Πέμπτη 19 Ιουλίου 2018
Anaerobic end-products and mitochondrial parameters as physiological biomarkers to assess the impact of urban pollutants on a key bioturbator
Abstract
The impact of long-term exposure (6 months) to highly or slightly polluted sediments on the energy metabolism of an ecosystem engineer (the oligochaete Limnodrilus hoffmeisteri) was investigated in laboratory conditions. We evaluated some mitochondrial parameters (respiratory chain activity and ATP production rate) and the accumulation of anaerobic end-products (lactate, alanine, succinate, and propionate). The sediments were collected from stormwater infiltration basins and presented high levels of heavy metals and polycyclic aromatic hydrocarbons (PAHs). These compounds had been drained by the runoff water on impervious surfaces of urban areas during rainfall events. A decrease in the activity of the mitochondrial electron transport chain was observed in worms exposed to the most polluted sediment. Urban contaminants disrupted both aerobic metabolism and mitochondrial functioning, forcing organisms to shift from aerobic to anaerobic metabolism (which is characteristic of a situation of functional hypoxia). Although L. hoffmeisteri is very tolerant to urban pollutants, long-term exposure to high concentrations can cause disruption in mitochondrial activity and therefore energy production. Finally, this study demonstrated that anaerobic end-products could be used as biomarkers to evaluate the impact of a mixture of urban pollutants on invertebrates.
Use of various biomarkers to explore the effects of GSM and GSM-like radiations on flowering plants
Abstract
Since last decade, GSM (Global System for Mobile Communication) technology has evidently revolutionized our digital world. It uses electromagnetic frequency radiations (EMFr), ranging 850–1900 MHz, and is being composed of three main units (i.e., mobile station, access and core networks). GSM technology has significant impact on our daily life as revealed by increased number of mobile users in the world over. The main goal of the present review is to critically revisit the available literature regarding the responses of various flowering plant species towards GSM and GSM-like radiations using physiological, biochemical, molecular and cytological markers using in vitro approaches. Different monocots (tomato, onion, wheat and maize etc.) and dicots (pulses, mustard and flax) have been studied using both GSM mobile phone and GSM simulators. Different studies revealed overall reductions in germination, root-shoot lengths, dry weight, in both dose and time-dependent manners. However, there could be found incline in various parameters at biochemical and molecular levels. Furthermore, there could be found disturbances at cytological levels upon exposure of roots of onion to EMFr radiations. The overall literature review shows the negative effects of GSM and GSM-like radiations on targeted plant species. In order to alleviate the stressful effects of EMFr radiations on plants, in vivo studies need to be done using various cost-effective approaches such as use of biochar and various organic amendments.
Diesel engine emission analysis using fuel from diverse emulsification methods
Abstract
The focus of this work is to investigate the emission characteristics of a stationary diesel engine while utilizing an emulsion fuel from a novel preparation process. The emulsion preparation was performed in real time without using any surfactant. Instead of mechanically breaking the water down into droplets, the water is delivered thermally, by changing its phase from gas to liquid. Steam is used in this proposed process, where it will be converted into suspended water droplets once it meets colder diesel. The product is called steam-generated water-in-diesel emulsion fuel (S/D). The method is expected to reduce the moving components of a previous surfactant-less system; therefore, reducing costs and increasing the system reliability. The emission characteristics of S/D were compared with EURO 2 diesel (D2), and a conventional emulsion denoted as E10. E10 was prepared using 10% water (volumetric) and SPAN80 as a surfactant. The emission characterizations were carried out based on the exhaust gas of a single cylinder naturally aspirated CI engine fueled with D2, S/D, and E10. Compared to D2, both emulsions significantly reduced the emissions of nitrogen oxides (NOx) (E10 max ↓58.0%, S/D max ↓40.0%) and particulate matter (PM) (E10 max ↓20.0%, S/D max ↓57.0%).
Lesión periungueal resistente a tratamiento
Publication date: Available online 20 July 2018
Source: Actas Dermo-Sifiliográficas
Author(s): J. Boix-Vilanova, N. Izquierdo-Herce, L.J. del Pozo
Microscopia confocal de reflectancia: una herramienta útil para diagnosticar malignidad en lesiones melanocíticas que presenten el signo de la isla
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): M. Elosua-González, R. Gamo-Villegas, U. Floristán-Muruzábal, F. Pinedo-Moraleda, J.L. López-Estebaranz
Resumen
El signo de la isla se define como un área bien delimitada en una lesión melanocítica, con un patrón dermatoscópico diferente al resto de la lesión. Es predictor de melanoma sobre todo cuando el patrón dermatoscópico de la isla es atípico. Presentamos las características con microscopia confocal de reflectancia (MCR) en un melanoma sobre nevus, un nevus melanocítico y un melanoma in situ con signo de la isla. El melanoma sobre nevus y el melanoma in situ, presentaban atipia celular (células atípicas aisladas y formando nidos) y distorsión arquitectural por MCR. El nevus presentaba un signo de la isla con un patrón globular típico con nidos densos sin atipia por MCR. El signo de la isla se relaciona sobre todo con melanomas in situ y melanomas sobre nevus. El MCR ofrece una buena resolución celular hasta dermis reticular, siendo útil en el diagnóstico de los melanomas con signo de la isla.
Abstract
The dermoscopic island is described as a well-defined area in a melanocytic lesion, with a different dermoscopic pattern from the rest of the lesion. It is predictive of melanoma, particularly when the pattern of the island is atypical. We present the reflectance confocal microscopy (RCM) findings in 3 lesions with dermoscopic islands: nevus-associated melanoma, melanocytic nevus, and in situ melanoma. The nevus-associated melanoma and in situ melanoma presented cellular atypia (atypical cells in isolation or forming nests) and architectural distortion on RCM. The nevus presented a dermoscopic island with a typical globular pattern with dense nests and no atypia on RCM. Dermoscopic island is mainly associated with in situ and nevus-associated melanomas. RCM offers good cellular resolution to the depth of the reticular dermis and is useful for diagnosing of melanomas presenting a dermoscopic island.
Rosácea papulopustulosa: respuesta al tratamiento con azitromicina oral
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): M. Lova Navarro, P. Sánchez-Pedreño Guillen, A.M. Victoria Martínez, T. Martínez Menchón, R. Corbalán Vélez, J. Frías Iniesta
Resumen
Introducción
El tratamiento de la rosácea papulopustulosa (RPP) ha consistido durante años en el uso de tetraciclinas orales y antibióticos tópicos. Pero no es infrecuente encontrar casos de RPP resistentes al tratamiento convencional. Azitromicina oral ha demostrado ser una opción eficaz para estos pacientes no respondedores.
Material y método
Se realizó un estudio piloto prospectivo con 16 pacientes con RPP no respondedores al tratamiento convencional (doxiciclina oral y metronidazol gel) que recibieron tratamiento con azitromicina oral. En la visita inicial (visita 1) se realizó una valoración basal del estadio clínico de la RPP, según 4 niveles de gravedad progresiva, y se inició tratamiento con azitromicina oral. A las 8 semanas de finalizar el tratamiento (visita 2) se evaluó la respuesta clínica según 3 niveles de mejoría respecto al estadio clínico basal. Posteriormente, para evaluar la eficacia de azitromicina oral a largo plazo, se realizaron visitas periódicas cada 12 semanas.
Resultados
Todos los pacientes que recibieron tratamiento con azitromicina oral mejoraron de su RPP. A las 8 semanas de finalizar el tratamiento se objetivó un eritema facial residual débil o nulo, con desaparición completa de las pápulas y/o pústulas en el 87,5% de los pacientes. En cuanto al mantenimiento de la eficacia a largo plazo, únicamente 2 pacientes presentaron una recidiva de lesiones inflamatorias de RPP.
Conclusiones
Los resultados de nuestro estudio evidencian que azitromicina oral podría ser un fármaco de gran eficacia a corto y largo plazo para el manejo de aquellos casos de RPP resistentes al tratamiento convencional.
