Mon May 18, 2020 03:00
Mon May 18, 2020 03:00
Nature Communications, Published online: 18 May 2020; doi:10.1038/s41467-020-15785-wThe causes of the Upper Pleistocene megafauna extinction in Australia and New Guinea are debated, but fossil data are lacking for much of this region. Here, Hocknull and colleagues report a new, diverse megafauna assemblage from north-eastern Australia that persisted until ~40,000 years ago.
Mon May 18, 2020 03:00
Nature Communications, Published online: 15 May 2020; doi:10.1038/s41467-020-15894-6In contrast to bird plumage, little is known about the evolution of bird skin color. Here, Nicolaï et al. find that black skin has evolved over 100 times in birds and is associated with baldness and/or white feathers as well as with high irradiation habitats, suggesting a role in UV protection.
Fri May 15, 2020 03:00
Nature Communications, Published online: 15 May 2020; doi:10.1038/s41467-020-15715-wThe dimensional dependence of charge density wave (CDW) in two-dimensional dichalcogenides remains puzzled. Here, Lin et al. study trends of CDW ordering in an isoelectronic group of materials 2H-MX2 and provide a unified understanding involving several microscopic factors.
Fri May 15, 2020 03:00
Nature Communications, Published online: 15 May 2020; doi:10.1038/s41467-020-15922-5The α-cardiac actin M305L hypertrophic cardiomyopathy-causing mutation is located near residues that help confine tropomyosin to an inhibitory position along thin filaments. Here the authors assessed M305L actin in vivo, in vitro, and in silico to characterize emergent pathological properties and define the mechanistic basis of disease.
Fri May 15, 2020 03:00
Nature Communications, Published online: 15 May 2020; doi:10.1038/s41467-020-15939-wCurrent theories predict that a plate-like particle rotates continuously in a shear flow. Kamal et al. instead show that even nanometric hydrodynamic slip may induce a thin plate-like particle to adopt a stable orientation, and discuss implications of this effect for flow processing of 2D nanomaterials.
Fri May 15, 2020 03:00
Nature Communications, Published online: 15 May 2020; doi:10.1038/s41467-020-16175-yOur efforts to build complex synthetic biology circuits are impeded by limited knowledge of optimal combinations. In this review, the authors consider current combinatorial methods and look to emerging technologies.
Fri May 15, 2020 03:00
Nature Communications, Published online: 15 May 2020; doi:10.1038/s41467-020-16095-xDNA polymerase epsilon (Pol ε) synthesizes half of the genome in every cell cycle. Here the authors uncover a dual role of a unique domain within the Pol ε catalytic core in replisome assembly and DNA synthesis and the impact of this domain on genome stability.
Fri May 15, 2020 03:00
Nature Communications, Published online: 15 May 2020; doi:10.1038/s41467-020-16279-5An increase in genomic selection (GS) accuracy can accelerate genetic gain by shortening the breeding cycles. Here, the authors introduce a network-based GS method that uses metabolic models and improves the prediction accuracy of Arabidopsis growth within and across environments.
Fri May 15, 2020 03:00
Nature Communications, Published online: 15 May 2020; doi:10.1038/s41467-020-16199-4The development of chemoresistance is a major hurdle in triple negative breast cancer (TNBC). Here, the authors show that lysyl oxidase (LOX) is overexpressed in chemoresistant TNBCs, and when inhibited reduces collagen cross-linking, fibronectin fibril assembly, and downstream integrin signalling, overcoming resistance.
Fri May 15, 2020 03:00
Fri May 15, 2020 03:00
Fri May 15, 2020 03:00
Fri May 15, 2020 03:00
Fri May 15, 2020 03:00
Fri May 15, 2020 03:00
Fri May 15, 2020 03:00
Related ArticlesClinical Application of Mass Spectrometry-Based Proteomics in Lung Cancer Early Diagnosis. Proteomics Clin Appl. 2020 May 17;:e1900138 Authors: Gasparri R, Sedda G, Noberini R, Bonaldi T, Spaggiari L Abstract OBJECTIVES: We summarized the current knowledge on proteomic biomarker analysis for the early diagnosis of lung cancer, underlining the diversity among the results and the current interest in translating research results into clinical...
Mon May 18, 2020 15:24
Related ArticlesUpdate of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology. Clin Transl Oncol. 2020 May 16;: Authors: García-Alfonso P, García-Carbonero R, García-Foncillas J, Pérez-Segura P, Salazar R, Vera R, Ramón Y Cajal S, Hernández-Losa J, Landolfi S, Musulén E, Cuatrecasas M, Navarro S Abstract In this update of the...
