IJMS, Vol. 21, Pages 3454: Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms International Journal of Molecular Sciences doi: 10.3390/ijms21103454 Authors: Yi Jeon Kwon Cho Yun Lee Ryu Park Cho Kim The aim of this study was to examine whether rubrofusarin, an active ingredient of the Cassia species, has an antidepressive effect in chronic restraint stress (CRS) mouse model. Although acute treatment using rubrofusarin failed,...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3452: P53: A Guardian of Immunity Becomes Its Saboteur through Mutation International Journal of Molecular Sciences doi: 10.3390/ijms21103452 Authors: Agupitan Neeson Williams Howitt Haupt Haupt Awareness of the importance of immunity in controlling cancer development triggered research into the impact of its key oncogenic drivers on the immune response, as well as their value as targets for immunotherapy. At the heart of tumour suppression is...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3438: Improving Anti-Neurodegenerative Benefits of Acetylcholinesterase Inhibitors in Alzheimer’s Disease: Are Irreversible Inhibitors the Future? International Journal of Molecular Sciences doi: 10.3390/ijms21103438 Authors: Donald E. Moss Decades of research have produced no effective method to prevent, delay the onset, or slow the progression of Alzheimer’s disease (AD). In contrast to these failures, acetylcholinesterase (AChE, EC 3.1.1.7) inhibitors...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3451: Metabolic Alterations in Spheroid-Cultured Hepatic Stellate Cells International Journal of Molecular Sciences doi: 10.3390/ijms21103451 Authors: Fujisawa Takami Sasai Matsumoto Yamamoto Sakaida Hepatic stellate cells (HSCs) play a vital role in liver fibrosis, and a greater understanding of their regulation is required. Recent studies have focused on relationships between extracellular matrix (ECM) stiffness and gene expression or cellular...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3447: Heterobasidion annosum Induces Apoptosis in DLD-1 Cells and Decreases Colon Cancer Growth in In Vivo Model International Journal of Molecular Sciences doi: 10.3390/ijms21103447 Authors: Anna Sadowska Ewa Zapora Diana Sawicka Katarzyna Niemirowicz-Laskowska Arkadiusz Surażyński Katarzyna Sułkowska-Ziaja Katarzyna Kała Marcin Stocki Marek Wołkowycki Sławomir Bakier Anna Pawlik Magdalena Jaszek Bożena Muszyńska Halina Car Application...
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IJMS, Vol. 21, Pages 3450: Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation International Journal of Molecular Sciences doi: 10.3390/ijms21103450 Authors: Martina Chiurazzi Martina Di Maro Mauro Cozzolino Antonio Colantuoni Energy homeostasis regulation is essential for the maintenance of life. Neuronal hypothalamic populations are involved in the regulation of energy balance. In order play this role, they require energy: mitochondria, indeed, have...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3453: Erythropoietin Ameliorates Ischemia/Reperfusion-Induced Acute Kidney Injury via Inflammasome Suppression in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21103453 Authors: Kwak Kim Jang Jung Cho Chang Kim Acute kidney injury (AKI) is the most common condition in hospitalized patients. As ischemia/reperfusion-induced AKI (IR-AKI) is as a major contributor to end-stage disease, an effective therapeutic intervention...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3448: Multiple Sulfatase Deficiency: A Disease Comprising Mucopolysaccharidosis, Sphingolipidosis, and More Caused by a Defect in Posttranslational Modification International Journal of Molecular Sciences doi: 10.3390/ijms21103448 Authors: Schlotawa Adang Radhakrishnan Ahrens-Nicklas Multiple sulfatase deficiency (MSD, MIM #272200) is an ultra-rare disease comprising pathophysiology and clinical features of mucopolysaccharidosis, sphingolipidosis and...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3446: Resveratrol Inhibits Particulate Matter-Induced Inflammatory Responses in Human Keratinocytes International Journal of Molecular Sciences doi: 10.3390/ijms21103446 Authors: Jung-Won Shin Hyun-Sun Lee Jung-Im Na Chang-Hun Huh Kyung-Chan Park Hye-Ryung Choi Particulate matter (PM), a major air pollutant, is a complex mixture of solid and liquid particles of various sizes. PM has been demonstrated to cause intracellular inflammation in human keratinocytes,...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3449: Selective Autophagy Maintains the Aryl Hydrocarbon Receptor Levels in HeLa Cells: A Mechanism That Is Dependent on the p23 Co-Chaperone International Journal of Molecular Sciences doi: 10.3390/ijms21103449 Authors: Yujie Yang William K. Chan The aryl hydrocarbon receptor (AHR) is an environmental sensing molecule which impacts diverse cellular functions such as immune responses, cell growth, respiratory function, and hematopoietic stem cell differentiation....
