International Journal of Dermatology, EarlyView.
Κυριακή 9 Σεπτεμβρίου 2018
The safety and efficacy of daylight photodynamic therapy in the treatment of actinic keratoses: a systematic review and meta‐analysis
Amino-Fe 3 O 4 -functionalized graphene oxide as a novel adsorbent of Methylene Blue: kinetics, equilibrium, and recyclability aspects
Abstract
Graphene oxide (GO) was synthetized from graphite oxidation via the modified Hummers method. Afterwards, the GO was functionalized with diethylenetriamine (DETA) and FeCl3 to obtain the novel amino-iron oxide functionalized graphene (GO-NH2-Fe3O4). FTIR, XRD, SEM with EDX, and Raman spectroscopy were performed to characterize both GO and GO-NH2-Fe3O4. The GO-NH2-Fe3O4 was then evaluated as adsorbent of the cationic dye Methylene Blue (MB); analysis of the point of zero net charge (pHPZC) and pH effect showed that the GO-NH2-Fe3O4 pHPZC was 8.2; hence, the MB adsorption was higher at pH 12.0. Adsorption kinetics studies indicated that the system reached the equilibrium state after 5 min, with adsorption capacity at equilibrium (qe) and kinetic constant (kS) of 966.39 mg g−1 and 3.17∙10−2 g mg−1 min−1, respectively; moreover, the pseudo-second-order model was better fitted to the experimental data. Equilibrium studies showed maximum adsorption capacity of 1047.81 mg g−1; furthermore, Langmuir isotherm better fitted the adsorption. Recycling experiments showed that the GO-NH2-Fe3O4 maintained the MB removal rate above 95% after 10 cycles. All the results showed sorbent high adsorption capacity and outstanding regeneration capability and evidenced the employment of novel GO-NH2-Fe3O4 as a profitable adsorbent of textile dyes.
Building a Cardio-Onco-Hematology Program
Abstract
Purpose of Review
This review aims to outline the general principles of how to build a cardio-onco-hematology clinic, acknowledging that there are diverse practices ranging from private community settings to academic hospitals and each practice environment has to build its own program.
Recent Findings
The refinement of regimens and introduction of molecularly directed therapies have substantially increased survival rates for patients with cancer. In fact, a number of previous imminently fatal malignant disease processes have been turned into chronic diseases, such that patients now live with certain incurable cancers as they do, for instance, with rheumatoid arthritis. Improved cure rates and longer survivals have raised side effects of cancer treatments to a completely new level of significance. Cardiovascular toxicities are of particular concern given their impact on morbidity and mortality. In most extreme cases, patients might be cured from cancer but remain debilitated or die prematurely because of cardiovascular disease. Furthermore, not an insignificant proportion of cancer patients start cancer therapy with cardiovascular risk factors and diseases at baseline. With the aging of the population, this "joint venture" is only expected to increase with important implications for the management of cancer patients.
Summary
Given the need for familiarity with both, cancer and cardiovascular diseases and their ever-evolving start-of-the-art therapy and interaction potential, specialized efforts have been invoked, which may collectively be termed "onco-cardiology," "cardio-oncology," or "cardio-onco-hematology." Herein, we provide recommendations for the creation and optimization of any such programmatic efforts.
Paediatric mastocytosis: long‐term follow‐up of 53 patients with whole sequencing of KIT. A prospective study
British Journal of Dermatology, EarlyView.
Cutaneous epidermotropic metastasis of an oesophageal squamous cell carcinoma: Wound healing and transepidermal elimination as possible mechanisms for epidermotropism
Australasian Journal of Dermatology, EarlyView.
A case of lymphomatoid papulosis, pityriasis lichenoides acuta, and mycosis fungoides coexistence
Australasian Journal of Dermatology, EarlyView.
Vitamin D receptor interacts with NLRP3 to restrict the allergic response
Clinical &Experimental Immunology, EarlyView.
Blood clotting and traumatic injury with shock mediates complement‐dependent neutrophil priming for extracellular ROS, ROS‐dependent organ injury and coagulopathy
Clinical &Experimental Immunology, EarlyView.
Ethyl 2,4-dicarboethoxy pantothenate, a derivative of pantothenic acid, prevents cellular damage initiated by environmental pollutants through Nrf2 activation
Recently, there has been increasing concern about the influence of environmental pollutants, such as particulate matter 2.5 (PM2.5), diesel fuel exhaust, cigarette smoke, ozone (O3), heavy metals and halogenated hydrocarbons, on public health. Therefore, the influence of environmental pollution on public health has been actively studied focusing on the lungs and the cardiovascular system because of the risk of inhalation. The effects of environmental pollution on cellular physiology have been clarified as follows: Polycyclic aromatic hydrocarbons (PAHs), which are the main components of pollutants, induce inflammation by activating the aryl hydrocarbon receptor (AHR) signaling pathway [1–3].
Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing
Publication date: Available online 8 September 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Timothy J. Watts, David Thursfield, Rubaiyat Haque
Is there an overlap in immune response between allergic bronchopulmonary and chronic pulmonary aspergillosis?
Publication date: Available online 8 September 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Inderpaul Singh Sehgal, Hansraj Choudhary, Sahajal Dhooria, Ashutosh Nath Aggarwal, Mandeep Garg, Arunaloke Chakrabarti, Ritesh Agarwal
ABSTRACT
Background
Chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA) are presumed to represent two distinct manifestations of Aspergillus species in the lung.
Objective
To investigate any possible overlap of the immunological tests used for diagnosing ABPA in proven cases of CPA.
Methods
In consecutive subjects with CPA, we calculated the proportion of subjects who tested positive for all the immunological investigations used to diagnose ABPA (A.fumigatus-specific IgE >0.35 kUA/L, total IgE ≥500 IU/mL and eosinophil count ≥500 cells/μL) or obligatory criteria (A.fumigatus-specific IgE >0.35 kUA/L and total IgE ≥500 IU/mL).
Results
269 subjects (53.5% males) of CPA with mean (SD) age of 44.3 (14.7) years were enrolled. The most common underlying disease was previously treated pulmonary tuberculosis (n=230, 85.5%). Ninety-three (34.6%) subjects had total IgE ≥500 IU/mL, while A.fumigatus-specific IgE >0.35 kUA/L was seen in 112 (41.6%) subjects. Thirteen (4.8%) subjects met all the immunological criteria for ABPA, while 59 (21.9%) subjects met the obligatory criteria. Subjects meeting the obligatory criteria had significantly higher eosinophil count (p=<0.0001), greater immediate cutaneous reactivity to Aspergillus antigen (CPA-others vs. obligatory criteria, 9.8±13.9 vs. 13.9±14.9 mm, p value=0.048), higher A.fumigatus-specific IgG (99.3±61.9 vs. 122±66.6 mgA/L, p=0.015) and greater number of fungal balls (0.9±0.7 [range, 0-3] vs. 1.1±0.9 [range, 0-4], p=0.026) compared to those without.
Conclusions
About 5% of subjects with CPA fulfilled all the immunological criteria used for diagnosing ABPA while 22% met the obligatory criteria for ABPA. Whether these patients would require a different management protocol requires further investigation.
Les prothèses mammaires : quelles offres sur le marché français
Publication date: Available online 8 September 2018
Source: Annales de Chirurgie Plastique Esthétique
Author(s): R. Sinna
Résumé
Le choix dans le type d'implant que le chirurgien utilise se fait souvent sur des arguments médico-commerciaux, des croyances, et du ressenti subjectif plutôt que sur de réels arguments scientifiques. Nous avons rarement l'occasion de comparer de manières objectives les fabricants entre eux. Ainsi notre objectif ici a été simplement de regrouper sur un même support l'ensemble des spécificités des différents acteurs du marché français. Ceci aussi bien sur le plan technique que sur le plan de l'offre commerciale.
Summary
The choice of an implant by a plastic surgeon is often based on marketing arguments, beliefs, and subjective reasons more than real high level evidence basis. Furthermore, we rarely compare manufacturers with each other objectively. Therefore our aim was to put together information coming from the different companies available in France in a single article.
Antibiotic exposure is associated with cutaneous adverse events in hairy cell leukemia patients treated with purine analogs
Publication date: Available online 8 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Rebecca F. Wang, Daniel Li, Gina J. Kuehn, Leslie A. Andritsos, Michael R. Grever, Benjamin H. Kaffenberger
Recurrent fevers, progressive lipodystrophy and annular plaques in a child
Publication date: Available online 8 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Michael A. Cardis, Gina A. Montealegre Sanchez, Raphaela Goldbach-Mansky, Chyi-Chia Richard Lee, Edward W. Cowen
Response to the Letter to the Editor entitled, “Use of immortal time within survival analysis”: JAAD-D-18-01157
Publication date: Available online 8 September 2018
Source: Journal of the American Academy of Dermatology
Author(s): Charles Kyung Min Lee, Shufeng Li, Duy Cong Tran, Gefei Alex Zhu, Jinah Kim, Bernice Y. Kwong, Anne Lynn S. Chang
News and Notices
Clinical and Experimental Dermatology, Volume 43, Issue 7, Page 863-863, October 2018.
Issue Information
Clinical and Experimental Dermatology, Volume 43, Issue 7, Page i‐ii, 757-758, October 2018.
List of opinions of the Scientific Committee on Consumer Safety (SCCS) adopted and published January to August 2018
Contact Dermatitis, Volume 79, Issue 4, Page 261-261, October 2018.
