Antimicrobial-resistant ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens represent a global threat to human health. The acquisition of antimicrobial resistance genes by ESKAPE pathogens has reduced the treatment options for serious infections, increased the burden of disease, and increased death rates due to treatment failure and requires a coordinated global response for antimicrobial...
Wed May 13, 2020 15:30
Antiviral drugs have traditionally been developed by directly targeting essential viral components. However, this strategy often fails due to the rapid generation of drug-resistant viruses. Recent genome-wide approaches, such as those employing small interfering RNA (siRNA) or clustered regularly interspaced short palindromic repeats (CRISPR) or those using small molecule chemical inhibitors targeting the cellular "kinome," have been used successfully to identify cellular factors that can support...
Wed May 13, 2020 15:30
In Racism without Racists, Eduardo Bonilla-Silva articulates why "color blindness," an ethos based on the belief that race is no longer relevant, is contradictory and harmful. Color-blind policies, such as race-neutral mortgage practices and Medicare and Medicaid rules, have resulted in…
Wed May 13, 2020 03:00
Publication date: Available online 13 May 2020Source: Radiotherapy and OncologyAuthor(s): Eric J. Lehrer, M. Harrison Snyder, Bhargav D. Desai, Chelsea E. Li, Aditya Narayan, Daniel M. Trifiletti, David Schlesinger, Jason P. Sheehan
Wed May 13, 2020 18:05
Publication date: Available online 13 May 2020Source: Radiotherapy and OncologyAuthor(s): Patries M Herst, Andre Aumata, Vanessa Sword, Rowan Jones, Gordon Purdie, Shaun Costello
Wed May 13, 2020 18:05
Publication date: Available online 13 May 2020Source: Radiotherapy and OncologyAuthor(s): Martijn van der Heijden, Paul B.M. Essers, Caroline V.M. Verhagen, Stefan M. Willems, Joyce Sanders, Reinout H. de Roest, David M. Vossen, C. René Leemans, Marcel Verheij, Ruud H. Brakenhoff, Michiel W.M. van den Brekel, Conchita Vens
Wed May 13, 2020 18:05
Publication date: Available online 13 May 2020Source: Radiotherapy and OncologyAuthor(s): Gerd Fastner, Christoph Gaisberger, Julia Kaiser, Philipp Scherer, Antonella Ciabattoni, Anna Petoukhova, Elena Sperk, Philip Poortmans, Felipe A. Calvo, Felix Sedlmayer, Maria Cristina Leonardi
Wed May 13, 2020 18:05
Publication date: Available online 12 May 2020Source: Gait & PostureAuthor(s): Gabriel Zeitoune, Gustavo Leporace, Luiz Alberto Batista, Leonardo Metsavaht, Paulo Roberto Garcia Lucareli, Jurandir Nadal
Wed May 13, 2020 18:03
Publication date: Available online 12 May 2020Source: Autoimmunity ReviewsAuthor(s): Savino Sciascia, Karen Schreiber, Massimo Radin, Dario Roccatello, Bernhard K. Krämer, Ksenija Stach
Wed May 13, 2020 18:02
Publication date: Available online 12 May 2020Source: Journal of the American College of SurgeonsAuthor(s): Yu Seob Shin
Wed May 13, 2020 17:39
Publication date: Available online 12 May 2020Source: Journal of the American College of SurgeonsAuthor(s): Gabrielle E. Hatton, John A. Harvin, Charles E. Wade, Lillian S. Kao
Wed May 13, 2020 17:39
Publication date: 15 June 2020Source: Journal of Proteomics, Volume 221Author(s):
Wed May 13, 2020 17:33
Publication date: Available online 13 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Stefano Bruschi, Maria Alessandra Bocchiotti, Ylenia Gugliotta, Antongiulio Mangia
Wed May 13, 2020 17:04
Publication date: Available online 13 May 2020Source: Academic RadiologyAuthor(s): S. Sefidbakht, P. Iranpour
Wed May 13, 2020 16:52
Purpose of review Omalizumab has been proposed for controlling adverse reactions during drug desensitization. Our aim is to know the current evidence involving the use of omalizumab in drug-allergy desensitization. Recent findings Drug-allergy desensitization is not risk free, but it is a useful procedure and has been applied for drug hypersensitivity reactions with mast cells degranulation through IgE and non-IgE mechanisms. Since 2007, omalizumab has been considered as a potential strategy...