Mon May 18, 2020 15:24
Related ArticlesDecreased natural killer cells in diffuse intrinsic pontine glioma patients. Childs Nerv Syst. 2020 May 16;: Authors: Zhang L, Yu H, Xue Y, Liu Y Abstract PURPOSE: Diffuse intrinsic pontine glioma (DIPG) remains the leading cause of death among pediatric brain tumor patients. Its pontine location and aggressive nature make developing effective treatment an ongoing challenge in pediatric oncology. Although studies have found that one of...
Mon May 18, 2020 15:24
Related ArticlesBuilding a hematopoietic cell transplantation outcomes registry in Mexico. Bone Marrow Transplant. 2020 May 16;: Authors: Rivera-Franco MM, Leon-Rodriguez E, Gómez-Almaguer D, Gutiérrez-Aguirre CH, Valero-Saldaña LM, Acosta-Maldonado BL, Limón-Flores JA, Pérez-Lozano U Abstract The aim of this study was to assess the feasibility of hematopoietic cell transplantation (HCT) data collection using an electronic platform at Mexican centers....
Mon May 18, 2020 15:24
Related ArticlesThe Utility of Liquid Biopsies in Radiation Oncology. Int J Radiat Oncol Biol Phys. 2020 May 14;: Authors: De Michino S, Aparnathi M, Rostami A, Lok BH, Bratman SV Abstract The use of therapeutic radiation is primarily guided by clinicopathologic factors and medical imaging, whereas molecular biomarkers currently play a comparatively minor role in most settings. Liquid biopsies provide a rich source of non-invasive tumor-specific biomarkers...
Mon May 18, 2020 15:24
Related ArticlesImproved Quantification of Cardiac Amyloid Burden in Systemic Light Chain Amyloidosis: Redefining Early Disease? JACC Cardiovasc Imaging. 2020 May 08;: Authors: Cuddy SAM, Bravo PE, Falk RH, El-Sady S, Kijewski MF, Park MA, Ruberg FL, Sanchorawala V, Landau H, Yee AJ, Bianchi G, Di Carli MF, Cheng SC, Jerosch-Herold M, Kwong RY, Liao R, Dorbala S Abstract OBJECTIVES: The purpose of this study was to determine phenotypes characterizing...
Mon May 18, 2020 15:24
Related ArticlesEffects of an exercise intervention for patients with advanced inoperable lung cancer undergoing chemotherapy: A randomized clinical trial. Lung Cancer. 2020 May 08;145:76-82 Authors: Quist M, Langer SW, Lillelund C, Winther L, Laursen JH, Christensen KB, Rørth M, Adamsen L Abstract OBJECTIVE: Exercise can improve treatment-related side effects, quality of life, and function in patients with various types of cancer; however, more evidence...
Mon May 18, 2020 00:50
Related ArticlesCheckpoint Inhibitor Pneumonitis: Mechanisms, Characteristics, Management Strategies, and Beyond. Curr Oncol Rep. 2020 May 16;22(6):56 Authors: Reuss JE, Suresh K, Naidoo J Abstract PURPOSE OF REVIEW: Checkpoint inhibitor pneumonitis (CIP) is a toxicity of immune checkpoint blockade (ICB) that can be highly morbid and at times fatal. Here, we review the proposed biologic mechanisms of CIP, epidemiology and risk factors for CIP development,...
Mon May 18, 2020 00:50
Related ArticlesWhat Drives High Costs of Cytoreductive Surgery and HIPEC: Patient, Provider or Tumor? Ann Surg Oncol. 2020 May 15;: Authors: Schwartz PB, Stahl CC, Vande Walle KA, Pokrzywa CJ, Cherney Stafford LM, Aiken T, Barrett J, Acher AW, Leverson G, Ronnekleiv-Kelly S, Weber SM, Abbott DE Abstract INTRODUCTION: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is utilized for peritoneal malignancies and is associated...
Mon May 18, 2020 00:50
Related ArticlesPrognostic impact of indoleamine 2,3-dioxygenase 1 (IDO1) mRNA expression on circulating tumour cells of patients with head and neck squamous cell carcinoma. ESMO Open. 2020 May;5(3): Authors: Economopoulou P, Kladi-Skandali A, Strati A, Koytsodontis G, Kirodimos E, Giotakis E, Maragoudakis P, Gagari E, Maratou E, Dimitriadis G, Kotsantis I, Vagia E, Anastasiou M, Gkotzamanidou M, Kavourakis G, Lianidou E, Psyrri A Abstract BACKGROUND:...
Mon May 18, 2020 00:50
Related ArticlesThe Society for Immunotherapy in Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validation. J Immunother Cancer. 2020 May;8(1): Authors: Taube JM, Akturk G, Angelo M, Engle EL, Gnjatic S, Greenbaum S, Greenwald NF, Hedvat CV, Hollmann TJ, Juco J, Parra ER, Rebelatto MC, Rimm DL, Rodriguez-Canales J, Schalper KA, Stack EC, Ferreira CS, Korski K, Lako A, Rodig SJ, Schenck E, Steele KE,...
