Adverse reactions to tattoos in the general population of Denmark

Safety and Efficacy of a Halobetasol/Tazarotene Fixed Combination in the Treatment of Moderate-to-Severe Plaque Psoriasis: Results of two Phase 3 randomized controlled trials

Topical corticosteroids are the mainstay of psoriasis treatment; long-term safety concerns limit use. Combination with tazarotene may optimize efficacy, minimizing safety/tolerability concerns, In patients with moderate-to-severe plaque psoriasis treated with HP/TAZ lotion, improvement is noted within 2 weeks with few adverse effects observed after 8 weeks., HP/TAZ lotion may provide a realistic topical option for psoriasis management

Use of immunology and immunodeficiency topics in UpToDate

Publication date: Available online 30 March 2018
Source:The Journal of Allergy and Clinical Immunology: In Practice
Author(s): E. Richard Stiehm, Elizabeth C. Tepas, Anna M. Feldweg

Type 2 biomarkers and prediction of future exacerbations and lung function decline in adult asthma

Publication date: Available online 30 March 2018
Source:The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Ruth Semprini, Mathew Williams, Alex Semprini, Alice McDouall, James Fingleton, Cecile Holweg, Mark Weatherall, Richard Beasley, Irene Braithwaite
BackgroundType 2 biomarkers that predict both likelihood of future severe exacerbations and response to monoclonal antibody therapy in asthma, would be useful clinically in identifying patients both at greater risk of hospitalization, and most likely to benefit from monoclonal antibody therapy.ObjectiveTo describe the association between the Type 2 biomarkers, blood eosinophils, FeNO, serum periostin, serum IgE and time to severe exacerbation in a broad asthma population.MethodsParticipants from two adult asthma cohorts with baseline measurements of blood eosinophils, FeNO, serum periostin and serum IgE were reviewed after at least 12 months to obtain an exacerbation history, corroborated with general practitioner and hospital medical records. The association between baseline Type 2 biomarkers and time to exacerbation was described by Cox Proportional Hazard Ratios (HR) using multivariate models.Results212 participants were followed for a median (range) 3.8 (1.1 to 5.3) years. 67/212 (32%) had at least one severe exacerbation. The HR (95% CI) of baseline Type 2 biomarkers and time to exacerbation were: blood eosinophils per 0.1x10⁹/L increase 0.89 (0.76-1.05), P=0.17; log FeNO per 0.693 increase 0.65 (0.52-0.81), P<0.001; log serum periostin per 0.693 increase 0.62 (0.35-1.09), P=0.10; log serum IgE per 0.693 increase 0.89 (0.80-1.00), P=0.05.ConclusionThe positive association between Type 2 biomarkers and risk of severe exacerbations in populations with severe refractory asthma does not extend to mild and moderate asthma. Non-Type 2 asthma may represent a phenotype associated with an increased risk of severe exacerbations in a broad asthma population.

Follicular Traction Urticaria

Publication date: Available online 31 March 2018
Source:The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Shiven S. Patel, Richard F. Lockey

Xantogranuloma necrobiótico, manifestación cutánea de las gammapatías monoclonales

Publication date: Available online 31 March 2018
Source:Actas Dermo-Sifiliográficas
Author(s): I. Pérez-López, J.D. Herrera-García, A. Martínez-López, E. García-Durá

Réplica a: «Mancha de vino de Oporto adquirida: ¡no es una simple mancha!»

Publication date: Available online 31 March 2018
Source:Actas Dermo-Sifiliográficas
Author(s): J.F. Millán-Cayetano, J. del Boz, P. García-Montero, M. de Troya Martín

Mancha de vino de Oporto adquirida: ¡no es una simple mancha!

Publication date: Available online 30 March 2018
Source:Actas Dermo-Sifiliográficas
Author(s): A. Abdelmaksoud, M. Vestita

Las decisiones editoriales en las revistas dermatológicas: ¿es el factor de impacto un arma de doble filo?

Publication date: Available online 31 March 2018
Source:Actas Dermo-Sifiliográficas
Author(s): P. Hernández Bel

The role of folic acid-conjugated polyglycerol coated iron oxide nanoparticles on radiosensitivity with clinical electron beam (6 MeV) on human cervical carcinoma cell line: In vitro study

Publication date: Available online 30 March 2018
Source:Journal of Photochemistry and Photobiology B: Biology
Author(s): Hamid Fakhimikabir, Mohamad Bagher Tavakoli, Ali Zarrabi, Alireza Amouheidari, Soheila Rahgozar
Background and PurposeThe objective of this study was to investigate the therapeutic effect of Folic Acid-Conjugated polyglycerol coated iron oxide nanoparticles on the radiosensitivity of HeLa cells when irradiated with 6 MeV electron beams.Materials and MethodsDifferent concentrations of iron oxide nanoparticles (PG-SPIONs and FA-PG-SPIONs (25, 50, 100, 200 μg ml⁻¹)) were synthesized by the thermal decomposition technique. The effect of PG-SPIONs and FA-PG-SPIONs in combination with radiation (2, 4, 6 Gy) on the viability of cells and cell survival were estimated using the trypan blue dye exclusion test and MTT assay immediately and 48 h after irradiations, respectively.ResultsIt was observed that the penetration rate of uptake for cells treated with >50 μg ml⁻¹ FA-PG-SPIONs was more than that of non-targeted nanoparticles. The data obtained by trypan blue dye exclusion test showed no significant reduction in cell viability for all groups in comparison with control group. The results revealed that increasing the radiation doses in the presence of the concentrations of the nanoparticles increased the value of radiosensitivity. The most radiosensitivity was obtained at the highest concentration of FA-PG-SPIONs (200 μg ml⁻¹) as well as the longest radiation doses.ConclusionIt was revealed that higher concentrations of the FA-PG-SPIONs in combination with 6 MeV electron beams could enhance radiosensitization of HeLa cells.

