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Παρασκευή 20 Ιουλίου 2018

Methodological empiricism and the choice of measurement models in social sciences

Abstract

Realism is generally assumed as the correct position with regards to psychological research and the measurement of psychological attributes in psychometrics. Borsboom et al. (Psychological Review, 110(2), 203–219 2003), for instance, argued that the choice of a reflective measurement model necessarily implies a commitment to the existence of psychological constructs as well as a commitment to the belief that empirical testing of measurement models can justify their correspondence with real causal structures. Hood (Erkenntnis, 78(4):739–761 2013) deemphasized Borsboom et al.'s position and argued that the choice of a reflective measurement model does not necessarily require ontological commitments, though, in his view, it does necessitate a commitment to minimal epistemic realism. Although these arguments are formulated with regard to psychological research, they can actually be generalized to other disciplines in social sciences that use similar methodologies and statistical techniques. In Hood's opinion, empiricism does not suffice to provide an adequate account of the choice of reflective measurement models given that this choice requires an appeal to causal explanations. In this paper, we argue against Hood and answer this challenge, providing epistemic foundations for social science research that do not appeal to realism.



Did carbon dioxide emission regulations inhibit investments? A provincial panel analysis of China

Abstract

Investments, especially fixed asset investments, greatly affect carbon dioxide (CO2) emissions. When investments are concentrated in regions with high CO2 emissions and high fossil energy consumption, the CO2 emission reduction targets in these areas are difficult to reach in the short term, and the cost of CO2 emission abatement is high. The current CO2 emission regulations focus on existing production activities and consumption behaviors. However, whether an investment, which may affect CO2 emissions in the long term, is effectively inhibited by CO2 emission regulations has not been investigated in previous studies. Using panel data from 30 provinces in China between 2003 and 2012, we tested whether the amount of provincial investment was constrained or promoted by the provincial CO2 emission regulations by creating a panel model with provincial samples. The results revealed that CO2 emission regulations did not inhibit the growth of an investment, but they stimulated investments to varying degrees in different provinces. A relatively positive result is that provinces with stronger CO2 emission regulations exhibited a relatively small contribution to investment promotion, while provinces with weaker CO2 reduction policies demonstrated a relatively large contribution to investment growth. We also found that investment was correlated with the growth rate of the gross domestic product (GDP) in the northeastern and western provinces. Finally, we proposed policy implications based on the utilization of policy tools from the perspectives of investment, energy structure, and local protectionism.



The impact of economic growth on CO 2 emissions in Australia: the environmental Kuznets curve and the decoupling index

Abstract

Australia is the sixth largest country in the world, celebrating its 26th consecutive year without a recession. However, the country is one of the ten largest emitters of greenhouse gases, mainly caused by energy use. As such, Australia is facing a trade-off between economic growth and reducing carbon dioxide (CO2) emissions. This paper empirically analyses the relationship between economic growth and CO2 emissions in Australia, based on annual data from 1965 to 2016, considering the consumption of the fossil fuels oil and coal and renewable energy. This analysis is performed using the environmental Kuznets curve (EKC) and the Decoupling Index (DI). The EKC is assessed by employing the autoregressive distributed lag model. In addition, a robustness check is provided through the vector error correction model, which allows for the employment of the Granger causality test. The results show that in Australia, there is evidence for the EKC hypothesis, and that the country is undergoing increasing relative decoupling. These results mean that economic growth causes CO2 emissions and consequently environmental degradation. To achieve environmental targets and reduce the rate of CO2 emissions while continuing to grow, Australia needs to implement measures and policies to cut CO2 emissions, such as energy demand management and control, energy efficiency, reducing fossil fuel consumption, and investing in renewable energy technology.



Different pollutant removal efficiencies of artificial aquatic plants in black-odor rivers

Abstract

Black-odor rivers have become a prominent environmental problem, especially for developing countries. A laboratory experiment was conducted to determine the optimum operating parameters of artificial aquatic plants (AAP) to provide a theoretical and scientific basis for their application in black-odor rivers. The purification mechanism of operating parameters for AAP was also explored at the micro-organic and genetic levels by high-throughput sequencing. Chemical oxygen demand (COD) and ammonia nitrogen (NH4+-N) were measured in systems with different AAP lengths and pH. After 24 days, the best removal efficiencies of APP for COD and NH4+-N were 90.07 and 82.40% for 100 cm and 90.70 and 91.90% for pH values of 8.0–9.0, respectively. High-throughput sequencing analysis revealed that the relative abundance of Flavobacterium in the AAP was 7.80% at 50 cm, while the proportion increased to 29.30% at 100 cm. The abundance of microorganisms improved continuously with increased length, and the ratio of Acinetobacter increased obviously at pH 8.0–9.0 relative to pH 6.0–7.0. Furthermore, the AAP were used in Qihe Artificial Wetland in Shandong Province, China. The results revealed that the average removal efficiencies of AAP for COD and NH4+-N were 27.75 and 14.34%, respectively, in the artificial wetland. Therefore, AAP was beneficial to the growth of bacteria and could be used in the treatment of black-odor rivers.



Inhibition of 1, 4-dioxane on the denitrification process by altering the viability and metabolic activity of Paracoccus denitrificans

Abstract

1,4-Dioxane is an emerging pollutant, which widely exists in natural environments and poses potential risks to the living organisms. However, its effect on the denitrification process is still unknown. In this study, the effects of 1,4-dioxane on the denitrification process were therefore investigated by using Paracoccus denitrificans as the model denitrifier. The obtained results showed that the exposure of 1,4-dioxane exhibited remarkable lag or inhibition on the denitrification process, especially with high dose. In the control without 1,4-dioxane exposure, Paracoccus denitrificans showed high denitrification efficiency (98.5%). However, the efficiency decreased to 78.5, 63.9, and 9.3% with 0.50, 0.75, and 1.0% (v/v) 1,4-dioxane dose, respectively. The dose-induced inhibition of denitrification by 1,4-dioxane could be partially attributed to the negative effects on proliferation and viability of functional microorganisms by conjugating and disrupting the cell membranes. Furthermore, 1,4-dioxane caused biotoxicity to the intracellular activities of denitrifiers via disturbing carbon source utilization and interfering the key enzymes responsible for glycolysis. The decrease of microbial viability and activity inevitably resulted in the decline of key enzymes (NAR, NIR, NOR, and N2OR) closely related with denitrification process, which could be the direct reason for the decrease of denitrification performance.



