This review validates the safety and feasibility of minimally invasive surgery for hilar cholangiocarcinoma by summarizing existing literature. The discussion of surgical methods and results are also necessary for the development of minimally invasive surgery. Abstract Background The role of laparoscopic surgery (Lap) and robotic surgery (Rob) for radical resection of hilar cholangiocarcinoma (HC) is not clear. We summarized the safety and feasibility of Lap and Rob for HC. Methods...
Tue May 12, 2020 12:40
Opioid over‐prescription, following surgery, is a significant public health issue in most developed countries. This study demonstrates a lower rate of opiate prescription on discharge for laparoscopic cholecystectomy and laparoscopic appendicectomy in an Australian setting when compared to US data. The urgency of the procedures and the experience of the prescriber also had an impact on opioid prescriptions. Increasing experience of the prescribing doctor appears to be correlated to decreased amounts...
Tue May 12, 2020 12:39
The article reports on a study that describes the accuracy of endoscopist estimation of polyp size. Using the methodology of retrospective review, we assessed the accuracy of estimation of polyp size at colonoscopy amongst different levels of endoscopists compared with histological size. Our study demonstrates that in accurate estimation of polyp size, there is a higher degree of precision amongst senior consultants with a greater degree of variability in the practice of junior endoscopists. ...
Tue May 12, 2020 12:39
Tue May 12, 2020 11:49
Tue May 12, 2020 11:39
Abstract Ionizing radiation produces reactive oxygen species (ROS) leading to cellular DNA damage. Therefore, patients undergoing radiation therapy or first responders in radiological accident scenarios could both benefit from the identification of specifically acting pharmacological radiomitigators. The synthetic triterpenoid bardoxolone-methyl (CDDO-Me) has previously been shown to exert antioxidant, anti-inflammatory and anticancer activities in several cell lines, in part by...
03:00
Gliosis means focal proliferation of glial cells following an insult. Encephalomalacia is the end result of liquefactive necrosis following an insult. Here is a brief video case presentation discussing the MRI findings in a patient with old traumatic sequel.Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
11:24
To date multimorbidity has not received much attention in health policies, even though multiple chronic diseases put high demands on the health care system in industrial nations. Enormous costs of care and a p...
Wed May 13, 2020 03:00
Abstract Background Twitter is an expanding social media network among cytopathologists to share knowledge. Tweets are made up of text which may also include images or video. All tweets labeled under a hashtag can be tracked. The #FNAFriday hashtag was created in 2015 by one of the authors (X.J.) to build a community of individuals, to educate and share interesting cases, and highlight a variety of diagnoses with FNA specimens. Methods We retrospectively extracted all tweets labeled with...
Wed May 13, 2020 13:04
Abstract Background Reporting cerebrospinal fluid (CSF) cytology within a narrow time frame is crucial as it is often indicated in critically ill patients and moreover, the cells in CSF are highly labile and tend to decline rapidly on standing. However, due to various logistic issues, delay in reporting is inevitable at times, especially if ancillary tools are required. In this study, we examine the effect of using formol saline and ethylenediaminetetraacetic acid (EDTA) as a preservative on...
Wed May 13, 2020 13:03
Abstract Background This study aims to evaluate the usefulness of endoscopic ultrasound‐guided fine‐needle aspiration cytology (EUS‐FNAC) in the diagnosis of the gastric gastrointestinal stromal tumor (GIST). Methods We retrospectively investigated the efficacy and accuracy of EUS‐FNAC in the diagnosis of gastric GIST. Cytological smears and cytoblock sections including immunohistochemistry and mutational studies from patients diagnosed as gastric GISTs were retrieved. Results Thirty...
Wed May 13, 2020 13:00
Abstract Ganglioneuromas are rare benign tumors that arise from the sympathetic nerve fibers and represent the final maturation stage of neuroblast tumors. The most common sites of involvement in the body include posterior mediastinum, followed by retroperitoneum, adrenal gland, and soft tissues of the head and neck. In the mediastinum, this tumor is most frequently located in posterior compartment, together with other neurogenic tumors. The reports of mediastinal ganglioneuroma diagnosed by fine...
