The Effect of Cranial Nerve Stimulation on Swallowing: A Systematic Review. Dysphagia. 2020 May 14;: Authors: Florie MGMH, Pilz W, Dijkman RH, Kremer B, Wiersma A, Winkens B, Baijens LWJ Abstract This systematic review summarizes published studies on the effect of cranial nerve stimulation (CNS) on swallowing and determines the level of evidence of the included studies to guide the development of future research on new treatment strategies for oropharyngeal...
Sat May 16, 2020 13:49
Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures. Neurology. 2020 May 14;: Authors: Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M Abstract OBJECTIVE: To evaluate the efficacy and safety of adjunctive cenobamate 200 mg/d in patients with uncontrolled focal (partial-onset) seizures despite treatment with 1 to 3 antiepileptic drugs. METHODS:...
Sat May 16, 2020 13:49
Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy. Neurobiol Aging. 2020 Apr 18;: Authors: Schijven D, Stevelink R, McCormack M, van Rheenen W, Luykx JJ, Koeleman BPC, Veldink JH, Project MinE ALS GWAS Consortium, International League Against Epilepsy Consortium on Complex Epilepsies Abstract Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide...
Sat May 16, 2020 13:49
The efficacy of cannabidiol on renal angiomyolipoma and subependymal giant cell tumor volume in tuberous sclerosis complex. J Clin Neurosci. 2020 May 11;: Authors: Barnett JR, Grinspoon RA, Harisinghani M, Caruso PA, Thiele EA Abstract In patients with tuberous sclerosis complex (TSC) the upregulation of the mechanistic target of rapamycin (mTOR) pathway leads to the development and growth of subependymal giant cell tumors (SGCTs) and renal angiomyolipomas...
Sat May 16, 2020 13:49
Lennox-Gastaut syndrome: New treatments and treatments under investigation. Rev Neurol (Paris). 2020 May 11;: Authors: Auvin S Abstract There are currently five compounds (clobazam, felbamate, lamotrigine, topiramate, rufinamide) available for prescription with a demonstrated efficacy on drop seizures for Lennox-Gastaut syndrome (LGS). There are also currently new and under-investigation compounds. This paper gives an overview on these novel developments...
Sat May 16, 2020 13:49
Related ArticlesIctal asystole with intercurrent cardiopathy: a complex combination leading to delayed diagnosis. Epileptic Disord. 2019 Dec 01;21(6):598-602 Authors: Toffa DH, Pana R, Nguyen DK Abstract Ictal asystole is a rare epileptic phenomenon, though usually self-limiting, which has been associated with an increased risk of sudden death in epileptic patients. Although early recognition is desirable, the diagnosis can be delayed until prolonged...
Sat May 16, 2020 13:49
Structure-Based Identification and Characterization of Inhibitors of the Epilepsy-Associated KNa1.1 (KCNT1) Potassium Channel. iScience. 2020 Apr 25;23(5):101100 Authors: Cole BA, Johnson RM, Dejakaisaya H, Pilati N, Fishwick CWG, Muench SP, Lippiat JD Abstract Drug-resistant epileptic encephalopathies of infancy have been associated with KCNT1 gain-of-function mutations, which increase the activity of KNa1.1 sodium-activated potassium channels. Pharmacological...
Fri May 15, 2020 15:36
Brivaracetam prevents the over-expression of synaptic vesicle protein 2A and rescues the deficits of hippocampal Long-term potentiation in vivo in chronic temporal lobe epilepsy rats. Curr Neurovasc Res. 2020 May 14;: Authors: Ge YX, Lin YY, Bi QQ, Chen YJ Abstract BACKGROUND: Patients with temporal lobe epilepsy (TLE) usually suffer from cognitive deficits and recurrent seizures. Brivaracetam (BRV) is a novel anti-epileptic drugs (AEDs) recently used...
Fri May 15, 2020 15:36
Orthostatic hypotension: clinical review and case study. Br J Nurs. 2020 May 14;29(9):506-511 Authors: Bailey R, Mortimore G Abstract Transient loss of consciousness (TLOC) accounts for 3% of all attendance in emergency departments within the UK. More than 90% of TLOC presentations are due to epileptic seizures, psychogenic seizures or syncope. However, in England and Wales in 2002, it was estimated that 92 000 patients were incorrectly diagnosed with...