Abstract
Introduction
Oral tetracyclines and topical antibiotics have been used to treat papulopustular rosacea (PPR) for years, but it is not uncommon to find patients who do not respond to this standard treatment. In such refractory cases, oral azithromycin has proven to be an effective option.
Material and method
We conducted a prospective pilot study of 16 patients with PPR who were treated with oral azithromycin after a lack of response to oral doxycycline and metronidazole gel. At the first visit, the patients were assessed for baseline severity of PPR on a 4-point clinical scale and started on oral azithromycin. At the second visit, response to treatment in terms of improvement from baseline was evaluated on a 3-point scale. Patients were then scheduled for follow-up visits every 12 weeks to assess long-term effectiveness.
Results
All 16 patients experienced an improvement in their PPR following treatment with oral azithromycin. Eight weeks after completion of treatment, 14 patients (87.5%) showed complete or almost complete recovery (slight or no residual redness and complete clearance of papules and pustules). Only 2 patients experienced a new episode of inflammatory PPR lesions during follow-up.
Conclusions
The findings of this pilot study suggest that oral azithromycin could be a very effective short-term and long-term treatment for RPP resistant to conventional treatment.
Graphical abstract
Dermatitis por contacto fotoalérgica a protectores solares con oxibenzona en La Plata, Argentina
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): J.P. Russo, A. Ipiña, J.F. Palazzolo, A.B. Cannavó, R.D. Piacentini, B. Niklasson
Resumen
Antecedentes
La dermatitis por contacto fotoalérgica (DCFA) a oxibenzona fue por primera vez documentada en 1980, siendo hoy el principal fotoalérgeno de Estados Unidos de América, Canadá y el cuarto en Europa. En Argentina no existen datos ni publicaciones con respecto a esta reacción cutánea.
Objetivo
Conocer el porcentaje de pacientes con fotosensibilidad afectados con fotoalergia a oxibenzona.
Metodología
Estudio descriptivo de corte transversal. Un total de 35 pacientes con reacciones fotosensibles con prueba del fotoparche en el Centro de investigación del Hospital Público San Martín, en la ciudad de La Plata, fueron estudiados durante los años 2015 y 2016.
Resultados
Se observó el 17,14% de DCFA, presentando 5 (14,28%) pacientes al menos una reacción positiva a oxibenzona en el test de fotoparche, 4 pacientes solo en la zona irradiada con 5 J/cm2 (de UVA) y solo un paciente tanto en la zona irradiada como en la no irradiada.
Conclusiones
La DCFA a protectores solares compuestos por oxibenzona es frecuente y se presume infradiagnosticada debido a la falta de estudios confirmatorios como la prueba del fotoparche. El porcentaje de sensibilización varía de acuerdo con cada región, sobre todo por las distintas composiciones y costumbres de uso en protectores solares, cosméticos y tratamiento tópico.
Abstract
Background
Photoallergic contact dermatitis (PACD) to oxybenzone was reported for the first time in 1980. Oxybenzone is the most common photoallergen in the United States and Canada and the fourth most common .in Europe. There are no studies or data on the prevalence of oxybenzone PACD in Argentina.
Objective
To determine the proportion of photosensitive patients with PACD to oxybenzone.
Methods
We conducted a descriptive cross-sectional study of 35 patients with photosensitivity reactions confirmed by photopatch testing at the Research Center of Hospital Público San Martín in La Plata, Argentina, in 2015 and 2016.
Results
PACD was identified in 6 patients (17.14%). Five of these (14.28%) had at least one positive reaction to oxybenzone in the photopatch test; 4 had a reaction at irradiated sites only (5 J/cm2 UVA) and one had a reaction at both irradiated and nonirradiated sites.
Conclusions
PACD to sunscreens containing oxybenzone is common and is probably underdiagnosed due to a lack of confirmation by photopatch tests or other diagnostic tools. Sensitization rates vary according to region and are influenced by sunscreen ingredients and variations in the use of sunscreen products, cosmetics, and topical drugs.
Graphical abstract
Aplicación del colgajo de keystone en dermatología. Experiencia clínica en 18 pacientes
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): R. Aragón-Miguel, M. Gutiérrez-Pascual, A. Sánchez-Gilo, J. Sanz-Bueno, F.J. Vicente-Martin
Resumen
Introducción y objetivos
El colgajo de keystone es un colgajo fasciocutáneo cuya vascularización proviene de las arteriolas perforantes musculares. Su aplicación en dermatología es para cubrir defectos en zonas de piel poco distensible (miembros inferiores, superiores y de la espalda). Presentamos nuestra experiencia clínica y los resultados quirúrgicos del centro.
Material y métodos
Estudio descriptivo retrospectivo de pacientes con tumores cutáneos malignos en miembros inferiores en los que se realizó el colgajo de keystone.
Resultados
Se operaron 18 pacientes con una edad media de 77,83 años. Se realizaron 17 mediante la técnica propuesta por Behan y uno con la técnica modificada de Moncrieff. El 38,8% de los tumores extirpados fueron carcinomas basocelulares, el 33,3% carcinomas epidermoides y el 27,7% tumores malignos pigmentados. El 72,22% presentaba algún factor de riesgo cardiovascular. Se observó un 38,8% de complicaciones menores y ningún caso de necrosis parcial o total del colgajo.
Conclusiones
Consideramos que el colgajo de keystone es una buena alternativa terapéutica a otros colgajos e injertos para la reconstrucción de defectos en miembros inferiores. Los resultados estéticos y funcionales son buenos, con una tasa de éxito elevada.
Abstract
Introduction and objectives
The keystone flap is a fasciocutaneous flap supplied by perforating arteries. It is used in dermatology to repair surgical defects in areas with low skin extensibility (the upper and lower limbs and the back). We review the clinical experience gained with keystone flap reconstruction at our hospital and report on the surgical outcomes.
Material and methods
Descriptive retrospective study of patients with malignant skin tumors on the lower limbs who underwent keystone flap reconstruction.
Results
Eighteen patients (mean age, 77.83 years) underwent keystone flap reconstruction using the Behan technique in 17 cases and the modified Moncrieff technique in one. Basal cell carcinomas accounted for 38.8% of the tumors excised, squamous cell carcinomas 33.3%, and malignant pigmented tumors 27.7%. Cardiovascular risk factors were observed in 72.2% of patients. Minor complications occurred in 38.8% of patients, and there were no cases of partial or total flap necrosis.
Conclusions
We consider the keystone flap to be a good alternative to other flaps and grafts for the surgical reconstruction of lower limb defects. The success rate was high, and the cosmetic and functional outcomes were good.
Graphical abstract
Dermatitis alérgica de contacto por acrilatos en esmaltes permanentes
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): M.E. Gatica-Ortega, M.A. Pastor-Nieto, J.F. Silvestre-Salvador
Resumen
Los primeros casos de dermatitis alérgica de contacto por acrilatos en procedimientos de manicura se describieron hace décadas en relación con la aplicación de uñas de porcelana. Recientemente se ha incrementado la frecuencia de sensibilización secundariamente a la implantación de los llamados esmaltes permanentes que contienen acrilatos UV curables, predominantemente entre las esteticistas que los aplican y en menor medida en usuarias. La reciente comercialización de kits de uso doméstico podría precipitar un aumento en la frecuencia aún mayor. En este artículo describimos su técnica de aplicación, la clínica, el diagnóstico, el tratamiento y la prevención. Los acrilatos están presentes en una amplia variedad de fuentes, incluidos múltiples materiales médicos. Una sensibilización desencadenada por un procedimiento puramente estético podría llegar a tener una importante repercusión en la salud, por lo que se imponen políticas restrictivas por parte de las autoridades que limiten su uso a profesionales cualificados y prohíban la venta indiscriminada de kits caseros.
Abstract
The first reported cases of allergic contact dermatitis from acrylates in manicure procedures in relation to the application of porcelain nails were published decades ago. The frequency of sensitization has increased due to the introduction of the so-called permanent nail polish containing photo-bonded acrylates, mainly involving the beauticians who apply them, and to a lesser extent, the consumers. The recent commercialized permanent polish kits for domestic use could trigger even higher degrees of sensitization. In this article, the clinical features, diagnostic procedures, treatment and preventive measures are described. Acrylates are present in a wide range of sources including multiple medical materials. Sensitization caused by a merely aesthetic procedure might end up having an eventual important impact in the future consumer's health which is why restrictive policies should be implemented limiting its use to qualified professionals and banning the indiscriminate sale of domestic kits.