Recurring acute urticaria and abdominal pain: Consider a diagnosis of alpha-galactose anaphylaxis

Publication date: Available online 20 July 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): A. Deschamps Huvier, F. Tetart, O. Bauvin, J. Martinet, P. Joly

Summary
Background

Food urticaria is common and generally benign, and it may be of viral or idiopathic aetiology. A food origin of the allergy is frequently sought but rarely found. Mammalian meat anaphylaxis, or alpha-galactose (α-gal) anaphylaxis, is a rare and recently discovered entity.

Patients and methods

Herein, we report a case of alpha-galactose (α-gal) anaphylaxis in a 60-year-old woman presenting four episodes of acute urticaria with signs of anaphylaxis occurring a few hours after meals containing mammalian meat (beef meat, pork meat and offal). The diagnosis was confirmed by a positive gelatine prick-test and the presence of α-gal IgE.

Discussion

In the event of acute urticaria associated with systemic symptoms, in particular gastrointestinal signs, allergy to α-galactose should be considered.

Résumé
Introduction

L'urticaire aiguë est fréquente et le plus souvent bénigne, d'étiologie virale ou idiopathique. Une origine allergique alimentaire est souvent cherchée et rarement trouvée. L'allergie aux viandes de mammifères, ou allergie à l'alpha-galactose (α-gal), est une entité rare de découverte récente.

Observation

Nous rapportons une observation d'allergie à l'α-galactose chez une femme de 60 ans ayant présenté quatre épisodes d'urticaire aiguë avec signes d'anaphylaxie apparus à distance des repas, après l'ingestion de viande de mammifères (viande de bœuf, viande et abats de porc). Le diagnostic a été confirmé par la positivité du prick-test à la gélatine et la présence d'IgE α-gal.

Discussion

Devant une urticaire aiguë associée à des symptômes systémiques, notamment signes digestifs, il faut savoir évoquer une allergie à l'α-galactose.



Response to “Comments on ‘The Stress Factor of Social Media’”

Dr Abrams has touched upon a very serious systemic problem with social media, which, as he rightly points out, produces tremendous stress.1 The dilemma we face with fake reviews and fabricated complaints posted on the Internet is discussed at length in my previous editorial, "Anonymous Sources,"2 and certainly deserves continued attention. The point of my more recent editorial3 on social media obsession (SMO), however, was to suggest that SMO stress—unlike stress produced by the untruthfulness of others—often may be mitigated through individual self-awareness and self-regulation.

Do Subspecialists Ask About and Refer Families with Psychosocial Concerns? A Comparison with General Pediatricians

Abstract

Objectives Calls for pediatricians to tend to children's psychosocial concerns have existed for decades because they are known to negatively impact child health. Children with chronic illnesses frequently have child- and family-level psychosocial concerns that complicate the care provided by their pediatric subspecialists. This study compares pediatricians who exclusively practice general pediatrics with subspecialists regarding their inquiring/screening and referring for psychosocial concerns. Physician and practice characteristics associated with these behaviors were examined. Methods We conducted a cross-sectional study using the 2013 American Academy of Pediatrics Periodic Survey of Fellows. Respondents included 304 pediatricians who exclusively practice general pediatrics and 147 subspecialists. The primary analysis compared the current practices of generalists vs. subspecialists with regard to inquiring/screening and referring children with 10 different psychosocial concerns. Covariates included socio-demographics, practice characteristics, and training experiences. Weighted univariate, bivariate and multivariable analyses were performed. Results Less than half of all pediatricians in the sample reported routinely inquiring/screening for most psychosocial concerns, and 2/3 of subspecialists failed to routinely inquire/screen for most of these conditions. Pediatricians who practice general pediatrics exclusively were more likely to inquire/screen (incident rate ratio (IRR) 1.41, p < .05) and refer (IRR 1.59, p < .001) for a greater number of psychosocial concerns than subspecialists, after adjusting for provider and practice characteristics. Having attended a child or adolescent mental health (MH) lecture/conference in the past 2 years was also related to inquiring/screening (IRR 1.24, p < .05). Conclusions Pediatricians infrequently inquire/screen and refer psychosocial concerns, with subspecialists addressing these concerns even less frequently.



A Systematic Approach to Translating Evidence into Practice to Reduce Infant Mortality

Abstract

Purpose To provide recommendations for improving rates of infant mortality in a U.S. southeastern city using a collective impact approach. Description A convening organization and its academic partner devised a systematic process involving national experts and local stakeholders. Assessment A panel of infant mortality experts reached consensus on eight recommendations and three key overarching principles. Local stakeholder groups advanced four recommendations, of which three aligned closely with expert panel recommendations: (1) increasing access to, and use of 17-alpha hydroxyprogesterone caproate (17P); (2) reshaping housing policy using a health lens, and (3) supporting pre-conception health, intra-conception health and family planning. Conclusion The dynamic process of recommendation development occurred within a larger collective impact framework and can be used to shape a community-based approach to infant mortality. Other communities interested in improving rates of infant mortality or tackling other challenging public health issues could engage in a similar process.



Association Between Maternal 2nd Trimester Plasma Folate Levels and Infant Bronchiolitis

Abstract

Objectives Viral bronchiolitis is the most common cause of infant hospitalization. Folic acid supplementation is important during the periconceptional period to prevent neural tube defects. An area of investigation is whether higher prenatal folate is a risk factor for childhood respiratory illnesses. We investigated the association between maternal 2nd trimester plasma folate levels and infant bronchiolitis. Methods We conducted a retrospective cohort analysis in a subset of mother-infant dyads (n = 676) enrolled in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study and Tennessee Medicaid. Maternal folate status was determined using 2nd trimester (16–28 weeks) plasma samples. Bronchiolitis diagnosis in the first year of life was ascertained using International Classification of Diagnosis-9 codes from Medicaid administrative data. We used multivariable logistic regression to assess the adjusted association of prenatal folate levels and infant bronchiolitis outcome. Results Half of the women in this lower-income and predominately African-American (84%) study population had high levels of folate (median 2nd trimester level 19.2 ng/mL) and 21% of infants had at least one bronchiolitis healthcare visit. A relationship initially positive then reversing between maternal plasma folate and infant bronchiolitis was observed that did not reach statistical significance (poverall = .112, pnonlinear effect = .088). Additional adjustment for dietary methyl donor intake did not significantly alter the association. Conclusions for Practice Results did not confirm a statistically significant association between maternal 2nd trimester plasma folate levels and infant bronchiolitis. Further work is needed to investigate the role of folate, particularly higher levels, in association with early childhood respiratory illnesses.



