The radial forearm snake flap: An underutilized technique for fasciocutaneous and osteocutaneous forearm flaps with primary closure

xlomafota13 shared this article with you from Inoreader The radial forearm snake flap: An underutilized technique for fasciocutaneous and osteocutaneous forearm flaps with primary closure Via Head & Neck Abstract Background The radial forearm free flap (RFFF) is associated with troublesome donor site morbidity related to split thickness skin grafting (STSG). The radial forearm snake flap with primary closure of the donor site may reduce donor site complications. Methods Single institution, retrospective cohort study comparing rates of delayed donor site wound healing and tendon exposure in 52 patients undergoing radial forearm snake flap and 95 patients undergoing conventional RFFF with STSG closure of the donor site. Results Tendon exposure occurred in zero (0%) patients undergoing snake flap and four (4.2%) patients undergoing conventional RFFF (0/52 vs. 4/95; p = 0.297). Delayed wound healing occurred in zero (0%) patients undergoing snake flap and 19 (20.0%) patients undergoing conventional RFFF (0/52 vs. 19/95; p < 0.001). Conclusions The radial forearm snake flap provides an alternative to conventional RFFF harvest, which enables primary donor site closure with reduced rates of delayed donor site healing. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

New AMM: Nivolumab as an adjuvant for oesophageal and gastroesophageal junction cancer

xlomafota13 shared this article with you from Inoreader New AMM: Nivolumab as an adjuvant for oesophageal and gastroesophageal junction cancer Via Association française pour l'étude du cancer Bull Cancer. 2022 Feb 11:S0007-4551(22)00009-1. doi: 10.1016/j.bulcan.2021.11.018. Online ahead of print. NO ABSTRACT PMID:35164916 | DOI:10.1016/j.bulcan.2021.11.018 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Behavioural Interventions in People with Oropharyngeal Dysphagia: A Systematic Review and Meta-Analysis of Randomised Clinical Trials

xlomafota13 shared this article with you from Inoreader Behavioural Interventions in People with Oropharyngeal Dysphagia: A Systematic Review and Meta-Analysis of Randomised Clinical Trials Via swallowing exercises J Clin Med. 2022 Jan 28;11(3):685. doi: 10.3390/jcm11030685. ABSTRACT OBJECTIVE: To determine the effects of behavioural interventions in people with oropharyngeal dysphagia. METHODS: Systematic literature searches were conducted to retrieve randomized controlled trials in four different databases (CINAHL, Embase, PsycINFO, and PubMed). The methodological quality of eligible articles was assessed using the Revised Cochrane risk-of-bias tool for randomised trials (RoB 2), afte r which meta-analyses were performed using a random-effects model. RESULTS: A total of 37 studies were included. Overall, a significant, large pre-post interventions effect size was found. To compare different types of interventions, all behavioural interventions and conventional dysphagia treatment comparison groups were categorised into compensatory, rehabilitative, and combined compensatory and rehabilitative interventions. Overall, significant treatment effects were identified favouring behavioural interventions. In particular, large effect sizes were found when comparing rehabilitative interventions with no dysphagia treatment, and combined interventions with compensatory conventional dysphagia treatment. When comparing selected interventions versus conventional dysphagia treatment, significant, large effect sizes were found in favour of Shaker exercise, chin tuck against resistance exercise, and expiratory muscle strength training. CONCLUSIONS: Behavioural interven tions show promising effects in people with oropharyngeal dysphagia. However, due to high heterogeneity between studies, generalisations of meta-analyses need to be interpreted with care. PMID:35160137 | DOI:10.3390/jcm11030685 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Secondary primary malignancy in patients with head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools Via Head and neck cancers by Shih-Wei Wang, Leong-Perng Chan, Ling-Feng Wang, Che-Wei Wu, Sheng-Hsuan Lin, Tzu-Yen Huang, Ka-Wo Lee Background The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) showed no significant improvement for decades, however, the impact of advances in diagnostic tools is rarely mentioned. This study investigated the clinical characteristic of HNSCC with SPM over a 27-year period especially from the perspective of diagnostic tools. Methods This study evaluated 157 HNSCC patients with SPM. The patients were divided into two groups according to the time of SPM diagnosis (Group A:1992–2003; Group B: 2004–2014). Age, gender, stage of first primary malignancy (FPM), SPM interval, overall survival, and disease-free survival were compared between groups. Results Group B had significantly more SPM developed rate (p = 0.002), more SPM patients with advanced stage of FPM (p = 0.001), synchronous SPM (p = 0.006), and shorter SPM interval (p Conclusion Among patients diagnosed with HNSCC recently, more SPMs are diagnosed in a shorter time interval and in a more advanced stage. The overall advances in diagnostic tools cannot significantly improve SPM survival, however, it enables more patients to receive corresponding treatment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Secondary primary malignancy in patients with head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools Via Head and neck squamous cell carcinoma by Shih-Wei Wang, Leong-Perng Chan, Ling-Feng Wang, Che-Wei Wu, Sheng-Hsuan Lin, Tzu-Yen Huang, Ka-Wo Lee Background The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) showed no significant improvement for decades, however, the impact of advances in diagnostic tools is rarely mentioned. This study investigated the clinical characteristic of HNSCC with SPM over a 27-year period especially from the perspective of diagnostic tools. Methods This study evaluated 157 HNSCC patients with SPM. The patients were divided into two groups according to the time of SPM diagnosis (Group A:1992–2003; Group B: 2004–2014). Age, gender, stage of first primary malignancy (FPM), SPM interval, overall survival, and disease-free survival were compared between groups. Results Group B had significantly more SPM developed rate (p = 0.002), more SPM patients with advanced stage of FPM (p = 0.001), synchronous SPM (p = 0.006), and shorter SPM interval (p Conclusion Among patients diagnosed with HNSCC recently, more SPMs are diagnosed in a shorter time interval and in a more advanced stage. The overall advances in diagnostic tools cannot significantly improve SPM survival, however, it enables more patients to receive corresponding treatment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Extent of Thyroid Surgery in Differentiated Thyroid Cancer Patients with Low and Intermediate Risks of Recurrence

