Combination treatments with immunotherapy in brain metastases patients. Future Oncol. 2020 May 15;: Authors: Henon C, Remon J, Hendriks LE Abstract Immune checkpoint inhibitors (ICI) have revolutionized the treatment of many advanced cancers. However, in most pivotal trials, patients with brain metastases (BM) were either excluded, or only selected patients were allowed. Therefore, there are still some concerns about the safety/efficacy ratio of ICI...
Sat May 16, 2020 13:30
Promising Immuno-Oncology Options for the Future: Cellular Therapies and Personalized Cancer Vaccines. Am Soc Clin Oncol Educ Book. 2020 May;40:1-6 Authors: Solomon BJ, Beavis PA, Darcy PK Abstract A common pathway for an effective immune anticancer response involves recognition of tumor neoantigens and subsequent targeting of cancer cells by T cells. In this article, we provide an overview of the current status of two approaches to directly enhance...
Sat May 16, 2020 13:30
Before It's Too Late: Multistakeholder Perspectives on Compassionate Access to Investigational Drugs for Pediatric Patients With Cancer. Am Soc Clin Oncol Educ Book. 2020 May;40:1-10 Authors: Gerasimov E, Donoghue M, Bilenker J, Watt T, Goodman N, Laetsch TW Abstract Patients and their families, physicians, drug companies, and regulatory agencies have common goals: to find effective therapies for life-threatening conditions. In oncology, the lines between...
Sat May 16, 2020 13:30
Pancreatic cancer in Australia: is not it time we address the inequitable resource problem? Future Oncol. 2020 May 15;: Authors: Barreto SG Abstract The present study reviewed the geographical variations in the delivery of pancreatic cancer therapy and whether this impacts overall survival. The evidence suggests a difference in the accessibility of pancreatic cancer care to patients in rural as compared with urban Australia. While centralization of pancreatic...
Sat May 16, 2020 13:30
Use of Tissue Plasminogen Activator as a Surrogate Measure for Central Venous Catheter Dysfunction and Survival Outcome in Children with Cancer: A Population-Based Retrospective Cohort Study. Pediatr Hematol Oncol. 2020 May 15;:1-7 Authors: Forbrigger Z, Kulkarni K Abstract Central venous catheter (CVC) dysfunction is often associated with thrombosis, which in turn has been linked with poorer survival outcomes in cancer patients. Our objective was to...
Sat May 16, 2020 13:30
The management of patients with metastatic prostate cancer during the COVID-19 pandemic. Future Oncol. 2020 May 15;: Authors: Assi T, Ibrahim N, K Abboud RM, Kattan C, Rassy E, Nemr E, Kattan J Abstract During the ongoing global pandemic of coronavirus disease 2019 (COVID-19), the benefit of treating patients with cancer must be weighed against the COVID-19 infection risks to patients, staff and society. Prostate cancer is one of the most common cancers...
Sat May 16, 2020 13:30
Human Uterine Biopsy: Research Value and Common Pitfalls. Int J Reprod Med. 2020;2020:9275360 Authors: Maclean A, Kamal A, Adishesh M, Alnafakh R, Tempest N, Hapangama DK Abstract The human uterus consists of the inner endometrium, the myometrium, and the outer serosa. Knowledge of the function of the uterus in health and disease is relevant to reproduction, fertility, embryology, gynaecology, endocrinology, and oncology. Research performed on uterine...
Sat May 16, 2020 13:30
Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. Front Med (Lausanne). 2020;7:162 Authors: Rekeland IG, Fosså A, Lande A, Ktoridou-Valen I, Sørland K, Holsen M, Tronstad KJ, Risa K, Alme K, Viken MK, Lie BA, Dahl O, Mella O, Fluge Ø Abstract Introduction: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disease with high symptom burden, of unknown etiology, with no established...
Sat May 16, 2020 13:30
A "Third Wheel" Effect in Health Decision Making Involving Artificial Entities: A Psychological Perspective. Front Public Health. 2020;8:117 Authors: Triberti S, Durosini I, Pravettoni G Abstract In the near future, Artificial Intelligence (AI) is expected to participate more and more in decision making processes, in contexts ranging from healthcare to politics. For example, in the healthcare context, doctors will increasingly use AI and machine learning...
Sat May 16, 2020 13:30
Evaluation and reflection on claudin 18.2 targeting therapy in advanced gastric cancer. Chin J Cancer Res. 2020 Apr;32(2):263-270 Authors: Zhang J, Dong R, Shen L Abstract Claudin 18.2 (CLDN18.2) is a tight-junction protein. CLDN18.2-targeting strategy has cut a striking figure in CLDN18.2 positive patients with advanced gastric cancer. Zolbetuximab, the CLDN18.2 antibody, obtained a better clinical benefit in patients compared with the controlled. In...