Graphical abstract
Dermatitis de contacto alérgica por regiones anatómicas. Claves diagnósticas
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): E. Rozas-Muñoz, D. Gamé, E. Serra-Baldrich
Resumen
La dermatitis de contacto alérgica (DCA) es una enfermedad frecuente en la práctica clínica diaria, con una prevalencia que ha aumentado en los últimos años. Clínicamente se caracteriza por grados variables de eritema, vesiculación, descamación y liquenificación, signos que también están presentes en otros procesos eccematosos. Las pruebas epicutáneas constituyen la principal herramienta diagnóstica para confirmar una DCA, sin embargo, su correcta interpretación requiere de una correcta correlación entre la anamnesis (historial de exposición) y el examen físico. En este artículo se describen de forma práctica y didáctica los patrones clínicos más frecuentes de DCA dependiendo de su localización. El conocimiento de estos patrones no solo ayudará al clínico en el diagnóstico diferencial, sino que también le permitirá sospechar el posible alérgeno y su forma de aplicación.
Abstract
Allergic contact dermatitis (ACD) is a common disease in daily clinical practice, and its prevalence has increased in recent years. It is characterized clinically by varying degrees of erythema, vesiculation, flaking, and lichenification, though these signs can also be present in other eczematous diseases. Patch testing is the main diagnostic tool to confirm ACD, but its accurate interpretation requires correct correlation with the medical history (details of exposure) and physical examination. We provide a practical and instructive description of the most common clinical patters of ACD depending on the area affected. Knowledge of these patterns will not only help the clinician reach the diagnosis but will suggest possible allergens and forms of contact.
Graphical abstract
Teledermatología urbana: concepto, ventajas y desventajas
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): G. Romero-Aguilera, L. Ferrandiz, D. Moreno-Ramírez
Sobre la necesidad y el futuro de las Unidades de Eczema
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): J.F. Silvestre
Utilidad de la ecografía en el diagnóstico diferencial de un nódulo doloroso en el tórax
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): D. Morgado-Carrasco, S. Gómez, L. Alós, P. Giavedoni
Respuesta a secukinumab tras fracaso terapéutico con ustekinumab en seis pacientes con psoriasis en placas
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): D. Morgado-Carrasco, J. Riera-Monroig, X. Fustà-Novell, M. Alsina Gibert
Mucormicosis cutánea primaria por Rhizopus arrhizus en una niña de 8 años
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): M.F. Albízuri-Prado, A. Sánchez-Orta, A. Rodríguez-Bandera, M. Feito-Rodríguez
Ampliando el perfil genético del síndrome de Hay-Wells
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): D. Romero-Pérez, B. Encabo-Durán, R. Ramón-Sapena
Un caso de poroqueratosis diseminada eruptiva en un paciente oncológico tratado con trastuzumab y exemestano: ¿fenómeno asociado al cáncer o inducido por fármacos?
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): C. Mangas, V. Espeli, R. Blum
Eritema postimplantación asociado a implante mamario tratado con láser de colorante pulsado
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): A. Alegre-Sánchez, D. Buendía-Castaño, P. Fernández-González, B. Pérez-García
Fenómeno de Koebner en el síndrome de Sweet
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): T. Hiraiwa, M. Ishikawa, T. Ohashi, T. Miura, M. Satoh, T. Yamamoto
Biopsia selectiva del ganglio centinela de la región inguinal: técnica quirúrgica
Publication date: July–August 2018
Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 6
Author(s): D. Moreno-Ramírez, J. Pérez-Anker, A. Perissinotti, R. Pigem, S. Podlipnik, I. Fragakis, T. Toledo Pastrana
Autonomous neuro-registration for robot-based neurosurgery
Abstract
Purpose
Neuro-registration is of primary importance as it has a bearing on the accuracy of neurosurgery. Although the accuracy of surgical robots is within the acceptable medical standards, the overall surgical accuracy is dictated by the errors in the neuro-registration process. The purpose of this work is to automate the neuro-registration process to improve the overall accuracy of the robot-based neurosurgery.
Method
A highly accurate 6-degree-of-freedom Parallel Kinematic Mechanism (6D-PKM) robot is used for both neuro-registration and neurosurgery. In neuro-registration, after measurement of points in the medical image space, the end-platform of the 6D-PKM surgical robot carrying the camera will autonomously navigate towards the fiducial markers to measure its coordinates in the real patient space. An accurate relationship between the medical image space and the real patient space is established, and the same robot will navigate the surgical tool to the target.
Results
In order to validate the proposed method for autonomous neuro-registration, experiments are performed using four phantoms. The four phantoms are as follows: PVC skull model, two acrylic blocks and a glass jar with coaxial shells. These phantoms are specifically designed to simulate the neurosurgical process. All the phantoms are registered successfully using the above-stated method. After autonomous neuro-registration, the coordinates of the target point are determined. Neurosurgery validation is carried out by attaching a 1-mm-diameter needle to the robot platform, which is autonomously traversed to reach the target point passing through the two 2-mm-diameter coaxial holes. The experiments are repeated, and the results reveal very good repeatability.
Conclusion
A method for autonomous neuro-registration has been developed. The robot has been successfully registered using the above method. After successful neuro-registration the overall accuracy of the robot-based neurosurgery is considerably improved. The other benefits of the above method are as follows: elimination of line-of-sight problem, no need of extra unit for neuro-registration, less time for registration, intraoperative registration, human error reduction and low cost.
MITF and UV responses in skin: from pigmentation to addiction
Pigment Cell &Melanoma Research, Volume 0, Issue ja, -Not available-.
A 4‐bp deletion promoter variant (rs984225803) is associated with mild OCA4 among Japanese patients
Pigment Cell &Melanoma Research, Volume 0, Issue ja, -Not available-.
Four! Drivers of melanoma differentiation – when to use iron
Pigment Cell &Melanoma Research, Volume 0, Issue ja, -Not available-.
Molecular properties of gp100‐reactive T cell receptors drive the cytokine profile and antitumor efficacy of transgenic host T cells
Pigment Cell &Melanoma Research, Volume 0, Issue ja, -Not available-.
Patterns of carriage of prescribed adrenaline auto injectors in 10-14 year old food allergic students: a population based study
Publication date: Available online 19 July 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Marnie Robinson, Jennifer J. Koplin, Michael J. Field, Mari Sasaki, Rachel L. Peters, Vicki McWilliam, Susan M. Sawyer, George C. Patton, Peter J. Vuillermin, Jo Douglass, Lyle C. Gurrin, Mimi L.K. Tang, Shyamali C. Dharmage, Katrina J. Allen, SchoolNuts investigators
Abstract
Background
Adolescence is well recognized as a period of increased risk for severe and fatal food induced anaphylaxis. Current Australian adrenaline auto injector (AAI) prescription guidelines therefore suggest that consideration is given to AAI prescription in all adolescents with a food allergy. To date, however few studies have assessed the carriage behaviour of adolescents prescribed AAI devices.
Objective
To determine carriage behaviour of prescribed AAI devices in a population-based sample of young Australian adolescents.
Methods
Students aged 10-14 years (and their parents) from randomly selected schools in metropolitan Melbourne completed self-administered questionnaires regarding history and management of food allergy, including prescription and carriage of AAI device in different domains of school and social life.
Results
A total of 9816 students completed the questionnaire (46% response): 620 students were assessed to have likely IgE-mediated food allergy and 234 (38%) of these had been prescribed an AAI. Most students (93%, 95%CI 89-96) prescribed AAIs reported that they provided their AAI and anaphylaxis action plan to their school. Adherence with AAI carriage in other domains of social life was poor with 49% (95%CI 42-56) never carrying their AAI in 1 or more locations. Carriage of the AAI device was particularly poor when students were independent of parental supervision: 32% (95%CI 25-39) never carried it when they were by themselves, 28% (95%CI 22-36) never carried it while out with friends whilst 36% (95%CI 30-43) never carried their AAI to sporting activities.