Hallazgos clínicos, dermatoscópicos y micológicos de onicomicosis causada por Trichosporon mucoides en un paciente inmunocompetente

Publication date: Available online 19 July 2018

Source: Piel

Author(s): Benigno Monteagudo, Susana Méndez-Lage, Óscar Suárez-Amor, Olalla Figueroa



Fenómeno de Koebner en paciente con vasculitis leucocitoclástica anular

Publication date: Available online 19 July 2018

Source: Piel

Author(s): Ana Varela-Veiga, Benigno Monteagudo, Olaya Suárez-Magdalena, Cristina de-las-Heras



In vitro activity of antifungal combinations against planktonic and sessile cells of Candida albicans isolated from medical devices in an intensive care department

Publication date: Available online 19 July 2018

Source: Journal de Mycologie Médicale

Author(s): H.F.Z. Touil, Z. Boucherit-Otmani, K. Boucherit

Abstract
Background

Invasive fungal infections are an emerging health problem worldwide. They are responsible for a significant rate of morbidity and mortality. Infections caused by Candida albicans involve proliferation of biofilms on biotic or abiotic surface. These adherent communities exhibit characteristics distinct from planktonic cells such as the ability to tolerate high concentrations of antifungal.

Objective

The object of our study was focused on the determination of the susceptibility to amphotericin B, caspofungin, voriconazole and two antifungal combinations (amphotericin B/caspofungin and amphotericin B/voriconazole) of both planktonic and sessile cells of C. albicans, which were isolated from catheters.

Material and methods

The susceptibility of C. albicans to antifungals was determined using the broth microdilution method according to Clinical Laboratory Standards Institute CLSI (2008). A Checkerboard assay was employed to evaluate the efficacy of drugs combinations. Biofilm susceptibility was determined using a metabolic [2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] (XTT) reduction assay.

Results

The minimal inhibitory concentrations of individual antifungal drugs determined against C. albicans biofilms (SMICs) were significantly higher (P < 0.05) than planktonic ones (MICs). They went from 2 to 64 μg/mL for amphotericin B, from 1 to 64 μg/mL for caspofungin and from 2 to 128 μg/mL for voriconazole. The combination of amphotericin B to caspofungin or to voriconazole decreased significantly the MIC values for planctonic (P < 0.0001) and sessile cells (P = 0.0016). Based on Fractional Inhibitory Concentration Index (FICI), no antagonistic interaction was observed.

Conclusion

The obtained results showed that the combination of amphotericin B with either caspofungin or voriconazole can be used as a new strategy for management of systemic mycoses associated to medical devices.



Cervical Branch of Facial Nerve: An Explanation for Recurrent Platysma Bands Following Necklift and Platysmaplasty

Abstract
Background
Recurrent platysma bands remain a common problem in neck rejuvenation.
Objectives
The goals of this cadaver study were to document the course of the cervical branches of the facial nerve and investigate the pattern of platysma muscle innervation before and after various platysmaplasty maneuvers.
Methods
A total of 8 fresh cadaver specimens were dissected for a total of 16 hemifaces/necks. After subcutaneous undermining and identification of the main trunk of the facial nerve, the cervical branch was dissected as distally/anteriorly as possible under loupe magnification. The following 4 platysmaplasty maneuvers were each performed on 4 hemifaces/necks: platysma window, extended SMAS with platysma flap, full width platysma transection, and lateral skin-platysma displacement (LSD). Upon completion of the techniques, the integrity of the cervical branches was evaluated.
Results
Contrary to some reports, all specimens in this study had only 1 main cervical branch. There were no branches detectable under 3.2× magnification until branches were given off to the platysma muscle at approximately the location of the facial vessels. The main cervical branch continued distally/anteriorly to the medial edge of the muscle below the thyroid cartilage. After performing the various platysma techniques, all cervical branches were in continuity in all specimens. Specifically, the main cervical branch was in continuity to the medial border of the muscle caudal to all platysmaplasty maneuvers.
Conclusion
Undermining the platysma muscle results in no injury to platysmal innervation unless continued beyond the facial vessels. Recurrent bands are likely related to persistent innervation of the medial platysma, which remains intact cranial and caudal to any described platysmal transection maneuvers.

Comments on “The Stress Factor of Social Media”

Thank you for your interesting editorial on "The Stress Factor of Social Media" in the June 2018 issue of Aesthetic Surgery Journal.1 But I was hoping to find some mention of the most important flaw with social media, which in my opinion is the prime reason for social media related stress, and which you did not touch upon at all. That flaw is the fact that any individual can create as many fake profiles and post as many fabricated posts as they desire. The social media have no way of, or are not interested in, authenticating such fake profiles. As a result, people are able to convert personal grudges into fabricated complaints about unreal procedures and jeopardize plastic surgeons' reputation under as many different guises as they want. Or worse yet, and believe me, this is happening in our part of the woods, plastic surgeons (or possibly cosmetic surgeons) are able to post fabricated negative reviews in order to jeopardize their competitors.

Genital Warts, Lymphangioma, and Treatment with Imiquimod

Publication date: Available online 20 July 2018

Source: Actas Dermo-Sifiliográficas (English Edition)

Author(s): B. Monteagudo, O. Figueroa, A. Varela-Veiga, O. Suárez-Amor



Genital Warts, Lymphangioma, and Treatment with Imiquimod

Publication date: Available online 20 July 2018

Source: Actas Dermo-Sifiliográficas (English Edition)

Author(s): L. Padilla-España, J.B. Repiso-Jiménez, J.F. Millán-Cayetano



A clinical study of efficacy of garlic extract versus cryotherapy in the treatment of male genital wart

Publication date: Available online 19 July 2018

Source: Dermatologica Sinica

Author(s): Zahra Beygom Mousavi, Abolfath Mehrabian, Fereshteh Golfakhrabadi, Foroogh Namjoyan

Abstract
Background/Objective

Genital warts are caused by human papilloma virus (HPV) and usually have no promising cure. Garlic (Allium sativum) belongs to Liliaceae family, which has a long history of medicinal use. The garlic extract had antiviral and anticarcinogenic effects and can be effective on complete resolution of cutaneous wart. The aim of this clinical study was to compare the garlic extract effect with cryotherapy in the treatment of male genital wart.