Mon May 18, 2020 00:50
Related ArticlesFGFR2c mesenchymal isoform expression is associated with poor prognosis and further refines risk stratification within endometrial cancer molecular subtypes. Clin Cancer Res. 2020 May 15;: Authors: Sengal AT, Patch AM, Snell CE, Smith DS, Leung S, Talhouk A, Williams ED, McAlpine JN, Pollock PM Abstract PURPOSE: The two most common molecular subtypes of endometrial cancers (EC), mismatch repair deficient (MMRd) and p53 wildtype (p53wt)...
Mon May 18, 2020 00:50
Related ArticlesImpact of COVID-19 on maxillofacial surgery practice: a worldwide survey. Int J Oral Maxillofac Surg. 2020 May 03;: Authors: Maffia F, Fontanari M, Vellone V, Cascone P, Mercuri LG Abstract The outbreak of coronavirus disease 2019 (COVID-19) is rapidly changing our habits. To date, April 12, 2020, the virus has reached 209 nations, affecting 1.8 million people and causing more than 110,000 deaths. Maxillofacial surgery represents an example...
Mon May 18, 2020 00:50
Related ArticlesRisk prediction models for postoperative outcomes of colorectal cancer surgery in the older population - a systematic review. J Geriatr Oncol. 2020 May 12;: Authors: Souwer ETD, Bastiaannet E, Steyerberg EW, Dekker JT, van den Bos F, Portielje JEA Abstract BACKGROUND: An increasing number of patients with Colorectal Cancer (CRC) is 65 years or older. We aimed to systematically review existing clinical prediction models for postoperative...
Mon May 18, 2020 00:50
Related ArticlesPast, Present and Future of Epigenetics in Adrenocortical Carcinoma. Cancers (Basel). 2020 May 13;12(5): Authors: Ettaieb M, Kerkhofs T, van Engeland M, Haak H Abstract DNA methylation profiling has been suggested a reliable technique to distinguish between benign and malignant adrenocortical tumors, a process which with current diagnostic methods remains challenging and lacks diagnostic accuracy of borderline tumors. Accurate distinction...
Mon May 18, 2020 00:50
Potential of CRISPR screen in target discovery for cancer immunotherapy. Biochim Biophys Acta Rev Cancer. 2020 May 12;:188378 Authors: Liu D, Zhao X, Tang A, Xu X, Liu S, Zha L, Ma W, Zheng J, Shi M Abstract CRISPR/Cas-based genetic perturbation screens have emerged as powerful tools for large-scale identification of new targets for cancer immunotherapy. Various strategies of CRISPR screen have been used for immune-oncology (IO) target discovery. The...
Sat May 16, 2020 13:30
Cranberry capsules are not superior to placebo capsules in managing acute non-haemorrhagic radiation cystitis in prostate cancer patients: a phase III double blinded randomised placebo controlled clinical trial. Radiother Oncol. 2020 May 12;: Authors: Herst PM, Aumata A, Sword V, Jones R, Purdie G, Costello S Abstract PURPOSE: Acute radiation cystitis affects the quality of life of many prostate cancer patients. A previous pilot study suggested that...
Sat May 16, 2020 13:30
Adjuvant chemotherapy in biliary tract cancer: state of the art and future perspectives. Curr Opin Oncol. 2020 May 13;: Authors: Sanoyan DA, McNamara MG, Lamarca A, Valle JW Abstract PURPOSE OF REVIEW: Biliary tract cancers (BTCs) have a poor prognosis; most patients present with advanced disease and, even after surgical resection for early-stage disease local and distant relapses are frequent. Involved resection margins and lymph node involvement are...
Sat May 16, 2020 13:30
Immune Therapy Opportunities in Ovarian Cancer. Am Soc Clin Oncol Educ Book. 2020 May;40:1-13 Authors: Kandalaft LE, Odunsi K, Coukos G Abstract Immunotherapy has emerged as a highly promising approach in the treatment of epithelial ovarian cancer (EOC). Immune checkpoint blockade (ICB) therapy, PARP inhibitors (PARPis), neoantigen vaccines, and personalized T-cell therapy have been associated with encouraging clinical activity in a small subset of patients....
Sat May 16, 2020 13:30
Combination treatments with immunotherapy in brain metastases patients. Future Oncol. 2020 May 15;: Authors: Henon C, Remon J, Hendriks LE Abstract Immune checkpoint inhibitors (ICI) have revolutionized the treatment of many advanced cancers. However, in most pivotal trials, patients with brain metastases (BM) were either excluded, or only selected patients were allowed. Therefore, there are still some concerns about the safety/efficacy ratio of ICI...
Sat May 16, 2020 13:30
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