Conclusion
Carriage of AAI devices is suboptimal in young adolescents prescribed AAIs, particularly when young adolescents are independent of parental supervision.
Arsenic removal from water by metal-organic framework MIL-88A microrods
Abstract
Fe-based metal-organic framework MIL-88A microrods were synthesized by hydrothermal method, which were used to adsorb As(V) in water for the first time. The experimental results indicated that MIL-88A has a very fast adsorption rate towards arsenic in water. The kinetic and isothermal data for arsenic removal were better fitted to the pseudo-second-order kinetic model and Langmuir model, respectively, implying a chemical and monolayer adsorption for As(V) on MIL-88A microrods. Two rate-controlling processes during adsorption were revealed by the intraparticle diffusion model. The maximum adsorption capacity of MIL-88A reached 145 mg g−1, higher than those of Fe-based MIL adsorbents reported previously, which probably originates from its unique microstructure with abundant OH− groups and an unusual large swelling towards water. These show that Fe-based MIL-88A is a good candidate for arsenic removal.
Epidermal grafting for leukoderma resulting from 1064‐nm quality‐switched neodymium‐doped yttrium aluminium garnet laser toning
International Wound Journal, EarlyView.
Immune‐bone interplay in the structural damage in rheumatoid arthritis
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
Functional status of immune cells in patients with long‐lasting type 2 diabetes mellitus
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
Heat shock proteins are differentially expressed in brain and spinal cord: implications for multiple sclerosis
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
Dendritic cells cross talk with tumor antigen‐specific CD8+T cells, Vγ9γδT cells, and Vα24NKT cells in patients with glioblastoma multiforme and in healthy donors
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
Porphyromonas gingivalis in the tongue biofilm is associated with the clinical outcome in rheumatoid arthritis patients
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
Enhanced expression of IFI16 and RIG‐I in human third‐trimester placentas following HSV‐1 infection
Clinical &Experimental Immunology, Volume 193, Issue 2, Page 255-263, August 2018.
Increased killer B cells in chronic HCV infection may lead to autoimmunity and increased viral load
Clinical &Experimental Immunology, Volume 193, Issue 2, Page 183-193, August 2018.
Tuftsin–phosphorylcholine (TPC) equally effective to methylprednisolone in ameliorating lupus nephritis in a mice model
Clinical &Experimental Immunology, Volume 193, Issue 2, Page 160-166, August 2018.
Tissue‐resident memory T cells are epigenetically cytotoxic with signs of exhaustion in human urinary bladder cancer
Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.
In-vitro anti-cancer activity of organic template-free hierarchical M (cu, Ni)-modified ZSM-5 zeolites synthesized using silica source waste material
Publication date: Available online 19 July 2018
Source: Journal of Photochemistry and Photobiology B: Biology
Author(s): S.K. Jesudoss, J. Judith Vijaya, K. Kaviyarasu, P. Iyyappa Rajan, S. Narayanan, L. John Kennedy
Abstract
The present paper is focused on a simple and economical route to synthesize the organic template-free hierarchical pure and M (Cu, Ni)-modified ZSM-5 zeolites (1%, 3% and 5%) using hydrothermal treatment in the presence of silica rich rice husk ash and its application studies through the evaluation of their anti-cancer activity on A459 human lung epithelial cancer cell lines. The physical properties of the samples were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, high resolution scanning electron microscopy, high resolution transmission electron microscopy, N2 adsorption/desorption techniques and thermogravimetric analysis respectively. These metals modified hierarchical ZSM-5 zeolites showed considerable in-vitro anticancer efficiency towards human lung cancer (A549) cell lines through (3-(4, 5-dimethyl thiazolyl)-2, 5-diphenyl tetrazolium bromide) MTT assay. Among the all M (Cu, Ni)-modified ZSM-5 zeolites, 5% Cu-ZSM-5 zeolites showed higher potential cytotoxicity against A459 cell lines. The possible mechanism was explored from the fundamental signaling pathways of cell death by hierarchical metal modified ZSM-5 zeolites in A459 human lung epithelial cancer cell lines. Finally, our experimental results revealed that the organic template-free hierarchical pure and M (Cu, Ni)-modified ZSM-5 zeolites have significant anti-cancer mediating action by inducing oxidative stress to intercede DNA damage and can be considered as a potential applicant in the biomedical field.
Graphical Abstract
Photodermatology and Photomedicine: Meeting Calendar
Photodermatology, Photoimmunology &Photomedicine, Volume 34, Issue 4, Page 223-223, July 2018.
Issue Information
Photodermatology, Photoimmunology &Photomedicine, Volume 34, Issue 4, Page 221-222, July 2018.
Potential of four aquatic plant species to remove 60 Co from contaminated water under changing experimental conditions
Abstract
This study aimed to compare the potential of Lemna minor, Spirodela sp., Eichhornia crassipes and Pistia stratiotes to remove 60Co from a realistic aquatic environment. Although all four plant species performed similarly well after 3 days of exposure to 50 kBq L−1 60Co, Lemna minor and Spirodela sp. came forward as having higher 60Co removal potential. This conclusion is, in first instance, based on the high 60Co removal percentage obtained after a short contact time (e.g. more than 95% could be removed after 6 h by Spirodela sp.). Additionally, Lemna minor and Spirodela sp. accumulated a high amount of 60Co per gram of biomass. For example, Lemna minor accumulated over three times more 60Co per gram of biomass compared to Pistia stratiotes and Eichhornia crassipes. Both plants also performed well in the pH range 5–9. We used Lemna minor to test the influence of the initial 60Co concentration (10, 50, 100 and 200 kBq L−1 60Co) on its phytoremediation capacity but no differences could be observed in removal percentage. In addition, it was shown that by optimising the initial amount of biomass, radioactive waste production can be minimised whilst maintaining high 60Co removal rates. Our study shows that these aquatic plants can be used for phytoremediation of 60Co from contaminated water and can be considered as a "green" addition or alternative for conventional remediation techniques.
Linearized Solar Elastosis of the Legs: A Novel Presentation and Review of the Literature
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
A micorvenular hemangioma with a rare expression of progesterone receptor immunocreativity and a review of the literature
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
Solitary fibrous tumor presenting on the scalp: a potential diagnostic pitfall
Journal of Cutaneous Pathology, Volume 45, Issue 8, Page 557-560, August 2018.
Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half‐side comparison
Journal of Cosmetic Dermatology, EarlyView.
Male‐pattern baldness, common latent viruses, and microcompetition
Journal of Cosmetic Dermatology, EarlyView.
Multipolydioxanone scaffold improves upper lip and forehead wrinkles: A 12‐month outcome
Journal of Cosmetic Dermatology, EarlyView.
Evaluation of the efficacy of transdermal drug delivery of calcipotriol plus betamethasone versus tacrolimus in the treatment of vitiligo
Journal of Cosmetic Dermatology, EarlyView.
Wrinkles, brown spots, and cancer: Relationship between appearance‐ and health‐based knowledge and sunscreen use
Journal of Cosmetic Dermatology, EarlyView.
Severe vision loss caused by cosmetic filler augmentation: Case series with review of cause and therapy
Journal of Cosmetic Dermatology, EarlyView.
Identification of a novel PLCD1 mutation in Chinese Han pedigree with hereditary leukonychia and koilonychia
Journal of Cosmetic Dermatology, EarlyView.
Vessel Wall Enhancement in Unruptured Intracranial Aneurysms: An Indicator for Higher Risk of Rupture? High-Resolution MR Imaging and Correlated Histologic Findings [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Recent studies have suggested that wall enhancement of unruptured intracranial aneurysms in high-resolution MR imaging might serve as an imaging biomarker for higher risk of rupture. Histologic studies have revealed a possible association among inflammatory processes, degeneration, and destabilization of the aneurysm wall preceding rupture. Understanding the histologic condition underlying aneurysm wall enhancement could be an important step toward assessing the value of this method for risk stratification. We present our observations of aneurysm wall enhancement in MR vessel wall imaging and underlying histologic changes.