Methods

35 male patients aged 20–54 years old with clinically diagnosed genital warts who had more than two warts on both sides of genital region enrolled in the study. Cryotherapy with liquid nitrogen (−196 °C temperature) was performed for all right sided warts and 10% garlic extract was applied on all left-sided warts for 2 months.

Results

Regarding response to treatment, at the end of weeks 2, 4, 6 and 8 there was no significant difference between two groups (P > 0.05). 69.7% and 78.8% of patients showed complete clearing of the lesions in the garlic and cryotherapy groups respectively (P value, 0.39).

Conclusions

The present study revealed 10% garlic extract after 2 months duration therapy on the male genital warts had the similar effect in compare to cryotherapy.



Issue Information

Journal of Medical Primatology, Volume 47, Issue 4, Page 209-210, August 2018.


Analysing the ethics of breast cancer overdiagnosis: a pathogenic vulnerability

Abstract

Breast cancer screening aims to help women by early identification and treatment of cancers that might otherwise be life-threatening. However, breast cancer screening also leads to the detection of some cancers that, if left undetected and untreated, would not have damaged the health of the women concerned. At the time of diagnosis, harmless cancers cannot be identified as non-threatening, therefore women are offered invasive breast cancer treatment. This phenomenon of identifying (and treating) non-harmful cancers is called overdiagnosis. Overdiagnosis is morally problematic as it leads to overall patient harm rather than benefit. Further, breast cancer screening is offered in a context that exaggerates cancer risk and screening benefit, minimises risk of harm and impedes informed choice. These factors combine to create pathogenic vulnerability. That is, breast cancer screening exacerbates rather than reduces women's vulnerability and undermines women's agency. This paper provides an original way of conceptualising agency-supporting responses to the harms of breast cancer overdiagnosis through application of the concept of pathogenic vulnerability.



Engineered protein hydrogel for open wound management in Canines

Publication date: Available online 20 July 2018

Source: Wound Medicine

Author(s): A. Manikandan, S. Thirupathi Kumara Raja, T. Thiruselvi, Mohan Vaishnavi, R. Siva, A. Gnanamani

Abstract

The present study explores the wound healing profile of the engineered protein based hydrogel in open wounds of Canine. In brief, fish scale gelatin has been tethered with di-hydroxy phenolic acids and the resultant product (Phenolic acid modified gelatin – PAMG) upon enzymatic oxidation transformed to a hydrogel with adhesive nature. The experimental study contains two groups: Group I – PAMG treated and Group – II standard cream treated. Each group contains six cases with wounds of ununiform size and area and the experimental period scheduled for 36 days. For Group I animals, PAMG solution (once in three days) applied to the wound site and which then transformed to adhesive hydrogel under in situ condition using tyrosinase enzyme. Group II animals received Loraxane cream every day. Despite different shapes and depth, wounds of Group I animals showed accelerated wound closure. Further, the percentage of wound contraction and H & E staining of sections of granulation tissue also support the faster healing of wounds of Group I animals. In conclusion, PAMG based adhesive hydrogel offers faster wound healing of open wounds of Canines.



A novel animal model for residence time evaluation of injectable hyaluronic acid-based fillers using high-frequency ultrasound-based approach.

A novel animal model for residence time evaluation of injectable hyaluronic acid-based fillers using high-frequency ultrasound-based approach.

Clin Cosmet Investig Dermatol. 2018;11:339-346

Authors: Merola F, Scrima M, Melito C, Iorio A, Pisano C, Giori AM, Ferravante A

Abstract
Background: Hyaluronic acid (HA)-based devices are among the most popular filler agents for skin rejuvenation. One of the principal goals is the improvement in residence time of HA-based products, to increase their performance and reduce frequency of the treatment. So, understanding fillers, behavior after subcutaneous injection is a fundamental aspect for discovery and optimization of new products. Current in vivo approaches to detect/quantify injected HA fillers are not always well optimized or easy to apply.
Objective: To develop more efficacious and noninvasive diagnostic tools to make a quantitative evaluation of the degradation of fillers in a small animal model.
Materials and methods: We evaluated the residence time of different HA-based fillers, fluorescein-labeled and not, injected subcutaneously in mice. Volumes of fillers were monitored through high-frequency ultrasound (HF-US) method while fluorescence intensity through the well-established fluorescence living imaging method. To confirm the effectiveness of HF-US, obtained volumetric measurements were compared with fluorescence intensity values.
Results: Both the presented methods revealed the same degradation kinetics for the tested products.
Conclusion: The two used methods are fully comparable and quantitatively accurate. The presented approach has been proved to be noninvasive, sensitive, and reproducible.

PMID: 30022845 [PubMed]



Idiopathic scrotal calcinosis: report of 2 cases, and review of pathogenesis and factors that determine patients' acceptance of surgical treatment.

Idiopathic scrotal calcinosis: report of 2 cases, and review of pathogenesis and factors that determine patients' acceptance of surgical treatment.

Clin Cosmet Investig Dermatol. 2018;11:333-337

Authors: Akinboro AO, Onilede DA, Babatunde TO, Oiwoh SO, Suleiman OA, Olabode OP

Abstract
Introduction: Idiopathic scrotal calcinosis is a benign and rare disease of the scrotal skin that presents as solitary or multiple asymptomatic calcified nodules in the absence of systemic disorders of calcium/phosphorus balance.
Case reports: We report the management of 2 cases and review the literature with comments on factors that determine acceptance or otherwise of surgical treatment. Our patients were 29 and 33 years old and presented with nodular scrotal lesions. Through multiple elliptical incisions, all nodules were excised from patient 1, but patient 2 refused surgery. Reasons for rejection included fear of future reproductive performances. Histology shows calcium deposition in basophilic globules of varying sizes and shapes within the reticular dermis, multinucleated giant cells, dense collagenous stroma, areas of fibrosis, and sparse lymphocytic infiltrate.
Conclusion: In the management of idiopathic scrotal calcinosis, factors that determine acceptance of surgical treatment could include impaired quality of life, reduced self-esteem, fear of future sexual dysfunction, and development of complications.

PMID: 30022844 [PubMed]



The development and validation of tau PET tracers: current status and future directions

Abstract

Purpose

To provide an overview on positron emission tomography (PET) imaging of tau pathology in Alzheimer's disease (AD) and other neurodegenerative disorders.

