Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Mon May 18, 2020 03:00
British Journal of Cancer, Published online: 18 May 2020; doi:10.1038/s41416-020-0887-6UGT2B17 modifies drug response in chronic lymphocytic leukaemia
Mon May 18, 2020 03:00
British Journal of Cancer, Published online: 18 May 2020; doi:10.1038/s41416-020-0881-zEnrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis
Mon May 18, 2020 03:00
British Journal of Cancer, Published online: 18 May 2020; doi:10.1038/s41416-020-0884-9miR-622 is a novel potential biomarker of breast carcinoma and impairs motility of breast cancer cells through targeting NUAK1 kinase
Mon May 18, 2020 03:00
British Journal of Cancer, Published online: 18 May 2020; doi:10.1038/s41416-020-0872-0KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
Mon May 18, 2020 03:00
Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
British Journal of Cancer, Published online: 18 May 2020; doi:10.1038/s41416-020-0882-yImmune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?
Mon May 18, 2020 03:00
British Journal of Cancer, Published online: 18 May 2020; doi:10.1038/s41416-020-0891-xCDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms
Mon May 18, 2020 03:00
Mon May 18, 2020 01:00
Publication date: Available online 18 May 2020Source: World NeurosurgeryAuthor(s): Erwin Cornips, Michelle Grouls, Kim Bekelaar
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Publication date: Available online 17 May 2020Source: World NeurosurgeryAuthor(s): Jung Hee Byon, Eun Hae Park, Chan-Hyuk Lee
Sun May 17, 2020 23:02
Publication date: July 2020Source: World Neurosurgery, Volume 139Author(s): Hongliang Zhang, Yugong Feng, Huanting Li, Bingke Lv, Lin Wang
Sun May 17, 2020 02:18
Publication date: Available online 16 May 2020Source: World NeurosurgeryAuthor(s): Ahmad Kh. Alhaj, Tariq Al-Saadi, Fadil Mohammad, Said Alabri
Sun May 17, 2020 02:18
The importance of eating behavior risk factors in the primary prevention of obesity has been established. Researchers mostly use the linear model to determine associations among these risk factors. However, in reality, the presence of nonlinearity among these factors causes a bias in the prediction models. The aim of this study was to explore the potential of a hybrid model to predict the eating behaviors. The hybrid model of structural equation modelling (SEM) and artificial neural networks (ANN)...
Mon May 18, 2020 17:50
The general linear regression model has been one of the most frequently used models over the years, with the ordinary least squares estimator (OLS) used to estimate its parameter. The problems of the OLS estimator for linear regression analysis include that of multicollinearity and outliers, which lead to unfavourable results. This study proposed a two-parameter ridge-type modified M-estimator (RTMME) based on the M-estimator to deal with the combined problem resulting from multicollinearity and...
Fri May 15, 2020 12:05
An analysis of land cover changes (LCCs) was done in Image Forest Reserve (IFR) from August to October 2019. Free satellite images for 1990, 2004, and 2018 were downloaded from Landsat 5 (TM) and Landsat 8 (OLI) available through the USGS portal. Ground surveys were conducted using systematically set plots of 20 m × 40 m to identify the existing land cover types and human illegal activities. Geographical coordinates for each of these plots were recorded using handheld GPS. We witnessed the changes...
Fri May 15, 2020 12:05
Diabetes affects the homeostasis of the circulatory system. Crassocephalum crepidioides Benth S. Moore (Asteraceae) is an edible plant locally used in the treatment of wounds, stomach ulcer, and skin-related conditions in Africa and some other parts of the world. This study investigated the effects of C. crepidioides leaf methanol extract and fractions on blood coagulation profile of diabetic Wistar rats. The effect of 100 mg/kg body weight of the methanol extract and partitioned fractions of C....
