New England Journal of Medicine, Volume 382, Issue 20, Page 1943-1950, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, May 2020.
Wed May 13, 2020 11:55
New England Journal of Medicine, Volume 382, Issue 20, Page 1933-1941, May 2020.
Wed May 13, 2020 11:55
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Abstract One of the challenges in esthetic implant supported restorations is to replicate the emergence profile of soft tissue contours created by provisional restorations. Various analog techniques have been used to achieve the most esthetic and natural emergence profile in final restorations. The evolution of digital dentistry has made dentistry easier and efficient albeit with a learning curve. The technique described here uses digital technology to describe a complete digital flow from the provisional...
Abstract Purpose To assess the management of sleep apnea and snoring disorders in Advanced Education Programs in Prosthodontics (AEPP) in the United States. Materials and Methods A 51 item, online survey was sent to program directors at 48 AEPPs in the United States in 2015. Data results were analyzed descriptively. Results Thirty‐five program directors responded to the survey. Twenty‐four (68.6%, N = 35) programs report not having a dedicated course for the treatment of sleep apnea...
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Background The Ki‐67 index is important for grading neuroendocrine tumors (NETs) in cytology. However, different counting methods exist. Recently, augmented reality microscopy (ARM) has enabled real‐time image analysis using glass slides. The objective of the current study was to compare different traditional Ki‐67 scoring methods in cell block material with newer methods such as ARM. Methods Ki‐67 immunostained slides from 50 NETs of varying grades were retrieved (39 from the pancreas and...
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Key points The decerebrate mouse provides a novel working model of the Exercise Pressor Reflex (EPR) The decerebrate mouse model of the EPR is similar to the previously described decerebrate rat model Studying the EPR in transgenic mouse models can define exact mechanisms of the EPR in health and disease Abstract The exercise pressor reflex (EPR) is defined by a rise in mean arterial pressure (MAP) and heart rate (HR) in response to exercise and is necessary to match metabolic demand...
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Abstract Early life adversity exerts a detrimental influence on developing brain neuronal networks and its consequences may include mental health disorders. In rats, prenatal stress may lead to anxiety and depressive‐like behavior in the offspring. Several lines of evidence implicated an involvement of prenatal stress in alterations of the brain serotonergic system functions, but the effects of prenatal stress on its core, the dorsal raphe nucleus (DRN), still remain incompletely understood. The...
Abstract Semipalmated sandpiper (Calidris pusilla) migration to the southern hemisphere includes a 5‐day non‐stop flight over the Atlantic Ocean, whereas semipalmated plover (Charadrius semipalmatus) migration, to the same area, is largely over land, with stopovers for feeding and rest. We compared the number and 3‐D morphology of hippocampal astrocytes of Charadrius semipalmatus before and after autumnal migration with those of Calidris pusilla to test the hypothesis that the contrasting migratory...
Abstract Visual input constantly recalibrates auditory spatial representations. Exposure to isochronous audiovisual stimuli with a fixed spatial disparity typically results in a subsequent auditory localization bias (ventriloquism aftereffect, VAE), whereas exposure to spatially congruent audiovisual stimuli improves subsequent auditory localization (multisensory enhancement, ME). Here we tested whether cross‐modal recalibration is affected by the stimulation rate and/or the distribution of audiovisual...
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Abstract Introduction Tinea capitis (TC) is a fungal infection of the hair and scalp. It mainly affects children, and treatment requires an extensive regimen including oral therapy, antifungal creams and shampoo as well as disinfection of fomites, bedlinen and clothes. Family members to patients with TC need prophylactic treatment to limit spread of the infection. Adherence to therapy in TC is time‐consuming, and the disease may cause psychosocial impairment to the caregivers. Methods and...
Abstract This study aims to describe the herbal and traditional remedies in the treatment of Cutaneous leishmaniasis (CL) with an overview on related available evidence in modern medicine. This study is a review which focuses on the most important TPM sources including Avicenna’s Canon of Medicine, Jorjani’s Zakhīra‐yi Khārazmshāhī, Aazam‐Khan’s Eksir‐e‐Aazam as well as pertinent information from Embase, PubMed, Scopus, Scientific Information Database (SID) and Google Scholar by using the keywords...