Results

Different classes of tau tracers such as flortaucipir, THK5317, and PBB3 have been developed and utilized in previous clinical studies. In AD, the topographical distribution of tracer binding follows the known distribution of neurofibrillary tangles and is closely associated with neurodegeneration as well as the clinical phenotype of dementia. Significant retention of tracers has also been observed in the frequent site of the 4-repeat (4R) tau isoform deposits in non-AD tauopathies, such as in progressive supranuclear palsy. However, in vitro binding studies indicate that most tau tracers are less sensitive to straight tau filaments, in contrast to their high binding affinity to paired helical filaments of tau (PHF-tau). The first-generation of tau tracers shows off-target binding in the basal ganglia, midbrain, thalamus, choroid plexus, and venous sinus. Off-target binding of THK5351 to monoamine oxidase B (MAO-B) has been observed in disease-associated brain regions linked to neurodegeneration and is associated with astrogliosis in areas of misfolded protein accumulation. The second generation of tau tracers, such as [18F]MK-6240, is highly selective to PHF-tau with little off-target binding and have enabled the reliable assessment of PHF-tau burden in aging and AD.

Conclusions

Tau PET tracers have enabled in vivo quantification of PHF-tau burden in human brains. Tau PET can help in understanding the underlying cause of dementia symptoms, and in patient selection for clinical trials of anti-dementia therapies.



The Present and Future of Liquid Biopsies in Non-Small Cell Lung Cancer: Combining Four Biosources for Diagnosis, Prognosis, Prediction, and Disease Monitoring

Abstract

Purpose of Review

Liquid biopsies have potential as tools for diagnosis, prognosis, and prediction of response to therapy. Herein, we will extensively review four liquid biosources, tumor-educated platelets (TEPs), cell-free DNA (cfDNA), circulating tumor cells (CTCs), and extracellular vesicles (EVs) and we will clarify their optimal application in non-small cell lung cancer (NSCLC) diagnosis and therapy.

Recent Findings

Liquid biopsies are a minimally invasive alternative to tissue biopsies—especially important in NSCLC patients—since tumor tissue is often unavailable or insufficient for complete genetic analysis. The main advantages of liquid biopsies include the possibility for repeated sampling, the lower cost, and the fact that they can reflect the complete molecular status of the patient better than a single-site biopsy. This is specifically important for lung adenocarcinoma patients since the detection of specific genetic alterations can predict response to targeted therapies.

Summary

Molecular analysis is currently cardinal for therapy decision-making and disease monitoring in lung cancer patients. Liquid biopsies can make easier our daily clinical practice and if prospectively tested and validated may serve as a means for lung cancer early detection.



Novel decision algorithm for the diagnosis of silicone gel breast implant ruptures

Abstract

Background

The main complications of breast implantation are caused by capsular contracture and implant rupture. Although the evaluation of implant rupture is primarily driven by patient symptoms, including change in breast shape, size, or firmness, most patients with breast implant rupture do not clinically manifest significant symptoms, thereby developing a so-called silent rupture. For all these reasons, its diagnosis generally relies on imaging techniques such as mammography, ultrasound, and magnetic resonance imaging.

Methods

We conducted a retrospective non-randomized study, carried out between March 2013 and August 2017. In this study, we evaluated 30 symptomatic patients who underwent mono or bilateral prosthetic breast reconstruction, a total of 51 implants after skin-sparing mastectomy or nipple-sparing mastectomy for breast cancer and following breast implant removal or replacement due to suspicious rupture or capsule contraction.

Results

Ultrasound suspected ruptures in 32/51 (62.7%) implants, while 19/51 implants resulted intact upon ultrasound examination. The sensitivity and specificity of ultrasound were 90 and 80% respectively. Magnetic resonance imaging suspected ruptures in 30/51 (58.8%) implants, while 21/51 (41.1%) implants resulted intact. The magnetic resonance imaging sensitivity and specificity were 87 and 85%, respectively.

Conclusions

Ultrasound evaluation may be the first level exam in case of suspicious symptomatic breast implant rupture. Importantly, our results demonstrate that magnetic resonance imaging could be avoided in all those cases where an extracapsular rupture has been diagnosed using ultrasound.

Level of Evidence: Level IV, diagnostic study.



Evaluating the OGG1 rs1052133 and rs293795 polymorphisms in a sample of rural workers from Central Brazil population: a comparative approach with the 1000 Genomes Project

Abstract

Brazilian population is one of the largest consumers of pesticides in the world, especially the Central Brazil population. Thus, the aim of this study was to evaluate the frequency of genotypes, alleles, haplotypes, and the linkage disequilibrium (DL) of the OGG1 gene in rural workers from Central Brazil, comparing with the populations of the 1000 genome. Three hundred thirty healthy individuals not related and randomly selected were included in this study. We obtained genomic DNA from peripheral blood lymphocytes. The 748-bp OGG1 gene was amplified by PCR and sequenced. Of the 330 individuals, 215 (65%) were males and 115 (35%) were females. There were no differences in the distribution of the rs1052133 and rs293795 with age and sexes. Haplotypes containing only conserved T/C alleles were the most common in our population. The frequency of the mutant alleles of rs1052133 and rs293795, in our population, was 20% and 30%, respectively, and it is noteworthy, worldwide, that mutant alleles are commonly associated to an increased risk for the development of cancer, specially due to direct or indirect contact to pesticides, as occurs in rural workers of Central Brazil population.



IgE repertoire and immunological memory: compartmental regulation and antibody function

Abstract
It is now generally recognised that bone marrow is the survival niche for antigen-specific plasma cells with long-lived immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the secondary immune response. These antibodies participate in the surveillance for antigen and afford immune defence against pathogens and toxins previously encountered in the primary immune response. IgE antibodies function together with their effector cells, mast cells, to exert "immediate hypersensitivity" in mucosal tissues at the front line of immune defence. The constant supply of IgE antibodies from bone marrow plasma cells allows the rapid "recall response" by mast cells upon re-exposure to antigen even after periods of antigen absence. The speed and sensitivity of the IgE recall response and potency of the effector cell functions are advantageous in the early detection and elimination of pathogens and toxins at the sites of attack. Local antigen provocation also stimulates de novo synthesis of IgE or its precursors of other isotypes that undergo IgE switching in the mucosa. Such process, however, introduces a delay before mast cells can be sensitized and resume activity; this is terminated shortly after the antigen is eliminated. Recent results from adaptive immune receptor repertoire sequencing (AIRR-Seq) of immunoglobulin genes suggest that the mucosal IgE+ plasmablasts, which have undergone affinity maturation in the course of their evolution in vivo, are a source of long-lived IgE+ plasma cells in the bone marrow that are already fully functional.

