organised. The mean EuroQol (EQ-5D-5L) Visual Analogue Scale score was 36.4/100 and median Headache Impact Test-6 score was 68/78 (very severe impact). More than half of the respondents reported that they had to amend work duties due to SIH, more than a quarter reported that they had lost their job and two-thirds reported that their condition had affected their financial health. Only 23.4% of patients felt that they had received enough help and advice to manage their pain due to SIH. CONCLUSIONS: SIH is a highly disabling disorder, affecting multiple domains, including pain, mobility, activities of daily living, financial circumstances and employment. Diagnostic delay and misdiagnosis are common, and currently there is a lack of consistency in the investigation and management of SIH in the UK. PMID:35058269 | DOI:10.1136/bmjopen-2021-057438 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Radioiodination and Purification of [131I]β-CIT and [131I]FP-CIT with an Automated Radiosynthesizer

xlomafota13 shared this article with you from Inoreader Radioiodination and Purification of [<sup>131</sup>I]β-CIT and [<sup>131</sup>I]FP-CIT with an Automated Radiosynthesizer Via radioactive iodine Pharmaceuticals (Basel). 2022 Jan 14;15(1):96. doi: 10.3390/ph15010096. ABSTRACT Dopaminergic transporter (DAT) imaging with single photon emission computed tomography (SPECT) is used to diagnose Parkinson's disease and to differentiate it from other neurodegenerative disorders without presynaptic dopaminergic dysfunction. The radioiodinated tropane alkaloids [123I]FP-CIT and [123I]β-CIT enable the evaluation of the integrity of DATs. Commonly, the labeling o f these compounds is performed by electrophilic substitution of the alkylstannylated precursors with radioactive iodine and following purification by HPLC or solid phase extraction (SPE). This work presents the first radioiodination of β-CIT and FP-CIT with no carrier added [131I]NaI on a Scintomics GRP synthesis module. Free iodine-131 and impurities were removed by SPE over a C-18 Sep-Pak cartridge. We achieved a radiochemical yield of >75% and a radiochemical purity of >98% with both compounds. Our development of an automated synthesis on a commercially available synthesizer ensures robust and efficient labeling of [131I]FP-CIT and [131I]β-CIT starting with low concentrated radioiodine. PMID:35056152 | DOI:10.3390/ph15010096 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clinicopathological Profile of Thyroid Carcinoma in Young Patients: An Indonesian Single-Center Study

xlomafota13 shared this article with you from Inoreader Clinicopathological Profile of Thyroid Carcinoma in Young Patients: An Indonesian Single-Center Study Via radioactive iodine J Thyroid Res. 2022 Jan 11;2022:9944083. doi: 10.1155/2022/9944083. eCollection 2022. ABSTRACT INTRODUCTION: Thyroid cancer is the third most common cancer that occurs in children and adolescents. Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy. Although the mortality rate of thyroid malignancy in children is usually low, the disease recurrence is higher in children with more severe clinical presentation than in adults. This study aimed to determine the demographic and clinicopathological characteristics and outcome of pediatric and adolescent patients with thyroid malignancy in Indonesia. METHODS: The retrospective study included all patients diagnosed with thyroid carcinoma aged <20 years, from January 1, 2015, to December 31, 2019. Twenty-nine subjects fulfilled the inclusion and exclusion criteria. We retrieved baseline characteristics, pathology features, TSH and fT4 status, radioactive iodine therapy data, and patients' outcomes. Then, data were analyzed using the chi-square or Fisher's exact method. RESULTS: We identified 29 eligible subjects, including 3 boys and 26 girls. The most common type of thyroid carcinoma was PTC (96.5%), and follicular type (31%) was the predominant variant of PTC. Lymph node involvement occurred in 24% of patients, while distant metastasis occurred in 17.2% of patients with PTC. Twenty-four (82.7%) patients had stage 1 disease. Disease recurrence was recorded in 31% of patients during the study period with a median follow-up time of 24 months. CONCLUSION: PTC is the most frequent type of thyroid carcinoma among children and adolescents. This malignancy has a low mortality rate, but the recurrence rate remains high among younger patients than adults even during a short-term follow-up analysis. Distant metastasis and lymph node involvement are commonly found in this age group. PMID:35059180 | PMC:PMC8766174 | DOI:10.1155/2022/9944083 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Clinical Characteristics in Children with Sinonasal Inverted Papilloma: A Case Report and Review of the Literature

xlomafota13 shared this article with you from Inoreader The Clinical Characteristics in Children with Sinonasal Inverted Papilloma: A Case Report and Review of the Literature Via ear nose throat Ear Nose Throat J. 2022 Jan 21:1455613211068567. doi: 10.1177/01455613211068567. Online ahead of print. ABSTRACT Sinonasal inverted papilloma (SNIP) is one of the most common benign epithelial tumors but rarely occurs in children. The case of a 9-year-old Chinese boy, who presented with a left maxillofacial hump, nasal obstruction, and left nasal cavity and maxillary sinus masses under nasal endoscopy, is reported. The lesion was first diagnosed as a sinonasal tumor. However , to our surprise, the mass was determined to be an inverted papilloma after a detailed histological examination. We retrospectively reported the clinical data of this case and reviewed the relevant literatures on SNIP. This report aims to provide new insights into the clinical characteristics in children with SNIP and improve the understanding of this disease. PMID:35060773 | DOI:10.1177/01455613211068567 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