MATERIALS AND METHODS:We reviewed records of patients with an unruptured middle cerebral artery aneurysm who underwent MR vessel wall imaging before aneurysm clipping. Contrast enhancement of the aneurysm wall was dichotomized into either none/faint or strong. Histologic analysis included myeloperoxidase stain for detection of inflammatory cell invasion and CD34 stain for assessment of neovascularization and vasa vasorum.
RESULTS:Thirteen aneurysms were included. Five aneurysms showed strong wall enhancement. Among these, myeloperoxidase staining revealed inflammatory cell infiltration in 4. Three showed neovascularization. In 2 aneurysms, vasa vasorum were present. Seven aneurysms did not show wall enhancement; 1 had only mild enhancement. None of these bore evidence of inflammatory cell invasion or neovascularization, and they all lacked vasa vasorum.
CONCLUSIONS:Wall enhancement in MR vessel wall imaging is associated with inflammatory cell invasion, neovascularization, and the presence of vasa vasorum. Enhancement does not occur when histologic signs of inflammation are absent. Our results support the hypothesis that MR vessel wall imaging could provide valuable information for risk stratification.
Application of Reduced-FOV Diffusion-Weighted Imaging in Evaluation of Normal Pituitary Glands and Pituitary Macroadenomas [ADULT BRAIN]
BACKGROUND AND PURPOSE:
FOV optimized and constrained undistorted single-shot imaging provides relatively high-resolution images with few artifacts. This study evaluated the image quality and value of FOV optimized and constrained undistorted single-shot DWI in the evaluation of normal pituitary glands and pituitary macroadenomas.
MATERIALS AND METHODS:Subjects with normal pituitary glands and patients with pituitary macroadenomas underwent FOV optimized and constrained undistorted single-shot and EPI DWI. Two neuroradiologists graded the image quality based on visualization of the pituitary stalk, pituitary gland, and pituitary macroadenoma. Intra- and interobserver agreements were assessed by statistics. Image quality and ADCs were compared between the 2 methods by the paired Wilcoxon signed rank test and t test. Differences in ADC between normal pituitary glands and macroadenomas were analyzed by the independent-samples t test.
RESULTS:Twenty-eight subjects with normal pituitary glands and 16 patients with macroadenomas were enrolled. Intra- and interobserver agreements for image-quality assessment were moderate to substantial. Relative to EPI DWI, FOV optimized and constrained undistorted single-shot DWI exhibited obviously better image quality both in normal pituitary glands and macroadenomas. There was no significant difference in ADCs of macroadenomas between the 2 methods. Macroadenomas with soft consistency (0.75 ± 0.14 x 10–3 mm2/s) had significantly lower mean ADC than normal pituitary glands (1.18 ± 0.19 x 10–3 mm2/s; P < .001).
CONCLUSIONS:FOV optimized and constrained undistorted single-shot DWI helps acquire high-resolution images of normal pituitary glands and pituitary macroadenomas with relatively few susceptibility artifacts in a clinically feasible scan time. This sequence might be helpful for evaluating the consistency of pituitary macroadenomas.
Clinical Value of Vascular Permeability Estimates Using Dynamic Susceptibility Contrast MRI: Improved Diagnostic Performance in Distinguishing Hypervascular Primary CNS Lymphoma from Glioblastoma [ADULT BRAIN]
BACKGROUND AND PURPOSE:
A small subset of primary central nervous system lymphomas exhibits high cerebral blood volume, which is indistinguishable from that in glioblastoma on dynamic susceptibility contrast MR imaging. Our study aimed to test whether estimates of combined perfusion and vascular permeability metrics derived from DSC-MR imaging can improve the diagnostic performance in differentiating hypervascular primary central nervous system lymphoma from glioblastoma.
MATERIALS AND METHODS:A total of 119 patients (with 30 primary central nervous system lymphomas and 89 glioblastomas) exhibited hypervascular foci using the reference method of leakage-corrected CBV (reference-normalized CBV). An alternative postprocessing method used the tissue residue function to calculate vascular permeability (extraction fraction), leakage-corrected CBV, cerebral blood flow, and mean transit time. Parameters were compared using Mann-Whitney U tests, and the diagnostic performance to distinguish primary central nervous system lymphoma from glioblastoma was calculated using the area under the curve from the receiver operating characteristic curve and was cross-validated with bootstrapping.
RESULTS:Hypervascular primary central nervous system lymphoma showed similar leakage-corrected normalized CBV and leakage-corrected CBV compared with glioblastoma (P > .05); however, primary central nervous system lymphoma exhibited a significantly higher extraction fraction (P < .001) and CBF (P = .01) and shorter MTT (P < .001) than glioblastoma. The extraction fraction showed the highest diagnostic performance (the area under the receiver operating characteristic curve [AUC], 0.78; 95% confidence interval, 0.69–0.85) for distinguishing hypervascular primary central nervous system lymphoma from glioblastoma, with a significantly higher performance than both CBV (AUC, 0.53–0.59, largest P = .02) and CBF (AUC, 0.72) and MTT (AUC, 0.71).
CONCLUSIONS:Estimation of vascular permeability with DSC-MR imaging further characterizes hypervascular primary central nervous system lymphoma and improves diagnostic performance in glioblastoma differentiation.
The Bone Does Not Predict the Brain in Sturge-Weber Syndrome [PEDIATRICS]
BACKGROUND AND PURPOSE:
It has been hypothesized that skull marrow signal alteration may represent an early disease manifestation of Sturge-Weber syndrome before development of its intracranial manifestations. We alternatively hypothesized that intraosseous changes are associated with the overlying port-wine stain rather than the intracranial stigmata of Sturge-Weber syndrome and hence are not a predictor of brain involvement.
MATERIALS AND METHODS:MR imaging of children presenting with port-wine stain and/or Sturge-Weber syndrome between 1998 and 2017 was evaluated by 2 pediatric neuroradiologists for marrow signal abnormality and pial angioma and other Sturge-Weber syndrome features: ocular hemangioma, atrophy, and white matter changes (advanced myelination). Groups were divided into port-wine stain–only (without intracranial Sturge-Weber syndrome features) and Sturge-Weber syndrome (the presence of cerebral pial angioma). The 2 test was performed to evaluate the association between port-wine stain and bone marrow changes and between osseous change and pial angioma.
RESULTS:We reviewed 139 cases: 40 with port-wine stain–only and 99 with Sturge-Weber syndrome with pial angioma. Fifteen of 99 cases of Sturge-Weber syndrome had no port-wine stain. In the port-wine stain–only cohort, 78% had ipsilateral bony changes and 17% had no intraosseous changes. In the Sturge-Weber syndrome cohort, 84/99 had associated port-wine stain, 91% (P < .01) had bony changes ipsilateral to the port-wine stain or had no bone changes in the absence of port-wine stain, and 77% (P = .27) had bony changes ipsilateral to a cerebral pial angioma. Eighty percent of patients with Sturge-Weber syndrome who lacked a port-wine stain also lacked marrow changes. Five patients with bilateral port-wine stain and bilateral marrow changes had only a unilateral pial angioma.
CONCLUSIONS:Intraosseous marrow changes are strongly associated with facial port-wine stain; no significant association was found between pial angioma and bone marrow changes.
Persistent pruritic rash, fever, and joint pains in a young female
Australasian Journal of Dermatology, EarlyView.
Congenital fibroblastic connective tissue nevi: Unusual and misleading presentations in three infantile cases
Pediatric Dermatology, EarlyView.
Orofacial granulomatosis and erythema multiforme in an adolescent with Crohn's disease
Pediatric Dermatology, EarlyView.
Influence of infantile hemangioma severity and activity on QoL of patients and their parents: A cross‐sectional study
Pediatric Dermatology, EarlyView.
Clinical studies evaluating abametapir lotion, 0.74%, for the treatment of head louse infestation
Pediatric Dermatology, EarlyView.
Sirolimus as initial therapy for kaposiform hemangioendothelioma and tufted angioma
Pediatric Dermatology, EarlyView.