Horizontal Forehead Lines: A Reflection of Eyelid Ptosis or Blepharodermachalasia

Abstract

Background

In his facial aesthetics practice, the senior author (B.G.) observed that many patients presenting with horizontal forehead lines also demonstrated upper eyelid ptosis or enough blepharodermachalasia to require compensation. This study was conducted to investigate this observation.

Methods

Photographs of patients presenting for facial rejuvenation were retrospectively reviewed for the presence of forehead lines, ptosis, brow ptosis, and blepharodermatochalasia. Patient age, gender, and race were reported. Only patients over age 50 were included. Patients who had previous eyelid or forehead surgery, congenital abnormalities, or post-traumatic deformities were excluded. Ptosis was defined as more than 1.5-mm overlap between the upper eyelid and the iris. Patients were divided into two groups based on presence of forehead lines for comparative analysis.

Results

One hundred sixty patients, including 100 patients with and 60 patients without horizontal forehead lines, were included. Patients with forehead lines were likely to be older (age 61.56 ± 8.93 vs. 58.58 ± 7.59; P = 0.0337), male (36 vs. 11.67%; P = 0.0008), have ptosis (90 vs. 76.67%; P = 0.0377), and have blepharodermatochalasis (20 vs. 5%; P = 0.0097). All 28 patients with unilateral forehead lines (17 left, 11 right) had ipsilateral ptosis.

Conclusions

Ptosis and blepharodermatochalasis may result in the development of horizontal forehead lines through compensatory frontalis activation. Whenever horizontal forehead rhytids are noted, it is imperative to search for ptosis or blepharodermachalasia in repose. Otherwise, forehead rejuvenation may fail to eliminate these compensatory forehead lines, and chemodenervation may have significant adverse effects on the visual field by forcibly blocking frontalis compensation.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



Topical micronutrients in atopic dermatitis—An evidence‐based review

Dermatologic Therapy, EarlyView.


Highly‐focused ultrasound in non‐invasive body contouring: Long‐term follow‐up in Korean patients

Dermatologic Therapy, EarlyView.


The 13th International Pan Arab League of Dermatology Conference Held Jointly with the Ninth Dermopolitan Congress Jordan at the Dead Sea, Jordan

Dermatologic Therapy, EarlyView.


Oral Isotretinoin for the treatment of Aripiprazol‐induced acneiform rash

Dermatologic Therapy, EarlyView.


PDT and BF‐200 ALA: The therapy option for the treatment of Poikiloderma of Civatte

Dermatologic Therapy, EarlyView.


10th International Conference of Jordanian Society of Dermatology, Venereology, Dermatosurgery & Laser, Amman, Kingdom of Jordan

Dermatologic Therapy, EarlyView.


Intralesional 5‐fluorouracil to treat extensive molluscum contagiosum in an immunocompromised patient: A novel therapeutic modality

Dermatologic Therapy, EarlyView.


Perioperative enteral supplementation with glutamine, fiber, and oligosaccharide reduces early postoperative surgical stress following esophagectomy for esophageal cancer

Abstract

Background

We clarified the effects of perioperative enteral supplementation with glutamine, fiber, and oligosaccharide (GFO) after an esophagectomy on preventing surgical stress.

Methods

Of 326 patients with esophageal cancer, 189 received GFO administration (GFO group) and 137 did not (control group). The propensity score matching method was used to identify 89 well-balanced pairs of patients to compare postoperative laboratory parameters and clinical and postoperative outcomes.

Results

The duration of the systemic inflammatory response syndrome (SIRS) was significantly shorter in the GFO group compared to the control group (p = 0.002). Moreover, the lymphocyte/neutrophil ratio (L/N ratio) had significantly recovered in the GFO group on postoperative day-3, and the CRP value was significantly lower in the GFO group than that in the control group on postoperative day-2.

Conclusions

Perioperative use of enteral supplementation with glutamine, fiber, and oligosaccharide likely contributes to a reduction in early surgical stress after an esophagectomy. These beneficial effects can bring about early recovery from postoperative immunosuppressive conditions after radical esophagectomy.



Accuracy of brain perfusion single-photon emission computed tomography for detecting misery perfusion in adult patients with symptomatic ischemic moyamoya disease

Abstract

Objective

The purpose of the present study was to determine how accurately relative cerebral blood flow (RCBF) and relative cerebrovascular reactivity (RCVR) to acetazolamide assessed using brain perfusion single-photon emission computed tomography (SPECT) detected misery perfusion identified on positron emission tomography (PET) in adult patients with ischemic moyamoya disease (MMD).

Methods

Oxygen extraction fraction (OEF), RCBF, and RCVR were assessed using 15O gas PET and N-isopropyl-p-[123I]-iodoamphetamine SPECT without and with acetazolamide challenge, respectively, in 45 patients. Regions of interest (ROIs) were automatically placed in the five middle cerebral artery (MCA) territories in the symptomatic cerebral hemisphere and in the ipsilateral cerebellar hemisphere using a three-dimensional stereotaxic ROI template. For RCBF and RCVR to acetazolamide, the ratio of the MCA ROI to cerebellar ROI was calculated. Of the five MCA ROIs in the symptomatic cerebral hemisphere in each patient, the ROI with the highest and lowest OEF value (two ROIs per patient) was selected for analyses.

Results

A significant square or linear correlation was observed between the OEF and RCBF (correlation coefficient, 0.780) or RCVR (correlation coefficient, − 0.345), respectively. The area under the receiver operating characteristic curve for detecting misery perfusion (OEF > 51.3%) was significantly greater for the RCBF than for the RCVR (difference between areas, 0.221; p < 0.0001). Sensitivity, specificity, and positive- and negative-predictive values for the RCBF for detecting misery perfusion were 100, 91, 67, and 100%, respectively. The specificity and positive-predictive value did not differ between the combination of the RCBF and RCVR and the CBF ratio alone.

Conclusions

RCBF assessed using brain perfusion SPECT detects misery perfusion with high sensitivity, a high negative-predictive value, and a low positive-predictive value in adult patients with ischemic MMD. The accuracy of RCVR to acetazolamide assessed using brain perfusion SPECT is lower than that of RCBF.



Anthropometric Analysis of the External Nose of the Egyptian Males

Abstract

Objective

The aim of this study was to describe average nasal anthropometric measurements for young Egyptian males by using the Rhinobase® software.

