Estimation of the COVID‐19 Mean Incubation Time: Systematic Review, Meta‐analysis, and Sensitivity Analysis

alexandrossfakianakis shared this article with you from Inoreader Estimation of the COVID‐19 Mean Incubation Time: Systematic Review, Meta‐analysis, and Sensitivity Analysis Via Journal of Medical Virology Abstract Objectives Providing sensible estimates of the mean incubation time for COVID-19 is important yet complex. This study aims to provide sensible estimates of the mean incubation time of COVID-19 by capitalizing on available estimates reported in the literature and exploring different ways to accommodate heterogeneity involved in the reported studies. Methods Online databases between January 1 of 2020 and May 20 of 2021 are first searched to obtain estimates of the mean incubation time of COVID-19 from available studies, and meta-analyses are then conducted to generate synthetic estimates. Heterogeneity of the studies is examined via the use of Cochran's Q statistic and Higgin's & Thompson's I2 statistic, and subgroup analyses are conducted using mixed effects models. The publication bias issue is assessed using the funnel plot and Egger's test. Results Using all those reported mean incubation estimates for COVID-19, the mean incubation time is estimated to be 6.43 days with a 95% confidence interval (CI) (5.90, 6.96), and using all those reported mean incubation estimates together with those transformed median incubation estimates, the estimated mean incubation time is 6.07 days with a 95% CI (5.70,6.45). Conclusions The reported estimates of the mean incubation time of COVID-19 vary considerably due to multiple reasons, including heterogeneity and publication bias. To alleviate these issues, we take different angles to provide a sensible estimate of the mean incubation time of COVID-19. Our analyses show that the mean incubation time of COVID-19 between January 1 of 2020 and May 20 of 2021 ranges from 5.68 days to 8.30 days. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Use of Saliva and RT‐PCR Screening for SARS‐CoV‐2 Variants of Concern: Surveillance and Monitoring

alexandrossfakianakis shared this article with you from Inoreader Use of Saliva and RT‐PCR Screening for SARS‐CoV‐2 Variants of Concern: Surveillance and Monitoring Via Journal of Medical Virology ABSTRACT Genomic surveillance has been applied since the beginning of the COVID-19 pandemic to track the spread of virus, leading to characterization of multiple SARS-CoV-2 variants, including Variants of Concern (VOC). Although sequencing is the standard method, rapid molecular test for screening and surveillance of VOC is considered for detection. Furthermore, using alternative saliva as specimen collection, facilitates the implementation of a less invasive, self-collected sample. In this study, we applied a combinatory strategy of saliva collection and RT-PCR for SARS-CoV-2 VOC detection. Saliva samples from patients attending at a tertiary hospital with suspected COVID-19 were collected and SARS-CoV-2 RNA was detected using SARS-CoV-2 RT-qPCR reagent kit (PerkinElmer). Positive saliva samples were screened for SARS-CoV-2 VOC with previously described RT-PCR for Alpha, Beta and Gamma variants. Saliva samples were positive in 171 (53%) of 324 tested. A total of 108 (74%) from positive samples were also positive for VOC by RT-PCR screening. Those samples were found between January and August 2021. This approach allowed us to successfully use an alternative and complementary tool to genomic surveillance to monitoring the circulation of SARS-CoV-2 VOC in the studied population. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Glibenclamide promoted functional recovery following sciatic nerve injury

alexandrossfakianakis shared this article with you from Inoreader Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats Via Fundamental & Clinical Pharmacology Abstract The impact of peripheral nerve damage on a patient's quality of life is severe. The most frequent peripheral nerve crush damage is a sciatic nerve injury. Previous research has shown that glibenclamide (GB) has neuroprotective properties in a variety of oxidative stress-related disorders, including Alzheimer and Parkinson. The goal of this study was to see how GB affected nerve regeneration and improved function of the sciatic nerve in a rat model following a crush injury. We evaluated motor function, sensory recovery, gene expression, and histomorphometry following damage at different time points. Additionally, we assessed atrophy in the gastrocnemius muscle using histology and mass ratio analyses. Our results suggest that 2-, 4-, 6-, and 8-weeks following glibenclamide therapy, promotes the recovery of motor and sensory function in the injured site. Following glibenclamid injection, the mRNA levels of neurotrophic factors (NGF and BDNF) are raised. According to histomorphometry assessment, glibenclamide injection also increased the number of myelinated fibers while decreasing their thickness. These results showed that glibenclamide therapy by decreasing the proinflammatory and oxidant factors may enhance the nerve regeneration. It is clear that more research is needed to confirm these findings. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Clinical considerations in the surgical management of peri‐implantitis lesions in the esthetic zone