Fri May 15, 2020 15:36
Exploring the mechanisms of action of the antidepressant effect of the ketogenic diet. Rev Neurosci. 2020 May 15;: Authors: Ricci A, Idzikowski MA, Soares CN, Brietzke E Abstract The ketogenic diet (KD) is characterized by a diet ratio of 4:1 fat to non-fat energy sources. For decades KD has been successfully used to control seizures in epilepsy patients. Investigations into its mechanism of action suggest that it may have an effect on the metabolic,...
Fri May 15, 2020 15:36
Carbamazepine and levetiracetam-loaded PLGA nanoparticles prepared by nanoprecipitation method: in vitro and in vivo studies. Drug Dev Ind Pharm. 2020 May 14;:1-30 Authors: Kandilli B, Ugur Kaplan AB, Cetin M, Taspinar N, Ertugrul MS, Aydin IC, Hacimuftuoglu A Abstract Objective: The aim of this study was to develop the PLGA nanoparticles (NPs) containing carbamazepine (CBZ) and levetiracetam (LEV) combination (CBZ + LEV) for the treatment of epilepsy...
Fri May 15, 2020 15:36
Related ArticlesCannabis-based medicinal products: summary of NICE guidance. BMJ. 2020 Apr 21;369:m1108 Authors: Chang-Douglass S, Mulvihill C, Pilling S, Guideline Committee PMID: 32317246 [PubMed - indexed for MEDLINE]
Fri May 15, 2020 15:36
Related ArticlesEffects of periconceptional folate on cognition in children of women with epilepsy: NEAD study. Neurology. 2020 02 18;94(7):e729-e740 Authors: Meador KJ, Pennell PB, May RC, Brown CA, Baker G, Bromley R, Loring DW, Cohen MJ, NEAD Investigator Group Abstract OBJECTIVE: Emerging evidence suggests potential positive neuropsychological effects of periconceptional folate in both healthy children and children exposed in utero to antiseizure...
Fri May 15, 2020 15:36
Related ArticlesSubicular Pyramidal Neurons: A Key to Unlock the "Black Box" of Drug Resistance in Temporal Lobe Epilepsy. Neurosci Bull. 2019 Dec;35(6):1123-1125 Authors: Hu Z, Wang X, Zhong K PMID: 31679106 [PubMed - indexed for MEDLINE]
Fri May 15, 2020 15:36
Related ArticlesHuman entorhinal cortex electrical stimulation evoked short-latency potentials in the broad neocortical regions: Evidence from cortico-cortical evoked potential recordings. Brain Behav. 2019 09;9(9):e01366 Authors: Takeyama H, Matsumoto R, Usami K, Nakae T, Kobayashi K, Shimotake A, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Takahashi R, Ikeda A Abstract OBJECTIVE: We aimed at clarifying the clinical significance of the responses...
Fri May 15, 2020 15:36
Related ArticlesClinical and neuroradiological characterisation of spinal lesions in adults with Neurofibromatosis type 1. J Clin Neurosci. 2020 May 13;: Authors: Curtis-Lopez CM, Soh C, Ealing J, Gareth Evans D, Burkitt Wright EMM, Vassallo G, Karabatsou K, Joshi George K Abstract Neurofibromatosis type 1 (NF1) manifests itself in many ways in the spine. This study aims to report the types of spinal lesions, clinical and demographic data in a large...
Mon May 18, 2020 15:08
Related ArticlesIntraventricular pseudolymphoma a case review. J Clin Neurosci. 2020 May 13;: Authors: Rajah J, Cain SA, Mews P Abstract Intracranial pseudolymphoma is a rare entity. We report the case of a 44 year old female who presented with headaches and was noted to have a right lateral ventricular lesion on a background history of Burkitt's lymphoma. She underwent biopsy of said lesion and was found to have benign reactive lymphoid tissue. This...
Mon May 18, 2020 15:08
Related ArticlesDoes endovascular therapy change outcomes in nonagenarians with acute ischemic stroke? J Clin Neurosci. 2020 May 13;: Authors: Caruso JP, Wu E, Vance AZ, Olson D, Ban VS, El-Ahmadieh T, Aoun SG, Barr JD, Novakovic R, Welch BG, White JA Abstract BACKGROUND: Ischemic strokes can be devastating for elderly patients, and randomized control trials of mechanical thrombectomy have shown encouraging results. We present the first analysis of clinical...
Mon May 18, 2020 15:08
Related ArticlesEffects of spasticity and hemiplegic posture on median nerve and carpal tunnel in stroke patients: Electrophysiological and ultrasonographic evaluation. J Clin Neurosci. 2020 May 13;: Authors: Güneş S, Genç A, Gök H, Gökmen D, Kutlay Ş Abstract This study aims to evaluate whether the upper extremity spasticity and hemiplegic posture have any effect on the morphology of the carpal tunnel and median nerve in stroke patients. Nerve conduction...