Materials and Methods

This was a cross-sectional study involving the evaluation of facial photographs. Frontal, right lateral and basal photographs for 300 healthy adult male Egyptian volunteers (n = 300) were taken; then, the photos were edited using Rhinobase® Software and CorelDraw graphics (2017) software. Twenty anthropometric landmarks were determined. The calculated measurements of the soft tissue of the external nose included ten linear measurements and five angles.

Results

The means of the linear measurements of the external nose in this study were as follows: nasal height (56.12 mm), nasal bridge length (47.0 mm), columella length (9.1 mm), alar length (29.3 mm), morphological nose width (41.0 mm), anatomical nose width (38.0 mm), nasal tip protrusion (21.0 mm), nasal tip projection using 'Goode's method' (29.36 mm), dorsum width (9.6 mm) and nasion height (2.04 mm). The means of the angular measurements of the nose were as follows: nasofacial angle (33.1°), nasofrontal angle (144.0°), nasolabial angle (104.5°), nasomental angle (127.6°) and mentocervical angle (104.7°).

Conclusions

Racial differences of the external nasal anthropometric values exist; hence, it is important to establish the average anthropometric measures for several races and ethnic groups. Measurements collected in this study can serve as a database for anthropometric average values of the external nose in healthy adult Egyptian males. Moreover, these measurements can aid in planning prior to nasal reconstruction and esthetic rhinoplasty by serving as a reference standard. Although the Rhinobase® software is an easy, reliable and safe indirect method for nasal analysis, we should be cautious during interpretation of some edited landmarks on Rhinobase® software pictures. In addition, inserting two rulers (in the horizontal and vertical dimension) allows accurate assessment of the linear anthropometric measurements.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



The temporal and environmental context of early animal evolution: considering all the ingredients of an ‘explosion’

Abstract
Animals originated and evolved during a unique time in Earth history—the Neoproterozoic Era. This paper aims to discuss 1) when landmark events in early animal evolution occurred, and 2) the environmental context of these evolutionary milestones, and how such factors may have affected ecosystems and body plans. With respect to timing, molecular clock studies—utilizing a diversity of methodologies—agree that animal multicellularity had arisen by ∼800 million years ago (Ma) (Tonian period), the bilaterian body plan by ∼650 Ma (Cryogenian), and divergences between sister phyla occurred ∼560-540 Ma (late Ediacaran). Most purported Tonian and Cryogenian animal body fossils are unlikely to be correctly identified, but independent support for the presence of pre-Ediacaran animals is recorded by organic geochemical biomarkers produced by demosponges. This view of animal origins contrasts with data from the fossil record, and the taphonomic question of why animals were not preserved (if present) remains unresolved, although Neoproterozoic environments demanding small, thin body plans and lower abundance/rarity in populations may have played a role. Considering environmental conditions, geochemical data suggest that animals evolved in a relatively low-oxygen ocean. Here, we present new analyses of sedimentary total organic carbon contents in shales suggesting that the Neoproterozoic ocean may also have had lower primary productivity—or at least lower quantities of organic carbon reaching the seafloor—compared to the Phanerozoic. Indeed, recent modeling efforts suggest that low primary productivity is an expected corollary of a low-O2 world. Combined with an inability to inhabit productive regions in a low-O2 ocean, earliest animal communities would likely have been more food limited than generally appreciated, impacting both ecosystem structure and organismal behavior. In light of this, we propose the 'fire triangle' metaphor for environmental influences on early animal evolution. Moving towards consideration of all environmental aspects of the Cambrian radiation (fuel, heat, and oxidant) will ultimately lead to a more holistic view of the event.

Effects of the urban environment on oxidative stress in early life: insights from a cross-fostering experiment

Abstract
As urban areas expand rapidly worldwide, wildlife is exposed to a wide range of novel environmental stressors, such as increased air pollution and artificial light at night. Birds in highly polluted and/or urbanised habitats have been found to have increased antioxidant protection, which is likely important to avoid accumulation of oxidative damage, which can have negative fitness consequences. Yet, the current knowledge about the ontogeny of antioxidant protection in urban areas is limited; i.e., is the capacity to up-regulate the antioxidant defences already established during pre-natal development, or does it manifest itself during post-natal development? We cross-fostered great tit (Parus major) nestlings within and between urban and rural habitats, to determine if oxidative stress (measured as non-enzymatic total antioxidant capacity, superoxide dismutase and plasma lipid peroxidation) is affected by habitat of origin and/or by habitat of rearing. The results demonstrate that being reared in the urban environment triggers an increase in superoxide dismutase (an intracellular, enzymatic antioxidant) independent of natal habitat. Oxidative damage increased with hatching date in urban-reared nestlings, but there was little seasonal change in rural-reared nestlings. Total antioxidant capacity was neither affected by habitat of rearing or habitat of origin, but we observed a decline with hatching date in both rearing habitats. Taken together, our results support the growing evidence that the urban environment induces a direct plastic adjustment in antioxidant protection, but that up-regulation is not sufficient to avoid increased oxidative damage in late-hatched broods. Future studies should explore the underlying causes for this effect in late-hatched broods and whether it has any negative long-term implications, both at the individual- and the population level.

Communication through Playful Systems: Presenting scientific worlds the way a game might do

Abstract
More than ever, science is in the unenviable position of competing for the hearts and minds of the public against utterly false accounts of our world. These false accounts are often deeply spiritual, poetic, sublime — despite being false, they can leave a mark on the human imagination. It is difficult to convey scientific research in a way that leaves the audience with a comparable sense of awe or a personal connection to the subject matter. This is an area where games as a cultural form can offer some assistance and insight. A game can convey its complex inner workings with ease by engaging an audience through play. It is expressive communication that sows intuitive understanding and fosters a personal connection between the human player and the represented world. Games like Minecraft and Portal are thus increasingly being used in classrooms to teach math, physics, spatial reasoning, and even the scientific method. I discuss the process of designing interactive experiences in games as a model for effective communication. Drawing on examples from my own work at Double Fine Productions and the work of others, I offer insights from game design to address parallel challenges in scientific communication. I explore ways of introducing an audience to an unfamiliar world through narrative and play. For example, by setting up the rules of an unfamiliar world in an interactive way, especially through iterative problem solving, you can lead a novice audience to a nuanced understanding of that world's complexity without overloading information. These strategies can enhance communication of scientific research in any format.