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3444: Bioresorbable Polymeric Scaffold in Cardiovascular Applications International Journal of Molecular Sciences doi: 10.3390/ijms21103444 Authors: Toong Toh Ng Wong Leo Venkatraman Tan Ang Huang Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3443: Enhanced Clearance of Neurotoxic Misfolded Proteins by the Natural Compound Berberine and Its Derivatives International Journal of Molecular Sciences doi: 10.3390/ijms21103443 Authors: Rusmini Cristofani Tedesco Ferrari Messi Piccolella Casarotto Chierichetti Cicardi Galbiati Geroni Lombardi Crippa Poletti Background: Accumulation of misfolded proteins is a common hallmark of several neurodegenerative disorders...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3445: Comprehensive Comparison of Clinically Relevant Grain Proteins in Modern and Traditional Bread Wheat Cultivars International Journal of Molecular Sciences doi: 10.3390/ijms21103445 Authors: Olha Lakhneko Maksym Danchenko Bogdan Morgun Andrej Kováč Petra Majerová Ľudovit Škultéty Bread wheat (Triticum aestivum L.) is one of the most valuable cereal crops for human consumption. Its grain storage proteins define bread quality, though they may cause...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3434: Unique Gut Microbiome Signatures Depict Diet-Versus Genetically Induced Obesity in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21103434 Authors: Ravinder Nagpal Sidharth P Mishra Hariom Yadav The gut microbiome plays an important role in obesity and Type 2 diabetes (T2D); however, it remains unclear whether the gut microbiome could clarify the dietary versus genetic origin of these ailments. Moreover, studies examining the gut microbiome...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3442: Injectable Biomaterials for Dental Tissue Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms21103442 Authors: Håvard Jostein Haugen Poulami Basu Mousumi Sukul João F Mano Janne Elin Reseland Injectable biomaterials scaffolds play a pivotal role for dental tissue regeneration, as such materials are highly applicable in the dental field, particularly when compared to pre-formed scaffolds. The defects in the maxilla-oral area...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3440: The Medial Prefrontal Cortex as a Central Hub for Mental Comorbidities Associated with Chronic Pain International Journal of Molecular Sciences doi: 10.3390/ijms21103440 Authors: Kai K. Kummer Miodrag Mitrić Theodora Kalpachidou Michaela Kress Chronic pain patients frequently develop and suffer from mental comorbidities such as depressive mood, impaired cognition, and other significant constraints of daily life, which can only insufficiently be overcome...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3441: Coating-Dependent Effects of Silver Nanoparticles on Tobacco Seed Germination and Early Growth International Journal of Molecular Sciences doi: 10.3390/ijms21103441 Authors: Renata Biba Dajana Matić Daniel Mark Lyons Petra Peharec Štefanić Petra Cvjetko Mirta Tkalec Dubravko Pavoković Ilse Letofsky-Papst Biljana Balen Silver nanoparticles (AgNPs) are used in a wide range of consumer products because of their excellent antimicrobial properties....
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3439: Anti-Inflammatory Effects of Lasia spinosa Leaf Extract in Lipopolysaccharide-Induced RAW 264.7 Macrophages International Journal of Molecular Sciences doi: 10.3390/ijms21103439 Authors: Thanh Q. C. Nguyen Tran Duy Binh Tuan L. A. Pham Yen D. H. Nguyen Dai Thi Xuan Trang Trong Tuan Nguyen Kenji Kanaori Kaeko Kamei Lasia spinosa (L.) Thwaites was used as a traditional medicine to treat many inflammatory diseases for centuries. However, its...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3436: Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes International Journal of Molecular Sciences doi: 10.3390/ijms21103436 Authors: Arnaud Bianchi Émilie Velot Hervé Kempf Kamil Elkhoury Laura Sanchez-Gonzalez Michel Linder Cyril Kahn Elmira Arab-Tehrany Investigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially in rats and humans, to be efficiently transfected....