E-health, digitalization, or digital transformation: Impact on cancer supportive care

xlomafota13 shared this article with you from Inoreader E-health, digitalization, or digital transformation: Impact on cancer supportive care Via Association française pour l'étude du cancer Bull Cancer. 2022 Jan 18:S0007-4551(21)00421-5. doi: 10.1016/j.bulcan.2021.08.015. Online ahead of print. ABSTRACT The value of comprehensive oncology management including supportive care is well established, but it remains challenged by the increasing need and access disparities. By enabling real-time, dynamic, technology-assisted assessments and interventions, e-health is a key for optimizing supportive care in Oncology in 2021. Indeed, e-health has the potential to improve communication between the patient and the healthcare professional, improve the assessment and management of symptoms and toxicities, and optimize patient engagement across the continuum of care. We are witnessing a new era of patient-centered care, where the patient becomes an actor in his or her own care. In this review, we present the definitions and the French legal framework of e-health, and some currently available e-health solutions in oncology focused on su pportive care, including the issues of their validation and financing. We will also discuss the challenges and access for patients, as well as the issues of access, security and transfer of health data. PMID:35063184 | DOI:10.1016/j.bulcan.2021.08.015 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

New European approval: Idecabtagene vicleucel in relapsed and/or refractory myeloma after at least 3 lines of treatment

xlomafota13 shared this article with you from Inoreader New European approval: Idecabtagene vicleucel in relapsed and/or refractory myeloma after at least 3 lines of treatment Via Association française pour l'étude du cancer Bull Cancer. 2022 Jan 18:S0007-4551(21)00686-X. doi: 10.1016/j.bulcan.2021.10.007. Online ahead of print. NO ABSTRACT PMID:35063182 | DOI:10.1016/j.bulcan.2021.10.007 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The management and outcome of large volume liposarcomas encasing the sciatic nerve

xlomafota13 shared this article with you from Inoreader The management and outcome of large volume liposarcomas encasing the sciatic nerve Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Oct 22:S1748-6815(21)00505-2. doi: 10.1016/j.bjps.2021.09.070. Online ahead of print. ABSTRACT This paper outlines the oncological outcomes of patients with large volume liposarcomas of the posterior thigh who underwent nerve-preserving surgery utilising epineural dissection. Thirty-seven consecutive patients (group I) with a mean age of 66.2 (31-96) were surgically treated with a planned marginal resection and epineurectomy for liposarcoma with known sciatic nerve involvement between March 1997 and January 2015. The mean follow-up was 79 months (15-192). All patients underwent multidisciplinary team (MDT) pre-operative assessment and staging, with follow-up in Sarcoma Clinic. Pre-operative function was assessed by applying the Toronto extremity salvage score (TESS). Oncological and functional outcomes were recorded. In grades 1, 2, and 3, 24, 6, and 7 liposarcomas, respectively, were included with m ean volume 1859 cm3. Sciatic nerve involvement extended for 13-30 cm; in one case, the nerve was abutting the tumour throughout its length. Soft tissue reconstructive surgery was required in three cases. The remainder underwent direct primary closure. Seventeen patients underwent post-operative adjuvant radiotherapy 46-60 Gy and three received chemotherapy. There was local recurrence of disease in three patients. One patient had post-radiation wound breakdown treated non-operatively. Three patients died of an unrelated cause. When compared to a cohort of 37 patients without sciatic nerve involvement (group II), there were no significant differences in local and systemic recurrence rate or post-operative survival. In conclusion, sciatic nerve-preserving surgery is both possible and safe when using a planned epineural dissection in large volume tumours encasing the sciatic nerve. PMID:35063385 | DOI:10.1016/j.bjps.2021.09.070 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Towards decoding selective attention through cochlear implant electrodes as sensors in subjects with contralateral acoustic hearing

xlomafota13 shared this article with you from Inoreader Towards decoding selective attention through cochlear implant electrodes as sensors in subjects with contralateral acoustic hearing Via cortical auditory J Neural Eng. 2022 Jan 21. doi: 10.1088/1741-2552/ac4de6. Online ahead of print. ABSTRACT OBJECTIVES: Focusing attention on one speaker in a situation with multiple background speakers or noise is referred to as auditory selective attention. Decoding selective attention is an interesting line of research with respect to future brain-guided hearing aids or cochlear implants (CIs) that are designed to adaptively adjust sound processing through cortical feedback loops. This study investigates the feasibility of using the electrodes and backward telemetry of a CI to record electroencephalography (EEG). APPROACH: The study population included 6 normal-hearing (NH) listeners and 5 CI users with contralateral acoustic hearing. Cortical auditory evoked potentials (CAEP) and selective attention were recorded using a state-of-the-art high-density scalp EEG and, in the case of CI users, also using two CI electrodes as sensors in combination with t he backward telemetry system of these devices (iEEG). MAIN RESULTS: In the selective attention paradigm with multi-channel scalp EEG the mean decoding accuracy across subjects was 94.8 % and 94.6 % for NH listeners and CI users, respectively. With single-channel scalp EEG the accuracy dropped but was above chance level in 8 to 9 out of 11 subjects, depending on the electrode montage. With the single-channel iEEG, the selective attention decoding accuracy could only be analyzed in 2 out of 5 CI users due to a loss of data in the other 3 subjects. In these 2 CI users, the selective attention decoding accuracy was above chance level. SIGNIFICANCE: This study shows that single-channel EEG is suitable for auditory selective attention decoding, even though it reduces the decoding quality compared to a multi-channel approach. CI-based iEEG can be used for the purpose of recording CAEPs and decoding selective attention. However, the study also points out the need for further tec hnical development for the CI backward telemetry regarding long-term recordings and the optimal sensor positions. PMID:35062007 | DOI:10.1088/1741-2552/ac4de6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.