Editorial board

Publication date: March 2018
Source:Annales de Dermatologie et de Vénéréologie, Volume 145, Issue 3

Actinomycose révélée par une ulcération du palais et de la gencive

Publication date: March 2018
Source:Annales de Dermatologie et de Vénéréologie, Volume 145, Issue 3
Author(s): F. Dessirier, J.-P. Arnault, J. Denamps, H. Sevestre, C. Attencourt, C. Lok
IntroductionL'actinomycose est une infection bactérienne granulomateuse chronique extensive. Elle est rarement révélée par une ulcération buccale.ObservationUne femme diabétique de 76 ans était traitée par dabrafenib pour un mélanome stade IV. Lors d'une consultation de suivi, on constatait deux lésions ulcérées du palais dur et de la gencive, infiltrées et hyperalgiques. Il n'y avait pas de signe associé. Le bilan biologique était sans particularité. La première hypothèse diagnostique évoquée était celle d'un carcinome épidermoïde muqueux survenu sous inhibiteurs de BRAF, bien que cette situation soit très peu décrite dans la littérature. L'examen histologique montrait un grain actinomycosique. La tomodensitométrie du massif facial ne montrait pas d'ostéite. Une antibiothérapie par amoxicilline était instaurée pendant quatre mois, avec une évolution favorable.DiscussionLes actinomycètes sont des bactéries filamenteuses Gram positif, saprophytes de la cavité buccale et du tractus gastro-intestinal, qui deviennent pathogènes sous l'influence de plusieurs facteurs. L'atteinte cervico-faciale, sous la forme d'un nodule inflammatoire péri-mandibulaire avec fistulisation secondaire à la peau ou dans la bouche, est la présentation la plus classique de l'actinomycose. Aucun cas d'infection opportuniste n'a été décrit à notre connaissance sous inhibiteurs de BRAF ; seuls deux cas de tuberculose ont été rapportés avec le sorafenib. Chez notre patiente, les soins dentaires et le diabète sont les deux facteurs favorisants retenus. Nous rappelons par ailleurs l'importance de l'examen des muqueuses chez les patients traités par inhibiteurs de BRAF.BackgroundActinomycosis is a chronic and extensive granulomatous, bacterial infection. Revelation by oral ulceration is rare.Patients and methodsA 76-year-old patient with diabetes was treated with dabrafenib for stage IV melanoma. A follow-up visit revealed two ulcerated, infiltrated and hyperalgesic lesions of the palate and gingiva. There were no associated signs. The laboratory findings were normal. The possibility of squamous cell carcinoma occurring with BRAF inhibitors was discussed, despite the rarity of such cases in the literature. Histological examination showed an actinomycotic grain. A scan of the facial mass showed no osteitis. Antimicrobial therapy was initiated with amoxicillin for four months, with a favorable outcome.DiscussionActinomycetes are Gram-positive filamentous saprophytic bacteria of the oral cavity and the gastrointestinal tract. They can become pathogenic under the influence of several factors. Cervicofacial involvement in the form of a peri-mandibular inflammatory nodule with secondary fistulation on the skin or in the mouth is the classic presentation. To our knowledge, no cases of opportunistic infection under BRAF inhibitors have been described. Only two cases of tuberculosis have been reported with sorafenib. The initial presentation led to suspicion of squamous cell carcinoma. In our patient, poor oral hygiene and diabetes were the two key factors considered. Moreover, this is the first case reported under dabrafenib, which does not appear to be a favoring factor. We would stress the importance of mucosal examination in patients treated with BRAF inhibitors.

Hydrochlorothiazide et cancers cutanés

Publication date: March 2018
Source:Annales de Dermatologie et de Vénéréologie, Volume 145, Issue 3
Author(s): J.-L. Schmutz

Linguistic convention and worldly fact

Abstract

Truth by convention, once thought to be the foundation of a uniquely promising approach to explaining our access to the truth in nonempirical domains, is nowadays widely considered an absurdity. Its fall from grace has been due largely to the influence of an argument that can be sketched as follows: our linguistic conventions have the power to make it the case that a sentence expresses a particular proposition, but they can't by themselves generate truth; whether a given proposition is true—and so whether the sentence that expresses it is true—is a matter of what the world is like, which means it isn't a matter of convention alone. The consensus is that this argument is decisive against truth by convention. Strikingly, though, it has rarely been formulated with much precision. Here I provide a new rendering of the argument, one that reveals its structure and makes transparent just what assumptions it requires, and then I assess conventionalists' prospects for resisting each of those assumptions. I conclude that the consensus is mistaken: contrary to what is almost universally thought, there remains a promising way forward for the conventionalist project. Along the way, I clarify conventionalists' commitments by thinking about what truth by convention would need to be like in order for conventionalism to do the epistemological work it's intended to do.