Characterisation of the Brochothrix thermosphacta sortase A enzyme

Abstract
Gram-positive bacteria utilise class A sortases to coat the surface of their cells with a diversity of proteins that facilitate interactions with their environment and play fundamental roles in cell physiology and virulence. A putative sortase A gene was identified in the genome of the poorly studied meat spoilage bacterium Brochothrix thermosphacta. To understand how this bacterium mediates interactions with its environment, an N-terminal truncated, His-tagged variant of this protein (His6-BtSrtA) was expressed and purified. Catalytic activity of recombinant His6-BtSrtA was investigated, including sorting motif recognition of target proteins and bioconjugation activity. Further, the B. thermosphacta genome was examined for the presence of sortase A (SrtA) protein substrates. His6-BtSrtA readily formed intermediate complexes with LPXTG-tagged proteins. Although the reaction was inefficient, nucleophilic attack of the resultant thioacyl intermediates by tri-glycine was observed. Genome examination identified 11 potential SrtA substrates, two of which contained protein domains associated with adherence of pathogens to host extracellular matrix proteins and cells, suggesting the B. thermosphacta SrtA may be indirectly involved in its attachment to meat surfaces. Thus, further work in this area could provide crucial insight into molecular mechanisms involved in the colonisation of meat by B. thermosphacta.

Elevated blood levels of Dickkopf‐1 are associated with acute infections

Immunity, Inflammation and Disease, EarlyView.


Arsenic forms in phytoextraction of this metalloid in organs of 2-year-old Acer platanoides seedlings

Abstract

The aim of the study was to estimate the significance of the role of arsenite (As(III)), arsenate (As(V)), and dimethylarsinic acid (DMA) presence in modified Knop medium in the efficiency of phytoextraction of arsenic (As) in Acer platanoides root, stem, and leaves. The addition of particular As forms in single, double, and triple experimental systems was associated with a lower increase of seedling biomass compared to control plants (system free of As forms addition). Depending on As forms and their concentration in solution, negative symptoms from slight visible changes (inorganic forms separately or jointly), through smaller and discolored leaves (after DMA addition), and finally to their withering (after high DMA addition) were observed. Changes of color and shape for root systems exposed to particular As forms separately or jointly were also observed, in spite of the fact that there were no significant changes in biomass of seedlings growing in all experimental systems. The highest mean concentrations of As in root, stem, and leaves (590, 70, and 140 mg kg−1 dry weight (DW), respectively) were observed in plants growing under different experimental systems. The highest bioconcentration factor values were 10.8 for plants exposed to 0.06 mM of As(III) and DMA, while the highest translocation factor (1.0) was recorded for plants growing under the same As forms (0.6 and 0.06 mM, respectively). The obtained results indicate that the presence of particular As forms not only determines As phytoextraction and transport of this metalloid form but also has a decisive influence on plant morphology and survivability. As regards the practical aspects of phytoremediation, the kind of As forms present in substrate are more important than their total concentration.



Assessing Individual and Disseminated Effects in Network-Randomized Studies

ABSTRACT
Implementation trials often involve clustering via risk networks, where only some participants directly received the intervention. The individual effect is that among directly treated persons beyond being in an intervention network; the disseminated effect is that among persons engaged with those directly treated. We employ a causal inference framework and discuss assumptions and estimators for individual and disseminated effects and apply them to HIV Prevention Trials Network 037. HIV Prevention Trials Network 037 was a Phase III, network-level, randomized controlled HIV prevention trial conducted in the US and Thailand from 2002 to 2006 that recruited persons who injected drugs, who received either intervention or control, and their risk network members, who received no direct intervention. Combining individual and disseminated, a 35% composite rate reduction was observed in the adjusted model (95% confidence interval = 0.47, 0.90). Methodology is now available to estimate the full set of these effects enhancing knowledge gained from network-randomized trials. Although the overall effect gains validity from network randomization, we show that it will, in general, be less than the composite effect. Additionally, if only index participants benefit from the intervention, as the network size increases, the overall effect tends to the null, an unfortunate and misleading conclusion.

Facile fabrication of sodium styrene sulfonate-grafted ethylene-vinyl alcohol copolymer as adsorbent for ammonium removal from aqueous solution

Abstract

An adsorbent EVOH-g-SSS(H) was successfully synthesized for ammonium removal by one-step grafting SSS onto EVOH particles directly using radiation-induced grafting technique followed by protonation. The effects of adsorbed dose and monomer concentration on grafting yield were investigated. The adsorption behaviors of the EVOH-g-SSS(H) towards ammonium ions (NH4+) were discussed. The adsorption isotherm of NH4+ was a followed Langmuir model with the maximum adsorption capacity of 22.53 mg/g at optimal pH 6.5. For comparison, adsorption kinetics towards NH4+ removal by EVOH-g-SSS(H) and commercially available DIAION PK228 were studied. Both adsorbents were better obeyed pseudo-second-order mode. EVOH-g-SSS(H) for NH4+ uptake was faster than PK228 and reached equilibrium within 5 min. Column experiment showed that the column adsorption capacity of EVOH-g-SSS(H) adsorbent was 9.69 mg/g-ad at SV 10 h−1. The NH4+ concentration in outlet solution can maintain at a very low level even SV was as high as 800 h−1. The elution curve showed the EVOH-g-SSS(H) adsorbent can be regenerated using 1 M HCl. Besides, the removal percentage of NH4+ can be 97% from actual groundwater within 1 min. Such high adsorption efficiency of EVOH-g-SSS(H) makes it to be employed as an adsorbent for NH4+ removal in practical application.



Optimal water resource management for sustainable development of the chemical industrial park under multi-uncertainty and multi-pollutant control

Abstract

Two major concerns over the chemical industrial park (CIP) operations are high consumption of water resources and large amount of pollutant emissions. This study develops an interval chance-constrained programming model for industrial water resources management (ICCP-IWM) with consideration of multi-uncertainty and multi-environmental constraints. Uncertainties expressed as intervals and probability distributions are merged in the ICCP-IWM framework. The developed model is used to solve a real-world water resource management problem in the Shenyang Chemical Industrial Park to demonstrate its capacity and effectiveness, where the objective is to minimize the system cost of water pathways and pollutant-emission control under a series of constraints. Interval solutions with respect to water resources allocation, wastewater management, and pollutant emissions could be generated. Results indicate that a lower violation risk leads to an increased strictness of the constraints, then to a higher system cost; conversely, a higher violation risk results in a lower system cost, at the expense of an increase in the risk. These findings would be recommended by the decision-makers because of their applicability for practical decision process providing the optimal strategy for sustainable water resource management under multiple uncertainties.