Stereotactic Ablative radiation therapy (SABR) for cardiac arrhythmia: A new therapeutic option? Radiol Med. 2020 May 13;: Authors: Fiorentino A, Gregucci F, Bonaparte I, Vitulano N, Surgo A, Mazzola R, Di Monaco A, Carbonara R, Alongi F, Langialonga T, Grimaldi M Abstract AIM: Stereotactic ablative radiation therapy (SABR) is used in non-oncologic indications, recently even for cardiac arrhythmias. Thus, aim of this analysis is to review preclinical,...
Fri May 15, 2020 14:14
Describing adverse events in Swiss hospitalized oncology patients using the Global Trigger Tool. Health Sci Rep. 2020 Jun;3(2):e160 Authors: Gerber A, Da Silva Lopes A, Szüts N, Simon M, Ribordy-Baudat V, Ebneter A, Perrinjaquet C, Gaignard ME, Nicodet D, Betticher D, Bula G, Cote M, Duchosal MA, Berret PA, Dietrich PY, Brennan C, Decosterd S, Ferreira Nobre S, Peters S, Koelliker R, Ninane F, Jeitziner MM, Colomer-Lahiguera S, Eicher M Abstract Background...
Fri May 15, 2020 14:14
Successful pregnancy following chemotherapy in a survivor of small cell carcinoma of the ovary, hypercalcemic type (SCCOHT): A case report and review of literature. Gynecol Oncol Rep. 2020 May;32:100576 Authors: Phoolcharoen N, Woodard T, James D, Patel D, Roder S, Holman D, Salcedo M, Frumovitz M, Gershenson D, Schmeler K Abstract •Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare neoplasm that mostly affects young women.•The chances...
Fri May 15, 2020 14:14
Association of PD-L1 expression by immunohistochemistry and gene microarray with molecular subtypes of ovarian tumors. Mod Pathol. 2020 May 13;: Authors: Chin CD, Fares CM, Campos M, Chen HW, Shintaku IP, Konecny GE, Rao J Abstract Identifying patients who respond to immune checkpoint blockade (ICB) is a significant challenge in oncology. While PD-L1 expression by immunohistochemistry (IHC) is the current diagnostic gold standard for patient selection,...
Fri May 15, 2020 14:14
Protein phosphorylation networks in spargana of Spirometra erinaceieuropaei revealed by phosphoproteomic analysis. Parasit Vectors. 2020 May 13;13(1):248 Authors: Liu W, Tang H, Abuzeid AMI, Tan L, Wang A, Wan X, Zhang H, Liu Y, Li G Abstract BACKGROUND: Sparganosis caused by Spirometra erinaceieuropaei spargana is a zoonotic parasitic infection that has been reported in many countries, including China, Japan, Thailand and Korea, as well as European...
Fri May 15, 2020 14:14
Combined endocrine approaches vs endocrine therapy alone as first line treatment in elderly patients with hormone receptor-positive, HER2 negative, advanced breast cancer: to prescribe for the patient or the physician? A meta-analysis of phase II and III randomized clinical trials. BMC Cancer. 2020 May 13;20(1):418 Authors: Omarini C, Piacentini F, Sperduti I, Barbolini M, Isca C, Toss A, Cortesi L, Barbieri E, Dominici M, Moscetti L Abstract BACKGROUND:...
Fri May 15, 2020 14:14
Atlas-based auto-segmentation for postoperative radiotherapy planning in endometrial and cervical cancers. Radiat Oncol. 2020 May 13;15(1):106 Authors: Kim N, Chang JS, Kim YB, Kim JS Abstract BACKGROUND: Since intensity-modulated radiation therapy (IMRT) has become popular for the treatment of gynecologic cancers, the contouring process has become more critical. This study evaluated the feasibility of atlas-based auto-segmentation (ABAS) for contouring...
Fri May 15, 2020 14:14
Coronavirus disease-2019 in cancer patients. A report of the first 25 cancer patients in a western country (Italy). Future Oncol. 2020 May 14;: Authors: Stroppa EM, Toscani I, Citterio C, Anselmi E, Zaffignani E, Codeluppi M, Cavanna L Abstract Background: We describe cancer patients with coronavirus disease-2019 (COVID-19) infection treated at the Piacenza's general hospital (north Italy). Materials & methods: Twenty-five cancer patients infected...