xlomafota13 shared this article with you from Inoreader The Extent of Thyroid Surgery in Differentiated Thyroid Cancer Patients with Low and Intermediate Risks of Recurrence Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 2, Page 63-66, February 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Is Extrathyroidal Extension an Indicator of Poor Prognosis in Papillary Thyroid Cancer?

xlomafota13 shared this article with you from Inoreader Is Extrathyroidal Extension an Indicator of Poor Prognosis in Papillary Thyroid Cancer? Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 2, Page 75-77, February 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Predisposition to and Prognosis of Thyroid Cancer May Not Be Affected by Graves’ Disease, But Some Questions Still Remain

xlomafota13 shared this article with you from Inoreader Predisposition to and Prognosis of Thyroid Cancer May Not Be Affected by Graves' Disease, But Some Questions Still Remain Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 2, Page 59-62, February 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Diagnostic Value of Preoperative Serum Calcitonin Levels in Medullary Thyroid Carcinoma

xlomafota13 shared this article with you from Inoreader Diagnostic Value of Preoperative Serum Calcitonin Levels in Medullary Thyroid Carcinoma Via Clinical Thyroidology Clinical Thyroidology, Volume 34, Issue 2, Page 85-88, February 2022. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The clinicopathological and prognostic characteristics of mucinous micropapillary carcinoma of the breast

xlomafota13 shared this article with you from Inoreader The clinicopathological and prognostic characteristics of mucinous micropapillary carcinoma of the breast Via Cellular and Molecular Biology Histol Histopathol. 2022 Feb 15:18436. doi: 10.14670/HH-18-436. Online ahead of print. ABSTRACT BACKGROUND: Mucinous micropapillary carcinoma (MMPC) is a unique subtype of breast cancer, and there is as yet no detailed report on the clinical characteristics of MMPC. METHODS: MMPC, pure mucinous breast carcinoma (PMBC), and invasive micropapillary carcinoma (IMPC) samples were enrolled simultaneously, and immunohistochemistry analysis was performed to explore the clinicopathological attributes of MMPC. Moreover, survival analyses of MMPC were performed among the MMPC, PMBC, and IMPC groups and within the MMPC group. RESULTS: The results showed that MMPC demonstrated distinct pathological features and that vascular invasion and lymph node metastasis were two significant clinical attributes of MMPC. MMPC leads to a shorter survival time than PMBC but an increased survival time compared to IMPC, while the tumor-node-metastasis stage and lymph node metastasis were identified as two independent prognostic elements for disease-free survival in discerning the MMPC prognosis. CONCLUSIONS: The gathered data implied that further understanding and classification of MMPC may provide better individualized therapeutic strategies for MMPC treatment. PMID:35166367 | DOI:10.14670/HH-18-436 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Quantitative lateral flow immunoassay for rapid detection and monitoring of cerebrospinal fluid leakage following incidental durotomy