Fri May 15, 2020 12:05
The FDA is investigating the accuracy of Abbott’s rapid coronavirus tests. (Pexels/)Follow all of PopSci’s COVID-19 coverage here, including tips on cleaning groceries, ways to tell if your symptoms are just allergies, and a tutorial on making your own mask.America is inching back to life. We still have a long way to go before we can safely do things like eat at a restaurant with family and friends, and many of the states that are rushing to reopen businesses actually still have a rising number of...
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The Earth’s atmosphere has an ozone-dense slice that prevents most UV radiation from seeping through. (NASA/)Jeremy Deaton writes for Nexus Media. You can follow him @deaton_jeremy. This story was published in partnership with Nexus Media, a syndicated newswire covering climate, energy, policy, art, and culture.You may have heard about the hole in the ozone layer, which hovers over Antarctica. It’s shrunk over time thanks to policies that curbed the use of ozone-depleting chemicals. In the nearly...
Mon May 18, 2020 23:00
Researchers at NASA and the Georgia Institute of Technology have recently devised a way for rovers to scoot over loose soils without getting stuck and even climb up steep hills without stalling. (Shrivastava et al., Sci. Robot. 5, eaba3499 (2020)/)After six years of exploring the plains of Mars, NASA’s Spirit rover was brought to a halt in May 2009 when it got stuck in soft soil near the Gusev crater. Though scientists made many attempts to free the rover, it was unable to escape and researchers...
Mon May 18, 2020 21:00
Keep vision clear with the right gear. (Hello I'm Nik via Unsplash/)If you spend hours in the pool swimming laps or regularly train in the ocean for a triathlon, protective eye gear is essential. The best swimming goggles shield your eyes from chlorine, salt water, and ultraviolet light while allowing you to clearly visualize your path to victory. Here are four great choices to help you meet your fitness goals, break a personal record, and feel as at home in the water as you do on land.These get...
Mon May 18, 2020 19:22
Yeah, that looks... complicated. (Math / Unsplash/)Cameras are complicated machines designed to harness the laws of physics to create a permanent visual record of the wonders that surround us. And take selfies. To make things easier, these gadgets—whether digital or analog—have various modes that give you different degrees of control over exposure settings, and tell your camera what you’re trying to do.If you just want to take a quick picture, use automatic mode—push the shutter and you’re done....
Mon May 18, 2020 19:00
A place for all your things. (Prashant Gurung via Unsplash/)When it comes to getting your equipment from your home to the court and back again safely, there’s no adequate alternative to a proper tennis bag. With padded zip compartments that keep your fragile, lightweight tennis racquets secure and airy ventilated pockets for sweaty shoes and clothes, tennis bags come in a variety of convenient shapes and sizes and are all designed to help your game flow and keep your commute worry-free. Keep track...
Mon May 18, 2020 18:21
Sun safety first. (Stanley Dai via Unsplash/)In as little as 15 minutes, the sun’s UV rays can do serious skin damage. Enter: sunscreen, your best friend for summers and vacations—though it should really be your best friend, every day. The sun’s UVA rays can cause sunburns, while UVB rays penetrate skin and lead to aging effects, like wrinkling, leathering or sagging skin. Both can lead to an increased risk of skin cancer. The best sunscreens provide broad-spectrum protection against both, are lightweight,...
Mon May 18, 2020 17:46
Wood wheels and 24 batteries helped this whip go down in infamy. (Courtesy american-automobiles.com/)Battery-powered whips might seem like novel additions to your local thoroughfares, but they’ve actually been around for more than a century. This is how the cars have progressed, from buggy to pickup.1890s: William Morrison’s ride (above)Scotland-native William Morrison was one of the first inventors to create an electric vehicle for America’s streets. Twenty-four batteries under the seats provided...
Mon May 18, 2020 17:18
Some places are starting to reopen—but it may still be too early (Dmitry Dreyer/Unsplash/)We’re all pretty sick of staying home by now. It’s been at least a couple long months of isolation for most Americans at this point, and as news about COVID-19 hotspots like New York City has gotten progressively less dire, more people have been itching to get out and asking at what point we’ll open back up again.That sentiment has spurred some states to start re-opening businesses and letting people back into...