Sat May 16, 2020 13:30
Disease-free survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials. BMC Cancer. 2020 May 14;20(1):421 Authors: Nie RC, Zou XB, Yuan SQ, Chen YB, Chen S, Chen YM, Chen GM, Chen XJ, Luo TQ, Li SM, Duan JL, Wang Y, Li YF Abstract BACKGROUND: We aimed to assess whether disease-free survival (DFS) could serve as a reliable surrogate endpoint for overall survival (OS)...
Sat May 16, 2020 13:30
Promising Use Of The New Biologics In The Management Of Drug-Induced Hypersensitivity Reactions: Preliminary Approaches. Endocr Metab Immune Disord Drug Targets. 2020 May 15;: Authors: Calogiuri G, Brockow K, Nettis E, Macchia L, Foti C, Vacca A Abstract Biologics are an innovative class of drugs that can selectively influence immunological responses at a cellular level. Although their use is usually restricted to some specific diseases such as autoimmune...
Sat May 16, 2020 13:30
Outcomes of retreatment with anti-PD-1 monotherapy after response to first course in patients with cutaneous melanoma. Future Oncol. 2020 May 15;: Authors: Whitman ED, Scherrer E, Ou W, Krepler C Abstract Aim: To determine outcomes of retreatment with anti-PD-1 monotherapy for melanoma. Materials & methods: This retrospective study included adults with unresectable cutaneous melanoma who achieved stable disease (SD) or better after anti-PD-1 monotherapy...
Sat May 16, 2020 13:30
Development of a core outcome set for myelodysplastic syndromes - a Delphi study from the EUMDS Registry Group. Br J Haematol. 2020 May 14;: Authors: Rochau U, Stojkov I, Conrads-Frank A, Borba HH, Koinig KA, Arvandi M, van Marrewijk C, Garelius H, Germing U, Symeonidis A, Sanz GF, Fenaux P, de Witte T, Efficace F, Siebert U, Stauder R Abstract Treatment options for myelodysplastic syndromes (MDS) vary widely, depending on the natural disease course...
Sat May 16, 2020 13:30
The Effect of Cranial Nerve Stimulation on Swallowing: A Systematic Review. Dysphagia. 2020 May 14;: Authors: Florie MGMH, Pilz W, Dijkman RH, Kremer B, Wiersma A, Winkens B, Baijens LWJ Abstract This systematic review summarizes published studies on the effect of cranial nerve stimulation (CNS) on swallowing and determines the level of evidence of the included studies to guide the development of future research on new treatment strategies for oropharyngeal...
Sat May 16, 2020 13:30
Highlights of the 32th Annual Congress of the EANM, Barcelona 2019: the nucleolympic games of nuclear medicine-a global competition for excellence. Eur J Nucl Med Mol Imaging. 2020 May 15;: Authors: Schwarzenböck SM, Garibotto V Abstract The 32th Annual Congress of the European Association of Nuclear Medicine (EANM) returned to Barcelona, Spain, from the 12th to the 16th of October 2019, under the chairmanship of Professor Francesco Giammarile. With...
Sat May 16, 2020 13:30
Engineering of 2D transition metal carbides and nitrides MXenes for cancer therapeutics and diagnostics. J Mater Chem B. 2020 May 15;: Authors: Sundaram A, Ponraj JS, Wang C, Peng WK, Manavalan RK, Dhanabalan SC, Zhang H, Gaspar J Abstract The 2D layered structured material with unique surface terminations and properties have showed great potential in variety of biomedical research fields including drug delivery and cancer therapeutics which forms the...
Sat May 16, 2020 13:30
Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex. Sci Rep. 2020 May 14;10(1):7959 Authors: Sharp MF, Murphy VJ, Twest SV, Tan W, Lui J, Simpson KJ, Deans AJ, Crismani W Abstract DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription. ICLs can be caused by endogenous reactive metabolites or from chemotherapeutics....
Sat May 16, 2020 13:30
Tuberculosis associated with Triplet therapy for lung cancer. Thorax. 2020 May 14;: Authors: Crawley D, Breen RA, Elkington PT, Karapanagiotou E Abstract We report the first case of TB associated with triplet therapy (chemotherapy and immunotherapy concurrently) for lung cancer, developing just 44 days after treatment initiation. We feel that several important learning points arise from the discussion that are likely to be very relevant to the broad...
Sat May 16, 2020 13:30
Methodological Development of Combination Drug and Radiation Therapy in Basic and Clinical Research.