Congenital‐type juvenile xanthogranuloma: A case series and literature review
Pediatric Dermatology, EarlyView.
Diffuse erythema with ‘angel wings’ sign in Japanese patients with anti‐small ubiquitin‐like modifier activating enzyme antibody‐associated dermatomyositis
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Mepacrine‐induced interstitial lung disease in discoid lupus erythematosus?
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Transepidermal water loss in healthy adults: a systematic review and meta‐analysis update
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Mosaicism due to postzygotic mutations in women with focal dermal hypoplasia
British Journal of Dermatology, Volume 0, Issue ja, -Not available-.
Gastrostomy for epidermolysis bullosa
British Journal of Dermatology, Volume 179, Issue 1, Page e71-e71, July 2018.
Methotrexate injections for psoriasis
British Journal of Dermatology, Volume 179, Issue 1, Page e73-e73, July 2018.
Development of psoriasis by continual neutrophil infiltration into the epidermis
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
Noninvasive analysis and minimally invasive in vivo experimental challenges of the skin barrier
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
Murine type VII collagen distorts outcome in human skin graft mouse model for dystrophic epidermolysis bullosa
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
Assessing the skin barrier via corneocyte morphometry
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
Maintenance of tight junction barrier integrity in cell turnover and skin diseases
Experimental Dermatology, Volume 0, Issue ja, -Not available-.
Favre‐Racouchot disease: systematic review and possible therapeutic strategies
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
A randomized, intra‐individual, non‐inferiority, phase III study comparing daylight photodynamic therapy with BF‐200 ALA gel and MAL cream for the treatment of actinic keratosis
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Development and validation of a new tool to assess the Burden of Sensitive Skin (BoSS)
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Biofilm production and antibiotic susceptibility of Staphylococcus epidermidis strains from Hidradenitis Suppurativa lesions
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
First homozygous large deletion in EDARADD gene associated with a severe form of anhidrotic ectodermal dysplasia
Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.
Anxiety and depression in patients with moderate‐to‐severe psoriasis and comparison of change from baseline after treatment with guselkumab vs. adalimumab: results from the Phase 3 VOYAGE 2 study
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Phaeohyphomycosis due to Pleurostomophora richardsiae: an uncommon cutaneous fungal infection
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Laser‐assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's disease: a randomized intrapatient comparison between a continuous and a fractional ablative CO2 laser mode
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Photoacoustic imaging system visualizes restoration of peripheral oxygenation in psoriatic lesions
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Azathioprine‐induced alopecia and leukopenia associated with NUDT15 polymorphisms
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Katharsis of the skin: peeling applications and agents of chemical peelings in Greek medical textbooks of Graeco‐Roman antiquity
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne at the Regional Dermatology Training Centre (RDTC), Tanzania: clinical, social and demographic characteristics of patients with focus on severity factors
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Laser hair removal after surgery vs. surgery alone for the treatment of pilonidal cysts: a retrospective case–control study
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Psoriasis and risk of myocardial infarction before and during an era with biological therapy: a population‐based follow‐up study
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Survey of disease awareness, treatment behavior and treatment satisfaction in patients with atopic dermatitis in Korea: A multicenter study
The Journal of Dermatology, EarlyView.
Cutaneous lymphomatoid granulomatosis with long‐term absence of lung involvement
The Journal of Dermatology, EarlyView.
Bullous pemphigoid with hyperkeratosis and palmoplantar keratoderma: Three cases
The Journal of Dermatology, EarlyView.
Reflectance confocal microscopy for the noninvasive diagnosis of cutaneous juvenile xanthogranuloma
Skin Research and Technology, EarlyView.
Predicting Sequential Bilateral Cochlear Implantation Performance in Postlingually Deafened Adults; a Retrospective Cohort Study
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
Ecthyma contagiosum (Orf): Reflectance confocal microscopy and histopathological correlates
Skin Research and Technology, EarlyView.
Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation
International Journal of Cosmetic Science, EarlyView.
Standardized extract of wild apple fruit in alkyl‐polyglucoside‐based cosmetic cream – estimation of stability, safety, antioxidant activity and efficiency
International Journal of Cosmetic Science, Volume 40, Issue 3, Page 285-294, June 2018.
Preservative efficacy of selected antimicrobials of natural origin in a cosmetic emulsion
International Journal of Cosmetic Science, Volume 40, Issue 3, Page 276-284, June 2018.
Determination of fatty acid methyl esters in cosmetic castor oils by flow injection–electrospray ionization–high‐resolution mass spectrometry
International Journal of Cosmetic Science, Volume 40, Issue 3, Page 295-302, June 2018.
Hair colour and skin colour together influence perceptions of age, health and attractiveness in lightly pigmented young women
International Journal of Cosmetic Science, Volume 40, Issue 3, Page 303-312, June 2018.
Issue Information
International Journal of Cosmetic Science, Volume 40, Issue 3, Page i-iv, June 2018.
Ag Nanoparticles Connected to the Surface of TiO2 Electrostatically for Antibacterial Photoinactivation Studies
Photochemistry and Photobiology, Volume 0, Issue ja, -Not available-.
Occupational systemic allergic dermatitis in a football player sensitized to colophonium
Contact Dermatitis, EarlyView.
Acute localized exanthematous pustulosis caused by a herbal medicine, dai‐kenchu‐to
Contact Dermatitis, EarlyView.
Contamination of skin and surfaces by cobalt in the hard metal industry
Contact Dermatitis, EarlyView.
Allergic contact dermatitis caused by dexpanthenol—Probably a frequent allergen
Contact Dermatitis, EarlyView.
Drug reaction with eosinophilia and systemic symptoms caused by spironolactone: Case report
Contact Dermatitis, EarlyView.
Infiltration of abdominal striae distensae by Hodgkin's lymphoma
International Journal of Dermatology, EarlyView.
Postherpetic abdominal pseudohernia. Presentation of a clinical case and literature review
International Journal of Dermatology, EarlyView.
Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus?
International Journal of Dermatology, EarlyView.
The hunt for the earliest cases of AIDS‐related Kaposi sarcoma: a retrospective outbreak investigation
International Journal of Dermatology, EarlyView.
Clinical subtypes and molecular basis of epidermolysis bullosa in Kuwait
International Journal of Dermatology, EarlyView.
News and Notices
Clinical and Experimental Dermatology, Volume 43, Issue 6, Page 756-756, August 2018.
Issue Information
Clinical and Experimental Dermatology, Volume 43, Issue 6, Page i‐ii, 651-652, August 2018.
Actualización del tratamiento tópico en psoriasis: aportación de la combinación de calcipotriol y dipropionato de betametasona en espuma
Publication date: Available online 19 July 2018
Source: Actas Dermo-Sifiliográficas
Author(s): L. Puig, G. Carretero
Resumen
Los agentes tópicos representan la primera línea de tratamiento para la psoriasis leve y moderada. Sin embargo, factores como la frecuencia de administración, las características organolépticas o los resultados limitados a corto plazo pueden disminuir la adherencia al tratamiento y su efectividad.
Las innovaciones en los tratamientos tópicos se basan en descubrir nuevas moléculas, pero también en la reformulación de principios activos ya conocidos, mejorando su administración, características organolépticas, biodisponibilidad y comodidad de uso. La espuma en aerosol de calcipotriol y dipropionato de betametasona es una nueva formulación donde los principios activos están disueltos en una mezcla de propelentes volátiles que se evaporan rápidamente dejando una solución sobresaturada de calcipotriol y dipropionato de betametasona, que aumenta la penetración de los fármacos en la epidermis.
En este artículo se hace un breve repaso de las principales evidencias sobre los tratamientos tópicos disponibles para la psoriasis y de la nueva formulación en espuma de calcipotriol y dipropionato de betametasona.
Abstract
Topical agents are the first-line treatment for mild and moderate psoriasis, but factors such as frequency of administration, organoleptic properties, and the limited short term results can reduce treatment adherence and effectiveness.