Fri May 15, 2020 14:14
Related ArticlesCirculating MicroRNAs as Potential Predictors of Anthracycline-Induced Troponin Elevation in Breast Cancer Patients: Diverging Effects of Doxorubicin and Epirubicin. J Clin Med. 2020 May 11;9(5): Authors: Gioffré S, Chiesa M, Cardinale DM, Ricci V, Vavassori C, Cipolla CM, Masson S, Sandri MT, Salvatici M, Ciceri F, Latini R, Staszewsky LI, Pompilio G, Colombo GI, D'Alessandra Y Abstract Anthracyclines are anti-neoplastic drugs presenting...
Fri May 15, 2020 14:14
Related ArticlesDrugComb: an integrative cancer drug combination data portal. Nucleic Acids Res. 2019 07 02;47(W1):W43-W51 Authors: Zagidullin B, Aldahdooh J, Zheng S, Wang W, Wang Y, Saad J, Malyutina A, Jafari M, Tanoli Z, Pessia A, Tang J Abstract Drug combination therapy has the potential to enhance efficacy, reduce dose-dependent toxicity and prevent the emergence of drug resistance. However, discovery of synergistic and effective drug combinations...
Fri May 15, 2020 14:14
This study investigates whether the prophylactic insertion of a Foley catheter into the afferent limb of the defunctioning loop ileostomy reduces post‐operative obstruction at the level of the fascia. Time to tolerating a low‐residue diet was similar between the Foley and no Foley group. Abstract Background Defunctioning ileostomies provide faecal diversion in major colorectal surgery. This reduces the consequences of an anastomotic leak. However, the formation of an ileostomy carries risks...
Sun May 17, 2020 19:04
Tracheostomy‐tube change protocols are implemented primarily due to concern regarding infections. However, currently no evidence‐based guidelines exist to justify these protocols. In this prospective cohort study, no statistically significant difference in colonisation in patients undergoing tube changes more than every 4 weeks to those less than every 4 weeks was found. The timing of tracheostomy‐tube changes may not affect colonisation and infection rates. Abstract Background Tracheostomy‐tube...
Sun May 17, 2020 18:58
Currently the South Pacific experience about 750 postoperative deaths per year, representing 1% of crude mortality in the region. Given that more than 400 000 procedures are needed in these countries to reach the Lancet Commission of Global Surgery target of 5000/100 000, surgical scale up would result in perioperative mortality contributing on average 3.3% of all national crude mortality, assuming the POMR stays the same which is challenging to predict. Although postoperative mortality as a proportion...
Sun May 17, 2020 18:57
Recent changes to the Australian Medicare Benefits Scheme funding for rhinoplasty on November 2018 have included a Nasal Obstruction Symptom Evaluation (NOSE) Scale threshold of >45 as a criteria for surgical intervention. The NOSE Scale is a patient‐reported outcome measure of nasal obstruction which is well validated for use in rhinoplasty and septorhinoplasty patients. Up until now, however, there has been minimal normative data for the NOSE Scale in the general population and no normative...
Sun May 17, 2020 18:56
Loop ileostomy formation is a common practice for patients undergoing low anterior resection or restorative ileo‐anal pouch surgery. Stapled and single‐layered hand‐sewn closures are similar in length of procedure, length of stay and complication rates. A two‐layer, hand‐sewn technique is associated with a significant increase in stay compared to a stapled ileostomy closure. Abstract Background Loop ileostomy (LI) formation is a common practice for patients undergoing low anterior resection...
Sun May 17, 2020 18:55
There has been a dramatic nationwide decline in the rate of ureteric re‐implantation procedure claims for children. Regional disparity between each side of the country is widening, with a current sevenfold higher claim rate in the west (Western Australia and South Australia). Further research is required to determine if this degree of variation is warranted or unwarranted. Abstract Background Management options for vesicoureteric reflux are numerous, increasingly diversifying and debated....