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3435: Understanding the Pathophysiology of Cerebral Amyloid Angiopathy International Journal of Molecular Sciences doi: 10.3390/ijms21103435 Authors: Gatti Tinelli Scelzo Arioli Di Fede Obici Pantoni Giaccone Caroppo Parati Bersano Cerebral amyloid angiopathy (CAA), one of the main types of cerebral small vessel disease, is a major cause of spontaneous intracerebral haemorrhage and an important contributor to cognitive decline...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3437: Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration International Journal of Molecular Sciences doi: 10.3390/ijms21103437 Authors: Chen Wu Ho Gung Tsai Orekhov Sobenin Lin Yet Zinc oxide nanoparticles (ZnONPs) are frequently encountered nanomaterials in our daily lives. Despite the benefits of ZnONPs in a variety of applications, many studies...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3431: Instability of Short Arm of Acrocentric Chromosomes: Lesson from Non-Acrocentric Satellited Chromosomes. Report of 24 Unrelated Cases International Journal of Molecular Sciences doi: 10.3390/ijms21103431 Authors: Redaelli Conconi Villa Sala Crosti Corti Catusi Garzo Romitti Martinoli Patrizi Malgara Recalcati Dalprà Lavitrano Riva Roversi Bentivegna Satellited non-acrocentric autosomal chromosomes...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3432: TP53 in Myelodysplastic Syndromes: Recent Biological and Clinical Findings International Journal of Molecular Sciences doi: 10.3390/ijms21103432 Authors: Cumbo Tota Anelli Zagaria Specchia Albano TP53 dysregulation plays a pivotal role in the molecular pathogenesis of myelodysplastic syndromes (MDS), identifying a subgroup of patients with peculiar features. In this review we report the recent biological and clinical findings of TP53-mutated...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3433: Evading the AAV Immune Response in Mucopolysaccharidoses International Journal of Molecular Sciences doi: 10.3390/ijms21103433 Authors: Piechnik Sawamoto Ohnishi Kawamoto Ago Tomatsu The humoral immune response elicited by adeno-associated virus (AAV)-mediated gene therapy for the treatment of mucopolysaccharidoses (MPS) poses a significant challenge to achieving therapeutic levels of transgene expression. Antibodies targeting the AAV capsid...
Wed May 13, 2020 03:00
IJMS, Vol. 21, Pages 3430: Molecular Analysis of the ABCA4 Gene Mutations in Patients with Stargardt Disease Using Human Hair Follicles International Journal of Molecular Sciences doi: 10.3390/ijms21103430 Authors: Aneta Ścieżyńska Marta Soszyńska Michał Komorowski Anna Podgórska Natalia Krześniak Aleksandra Nogowska Martyna Smolińska Kamil Szulborski Jacek P. Szaflik Bartłomiej Noszczyk Monika Ołdak Jacek Malejczyk ABCA4 gene mutations are the cause...
Wed May 13, 2020 03:00
JCM, Vol. 9, Pages 1472: No Autopsies on COVID-19 Deaths: A Missed Opportunity and the Lockdown of Science Journal of Clinical Medicine doi: 10.3390/jcm9051472 Authors: Salerno Sessa Piscopo Montana Torrisi Patanè Murabito Volti Pomara Background: The current outbreak of COVID-19 infection, which started in Wuhan, Hubei province, China, in December 2019, is an ongoing challenge and a significant threat to public health requiring surveillance, prompt diagnosis,...
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JCM, Vol. 9, Pages 1473: Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site Journal of Clinical Medicine doi: 10.3390/jcm9051473 Authors: Kalathiya Padariya Mayordomo Lisowska Nicholson Singh Baginski Fahraeus Carragher Ball Haas Daniels Hupp Alfaro An important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein...
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JCM, Vol. 9, Pages 1471: Acute Kidney Injury after Endovascular Treatment in Patients with Acute Ischemic Stroke Journal of Clinical Medicine doi: 10.3390/jcm9051471 Authors: Joonsang Yoo Jeong-Ho Hong Seong-Joon Lee Yong-Won Kim Ji Man Hong Chang-Hyun Kim Jin Wook Choi Dong-Hun Kang Yong-Sun Kim Yang-Ha Hwang Jin Soo Lee Sung-Il Sohn Acute kidney injury (AKI) is often associated with the use of contrast agents. We evaluated the frequency of AKI, factors...
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JCM, Vol. 9, Pages 1470: Neonatal Immune Incompatibilities between Newborn and Mother Journal of Clinical Medicine doi: 10.3390/jcm9051470 Authors: Borros Arneth Background: Incompatibilities between the mother and unborn baby can cause complications that must be identified early to initiate the appropriate treatment. For example, neonatal alloimmune thrombocytopenia (NAIT), neonatal alloimmune neutropenia (NAIN), and morbus hemolyticus neonatorum affect children worldwide. Aim: This...
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JCM, Vol. 9, Pages 1468: Innate Immune System and Multiple Sclerosis. Granulocyte Numbers Are Reduced in Patients Affected by Relapsing-Remitting Multiple Sclerosis during the Remission Phase Journal of Clinical Medicine doi: 10.3390/jcm9051468 Authors: Zbyšek Pavelek Francesco Angelucci Ondřej Souček Jan Krejsek Lukáš Sobíšek Blanka Klímová Jana Šarláková Simona Halúsková Kamil Kuča Martin Vališ Background: Multiple sclerosis (MS) is a neurodegenerative disease...
