Imaging lutein and zeaxanthin in the human retina with confocal resonance Raman microscopy. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Li B, George EW, Rognon GT, Gorusupudi A, Ranganathan A, Chang FY, Shi L, Frederick JM, Bernstein PS Abstract Lutein and zeaxanthin are xanthophyll carotenoids that are highly concentrated in the human macula, where they protect the eye from oxidative damage and improve visual performance. Distinguishing lutein...
Sat May 16, 2020 14:05
Tenofovir prodrugs potently inhibit Epstein-Barr virus lytic DNA replication by targeting the viral DNA polymerase. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Drosu NC, Edelman ER, Housman DE Abstract Epstein-Barr virus (EBV) is a ubiquitous human γ-herpesvirus that establishes life-long infection and increases the risk for the development of several cancers and autoimmune diseases. The mechanisms by which chronic EBV infection leads to subsequent...
Sat May 16, 2020 14:05
Kinetics of pHLIP peptide insertion into and exit from a membrane. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Slaybaugh G, Weerakkody D, Engelman DM, Andreev OA, Reshetnyak YK Abstract To advance mechanistic understanding of membrane-associated peptide folding and insertion, we have studied the kinetics of three single tryptophan pHLIP (pH-Low Insertion Peptide) variants, where tryptophan residues are located near the N terminus, near the middle,...
Sat May 16, 2020 14:05
Genomic evidence for convergent evolution of gene clusters for momilactone biosynthesis in land plants. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Mao L, Kawaide H, Higuchi T, Chen M, Miyamoto K, Hirata Y, Kimura H, Miyazaki S, Teruya M, Fujiwara K, Tomita K, Yamane H, Hayashi KI, Nojiri H, Jia L, Qiu J, Ye C, Timko MP, Fan L, Okada K Abstract Momilactones are bioactive diterpenoids that contribute to plant defense against pathogens and allelopathic...
Sat May 16, 2020 14:05
Lumefantrine, an antimalarial drug, reverses radiation and temozolomide resistance in glioblastoma. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Rajesh Y, Biswas A, Kumar U, Banerjee I, Das S, Maji S, Das SK, Emdad L, Cavenee WK, Mandal M, Fisher PB Abstract Glioblastoma multiforme (GBM) is an aggressive cancer without currently effective therapies. Radiation and temozolomide (radio/TMZ) resistance are major contributors to cancer recurrence and...
Sat May 16, 2020 14:05
Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Back PS, O'Shaughnessy WJ, Moon AS, Dewangan PS, Hu X, Sha J, Wohlschlegel JA, Bradley PJ, Reese ML Abstract Apicomplexan parasites use a specialized cilium structure called the apical complex to organize their secretory organelles and invasion machinery. The apical complex is integrally...
Sat May 16, 2020 14:05
Atomic fluctuations in electronic materials revealed by dephasing. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Palato S, Seiler H, Nijjar P, Prezhdo O, Kambhampati P Abstract The microscopic origin and timescale of the fluctuations of the energies of electronic states has a significant impact on the properties of interest of electronic materials, with implication in fields ranging from photovoltaic devices to quantum information processing. Spectroscopic...
Sat May 16, 2020 14:05
Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α-dependent pathways. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Morianos I, Trochoutsou AI, Papadopoulou G, Semitekolou M, Banos A, Konstantopoulos D, Manousopoulou A, Kapasa M, Wei P, Lomenick B, Belaidi E, Kalamatas T, Karageorgiou K, Doskas T, Sallusto F, Pan F, Garbis SD, Quintana FJ, Xanthou G Abstract In multiple sclerosis (MS),...
Sat May 16, 2020 14:05
foxl3, a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Kikuchi M, Nishimura T, Ishishita S, Matsuda Y, Tanaka M Abstract Germ cells have the ability to differentiate into eggs and sperm and must determine their sexual fate. In vertebrates, the mechanism of commitment to oogenesis following the sexual fate decision in germ cells remains...