Mon May 18, 2020 15:08
Related ArticlesDeep slow nasal respiration with tight lip closure for immediate attenuation of severe tics. J Clin Neurosci. 2020 May 13;: Authors: Kaido T, Hirabayashi H, Murase N, Sasaki R, Shimokawara T, Nagata K, Bando C, Aono Y Abstract BACKGROUND: Severe intractable tics, which are associated with Tourette syndrome and chronic tic disorder (TS/CTD), severely affect the quality of life. Common less-invasive treatments are often unable to attenuate...
Mon May 18, 2020 15:08
Related ArticlesCOVID-19, SARS and MERS: A neurological perspective. J Clin Neurosci. 2020 May 05;: Authors: Ng Kee Kwong KC, Mehta PR, Shukla G, Mehta AR Abstract Central to COVID-19 pathophysiology is an acute respiratory infection primarily manifesting as pneumonia. Two months into the COVID-19 outbreak, however, a retrospective study in China involving more than 200 participants revealed a neurological component to COVID-19 in a subset of patients....
Mon May 18, 2020 15:08
Related ArticlesIntravenous Thrombolysis for Stroke in a COVID-19 Positive Filipino Patient, a Case Report. J Clin Neurosci. 2020 May 11;: Authors: Co COC, Yu JRT, Laxamana LC, David-Ona DIA Abstract The 2019 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) which was first reported in Wuhan, China last December 2019, has been declared an emergency by the World Health Organization but eventually progressed to become a Pandemic. To date, Coronavirus...
Mon May 18, 2020 03:11
Related ArticlesDeterminants of Chiari I progression in pregnancy. J Clin Neurosci. 2020 May 07;: Authors: Janjua MB, Haynie AE, Bansal V, Bhattacharia S, Grant T, McQuillan D, Passias PG, Ozturk AK, Hwang SW Abstract Chiari Malformation type 1 (CM-I) is congenital or an acquired anomaly of the hind brain; develops when the cerebellar tonsils recede downwards below the foramen magnum. Recurrent post tussive suboccipital headache is the common presentation...
Mon May 18, 2020 03:11
Facial diplegia, a possible atypical variant of Guillain-Barré Syndrome as a rare neurological complication of SARS-CoV-2. J Clin Neurosci. 2020 May 14;: Authors: Juliao Caamaño DS, Alonso Beato R Abstract We present a case of facial diplegia after 10 days of SARS-CoV-2 confirmed infection symptoms in a 61 year old patient without prior clinically relevant background. There are few known cases of Guillain-Barré Syndrome (GBS) related to SARS-CoV-2 infection;...
Sat May 16, 2020 15:18
Standard awake surgery versus hypnosis aided awake surgery for the management of high grade gliomas: A non-randomized cohort comparison controlled trial. J Clin Neurosci. 2020 May 11;: Authors: Pesce A, Palmieri M, Cofano F, Iasanzaniro M, Angelini A, D'Andrea G, Monticelli M, Zeppa P, Santonio FV, Zenga F, Salvati M, Santoro A, Garbossa D, Frati A Abstract Hypnosis could extend the time of Intraoperative Neuropsychological Testing and Brain Mapping...
Sat May 16, 2020 15:18
Direct evidence of the relationship between brain metastatic adenocarcinoma and white matter fibers: A fiber dissection and diffusion tensor imaging tractography study. J Clin Neurosci. 2020 May 11;: Authors: Liu X, Kinoshita M, Shinohara H, Hori O, Ozaki N, Hatta T, Honma S, Nakada M Abstract It is commonly known that brain metastases usually have clear boundaries in magnetic resonance imaging. However, little is known regarding the trajectory of white...
Sat May 16, 2020 15:18
Anterior spinal artery syndrome caused by thoracic disc herniation. J Clin Neurosci. 2020 May 11;: Authors: Santillan A, Goldberg JL, Carnevale JA, Kirnaz S, Hartl R, Knopman J Abstract We present a case of a midline thoracic disc herniation causing acute anterior spinal artery (ASA) syndrome successfully managed surgically. A 54-year-old female with no significant past medical history presented with sudden onset severe back pain followed by rapidly...