Abstract Pustular psoriasis of pregnancy (PPP), also known as impetigo herpetiformis, is a rare gestational dermatosis that may induce life‐threatening complications for both the mother and fetus. Treatment of recalcitrant generalized PPP may be challenging as available therapeutic options are limited. We herein present a 24‐year‐old pregnant woman with generalized PPP accompanied by high fever, fatigue, leukocytosis, and elevated levels of serum acute phase reactants. The patient was resistant...
Abstract The COVID‐19 emerged late in Turkey but it showed a rapid progression later. We aimed to investigate the changes in the number of patients who requested a dermatology outpatient clinic visit due to the increased social and medical burden caused by COVID‐19 in Turkey during the first days of the pandemic. We also examined the most common dermatologic diseases diagnosed during the COVID‐19 outbreak. A statistically significant negative correlation was found between the number of COVID‐19...
Abstract Background The treatment of keloids and hypertrophic scars remains a challenge. Although triamcinolone acetonide (TAC) is one of the most common and effective treatments for keloids and hypertrophic scars, TAC is not effective in some patients, and some may even experience adverse outcomes. Verapamil might be considered a safe alternative to TAC. The aim of this study was to compare the efficacy and safety of verapamil and TAC for the treatment of keloids and hypertrophic scars. ...
Abstract The pandemic of covid‐19 has captivated more than 3 Million people across the globe affecting the dermatology practice as well. Due to the novel nature of the virus and concomitant lack of research, standard guidelines have not been set in place regarding the procedures. Currently, due to fear and spread of coronavirus aesthetic practice has taken a seat back. Dermatologic surgeon/aesthetician have to be prepared for the forthcoming alterations in the practice and adjust to the necessary...
Abstract Frontal fibrosing alopecia (FFA) mainly affects the anterior hairline and eyebrows and its etiology and associated factors remain obscure. The aim of this study was to evaluate the allergic contact dermatitis with patch test in patients with FFA. In this prospective study, 20 patients with FFA and 24 age and sex‐matched healthy individuals were evaluated with patch testing. Diagnosis was made histologically, clinically and based on dermoscopic findings. Demographic data, age of onset, disease...
Abstract Background Plantar warts can cause pain near the toes and the sole of the foot and may result in referral for treatment. This study was aimed at comparing 40% trichloroacetic acid (TCA) and cryotherapy (Cryo) for the treatment of plantar warts. Methods This single‐blind, randomized clinical trial was performed on 60 subjects presenting with plantar wart in Sabzevar, Iran in 2018. The first intervention group was treated with 40% TCA in four sessions within four weeks. The second...
Abstract The role of psychotropic drugs in Psychodermatology is still debatable, due to the quality of the evidence that supports it. There are several case reports and open trials with variable results. There is an additional difficulty in finding therapists trained in effective psychotherapy techniques, justify the need for more research on the available pharmacological options. The present review emphasizes pharmacological treatment in Psychodermatology, specifically in cases of primary psychiatric...
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Abstract Objective A hitherto undescribed phenotype of early onset muscular dystrophy associated with sensorineural hearing loss and primary ovarian insufficiency was initially identified in two siblings and in subsequent patients with a similar constellation of findings. The goal of this study was to understand the genetic and molecular etiology of this condition. Methods We applied whole exome sequencing (WES) superimposed on shared haplotype regions to identify the initial biallelic...
Objective Pharmaco‐refractory focal motor epileptic seizures pose a significant challenge. Deep brain stimulation (DBS) is recently a recognized therapeutic option for the treatment of refractory epilepsy. To identify the specific target for focal motor seizures, we evaluate the modulatory effects of the subthalamic nucleus (STN) stimulation because of the critical role of STN in cortico‐subcortical motor processing. Methods Seven epilepsy patients with refractory seizures who underwent chronic...
In response to the coronavirus disease 2019 (COVID‐19) pandemic, the scientific community has accelerated its process for knowledge synthesis and dissemination at multiple levels, from creating pathways for expedited journal peer review to establishing specialty task forces that curate information most relevant to individual fields of expertise. We describe our experience engaging with the latter to fill a gap in knowledge. At our institution, we established a group of fifteen neurologists from six...
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Abstract Background Magnetic resonance imaging (MRI) T1 relaxometry (mapping) has been reported as a quantitative biomarker of liver injury due to inflammation and fibrosis. Objective To assess the relationship between liver MRI T1 relaxometry measurements obtained using a modified Look-Locker inversion recovery (MOLLI) pulse sequence without and with...
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