Methodological Development of Combination Drug and Radiation Therapy in Basic and Clinical Research. Clin Cancer Res. 2020 May 14;: Authors: Chargari C, Levy A, Paoletti X, Soria JC, Massard C, Weichselbaum RR, Deutsch E Abstract Newer technical improvements in radiation oncology have been rapidly implemented in recent decades, allowing an improved therapeutic ratio. The development of strategies using local and systemic treatments concurrently, mainly...
Sat May 16, 2020 13:30
How we treat patients with brain tumour during the COVID-19 pandemic. ESMO Open. 2020 May;4(Suppl 2): Authors: Weller M, Preusser M Abstract The COVID-19 pandemic has created major insecurities regarding whether we can and should maintain the current standards of diagnosis and treatment and access to care for patients with cancer. This is particularly true in the field of neuro-oncology, where the perceived benefit of therapeutic interventions is often...
Sat May 16, 2020 13:30
Understanding novel COVID-19: Its impact on organ failure and risk assessment for diabetic and cancer patients. Cytokine Growth Factor Rev. 2020 May 06;: Authors: Dariya B, Nagaraju GP Abstract The current pandemic outbreak of COVID-19 originated from Wuhan, China. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significant mortality and morbidity rate. The severe risk factors are commonly detected in patients of...
Sat May 16, 2020 13:30
Association between metabolic syndrome and recurrence of nonmuscle-invasive bladder cancer in older adults. Urol Oncol. 2020 May 11;: Authors: Garg T, Young AJ, O'Keeffe-Rosetti M, McMullen CK, Nielsen ME, Murphy TE, Kirchner HL Abstract BACKGROUND: Nonmuscle-invasive bladder cancer (NMIBC) disproportionately affects older adults who often have coexisting chronic conditions such as metabolic syndrome (MetS). Although prior research suggests that MetS...
Sat May 16, 2020 13:30
Podoplanin is a useful prognostic marker and indicates better differentiation in lung squamous cell cancer patients? A systematic review and meta-analysis. BMC Cancer. 2020 May 14;20(1):424 Authors: Hu L, Zhang P, Mei Q, Sun W, Zhou L, Yin T Abstract BACKGROUND: The CSC (cancer stem cell) markers often indicate poor prognosis and more cell invasion or migration of cancer patients. Podoplanin was assumed as a candidate CSC marker and predict poor prognosis...
Sat May 16, 2020 13:30
It takes two to tango: carers' reflections on their participation and the participation of people with dementia in the James Lind Alliance process. BMC Geriatr. 2020 May 14;20(1):175 Authors: Nygaard A, Halvorsrud L, Bye A, Bergland A Abstract BACKGROUND: Worldwide, patient and public involvement (PPI) in health research has grown steadily in recent decades. The James Lind Alliance (JLA) is one approach to PPI that brings patients, carers and clinicians...
Sat May 16, 2020 13:30
Engineering nanoparticles to reprogram radiotherapy and immunotherapy: recent advances and future challenges. J Nanobiotechnology. 2020 May 14;18(1):75 Authors: Jin J, Zhao Q Abstract Nanoparticles (NPs) have been increasingly studied for radiosensitization. The principle of NPs radio-enhancement is to use high-atomic number NPs (e.g. gold, hafnium, bismuth and gadolinium) or deliver radiosensitizing substances, such as cisplatin and selenium. Nowadays,...
Sat May 16, 2020 13:30
Galectins as Checkpoints of the Immune System in Cancers, Their Clinical Relevance, and Implication in Clinical Trials. Biomolecules. 2020 May 12;10(5): Authors: Compagno D, Tiraboschi C, Garcia JD, Rondón Y, Corapi E, Velazquez C, Laderach DJ Abstract Galectins are small proteins with pleiotropic functions, which depend on both their lectin (glycan recognition) and non-lectin (recognition of other biomolecules besides glycans) interactions. Currently,...
Sat May 16, 2020 13:30
Diabetes and Calcification: The Potential Role of Anti-Diabetic Drugs on Vascular Calcification Regression. Pharmacol Res. 2020 May 11;:104861 Authors: Ghosh S, Luo D, He W, Chen J, Su X, Huang H Abstract Vascular calcification (VC) has been well-established as an independent and strong predictor of cardiovascular diseases (CVD) as well as major cardiac adverse events (MACE). VC is associated with increased mortality in patients with CVD. Pathologically,...
Fri May 15, 2020 14:14
Future avenues for Alzheimer's disease detection and therapy: Liquid biopsy, intracellular signaling modulation, systems pharmacology drug discovery. Neuropharmacology. 2020 May 11;:108081 Authors: Hampel H, Vergallo A, Caraci F, Cuello AC, Lemercier P, Vellas B, Giudici KV, Baldacci F, Hänisch B, Haberkamp M, Broich K, Nisticò R, Emanuele E, Llavero F, Zugaza JL, Lucía A, Giacobini E, Lista S, Alzheimer Precision Medicine Initiative (APMI) Abstract ...