Sun May 17, 2020 18:55
Sun May 17, 2020 15:09
Neoadjuvant therapy is associated with significantly lower rates of post‐operative pancreatic fistula after pancreatoduodenectomy but not after distal pancreatectomy. Further studies are required to determine whether neoadjuvant therapy should be added to post‐operative pancreatic fistula risk calculators. Abstract Introduction The use of neoadjuvant therapy (NAT) for pancreatic cancer is increasing, although its impact on post‐operative pancreatic fistula (POPF) is variably reported. This...
Sun May 17, 2020 13:34
Laparoscopic surgery is associated with a lower risk of failure of early feeding compared with open surgery. Patients undergoing subtotal or total colectomy have a high rate (54%) of failure. This may assist in selecting appropriate patients for early feeding after colorectal surgery. Abstract Background Early enteral feeding and avoidance of routine nasogastric tube (NGT) placement have become standard care following colorectal surgery. However, some patients require NGT decompression post‐operatively...
Sun May 17, 2020 13:30
Abstract Background Serum C‐reactive protein (CRP) has been one of the most commonly used markers to rule out early post‐operative infection following total joint arthroplasty. The phenomenon that CRP values rise after prolonged drainage removal may occur in clinical settings. The purpose of this study is to investigate (i) the prevalence and risk factors of such a phenomenon and (ii) whether the raised CRP is associated with post‐operative infection. Methods A retrospective review of 72...
Sun May 17, 2020 13:28
Novel human factors systems analysis tool for surgical mortality and morbidity review was developed. Abstract Background The impact of systems problems and human factors on delivering safe, high‐quality patient care is well recognized. In the surgical setting, mortality and morbidity reviews (MMRs) are the key forum for reviewing and analysing adverse events in patient care yet there is a paucity of simple tools for undertaking such analyses. The aim of this study was to develop and pilot...
Sun May 17, 2020 13:24
Fri May 15, 2020 19:22
Thu May 14, 2020 21:29
There is a growing opioid crisis in the Western world. Addiction to opioids often starts with prescriptions after a hospital admission. We evaluated the feasibility of an opioid‐scarce Enhanced Recovery After Surgery (ERAS) protocol after colorectal surgery and found that opioid use was significantly reduced when this new protocol was implemented. Abstract Background The high and increasing rate of opioid use is a serious issue in the Western world affecting the population's physical and...
Thu May 14, 2020 17:16
Research about the long‐term outcomes of oesophagogastric devascularization and splenectomy (OGDS) to treat portal hypertension is scarce. The aim of this study was to evaluate the safety and the long‐term treatment efficacy of OGDS, especially in elderly patients. OGDS remains safe and effective to treat portal hypertension secondary to liver cirrhosis and it can be performed successfully in elderly patients and achieve a curative effect that is not inferior to young patients. Abstract Background...
Thu May 14, 2020 17:15
In this study, we present a retrospective review of 365 patients diagnosed with breast cancer in Counties Manukau District Health Board in 2017 and their treatment. We found a significant difference in eligibility between Māori and Pasifika women for post‐mastectomy breast reconstruction contributing to lower rates of post‐mastectomy breast reconstruction in these populations. Abstract Background Post‐mastectomy breast reconstruction (PMBR) is associated with greater quality of life and...
Thu May 14, 2020 17:14
Bleeding related to rectal varices associated with portal hypertension is rare but life‐threatening, and requires prompt treatment. Currently there is no established treatment algorithm for rectal variceal bleeding in patients with hepatic encephalopathy. We reviewed a case report of a 68‐year‐old man with Child‐Pugh B alcoholic liver cirrhosis and pre‐existing hepatic encephalopathy, of whom presented with profuse life‐threatening rectal variceal bleeding, and reviewed the literature for treatment...
Thu May 14, 2020 17:13
Laparoscopic and open techniques in rectal cancer are well published; however, technical challenges remain for mid to low rectal cancer resections in the narrow pelvis. Transanal total mesorectal excision has been pioneered to potentially circumvent these challenges. Abstract Background Laparoscopic and open techniques in rectal cancer are well‐published, however, technical challenges remain for mid to low rectal cancer resections in the narrow pelvis. Transanal total mesorectal excision...