xlomafota13 shared this article with you from Inoreader Quantitative lateral flow immunoassay for rapid detection and monitoring of cerebrospinal fluid leakage following incidental durotomy Via leak of cerebrospinal fluid Anal Chim Acta. 2022 Mar 1;1196:339544. doi: 10.1016/j.aca.2022.339544. Epub 2022 Jan 25. ABSTRACT Cerebrospinal fluid (CSF) leakage due to incidental durotomy is an inherent complication of spine surgery. With appropriate treatment, complications of CSF leakage, such as headache and even meningitis, can be reduced. CSF leakage could be detected on the basis of correlated clinical symptoms; diagnosis should be based on these symptoms and appropriate imaging studies. However, the diagnosis of CSF leakage remains a challenge, especially if incidental durotomy is unrecognized during surgery; even if incidental durotomy is detected and repaired intraoperatively, the severity of the leakage and quality of the primary dural repair are difficult to evaluate postoperatively. Rapid, inexpensive, and safe methods of detecting CSF-containing samples are currently lacking; hence, the development of a point-of-care test (POCT) method to improve diagnostic efficiency is necessary. We developed a high-sensitivity lateral flow immunoassay with a stacking pad (sLFIA) for quantitative detection of β-trace protein (BTP), a specific CSF marker. The BTP concentration in 39 clinical samples was calculated using a calibration equation for test-line intensity and evaluated by a standard laboratory method. To avoid the hook effect, we diluted each sample prior to testing. The correlation coefficient between the enzyme-linked immunosorbent assay and our BTP sLFIA method was 0.991 A 75-fold sample dilution was applied owing to the hook effect point, identified as 175 ng mL-1. We established an optimal sample-specific cutoff point at a value of 4.0 μg mL-1 for CSF leakage in subfascial drainage samples following spinal posterior decompression. The sensitivity and specificity of the BTP sLFIA method were 90% and 97%, respectively, according to a receiver operating characteristic curve analysis. In addition, clinical samples from patients who underwent primary dural repair intraoperatively were tested, and CSF leakage was successfully diagnosed using our method. Finally, the quantitation of BTP in samples collected daily provided an accurate assessment of the severity of the residual leakage. Our results demonstrate that the BTP sLFIA method possesses the potential to serve as a POCT method for screening and monitoring postoperative CSF leakage. PMID:35151406 | DOI:10.1016/j.aca.2022.339544 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of outcomes between intracapsular resection and pseudocapsule-based extracapsular resection for pituitary adenoma: a systematic review and meta-analysis

xlomafota13 shared this article with you from Inoreader Comparison of outcomes between intracapsular resection and pseudocapsule-based extracapsular resection for pituitary adenoma: a systematic review and meta-analysis Via leak of cerebrospinal fluid BMC Neurol. 2022 Feb 12;22(1):52. doi: 10.1186/s12883-022-02574-9. ABSTRACT BACKGROUND: Transsphenoidal surgery is the preferred first-line therapy for most pituitary adenoma(PA), and the conventional strategy of treatment is intracapsular resection(IR). The protocol of extracapsular resection(ER), which considers the pseudocapsule as the PA boundary for surgical removal, has also been introduced gradually. In this study, the clinical efficacies and complications were explored and compared between these two procedures. METHODS: A systematic literature review was performed in the PubMed, EMBASE, Web of Science and Cochrane databases. Articles comparing between IR and ER were included. RESULTS: There were 7 studies containing 1768 cases in accordance with the inclusion criteria. Although the meta-analysis showed no significant difference in complete resection, a sensitivity analysis revealed that ER was more conducive to total PA re section than IR. Moreover, we found a significant difference in favor of ER regarding biochemical remission. Furthermore, there was no significant difference in the incidence rate of certain complications, such as hormone deficiency, diabetes insipidus, intraoperative cerebrospinal fluid(CSF) and postoperative CSF leakage. However, a sensitivity analysis suggested that IR decreased the risk of intraoperative CSF leakage. CONCLUSIONS: This meta-analysis unveiled that ER contributed to biochemical remission. To some extent, our results also showed that ER played a positive role in complete resection, but that IR reduced the incidence of intraoperative CSF leakage. However, the available evidence needs to be further authenticated using well-designed prospective, multicenter, randomized controlled clinical trials. PMID:35151259 | DOI:10.1186/s12883-022-02574-9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.