Inducción de fototolerancia con ultravioleta B de banda estrecha en urticaria solar
Publication date: Available online 8 September 2018
Source: Actas Dermo-Sifiliográficas
Author(s): P. Chicharro, P. Rodríguez-Jiménez, T.M. Capusan, M. Herrero-Moyano, D. de Argila
Resumen
Introducción
La urticaria solar (US) es una fotodermatosis infrecuente. Los antihistamínicos constituyen la primera línea de tratamiento, incluyéndose en segunda línea la inducción de fototolerancia mediante fototerapia con ultravioleta.
Objetivos
Describir y evaluar la eficacia de un protocolo de desensibilización, con UVB de banda estrecha (UVB-BE) en pacientes con US.
Material y métodos
Estudio retrospectivo de pacientes diagnosticados de US con espectro de acción en UVA, luz visible (LV) o ambas, que habían realizado fototerapia con UVB-BE para inducir fototolerancia. Se realizan cursos cortos (menos de 20 sesiones, 3 por semana) durante la primavera, con dosis inicial determinada por el fototipo. Se recogen resultados del Skindex-29 antes del tratamiento y después del verano, y un cuestionario no validado de efectividad terapéutica después del verano para valorar actividad de la enfermedad y grado de satisfacción.
Resultados
Se incluyen 8 pacientes con espectro de acción: 50% LV y 50% UVA más luz visible. Se realizaron 17 cursos anuales (1-6 cursos por paciente), de 11 a 20 sesiones. La dosis media de UVB-BE por curso fue 7,45 J/cm2. Ningún paciente presentó brotes o efectos adversos durante el tratamiento. La respuesta fue satisfactoria en 6 pacientes. En el 78,6% de los tratamientos la mejoría en el Skindex-29 global fue superior al 20%. La mejoría en las subescalas sintomática y funcional fue superior al 20% en el 71% y el 64% respectivamente.
Conclusión
La inducción de fototolerancia con UVB-BE en la US es un procedimiento seguro y efectivo en un elevado porcentaje de pacientes.
Abstract
Introduction
Solar urticaria is an uncommon photodermatosis. First-line treatment is with antihistamines; second-line treatment includes induction of light tolerance using UV phototherapy.
Objectives
We aimed to describe and evaluate the effectiveness of a desensitization protocol with narrowband UV-B in patients with solar urticaria.
Material and methods
We performed a retrospective study of patients with solar urticaria with an action spectrum in the UV-A range, the visible light range, or both who had received therapy with narrowband UV-B for induction of light tolerance. Short courses of treatment were administered (< 20 sessions, 3 per week) during spring. The initial dose was determined according to the skin type. The Skindex-29 was administered before treatment and after summer; a nonvalidated questionnaire was also administered after summer to evaluate disease activity and satisfaction with treatment.
Results
We included 8 patients with an action spectrum (4 with visible light and 4 with UVA plus visible light). Seventeen courses (1-6 per patient) were administered per year. The number of sessions per year ranged from 11 to 20. The mean dose of narrowband UV-B per course was 7.45 J/cm2. No patients experienced flares or adverse effects during treatment. The response was satisfactory in 6 patients. The improvement in the overall Skindex-29 score was greater than 20% in 78.6% of cases. The improvement in the function and symptoms subscales was over 20% in 71% and 64% of cases, respectively.
Conclusion
Induction of light tolerance with narrowband UV-B in solar urticaria is safe and effective in a high percentage of patients.
Graphical abstract
STAT6 & IL‐10 are required for the anti‐arthritic effects of Schistosoma mansoni via different mechanisms
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
Submicroscopic Plasmodium infection during pregnancy is associated with reduced antibody levels to tetanus toxoid
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
Tolerability and efficacy of a medical device repairing emollient cream in adults with chronic hand dermatitis
Journal of Cosmetic Dermatology, EarlyView.
Image gallery: Hairy‐cell leukaemia presenting with Sweet syndrome
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Protopanaxatriol inhibits melanin synthesis through inactivation of the pCREB–MITF–tyrosinase signalling pathway in melanocytes
Clinical and Experimental Dermatology, EarlyView.
Topical ingenol mebutate for viral wart on the ear
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
Efficacy of omalizumab in severe chronic spontaneous urticaria: real life data from a Greek tertiary center
Dermatologic Therapy, Volume 0, Issue ja, -Not available-.
Milia‐like idiopathic calcinosis cutis and plaque‐type syringoma in a girl with Down syndrome
The Journal of Dermatology, EarlyView.
Monitoring serum cytokeratin 19 fragment 21‐1 to determine the efficacy of docetaxel chemotherapy in advanced extramammary Paget's disease
The Journal of Dermatology, EarlyView.
Wound, pressure ulcer and burn guidelines – 2: Guidelines for the diagnosis and treatment of pressure ulcers, second edition
The Journal of Dermatology, EarlyView.
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