Tue May 12, 2020 15:50
Abstract The COVID‐19 pandemic is posing a worldwide challenge to control and contain. SARS‐CoV‐2 is a highly infectious virus. Health care providers at the front lines are at high risk of getting the infection and the risk applies also to laboratory personnel as they deal with specimens that might be contaminated with infectious materiel. Cytopathology teams specifically are at high risk of dealing with contaminated material because of patients encounter during fine‐needle aspiration biopsies or...
Tue May 12, 2020 15:49
ABSTRACT World Health Organization declared on 11 March, COVID 19 as a pandemic infection that has spread rapidly across the globe. Covid‐19 currently has no known treatment or a vaccine. Oral health professionals are at risk of developing COVID 19 infection as they come into close contact with patients and accompanying relatives who may be carrying the virus. Since January 2020, and by the end of April this year, more than 150 medical doctors in Italy and over 100 National Health Service workers...
Wed May 13, 2020 18:10
Abstract Purpose The aim of this study was to evaluate the clinical, histological, hematological and oxidative stress effects of cannabidiol (CBD) in mice with induced oral mucositis. Methods We used 90 mice of the CF‐1 strain in which oral mucositis was induced using a protocol with 5‐fluorouracil (5‐FU) chemotherapy. The animals were divided randomly into 10 study groups. Three groups were treated with different doses of CBD (3, 10 and 30 mg/kg), while 2 were control groups (positive...
Wed May 13, 2020 13:53
Endothelial progenitors increase vascularization and improve fibroblasts function that prevent MRONJ
Abstract Objectives in a previous rat model, MRONJ occurrence was 50%. Our aim was to investigate the potential of endothelial progenitor cells (EPCs) to improve fibroblasts function and prevent MRONJ. Methods Human gingival fibroblasts were cultured with EPC conditioned media (EPC‐CM); endothelial growth media (EGM‐2) or DMEM followed by incubation with 10µM zoledronic (ZOL) and dexamethasone (DEX). Cell proliferation and migration were assessed by XTT and scratch wound healing assays....
Wed May 13, 2020 13:34
Abstract Oral squamous cell carcinoma (OSCC), the most common oral malignancy, shows an increasing rate of incidence worldwide. In spite of the recent advances in cancer research, OSCC therapy continues to have unfavourable outcomes, and thus patient’s prognosis remains relatively poor. Current research has been devoted to identifying novel therapeutic targets also in the tumour microenvironment (TME). Histamine and its G‐protein coupled receptors (H1R‐H4R) play vital roles in multiple cancer‐associated...
Tue May 12, 2020 14:40
Abstract Background The superiority of robot‐assisted thoracic surgery (RATS) over video‐assisted thoracic surgery (VATS) and thoracotomy remains controversial for lung cancer. Methods A network meta‐analysis (NMA) and pairwise meta‐analysis (PMA) were performed to evaluate the perioperative outcomes using 5 databases. Results Thirty‐two studies involving 6593 patients were included for analysis. The NMA showed that RATS had similar operative time, conversion rate to thoracotomy,...
Wed May 13, 2020 14:50
New England Journal of Medicine, Ahead of Print.
Wed May 13, 2020 12:01
New England Journal of Medicine, Ahead of Print.
Wed May 13, 2020 12:01
New England Journal of Medicine, Ahead of Print.
Wed May 13, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Wed May 13, 2020 12:00
New England Journal of Medicine, Ahead of Print.
Wed May 13, 2020 12:00
New England Journal of Medicine, Volume 382, Issue 20, Page 1953-1955, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1876-1877, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1958-1960, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1952-1953, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1960-1962, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1956-1957, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1942-1942, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1894-1905, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1880-1881, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1906-1915, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1926-1932, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, May 2020.
Wed May 13, 2020 11:55
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