Thu May 07, 2020 03:00
Related ArticlesClinical orthodontic management during the COVID-19 pandemic. Angle Orthod. 2020 Apr 27;: Authors: Suri S, Vandersluis YR, Kochhar AS, Bhasin R, Abdallah MN Abstract OBJECTIVES: To provide a comprehensive summary of the implications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) on orthodontic treatment, contingency management, and provision of emergency orthodontic...
Wed May 13, 2020 16:16
Publication date: Available online 13 May 2020Source: Journal of Neuroscience MethodsAuthor(s): Alessandro Piva, Nicholas Pintori, Laura Padovani, Cristiano Chiamulera
Wed May 13, 2020 16:13
Zusammenfassung Der klassische M. Paget der Mamille ist histologisch charakterisiert durch eine intraepidermale Tumorinfiltration, die von einem intraduktalen oder invasiven Mammakarzinom ausgeht, immunhistologisch durch eine regelhafte Überexpression von HER2 und klinisch durch ekzemartige Veränderungen von Mamille und Areola. Zu den Varianten mit davon abweichenden histologischen, immunhistologischen und klinischen Erscheinungsformen gehören der isolierte M. Paget der Mamille,...
Wed May 13, 2020 03:00
Publication date: Available online 13 May 2020Source: Behavioural Brain ResearchAuthor(s): Edward D. Huntley, Hilary A. Marusak, Sarah E. Berman, Clara G. Zundel, Joshua R.B. Hatfield, Daniel P. Keating, Christine A. Rabinak
Wed May 13, 2020 15:55
Publication date: Available online 13 May 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): H.J. Gould, L.K. James
Wed May 13, 2020 15:51
Abstract Objectives There is a lack of data on patients’ and diagnostic factors for prognostication of complete recovery in patients with Bell’s palsy. Design and setting Cohort register‐based study of 368 patients with Bell’s palsy and uniform diagnostics and standardized treatmentin a university hospital from 2007 to 2017 (49% female, median age: 51 years). Main outcome measures Clinical data, facial grading,electrodiagnostics, motor function tests, non‐motor function tests, and...
Tue May 12, 2020 14:50
Abstract Over the last decade next generation sequencing (NGS) has been extensively used to identify new pathogenic mutations and genes causing rare genetic diseases. The efficient analyses of NGS data is not trivial and requires a technically and biologically rigorous pipeline that addresses data quality control, accurate variant filtration to minimize false positives and false negatives, and prioritization of the remaining genes based on disease genomics and physiological knowledge....
Wed May 13, 2020 03:00
Related ArticlesNonspecific Expression in Limited Excitatory Cell Populations in Interneuron-Targeting Cre-driver Lines Can Have Large Functional Effects. Front Neural Circuits. 2020;14:16 Authors: Müller-Komorowska D, Opitz T, Elzoheiry S, Schweizer M, Ambrad Giovannetti E, Beck H Abstract Transgenic Cre-recombinase expressing mouse lines are widely used to express fluorescent proteins and opto-/chemogenetic actuators, making them a cornerstone of modern...
Wed May 13, 2020 15:32
Condition: Nasopharyngeal CarcinomaIntervention: Radiation: modified reduce-volume target IMRTSponsor: Fujian Cancer HospitalNot yet recruiting
Wed May 13, 2020 15:30
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on a botanical extract derived from both Panax notoginseng and Astragalus membranaceus (AstraGin™) as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is a combination of an ethanol extract of the roots of A. membranaceus and a hot water extract of the roots of P. notoginseng. The NF contains 1.5–5% total saponins, 0.1–0.5%...
Wed May 13, 2020 13:27
Abstract The EFSA Panel on Plant health was requested to prepare and deliver risk assessments for commodities listed in the relevant Implementing Acts as ‘High risk plants, plant products and other objects’ (Commission Implementing Regulation (EU) 2018/2019 establishing a provisional list of high‐risk plants, plant products or other objects, within the meaning of Article 42 of Regulation (EU) 2016/2031). The current scientific opinion covers all plant health risks posed by dormant bare rooted plants...
Wed May 13, 2020 13:25
Abstract The applicant ISK Biosciences Europe N.V, submitted a request to the competent national authority in Finland to evaluate the confirmatory data that were identified for flonicamid in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396/2005 as not available. In order to address the data gaps, the applicant provided method validation data for hops, residue trials on cherries, plums, tomatoes and melons and referred to results from trials in cucumbers...