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JCM, Vol. 9, Pages 1469: Degree of Glomerulosclerosis in Procurement Kidney Biopsies from Marginal Donor Kidneys and Their Implications in Predicting Graft Outcomes Journal of Clinical Medicine doi: 10.3390/jcm9051469 Authors: Wisit Cheungpasitporn Charat Thongprayoon Pradeep K Vaitla Api Chewcharat Panupong Hansrivijit Felicitas L. Koller Michael A Mao Tarun Bathini Sohail Abdul Salim Sreelatha Katari Lee S Cummings Eddie Island Jameson Forster Napat...
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JCM, Vol. 9, Pages 1466: Glomerular Filtration Rate as a Predictor of Outcome in Acute Coronary Syndrome Complicated by Atrial Fibrillation Journal of Clinical Medicine doi: 10.3390/jcm9051466 Authors: Domenico Santoro Guido Gembillo Giuseppe Andò The close relationship between kidney and heart is well known. Cardiovascular impairment contributes to the worsening of renal function and kidney failure worsens cardiovascular health. Atrial fibrillation (AF) is a frequent issue in...
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JCM, Vol. 9, Pages 1467: Increased Endotoxin Activity Is Associated with the Risk of Developing Acute-on-Chronic Liver Failure Journal of Clinical Medicine doi: 10.3390/jcm9051467 Authors: Hiroaki Takaya Tadashi Namisaki Shinya Sato Kosuke Kaji Yuki Tsuji Daisuke Kaya Yukihisa Fujinaga Yasuhiko Sawada Naotaka Shimozato Hideto Kawaratani Kei Moriya Takemi Akahane Akira Mitoro Hitoshi Yoshiji Acute-on-chronic liver failure (ACLF) leads to systematic...
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JCM, Vol. 9, Pages 1465: Endoscopic Submucosal Dissection of Papillary Gastric Adenocarcinoma; Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9051465 Authors: Chang Seok Bang Jae Jun Lee Gwang Ho Baik This study evaluated the possibility of endoscopic submucosal dissection (ESD) for early gastric cancer with papillary adenocarcinoma (EGC-PAC). PAC, an uncommon pathologic type of stomach cancer, is classified into differentiated-type histology. However, aggressive...
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JCM, Vol. 9, Pages 1464: Unrealistic Optimism in the Time of Coronavirus Pandemic: May It Help to Kill, If So—Whom: Disease or the Person? Journal of Clinical Medicine doi: 10.3390/jcm9051464 Authors: Dolinski Dolinska Zmaczynska-Witek Banach Kulesza Objective: The results of numerous empirical studies have showed the occurrence of so-called unrealistic optimism. Thus, we aimed to investigate whether in the situation of an imminent coronavirus pandemic, people would...
Wed May 13, 2020 03:00
JCM, Vol. 9, Pages 1462: Relationships among Retinal Nonperfusion, Neovascularization, and Vascular Endothelial Growth Factor Levels in Quiescent Proliferative Diabetic Retinopathy Journal of Clinical Medicine doi: 10.3390/jcm9051462 Authors: Ra Park Baek Baek Purpose: To investigate the relationships among the retinal nonperfusion (NP) area, neovascularization (NV) area, and aqueous humor vascular endothelial growth factor (VEGF) levels in quiescent proliferative diabetic...
Wed May 13, 2020 03:00
JCM, Vol. 9, Pages 1461: Differences in Results and Related Factors Between Hospital-at-Home Modalities in Catalonia: A Cross-Sectional Study Journal of Clinical Medicine doi: 10.3390/jcm9051461 Authors: Arias-de la Torre Zioga Macorigh Muñoz Estrada Mias Estrada Puigdomenech Valderas Martín Molina Espallargues Hospital-at-home (HaH) is a healthcare modality that provides active treatment by healthcare staff in the patient’s home...
Wed May 13, 2020 03:00
JCM, Vol. 9, Pages 1463: The Marker of Tubular Injury, Kidney Injury Molecule-1 (KIM-1), in Acute Kidney Injury Complicating Acute Pancreatitis: A Preliminary Study Journal of Clinical Medicine doi: 10.3390/jcm9051463 Authors: Wajda Dumnicka Kolber Sporek Maziarz Ceranowicz Kuźniewski Kuśnierz-Cabala Acute pancreatitis (AP) may be associated with severe inflammation and hypovolemia leading to organ complications including acute kidney injury (AKI). According...
Wed May 13, 2020 03:00
JCM, Vol. 9, Pages 1453: Alcohol Hangover Does Not Alter the Application of Model-Based and Model-Free Learning Strategies Journal of Clinical Medicine doi: 10.3390/jcm9051453 Authors: Julia Berghäuser Wiebke Bensmann Nicolas Zink Tanja Endrass Christian Beste Ann-Kathrin Stock Frequent alcohol binges shift behavior from goal-directed to habitual processing modes. This shift in reward-associated learning strategies plays a key role in the development and maintenance of...
Wed May 13, 2020 03:00
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