Sat May 16, 2020 14:05
Patterns of sociocognitive stratification and perinatal risk in the child brain. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Alnæs D, Kaufmann T, Marquand AF, Smith SM, Westlye LT Abstract The expanding behavioral repertoire of the developing brain during childhood and adolescence is shaped by complex brain-environment interactions and flavored by unique life experiences. The transition into young adulthood offers opportunities for adaptation and...
Sat May 16, 2020 14:05
l-Arginine sensing regulates virulence gene expression and disease progression in enteric pathogens.
l-Arginine sensing regulates virulence gene expression and disease progression in enteric pathogens. Proc Natl Acad Sci U S A. 2020 May 14;: Authors: Menezes-Garcia Z, Kumar A, Zhu W, Winter SE, Sperandio V Abstract Microbiota, host and dietary metabolites/signals compose the rich gut chemical environment, which profoundly impacts virulence of enteric pathogens. Enterohemorrhagic Escherichia coli (EHEC) engages a syringe-like machinery named type-III...
Sat May 16, 2020 14:05
Evaluation of musculoskeletal phenotype of the G608G progeria mouse model with lonafarnib, pravastatin, and zoledronic acid as treatment groups. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Cubria MB, Suarez S, Masoudi A, Oftadeh R, Kamalapathy P, DuBose A, Erdos MR, Cabral WA, Karim L, Collins FS, Snyder BD, Nazarian A Abstract Hutchinson-Gilford progeria syndrome (HGPS) is a uniformly fatal condition that is especially prevalent in skin, cardiovascular,...
Fri May 15, 2020 14:21
Chloroplast Sec14-like 1 (CPSFL1) is essential for normal chloroplast development and affects carotenoid accumulation in Chlamydomonas. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: García-Cerdán JG, Schmid EM, Takeuchi T, McRae I, McDonald KL, Yordduangjun N, Hassan AM, Grob P, Xu CS, Hess HF, Fletcher DA, Nogales E, Niyogi KK Abstract Plastid isoprenoid-derived carotenoids serve essential roles in chloroplast development and photosynthesis. Although...
Fri May 15, 2020 14:21
β-Arrestin2 is a critical component of the GPCR-eNOS signalosome. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Liu S, Luttrell LM, Premont RT, Rockey DC Abstract Endothelial cell nitric oxide (NO) synthase (eNOS), the enzyme responsible for synthesis of NO in endothelial cells, is regulated by complex posttranslational mechanisms. Sinusoidal portal hypertension, a disorder characterized by liver sinusoidal endothelial cell (SEC) injury with resultant...
Fri May 15, 2020 14:21
A trait-based understanding of wood decomposition by fungi. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Lustenhouwer N, Maynard DS, Bradford MA, Lindner DL, Oberle B, Zanne AE, Crowther TW Abstract As the primary decomposers of organic material in terrestrial ecosystems, fungi are critical agents of the global carbon cycle. Yet our ability to link fungal community composition to ecosystem functioning is constrained by a limited understanding of...
Fri May 15, 2020 14:21
Rad51 facilitates filament assembly of meiosis-specific Dmc1 recombinase. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Lan WH, Lin SY, Kao CY, Chang WH, Yeh HY, Chang HY, Chi P, Li HW Abstract Dmc1 recombinases are essential to homologous recombination in meiosis. Here, we studied the kinetics of the nucleoprotein filament assembly of Saccharomyces cerevisiae Dmc1 using single-molecule tethered particle motion experiments and in vitro biochemical...
Fri May 15, 2020 14:21
Hepsin enhances liver metabolism and inhibits adipocyte browning in mice. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Li S, Peng J, Wang H, Zhang W, Brown JM, Zhou Y, Wu Q Abstract Hepsin is a transmembrane serine protease primarily expressed in the liver. To date, the physiological function of hepsin remains poorly defined. Here we report that hepsin-deficient mice have low levels of blood glucose and lipids and liver glycogen, but increased adipose...