Innovations in topical treatments are linked not only to the discovery of new molecules, but also to the reformulation of existing active ingredients based on improvements to administration, organoleptic properties, bioavailability, and ease of use. Calcipotriol and betamethasone dipropionate aerosol foam is a new formulation in which the active ingredients are dissolved in a mixture of volatile propellants that evaporate quickly, leaving a supersaturated solution of calcipotriol and betamethasone dipropionate that enhances penetration into the epidermis.
In this article, we take a look at the new calcipotriol and betamethasone dipropionate aerosol formulation and briefly review the main evidence supporting the use of topical treatments for psoriasis.
Graphical abstract
Treatment of synthetic dye baths by Fenton processes: evaluation of their environmental footprint through life cycle assessment
Abstract
Inorganic and organic constituents present in textile effluents have a noticeable effect on the performance of Fenton processes. However, studies have been focused on simple wastewater matrices that do not offer enough information to stakeholders to evaluate their real potential in large-scale facilities. Chemical auxiliaries, commonly present in textile wastewaters (NaCl = 30 g/L, Na2CO3 = 5 g/L, and CH3COONa = 1 g/L), affect both the economic and environmental performance of the process because they increase the treatment time (from 0.5 to 24 h) and the consumption of H2SO4 (657%) and NaOH (148%) during conditioning steps. The life cycle assessment (LCA) performed with the IPCC-2013 method revealed that dyeing auxiliaries increase from 1.06 to 3.73 (252%) the emissions of carbon dioxide equivalent (CO2-Eqv/m3). Electricity consumption can be considered an environmental hotspot because it represents 60% of the carbon footprint of the Fenton process. Also, the presence of auxiliaries is critical for the process because it results in the increase of the relative impact (between 50 and 80%) in all environmental categories considered by the ReCiPe-2008 method. Chemical auxiliaries increased the costs of the treatment process in 178% (US$2.22/m3) due to the higher energy consumption and the additional reagent requirements. It is worthwhile mentioning that the technical simplicity of the Fenton process and its low economic and environmental costs turn this process into an attractive alternative for the treatment of textile effluents in emerging economies.
A Scarless Repair Technique for the Lower Lip in Patients With Facial Palsy
This Surgical Pearl describes the vermilion-mucosal advancement flap, a technique that provides the benefits of surgery without the stigma of a surgical facial scar.
Psychometric Properties of the Standardized Cosmesis and Health Nasal Outcomes Survey
This analysis evaluates the ability of the Standardized Cosmesis and Health Nasal Outcomes Survey to discriminate among different symptom severities and its performance at different severity levels.
Computer-Assisted Bilateral Orbitozygomatic Reconstruction
This Teachable Moment describes the case of a 27-year-old man withTreacher Collins syndrome who underwent computer-assisted surgery using bicortical calvarial bone for the reconstruction of bilateral zygomatic aplasia.
Evaluation of the Noma Disease Burden Within the Noma Belt
This study estimates the disease burden of noma, an opportunistic infection of the face that occurs in the setting of extreme poverty.
Missing Video and Citation
In the Original Investigation titled "Association of Nasal Tip Rotation Outcome Estimation With the New Domes Technique in Primary Rhinoplasty," published online February 22, 2018, the video and citation to the video were missing. This article has been corrected online.
Evaluating Inferior Turbinate Reduction Techniques
This study uses computational fluid dynamics analysis to assess the effects of inferior turbinate resection techniques on nasal airflow in 5 patients.
Limitations, Transparency, and Conclusions—Reply
In Reply We thank Bornemann-Cimenti and Szilagyi for their interest in our study on complications related to anesthesia duration in head and neck microvascular reconstructive surgery. The intent of the study was to see if anesthesia duration was at all related to complications in long microvascular reconstructive surgical procedures involving the head and neck. We postulated that longer duration of anesthesia might be correlated with an increased rate of complications in this particular type of surgery.
Societal Identification of Facial Paralysis and Paralysis Location
This observational study examines the ability of casual observers to identify paralysis of varying degrees of severity and to localize the defect on the face.
Cosmetic Augmentation of the Nasal Tip and Nasal Dorsum With ePTFE
This randomized clinical trial investigates whether attaching the conchal cartilage as shield grafts at the distal end of the graft can prevent extrusion and whether the use of ePTFE in the nasal tip can achieve a stable aesthetic outcome.
Automated Facial Measurements in Facial Palsy
This Observation describes Emotrics, a software platform that uses machine learning techniques to enable automatic facial landmark localization and computation of facial measurements for use in the treatment of facial palsy.
Mental Health and Patient Satisfaction With Outcomes of Rhinoplasty
This case-control study compares satisfaction with the functional outcomes of rhinoplasty between patients with normal mental well-being and those with poor mental well-being.
Autologous Costal Cartilage Harvesting and Donor-Site Pain in Patients Undergoing Rhinoplasty—Reply
In Reply We read the letter by Lu and Fan regarding our recently published article. We are happy with the authors' interest, praise, and the discussions they've contributed. Although the technique has been widely used and reported by many influential authors, we agree with the opinion of Lu and Fan that monopolar electrocautery (ME) causes tissue damage and prolongs wound healing. Nevertheless, we don't think it is an interference factor for this study because the major aim of what we are investigating is the downside of ME in that aspect.
Nasal Tip Rotation Outcome With the New Domes Technique in Rhinoplasty
This analytic cohort study assesses whether the definitive outcome of the rotation angle of the nasal tip in patients undergoing primary rhinoplasty can be determined with the new domes technique.
Review of Aesthetic Nasal Reconstruction: Principles and Practice
There are a limited number of people in our relatively broad subspecialty who have devoted their entire careers to a focused area, truly pioneering the way we approach and manage specific clinical problems in facial plastic surgery. There are even fewer who are so passionate about a specific topic that they have taken it upon themselves to share their knowledge and vast experience through extensive writing and publication, allowing this information to perpetuate and help others in our field grow and learn from their successes and their mistakes.
The Multivector Gracilis Free Functional Muscle Flap for Facial Reanimation
This cohort study analyzes use of a double-paddle multivector gracilis flap for treatment of patients with complete facial paralysis.
Spanish Linguistic Validation of the VELO Instrument
This Research Letter describes the methodology of developing a Spanish translation of the VPI Effects on Life Outcomes (VELO) instrument through the linguistic validation.
Repair of the Lateral Nasal Wall in Nasal Airway Obstruction
This systematic review and meta-analysis examines the effectiveness of lateral wall repair in patients with nasal airway obstruction.
Nasal Distortion in Short-Distance Photographs
This study presents a mathematical model to describe the distortive effects of self-photographs, prove the increased perceived nasal size, and calculate the magnitude of this effect from different camera distances.
Data-Driven Surgical Decision Making in Nasal Airway Surgery
What are the factors that influence our surgical decision making in functional nasal airway surgery? Certainly, we rely on individual patient symptoms, medical history, and physical examination to help us determine the specific interventions that we believe will most benefit our patients. However, there is undoubtedly a great deal of variability in the specific approaches or techniques that we use. Our surgical decision making is based on our prior training, personal experiences, and in many cases, surgical dogma that has been passed down to us from mentors or conferences that we have attended. Unfortunately, surgical dogma is often pervasive but lacking in evidence or data to support it. With the emphasis on evidence-based medicine and patient outcomes over the past few decades, there is an increasing importance on data-driven surgical decision making.
Limitations, Transparency, and Conclusions
To the Editor With great interest, we read the recent article by Brady et al. The authors present an association of anesthesia duration in free flap surgery with postoperative complications. Based on their findings that anesthesia duration is an independent risk factor for complications, they conclude that "… reduced anesthesia time, particularly to less than 11 hours, should be the goal…." Everyone involved in the treatment of these patients will sign this statement. However, we want to raise some questions about why we are not entirely in accord that this suggestion is supported by the presented data.
Patient and Physician Assessment of Surgical Scars
This systematic review summarizes published studies assessing patient and physician ratings of surgical scars, rates of patient and physician agreement in scar assessment, and elements of cutaneous scar assessment that differ between patients and physicians.