Fri May 15, 2020 14:14
Glycolytic activation of monocytes regulates the accumulation and function of neutrophils in human hepatocellular carcinoma. J Hepatol. 2020 May 11;: Authors: Peng ZP, Jiang ZZ, Guo HF, Zhou MM, Huang YF, Ning WR, Huang JH, Zheng L, Wu Y Abstract BACKGROUND & AIMS: Neutrophil is one of the most abundant components in human hepatocellular carcinoma (HCC) and has been shown to play important roles in regulating disease progression. But neutrophils...
Fri May 15, 2020 14:14
Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis. PLoS Med. 2020 May;17(5):e1003084 Authors: Pfeffer DA, Ley B, Howes RE, Adu P, Alam MS, Bansil P, Boum Y, Brito M, Charoenkwan P, Clements A, Cui L, Deng Z, Egesie OJ, Espino FE, von Fricken ME, Hamid MMA, He Y, Henriques G, Khan WA, Khim N, Kim S, Lacerda M, Lon C, Mekuria AH, Menard D, Monteiro W, Nosten F, Oo NN, Pal S, Palasuwan D, Parikh S, Pitaloka...
Fri May 15, 2020 14:14
Cost-effectiveness analysis of nivolumab in the second-line treatment for advanced esophageal squamous cell carcinoma. Future Oncol. 2020 May 14;: Authors: Zhang PF, Xie D, Li Q Abstract Background: To investigate the cost-effectiveness of nivolumab versus chemotherapy in the second-line treatment for advanced esophageal squamous cell carcinoma. Materials & methods: A Markov model reflecting the patients in the ATTRACTION-3 trial was established....
Fri May 15, 2020 14:14
Using biomarkers to determine optimal combinations with immunotherapy (biomarker discovery perspective). Future Oncol. 2020 May 14;: Authors: Teixido C, Reguart N PMID: 32407147 [PubMed - as supplied by publisher]
Fri May 15, 2020 14:14
Safety first: evidence for delay of radical prostatectomy without use of androgen deprivation therapy during COVID-19. Future Oncol. 2020 May 14;: Authors: Sean Ong XR, Condon B, Bagguley D, Lawrentschuk N, Azad A, Murphy D PMID: 32407145 [PubMed - as supplied by publisher]
Fri May 15, 2020 14:14
The Mediterranean diet, plasma metabolome, and cardiovascular disease risk. Eur Heart J. 2020 May 14;: Authors: Li J, Guasch-Ferré M, Chung W, Ruiz-Canela M, Toledo E, Corella D, Bhupathiraju SN, Tobias DK, Tabung FK, Hu J, Zhao T, Turman C, Feng YA, Clish CB, Mucci L, Eliassen AH, Costenbader KH, Karlson EW, Wolpin BM, Ascherio A, Rimm EB, Manson JE, Qi L, Martínez-González MÁ, Salas-Salvadó J, Hu FB, Liang L Abstract AIMS: To investigate whether metabolic...
Fri May 15, 2020 14:14
Oncology clinical trials in the time of COVID-19: how a pandemic can revolutionize patients' care. Future Oncol. 2020 May 14;: Authors: Massari F, Mollica V, Salvagni S, Tognetto M, Ardizzoni A PMID: 32406749 [PubMed - as supplied by publisher]
Fri May 15, 2020 14:14
Bacillus Calmette Guérin (BCG) vaccination use in the fight against COVID-19 - what's old is new again? Future Oncol. 2020 May 14;: Authors: O'Connor E, Teh J, Kamat AM, Lawrentschuk N PMID: 32406253 [PubMed - as supplied by publisher]
Fri May 15, 2020 14:14
Advances and future directions in the use of mobile health in supportive cancer care: proceedings of the 2019 MASCC Annual Meeting symposium. Support Care Cancer. 2020 May 14;: Authors: Chan RJ, Howell D, Lustberg MB, Mustian K, Koczwara B, Ng CC, Kim Y, Nápoles AM, Dixit N, Klemanski D, Ke Y, Toh YL, Fitch MI, Crichton M, Agarawal S, Chan A Abstract PURPOSE: The role of mobile health (mHealth) technology in cancer care has evolved alongside the rapid...
Fri May 15, 2020 14:14
Patient interactive digital support for women with adjuvant endocrine therapy in order to increase compliance and quality of life. Support Care Cancer. 2020 May 13;: Authors: Bergqvist J, Lundström S, Wengström Y Abstract PURPOSE: The primary aim of the study was to develop and investigate a patient interactive digital support (an app) for patients on adjuvant endocrine breast cancer treatment. Patient's interactive digital applications are a fast-growing...
Fri May 15, 2020 14:14
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