Fri May 15, 2020 14:21
Behavioral and environmental contributions to drosophilid social networks. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Jezovit JA, Rooke R, Schneider J, Levine JD Abstract Animals interact with each other in species-specific reproducible patterns. These patterns of organization are captured by social network analysis, and social interaction networks (SINs) have been described for a wide variety of species including fish, insects, birds, and mammals....
Fri May 15, 2020 14:21
Endogenous oxidized DNA bases and APE1 regulate the formation of G-quadruplex structures in the genome. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Roychoudhury S, Pramanik S, Harris HL, Tarpley M, Sarkar A, Spagnol G, Sorgen PL, Chowdhury D, Band V, Klinkebiel D, Bhakat KK Abstract Formation of G-quadruplex (G4) DNA structures in key regulatory regions in the genome has emerged as a secondary structure-based epigenetic mechanism for regulating...
Fri May 15, 2020 14:21
The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Saunders PM, MacLachlan BJ, Pymm P, Illing PT, Deng Y, Wong SC, Oates CVL, Purcell AW, Rossjohn J, Vivian JP, Brooks AG Abstract Micropolymorphisms within human leukocyte antigen (HLA) class I molecules can change the architecture of the peptide-binding cleft, leading to differences in peptide...
Fri May 15, 2020 14:21
Single-nucleus RNA sequencing of mouse auditory cortex reveals critical period triggers and brakes. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Kalish BT, Barkat TR, Diel EE, Zhang EJ, Greenberg ME, Hensch TK Abstract Auditory experience drives neural circuit refinement during windows of heightened brain plasticity, but little is known about the genetic regulation of this developmental process. The primary auditory cortex (A1) of mice exhibits a...
Fri May 15, 2020 14:21
Inner Workings: Technique to study poop offers a snapshot of diets, ecosystems, and climate. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: McDermott A PMID: 32404417 [PubMed - as supplied by publisher]
Fri May 15, 2020 14:21
The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission. Proc Natl Acad Sci U S A. 2020 May 13;: Authors: Stadnytskyi V, Bax CE, Bax A, Anfinrud P Abstract Speech droplets generated by asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasingly considered to be a likely mode of disease transmission. Highly sensitive laser light scattering observations have revealed...
Fri May 15, 2020 14:21
Mon May 18, 2020 03:00
Abstract Identifying physiological impairments of swallowing is essential for determining accurate diagnosis and appropriate treatment for patients with dysphagia. The hyoid bone is an anatomical landmark commonly monitored during analysis of videofluoroscopic swallow studies (VFSSs). Its displacement is predictive of penetration/aspiration and is associated with other swallow kinematic events. However, VFSSs are not always readily available/feasible and expose patients to radiation....
Sun May 17, 2020 03:00
Abstract Videofluoroscopy (VFS) is considered one of the gold-standard assessments of swallowing. Whilst guidelines for the application and conduct of VFS exist, their translation into clinical practice remain challenging. To build a greater understanding on how VFS clinics operate in the UK. A web-based survey was shared with speech and language therapists (SLTs) working in VFS clinics via professional networks and social media from October 2018 to January 2019. 101 responses...
Sat May 16, 2020 03:00
Abstract Dysphagia associated with radiotherapy for head and neck cancer is complex and can be difficult to treat. Videofluoroscopic swallow studies (VFSS) are the current gold-standard instrumented swallow assessment. High-resolution manometry (HRM) is an additional approach that provides objective measurements of swallowing-related pressures in the pharynx and esophagus. This can provide functional information on the pressure gradients underlying bolus propulsion, and is relevant...