alexandrossfakianakis shared this article with you from Inoreader Clinical considerations in the surgical management of peri‐implantitis lesions in the esthetic zone Via Journal of Esthetic and Restorative Dentistry Abstract Objective The treatment of peri-implantitis is commonly associated to soft tissue changes as part of disease resolution. These changes may alter harmony in the esthetic area, and thus may negatively affect patient satisfaction. This technical note presents the key features that may lead to an unsatisfactory esthetic outcome when managing peri-implantitis in the anterior zone. Clinical Significance It is essential to consider four pivotal elements in securing therapeutic success through the resolution of inflammation while maintaining esthetics: (1) patient-related factors, including patient willingness to treat and the smile line; (2) implant-related factors that influence implant position; (3) site-related factors related to defect configuration; and (4) prosthetic-related factors referred to the prosthetic emergence profile and the type of prosthesis. A comprehensive examination must be carried out preoperatively to assess the impact of the surgical treatment upon the esthetic outcomes. Conclusion The clinician must be aware of the key features that condition the esthetic outcome when managing peri-implantitis. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sex‐specific role of alexithymia in associations between parental bonding and mental health: A moderated mediation model

alexandrossfakianakis shared this article with you from Inoreader Sex‐specific role of alexithymia in associations between parental bonding and mental health: A moderated mediation model Via Journal of Clinical Psychology Abstract Objective This study aimed to explore the role of alexithymia and potential sex differences in the associations between perceived parental bonding and mental health. Methods The sample consists of 2421 parents from the FinnBrain Birth Cohort Study who completed the parental bonding instrument, the Toronto alexithymia scale, the Edinburgh postnatal depression scale, and the anxiety subscale of the symptom checklist-90. Moderated mediation analyses were conducted to examine the possible mediating role of alexithymia and moderating role of sex in the associations between parental bonding and depressive/anxiety symptoms. Results Alexithymia was found to be a potential mediator and sex be a moderator in the relations between perceived dysfunctional parental bonding and the psychological symptoms. Specifically, dysfunctional paternal bonding, especially paternal overprotection, had stronger indirect effects (via alexithymia) on the psychological symptoms in males. Conclusions This study indicates the importance of alexithymia in the parenting-related mental health impacts and highlights the significance of paternal bonding for the development of alexithymia and mental health problems in male populations. The findings improve the limited understanding of sex-related parental factors for alexithymia and mental health problems. Future studies in longitudinal designs are warranted to clarify the causal process of the mediation. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Loss of dimethylated H3K27 (H3K27me2) expression is not a specific marker of malignant peripheral nerve sheath tumor (MPNST): An immunohistochemical study of 137 cases, with emphasis on MPNST and melanocytic tumors

alexandrossfakianakis shared this article with you from Inoreader Loss of dimethylated H3K27 (H3K27me2) expression is not a specific marker of malignant peripheral nerve sheath tumor (MPNST): An immunohistochemical study of 137 cases, with emphasis on MPNST and melanocytic tumors Via Annals of Diagnostic Pathology Publication date: Available online 6 May 2022 Source: Annals of Diagnostic Pathology Author(s): Judith Jebastin Thangaiah, Brooke E. Westling, Anja C. Roden, Caterina Giannini, Michael Tetzlaff, Woo Cheal Cho, Andrew L. Folpe View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Mass drug administration of ivermectin, diethylcarbamazine, plus albendazole compared with diethylcarbamazine plus albendazole for reduction of lymphatic filariasis endemicity in Papua New Guinea: a cluster-randomised trial

alexandrossfakianakis shared this article with you from Inoreader Mass drug administration of ivermectin, diethylcarbamazine, plus albendazole compared with diethylcarbamazine plus albendazole for reduction of lymphatic filariasis endemicity in Papua New Guinea: a cluster-randomised trial Via ScienceDirect Publication: The Lancet Infectious Diseases Publication date: Available online 6 May 2022 Source: The Lancet Infectious Diseases Author(s): Moses Laman, Livingstone Tavul, Stephan Karl, Bethuel Kotty, Zebede Kerry, Stephen Kumai, Anna Samuel, Lina Lorry, Lincoln Timinao, S Cade Howard, Leo Makita, Lucy John, Sibauk Bieb, James Wangi, Jeffrey M Albert, Michael Payne, Gary J Weil, Daniel J Tisch, Catherine M Bjerum, Leanne J Robinson View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway

alexandrossfakianakis shared this article with you from Inoreader The anti-tumor effect of proteasome inhibitor MG132 for human adenoid cystic carcinoma: correlate with the emerging role of Nrf2/Keap1 signaling pathway Via Head & Face Medicine - Latest Articles Adenoid cystic carcinoma (ACC) is one of the most common malignant salivary gland tumors. Moreover, the unique biological characteristics and complex structures of ACC contribute to its poor survival rates. Re... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Early-onset adverse events after stereotactic radiosurgery for jugular foramen schwannoma: a mid-term follow-up single-center review of 46 cases

alexandrossfakianakis shared this article with you from Inoreader Early-onset adverse events after stereotactic radiosurgery for jugular foramen schwannoma: a mid-term follow-up single-center review of 46 cases Via Radiation Oncology - Latest Articles Recently, stereotacitc radiosurgery (SRS) has been in the spotlight as an alternative therapeutic option for jugular foramen schwannomas (JFS). While most reported studies focus on the long-term efficacy and s... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Application of piecewise VMAT technique to whole-brain radiotherapy with simultaneous integrated boost for multiple metastases

alexandrossfakianakis shared this article with you from Inoreader Application of piecewise VMAT technique to whole-brain radiotherapy with simultaneous integrated boost for multiple metastases Via Radiation Oncology - Latest Articles This study implemented a piecewise volumetric modulated arc therapy (P-VMAT) for realizing whole-brain radiation therapy (WBRT) with simultaneous integrated boost (SIB) for multiple brain metastases (> 40 meta... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparison of the effects of neostigmine and sugammadex on postoperative residual curarization and postoperative pulmonary complications by means of diaphragm and lung ultrasonography: a study protocol for prospective double-blind randomized controlled trial

alexandrossfakianakis shared this article with you from Inoreader Comparison of the effects of neostigmine and sugammadex on postoperative residual curarization and postoperative pulmonary complications by means of diaphragm and lung ultrasonography: a study protocol for prospective double-blind randomized controlled trial Via Trials - Latest Articles Postoperative residual curarization (PORC) may be a potential risk factor of postoperative pulmonary complications (PPCs), and both of them will lead to adverse consequences on surgical patient recovery. The t... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The utility of PAX8 in comparison with PAX5 immunohistochemical staining in the diagnosis of Hodgkin lymphoma

alexandrossfakianakis shared this article with you from Inoreader The utility of PAX8 in comparison with PAX5 immunohistochemical staining in the diagnosis of Hodgkin lymphoma Via Annals of Diagnostic Pathology Publication date: Available online 7 May 2022 Source: Annals of Diagnostic Pathology Author(s): Fereshteh Ameli, Zahra Zahavi, Farid Kosari, Vahid Soleimani View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Characteristics of Benign Paroxysmal Positional Vertigo in Young Children

alexandrossfakianakis shared this article with you from Inoreader Characteristics of Benign Paroxysmal Positional Vertigo in Young Children Via The Laryngoscope Objectives This study aimed to determine the clinical characteristics of benign paroxysmal positional vertigo (BPPV) in young children. Study Design Retrospective case review. Methods All children <10 years old that have been diagnosed with BPPV at our pediatric vestibular program between December 2012–July 2021 were selected. Clinical features were identified by medical record review, including demographics, comorbidities, canal involvement, response to treatment, and incidence of recurrence. Results A total of 34 children were diagnosed with BPPV with a mean age of 7.9 years old (SD ± 1/7; range 5–9) at the time of diagnosis and a male:female ratio of 1:1. Involved semicircular canals included posterior in 82% (n = 28), horizontal in 41% (n = 14), and superior in 24% (n = 8) of patients, respectively. Comorbid diagnoses included migraine (n = 14), concussion (n = 10), acute vestibular syndrome (n = 4), and persistent postural perceptual dizziness (n = 6). Recurrence with initially confirmed resolution occurred in 10 patients (29%) with a mean of 2.5 recurrences per patient (SD: 2.2; range 1–8). A family history of vertigo or migraine was identified in 11 and 17 patients, respectively. Conclusions BPPV is a cause of vertigo in children that may be overlooked. A relatively high proportion of patients demonstrated horizontal or superior canal involvement, recurrence, and additional comorbid causes of dizziness. Thus, providers evaluating young children with dizziness should perform diagnostic maneuvers to evaluate BPPV of all semicircular canals and continue to monitor children after successful treatment for recurrence. Level of Evidence 4, Case Series Laryngoscope, 2022 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.