Mon May 18, 2020 17:31
You don't need expensive gear to catch a few fish at the lake. (Kelly Sikkema/Unsplash/)This story was originally featured on Field & Stream.You could use one of those fancy side-scan sonar depthfinders with the new underwater fish-eye orthographic readouts. Or you could go cut a switch of bamboo and do a little cane-pole fishing. If you choose the latter, a decent cane pole is as close as the nearest stand of bamboo. Everyday ordinary, backyard bamboo works just fine for panfish, bass, and small...
Sun May 17, 2020 22:00
Video game developers often talk about immersion—a title’s ability to draw players in and create a realistic experience that helps players forget about the outside world and its litany of horrors. Battling in-game orcs sometimes sounds a lot better than tackling real-world issues—like now, for instance. But creating immersion isn’t easy. Subtle details like textures on backgrounds, light bouncing around an environment, or even the way a character’s foot interacts with the ground, can make a huge...
Sun May 17, 2020 19:00
How many triangles are actually pictured here? (Gordon Burgin/)We know you are bored at home right now—we are too. Here are some puzzles and brainteasers to challenge your family and friends with, either in person or over video chat.Whether it’s a simple square or a wonky equilateral, every polygon contains multitudes. These shapes are no different; each has dozens of smaller geometric units nested inside. Can you count them all?For a high-res printable version: Click hereTo see the answers: Click...
Sun May 17, 2020 16:00
The OnePlus website offers this see-through view of the actual 8 Pro camera modules. (OnePlus /)When OnePlus announced its 8 Pro smartphone, it included details about a curious camera that it calls the Color Filter camera. In reality, it’s an infrared (IR) camera that can pick up a part of the spectrum that your eye—and most commercial digital cameras—can’t. This gives the photos a unique, if slightly odd, look, especially after the phone has added some processing to it. Under normal circumstances,...
Sat May 16, 2020 18:00
Hardy Reef in Queensland, Australia, which is still healthy and vibrant (The Commonwealth Scientific and Industrial Research Organization (CSIRO)/)Coral reefs are in trouble. In April, Australian scientists reported that the Great Barrier Reef was suffering from another large-scale coral bleaching episode—the third in five years. This year’s bleaching appears to be even more widespread than those caused by marine heat waves in 2016 and 2017, which halved the coral cover across the reef. The trend...
Fri May 15, 2020 21:00
If you've neglected your grill, a bit of work will have it looking (and cooking) great. (Whitson Gordon/)Few things are more exciting than that first 60-degree day after a harsh winter, when you can finally break out the grill and… stare in disbelief at the rusty, charred mess in front of you. Before you admit defeat and order pizza, give that grill a good deep cleaning—you’d be surprised what a bit of elbow grease can do.“People have a tendency to forget how old their grills are, and when the last...
Fri May 15, 2020 19:00
The first finished "Loyal Wingman" prototype. (Boeing /)The US military’s most futuristic and problematic fighter jet is the F-35, a very expensive aircraft that costs the Air Force around $82 million a pop. Exorbitant price tags like that, and other considerations, are spurring aircraft makers and air forces to think about ways to augment the fighter jets they have—planes flown by people—with smaller aircraft that have no one on board.The latest full-sized prototype in this category comes from Boeing,...
Mon May 18, 2020 17:47
It's chow time. (Amazon/)When you’re rushing through coffee, collecting dry cleaning to drop off, and answering emails at the same time, sometimes you forget (or almost forget) to feed your dog before leaving the house. That’s one scenario in which a pet feeder comes in handy. Another? When you want to take a weekend trip but can’t find a cat sitter. Give yourself (and your best friend) a bit of insurance with one of these automatic pet feeders.If you tend to be forgetful, this is the feeder for...
Fri May 15, 2020 16:30
Stay chill. (Depositphotos/)There’s no denying it—when you’re far from your kitchen or takeout, an ordinary sandwich can taste extraordinary. With the right cooler, you can save lunches, snacks, and even multi-course meals for later that retain their temperature and freshness. Clever use of aluminum foil, insulated containers, and even heated bricks can turn your cooler into a warmer for use all year long. Here are four great options for the perfect outdoor nosh.Is it lunchtime yet? (Amazon/)Do you...