Fri May 15, 2020 03:00
Publication date: Available online 17 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): James B. Yu, Kristy K. Brock, Allison M. Campbell, Aileen L. Chen, Roberto Diaz, Freddy Escorcia, Gaorav Gupta, William T. Hrinivich, Sabrina Joseph, Mark Korpics, Benjamin E. Onderdonk, Neeta Pandit-Taskar, Bradley Wood, Wendy A. Woodward
Mon May 18, 2020 18:00
Publication date: Available online 17 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Hwa Kyung Byun, Hong In Yoon, Jaeho Cho, Kyu-Won Shim, Jung Woo Han, Chuhl Joo Lyu, Dong-Seok Kim, Chang-Ok Suh
Mon May 18, 2020 18:00
Publication date: Available online 17 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Corey Speers, S. Laura Chang, Andrea Pesch, Cassandra Ritter, Eric Olsen, Ben Chandler, Leah Moubadder, Meilan Liu, Meleah Cameron, Anna Michmerhuizen, Kari Wilder-Romans, Shuang G. Zhao, Shyam Nyati, Harry Bartelink, Felix Y. Feng, Lori J. Pierce
Mon May 18, 2020 18:00
Publication date: Available online 16 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Hanghang Li, Xiang Chen, Wenjing Zeng, Weibing Zhou, Qin Zhou, Zhan Wang, Wuzhong Jiang, Bowen Xie, Lun-Quan Sun
Sun May 17, 2020 23:48
Publication date: Available online 15 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Limei Yin, Jianxin Xue, Rui Li, Lin Zhou, Lei Deng, Lin Chen, Yan Zhang, Yanying Li, Xuanwei Zhang, Weigang Xiu, Ruizhan Tong, Youling Gong, Meijuan Huang, Yong Xu, Jiang Zhu, Min Yu, Mengqian Li, Jie Lan, Jin Wang, Xianming Mo
Sat May 16, 2020 14:40
Publication date: Available online 14 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Whitney H. Beeler, Kent A. Griffith, Suzanne B. Evans, Daniel W. Golden, Reshma Jagsi
Fri May 15, 2020 18:52
Publication date: Available online 14 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Alice Y. Ho, Jean L. Wright, Rachel C. Blitzblau, Robert W. Mutter, Gabriel D. Duda, Larry Norton, Aditya Bardia, Laura Spring, Steven J. Isakoff, Jonathan H. Chen, Clemens Grassberger, Jennifer R. Bellon, Sushil Beriwal, Atif J. Khan, Corey Speers, Samantha A. Dunn, Alastair Thompson, Cesar A. Santa-Maria, Ian E. Krop, Elizabeth Mittendorf
Fri May 15, 2020 18:52
Publication date: Available online 14 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Rifaquat Rahman, Lorenzo Trippa, Stephanie Alden, Geoffrey Fell, Taher Abbasi, Yatin Mundkur, Neeraj K. Singh, Anay Talawdekar, Zakir Husain, Shireen Vali, Keith L. Ligon, Patrick Y. Wen, Brian M. Alexander
Fri May 15, 2020 18:52
Publication date: Available online 14 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Emilie Alvarez Andres, Lucas Fidon, Maria Vakalopoulou, Marvin Lerousseau, Alexandre Carré, Roger Sun, Guillaume Klausner, Samy Ammari, Nathan Benzazon, Sylvain Reuzé, Théo Estienne, Stéphane Niyoteka, Enzo Battistella, Angéla Rouyar, Georges Noël, Anne Beaudre, Frédéric Dhermain, Eric Deutsch, Nikos Paragios, Charlotte Robert
Fri May 15, 2020 18:52
Publication date: Available online 14 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Jeremy G. Price, Daphna Y. Spiegel, David S. Yoo, Michael J. Moravan, Yvonne M. Mowery, Donna Niedzwiecki, David M. Brizel, Joseph K. Salama
Fri May 15, 2020 18:52
Publication date: Available online 14 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Qi Liu, Zhengfei Zhu, Yun Chen, Jiaying Deng, Dashan Ai, Quan Liu, Shengping Wang, Shixiu Wu, Junqiang Chen, Kuaile Zhao
Fri May 15, 2020 18:52
Publication date: Available online 14 May 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Steven De Michino, Mansi Aparnathi, Ariana Rostami, Benjamin H. Lok, Scott V. Bratman
Fri May 15, 2020 18:52
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