Sat May 16, 2020 15:18
Neurocognitive recovery and global cerebral perfusion improvement after cranioplasty in chronic sinking skin flap syndrome of 18 years: Case report using arterial spin labelling magnetic resonance perfusion imaging. J Clin Neurosci. 2020 May 11;: Authors: Woo PYM, Mak CHK, Mak HKF, Tsang ACO Abstract Sinking skin flap syndrome (SSFS) is a complication among long-term survivors of stroke or traumatic brain injury treated by decompressive craniectomy....
Sat May 16, 2020 15:18
Neurological manifestations and complications of COVID-19: A literature review. J Clin Neurosci. 2020 May 06;: Authors: Ahmad I, Rathore FA Abstract The Coronavirus disease due to SARS-CoV-2 emerged in Wuhan city, China in December 2019 and rapidly spread to more than 200 countries as a global health pandemic. There are more than 3.5 million confirmed cases and around 165,000 to 243,000 fatalities. The primary manifestation is respiratory and cardiac...
Sat May 16, 2020 15:18
Clinically suspected concomitant spinal cord and vertebrobasilar infarctions caused by fibrocartilaginous embolism. J Clin Neurosci. 2020 May 11;: Authors: Quesney G, Lefaucheur R, Hebant B Abstract Fibrocartilaginous embolism (FCE) is a rare and probably under diagnosed cause of spinal cord infarction presumably due to acute embolization of nucleus pulposus fragments into the spinal circulation. Concomitant cerebral involvement is much rarer and often...
Sat May 16, 2020 15:18
Cauda equina biopsy as a tool in the diagnosis of malignant tumors. J Clin Neurosci. 2020 May 11;: Authors: Ito K, Nakamura T, Horiuchi T, Takeshi U Abstract The prevalence of malignant lymphoma is increasing. With the advent of novel therapeutic approaches, the distinct pathology of each type of malignant lymphoma is used to tailor its treatment for the most effective outcome. Therefore, analysis of the malignant cell pathophysiology within the cauda...
Sat May 16, 2020 15:18
Spontaneous symptomatic orbital meningoencephalocele in an adult patient. Case report and review of the literature. J Clin Neurosci. 2020 May 11;: Authors: Zurita M, Candanedo C, Moscovici S, Kaye AH, Spektor S Abstract Symptomatic spontaneous meningoencephalocele (MEC) is a very rare entity in adults and there have been no reported cases of spontaneous MEC through the orbital roof in an adult. We report a 41-year-old woman who presented with a left...
Sat May 16, 2020 15:18
Lumbar cystic epidural lipomatosis with mass effect. Report of an unusual case. J Clin Neurosci. 2020 May 11;: Authors: Roberti F, Bell J, Arsenault K Abstract We present a rare case of symptomatic cystic lumbar spinal epidural lipomatosis that required surgical treatment via a minimally invasive tubular laminectomy. To our knowledge this is the first pathology confirmed report of compressive cystic lumbar spinal epidural lipomatosis available in literature.PMID:...
Sat May 16, 2020 15:18
Coexistence of COVID-19 and acute ischemic stroke report of four cases. J Clin Neurosci. 2020 May 06;: Authors: Tunç A, Ünlübaş Y, Alemdar M, Akyüz E Abstract Coronaviruses are revealed to target the human respiratory system mainly. However, they also have neuro-invasive abilities and might spread from the respiratory system to the central nervous system. Herein, we report four patients with COVID-19 simultaneously diagnosed with acute ischemic stroke....
Sat May 16, 2020 15:18
Functional outcome after surgical treatment of spinal meningioma. J Clin Neurosci. 2020 May 11;: Authors: Hohenberger C, Gugg C, Schmidt NO, Zeman F, Schebesch KM Abstract OBJECTIVE: Space-occupying spinal meningiomas (SM), commonly diagnosed due to gradual neurological deterioration, are treated surgically by decompression and tumor resection. In this series of patients with surgically treated SM, we determined individual predictors of functional outcome...
Sat May 16, 2020 15:18
Publication date: Available online 17 May 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Manil Subesinghe, Meghana Kulkarni, Gary J Cook
Mon May 18, 2020 15:06
Publication date: Available online 17 May 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Amit Gupta, Besma Musaddaq, Conrad von Stempel, Shahzad Ilyas
Sun May 17, 2020 14:56
Publication date: Available online 15 May 2020Source: Seminars in Ultrasound, CT and MRIAuthor(s): Besma Musaddaq, Talal Musaddaq, Amit Gupta, Shahzad Ilyas, Conrad von Stempel
Sat May 16, 2020 14:20
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