Autologous Costal Cartilage Harvesting Technique and Donor-Site Pain in Patients Undergoing Rhinoplasty
To the Editor We read with great interest the article by Özücer et al. The authors did well to compare the postoperative donor-site pain in patients who underwent costal cartilage harvest, and the separated evaluation of resting pain and movement pain is thoughtful and exquisitely considered and worthy of praise. In this communication, we would like to propose some discussions with the authors.
Role of tyrosine residue (Y213) in nuclear retention of PCNA1 in human malaria parasite Plasmodium falciparum
Abstract
Proliferating Cell Nuclear Antigen (PCNA) undergoes several Post Translational Modifications including phosphorylation leading to its regulation in mammalian and yeast systems. Plasmodium falciparum possesses two PCNAs (PCNA1 & PCNA2) with an edge of PfPCNA1 over PfPCNA2 for DNA replication. Recent phosphoproteome data report phosphorylation of S191 residue without its functional implication. In mammalian cells, phosphorylation of HsPCNA at Y211 stabilizes chromatin bound PCNA. We find tyrosine (but not S191) to be conserved in PfPCNAs and it is important for its nuclear localization and foci formation of PfPCNA1. Further, a Y213F mutation in PfPCNA1 leads to its functional loss both in yeast and parasite. We highlight the importance of evolutionarily conserved tyrosine in PCNA from parasite to mammal linked with DNA replication and cell proliferation.A yeast for all seasons – is Pichia pastoris a suitable chassis organism for future bioproduction?
Abstract
The methylotrophic yeast Pichia pastoris (Komagataella spp.) is well established as a host for recombinant protein production. Since a few years it has also been subject to metabolic engineering to produce a diversity of biochemicals. Based on these developments we discuss here why P. pastoris is a suitable future chassis organism for synthetic biology, and we provide a roadmap for a community effort towards this aim.Characterisation and pure culture of putative health-associated oral bacterium BU063 (Tannerella sp. HOT-286) reveals presence of a potentially novel glycosylated S-layer
Abstract
Tannerella HOT-286 (phylotype BU063) is a recently identified novel filamentous Gram-negative anaerobic oral bacterium cultured for the first time recently in co-culture with Propionibacterium acnes. In contrast to the related periodontal disease associated pathobiont Tannerella forsythia it is considered a putative health-associated bacterium. In this paper we identified that this organism could be grown in pure culture if N-acetyl muramic acid (NAM) was provided in the media, although surprisingly the genetic basis of this phenomenon is not likely to be due to a lack of NAM synthesis genes. During further microbiological investigations we showed for the first time that Tannerella HOT-286 possesses a prominent extracellular S-layer with a novel morphology putatively made up of two proteins modified with an unknown glycan. This data furthers our knowledge of this poorly understood organism and genus that is an important part of the oral and human microbiome.Dysbiosis and early mortality in zebrafish larvae exposed to subclinical concentrations of streptomycin
Abstract
Exposure to low concentrations of antibiotics found in aquatic environments can increase susceptibility to infection in adult fish due microbiome disruption. However, little is known regarding the effect of antibiotic pollution on fish larvae. Here, we show that exposure to streptomycin, a common antibiotic used in medicine and aquaculture, disrupts the normal composition of zebrafish larvae microbiomes, significantly reducing the microbial diversity found in the fish. Exposure to streptomycin also significantly increased early mortality among fish larvae, causing full mortality within a few days of exposure at 10 μg/mL. Finally, we found that subclinical concentrations of streptomycin also increased the abundance of class 1 integrons, an integrase-dependent genetic system associated to the horizontal transfer of antibiotic resistance genes, in the larvae microbiomes. These results suggest that even low concentrations of streptomycin associated with environmental pollution could impact on fish populations and lead to the creation of antibiotic resistance reservoirs.Fully automatic cross-modality localization and labeling of vertebral bodies and intervertebral discs in 3D spinal images
Abstract
Purpose
We present a cross-modality and fully automatic pipeline for labeling of intervertebral discs and vertebrae in volumetric data of the lumbar and thoracolumbar spine. The main goal is to provide an algorithm that is applicable to a wide range of different sequences and acquisition protocols, like T1- and T2- weighted MR scans, MR Dixon data, and CT scans. This requires that the learned models generalize without retraining to modalities and scans with unseen image contrasts.
Methods
We address this challenge by automatically localizing the sacral region combining local entropy-optimized texture models with convolutional neural networks. For subsequent labeling, local three-disc entropy models are matched iteratively to the spinal column. Every model-matched position is further refined by an intensity-based template-matching approach, based solely on the reduced intensity scale provided by the entropy models.
Results
We evaluated our method on 161 publicly available scans, acquired on various scanners. We showed that our method can deal with a wide range of different MR protocols as well as with CT data. We achieved a sacrum detection rate of 93.6%. Mean center accuracies ranged from 2.5 ± 1.5 to 5.7 ± 3.8 mm for the different sets of scans.
Conclusion
We present a novel spine labeling framework that is applicable to a highly heterogeneous set of scans without retraining of the method. Our approach achieves high sacrum localization accuracy and shows promising labeling results. To the best of our knowledge, an algorithm able to deal with such a diverse set of MR and CT scans has not yet been presented in the literature.
Conscientious objection and person-centered care
Abstract
Person-centered care offers a promising way to manage clinicians' conscientious objection to providing services they consider morally wrong. Health care centered on persons, rather than patients, recognizes clinicians and patients on the same stratum. The moral interests of clinicians, as persons, thus warrant as much consideration as those of other persons, including patients. Interconnected moral interests of clinicians, patients, and society construct the clinician as a socially embedded and integrated self, transcending the simplistic duality of private conscience versus public role expectations. In this milieu of blurred boundaries, person-centered care offers a constructive way to accommodate conscientious objection by clinicians. The constitutionally social nature of clinicians commits and enables them, through care mechanisms such as self-care, to optimize the quality of health care and protect the welfare of patients. To advance these conditions, it is recommended that the medical profession develop a person-centered culture of care, along with clinician virtues and skills for person-centered communication.
Harming as making worse off
Abstract
A powerful argument against the counterfactual comparative account of harm is that it cannot distinguish harming from failing to benefit. In reply to this problem, I suggest a new account of harm. The account is a counterfactual comparative one, but it counts as harms only those events that make a person (rather than merely allow him to) occupy his level of well-being at the world at which the event occurs. This account distinguishes harming from failing to benefit in a way that accommodates our intuitions about the standard problem cases. In laying the groundwork for this account, I also demonstrate that rival accounts of harm are able to distinguish harming from failing to benefit only if, and because, they also appeal to the distinction between making upshots happen and allowing upshots to happen. One important implication of my discussion is that preserving the moral asymmetry between harming and failing to benefit requires a commitment to the existence of a metaphysical and moral distinction between making and allowing.
Sensory feedback and animal locomotion: perspectives from biology and biorobotics: An introduction to the symposium
Synopsis
The successful completion of many behaviors relies on sensory feedback. This symposium brought together researchers using novel techniques to study how different stimuli are encoded, how and where multimodal feedback is integrated, and how feedback modulates motor output in diverse modes of locomotion (aerial, aquatic, and terrestrial) in a diverse range of taxa (insects, fish, tetrapods), and in robots. Similar to biological organisms, robots can be equipped with integrated sensors and can rely on sensory feedback to adjust the output signal of a controller. Engineers often look to biology for inspiration on how animals have evolved solutions to problems similar to those experienced in robotic movement. Similarly, biologists too must proactively engage with engineers to apply computer and robotic models to test hypotheses and answer questions on the capacity and roles of sensory feedback in generating effective movement. Through a diverse group of researchers, including both biologists and engineers, the symposium attempted to catalyze new interdisciplinary collaborations and identify future research directions for the development of bioinspired sensory control systems, as well as the use of robots to test hypotheses in neuromechanics.4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)†
breast cancermetastaticadvancedguidelinesABCESO-ESMO
Editorial Board
Publication date: July 2018
Source: Annales de Chirurgie Plastique Esthétique, Volume 63, Issue 4
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Publication date: Available online 28 September 2017 Source: Actas Dermo-Sifiliográficas Author(s): F.J. Navarro-Triviño