Wed May 13, 2020 13:25
Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Tilco‐Alginure GmbH submitted a request to the competent national authority in Germany to modify the existing maximum residue levels (MRL) for the active substance potassium phosphonates in flowering brassica, Chinese cabbages, kales and spinaches. The data submitted in support of the request were found to be sufficient to derive MRL proposals for all the crops under assessment. Adequate analytical methods for enforcement...
Wed May 13, 2020 13:25
Abstract The European Commission asked EFSA to update their 2006 opinion on ochratoxin A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and found as a contaminant in various foods. OTA causes kidney toxicity in different animal species and kidney tumours in rodents. OTA is genotoxic both in vitro and in vivo; however, the mechanisms of genotoxicity are unclear. Direct and indirect genotoxic and non‐genotoxic modes of action might each contribute to tumour formation....
Wed May 13, 2020 12:56
Young children rely on their parents with respect to oral health routines. However, parental knowledge on this topic is often insufficient. Well‐child care may be an excellent route to reach parents because almost all of them attend. To evaluate the effectiveness of an 8.5 min web‐based film about oral health, provided by well‐child care, a non‐blinded quasi‐experimental study was performed. Parents attending well‐child care clinics in the Netherlands were assigned to an intervention (n = 88) or...
Tue May 12, 2020 21:40
The objectives of this study were to evaluate the micro‐tensile bond strength (μTBS) of composite bonded to human occlusal sclerotic dentin following different surface treatments to determine the sclerotic dentin morphology. Human molars without (normal dentin; group 1) or with occlusal wear (sclerotic dentin; groups 2–5) were divided and subjected to different surface treatments, including the normal protocol for the Contax self‐etch bonding system (group 1 and 2); doubled etch‐prime time (group...
Tue May 12, 2020 20:35
Using transmission electron microscopy (TEM), this study investigated the characteristics of smear layers after preparation of dentin surfaces using different methods. In addition, this study analyzed, using scanning electron microscopy (SEM), the interactions of smear layers with the various acidic agents used subsequently to treat the dentin surface. Mid‐coronal dentin surfaces were prepared according to one of five instrumentation methods: fracture; grinding with carbide bur; grinding with regular‐grit...
Tue May 12, 2020 15:59
In order to evaluate the influence of 38% silver diamine fluoride (SDF) application on enamel and dentin bond stability of universal adhesives in self‐etch mode, a 38% SDF and three universal adhesives were used in this study. Initial shear bond strength (ISBS), fatigue bond strength (FBS), and shear bond strength of survivors (SBSS) to enamel and dentin of universal adhesives in self‐etch mode, with and without SDF application, were determined. SDF was applied to the polished enamel or dentin surface...
Tue May 12, 2020 14:13
Related ArticlesComprehensive Analysis of Clinicopathologic Factors Predictive of an Unfavorable Prognosis in Patients With Acinic Cell Carcinoma of the Parotid Gland. Clin Exp Otorhinolaryngol. 2020 May 13;: Authors: Park YM, Yoon SO, Kim JH, Kang MS, Kim DH, Koh YW, Kim SH, Lim JY, Choi EC Abstract Objectives.: In subset of patients, acinic cell carcinoma (AcCC) exhibits aggressive features such as recurrence, distant metastasis, and mortality. This...
Wed May 13, 2020 15:22
Introduction: Contact hearing aids (CHA) offer potential advantages over conventional acoustic hearing aids (AHA) in terms of sound quality, reduced occlusion, and increased high-frequency gain. This study evaluates objective and subjective outcome data for CHA compared to AHA. Methods: Clinical outcome data were retrospectively reviewed for patients wearing CHA. Individual and group data were analyzed and then compared to unaided and AHA data. Adverse effects, device complaints, and clinical utility...
Wed May 13, 2020 14:29
The auditory brainstem response (ABR) is a commonly used objective clinical measure for hearing evaluation. It can be also used to draw conclusions about the functioning of distinct stages of the auditory pathway including the binaural processing stages using the binaural interaction component (BIC) of the ABR. Objective: To study binaural processing in normal hearing subjects complaining of tinnitus. Methods: Sixty cases with bilateral normal peripheral hearing were included in this work, divided...
Wed May 13, 2020 14:28
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