Thu May 14, 2020 14:04
A universal analysis of the research output in Otolaryngology – Head and Neck Surgery (ORL‐HNS) in Australia and worldwide between 2008 and 2018 was conducted in this study. Furthermore, the research impact of Australian clinicians as well as trends over time were analysed. Results revealed that when adjusted for the number of practicing ORL‐HNS clinicians in each country, Australia emerged first, thus establishing itself as a research leader in ORL‐HNS. Abstract Background Obtaining research...
Thu May 14, 2020 14:04
Related ArticlesBrain herniation into the subdural space: rare iatrogenic complication of treatment of a giant calcified subdural hematoma. World Neurosurg. 2020 May 14;: Authors: Marini A, Spennato P, Aliberti F, Imperato A, Cascone D, Nastro A, Parlato S, Cinalli G Abstract BACKGROUND: Chronic subdural hematoma associated with dural calcifications in previously pediatric shunted patients is a rare condition. The inner dural membrane opening can lead...
Mon May 18, 2020 16:26
Related ArticlesPontine neoplasm or myelinolysis despite normal sodium levels. World Neurosurg. 2020 May 13;: Authors: Andereggen L, Remonda L Abstract An elderly woman was transferred for biopsy of a pontine lesion. Her condition, including gait disturbances, truncal ataxia, and dysarthria - presumed to be due to a history of severe alcohol abuse - deteriorated over the course of treatment for ambulatory-acquired pneumonia. No electrolyte abnormalities...
Sun May 17, 2020 23:59
Related ArticlesVertebral bone quality score and postoperative lumbar lordosis associated with need for reoperation after lumbar fusion. World Neurosurg. 2020 May 13;: Authors: Ehresman J, Ahmed AK, Lubelski D, Schilling A, Pennington Z, Cottrill E, McCracken J, Khan M, Witham T, Sciubba DM PMID: 32416239 [PubMed - as supplied by publisher]
Sun May 17, 2020 23:59
Related ArticlesResection of Invasive Sphenoorbital and Cavernous Sinus Meningioma via Frontotemporal Craniotomy. World Neurosurg. 2020 May 13;: Authors: Cohen MA, Cannon RB, Couldwell WT Abstract Spheno-orbital meningiomas require extensive bone removal around the superior and lateral orbital walls, superior orbital fissure, and anterior middle fossa floor. Incomplete resection can lead to recurrence or growth into the cavernous sinus (CS). This case...
Sun May 17, 2020 23:59
Related ArticlesPredicting Trends in Cervical Spinal Surgery in the United States from 2020 to 2040. World Neurosurg. 2020 May 13;: Authors: Neifert SN, Martini ML, Yuk F, McNeill IT, Caridi JM, Steinberger J, Oermann EK Abstract OBJECTIVE: To predict surgical volumes for two common cervical spine procedures from 2020 to 2040. METHODS: Utilizing the National Inpatient Sample from 2003-2016, nationwide estimates of anterior cervical discectomy...
Sun May 17, 2020 23:59
Related ArticlesIncreases in Subdural Hematoma with an Aging Population - the Future of American Cerebrovascular Disease. World Neurosurg. 2020 May 13;: Authors: Neifert SN, Chaman EK, Hardigan T, Ladner TR, Feng R, Caridi JM, Kellner CP, Oermann EK Abstract BACKGROUND: /Objective: Subdural hematomas (SDH) are a common and dangerous condition, with potential for a rapid rise in incidence given the aging United States population, but the magnitude of...
Sun May 17, 2020 23:59
Related ArticlesHow Neurosurgeons Are Coping with COVID-19 and How It Impacts Our Neurosurgical Practice: Report from Geneva University Medical Center. World Neurosurg. 2020 May 08;: Authors: Molliqaj G, Schaller K PMID: 32414671 [PubMed - as supplied by publisher]
Sun May 17, 2020 23:59
Related ArticlesNeurosurgical Training During COVID-19 Pandemic: British Perspective. World Neurosurg. 2020 May 04;: Authors: Low JCM, Visagan R, Perera A PMID: 32414670 [PubMed - as supplied by publisher]
Sun May 17, 2020 23:59
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