Fri May 15, 2020 16:16
Keep your wheels where you want them. (Josh Bean via Unsplash/)Heist film fans know that for every security system that can’t be beat, there’s someone who can beat it. Protecting your bike is no different. If someone really wants your red vintage Schwinn, they can probably figure out how to steal it. However, good bike locks can offer powerful deterrents to bike rustlers on the prowl, especially when there’s another bike just a few feet away that’s carelessly secured. These solid choices will help...
Fri May 15, 2020 16:08
A storm on Lake Michigan isn't the same as a storm on the ocean: There are different atmospheric factors and water-flow patterns that determine its ferocity. (Jentara/Deposit Photos/)A single road near Lake Superior connects Michigan’s Keweenaw Bay Indian Community to the rest of the state. During major rains, rocks and wood litter the route and cut off travel in and out. Over the summer, drivers have to take a 30-minute detour; in the winter, the trip can take more than two hours. Work crews eventually...
Sat May 16, 2020 21:02
Mon May 18, 2020 23:49
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Mon May 18, 2020 01:59
Abstract Anethole (AN) is a natural compound that has attracted great scientific interest because of its numerous biological activities, including anti-inflammatory effects. However, these effects were obtained with high doses of AN, which may be one limitation of its therapeutic use. This study evaluated the effects of a low-dose AN and ibuprofen (IB) combination on inflammatory parameters in Freund’s complete adjuvant-induced arthritis...
Mon May 18, 2020 03:00
Abstract Epilepsy is a common neurological disorder characterized by recurrent epileptic seizures. The cause of most cases of epilepsy is unknown. Although changes of calcium events in a single brain region during seizures have been reported before, there have been few studies on relations between calcium events of two different brain regions and epileptic behaviors in freely moving mice. To analyze calcium events simultaneously recorded in hippocampal CA1 (CA1) and primary motor...
Mon May 18, 2020 03:00
Abstract When an individual embodies an avatar, the latter’s characteristics or stereotype can change the individual’s behavior and attitudes; this is known as the Proteus effect. Here, we looked at whether the embodiment of an avatar resembling an elderly adult (seen from a first-person perspective and facing a virtual mirror) changed mentally represented physical activity in a motor imagery task performed by young adult participants (N = 52). To ensure that the impact of embodiment...
Sat May 16, 2020 03:00
Tissue Engineering Part A, Volume 26, Issue 9-10, Page 580-581, May 2020.
Fri May 15, 2020 10:00
Tissue Engineering Part A, Volume 26, Issue 9-10, Page 465-465, May 2020.
Fri May 15, 2020 10:00
Tissue Engineering Part A, Volume 26, Issue 9-10, Page 466-467, May 2020.
Fri May 15, 2020 10:00
Tissue Engineering Part A, Volume 26, Issue 9-10, Page 578-579, May 2020.
Fri May 15, 2020 10:00
Key PointsCALML6 attenuates NF-B signaling in vitro and in vivo. CALML6 recruits CYLD to suppress K63-linked ubiquitination of TAK1. CALML6 protects mice from LPS-induced sepsis.
Mon May 18, 2020 23:00
Key PointsThe i.t. infection of B16 melanomas by MCMV is sensed by STING. MCMV activation of STING in host cells induces antitumor immunity in B16 tumors. MCMV-infected macrophages delay tumor growth and recruit CD8 T cells via STING.
Mon May 18, 2020 23:00
In the past decade, the study of NK cells was transformed by the discovery of three ways these "innate" immune cells display adaptive immune behavior, including the ability to form long-lasting, Ag-specific memories of a wide variety of immunogens. In this review, we examine these types of NK cell memory, highlighting their unique features and underlying similarities. We explore those similarities in depth, focusing on the role that Ly49 receptors play in various types of NK cell memory. From this...
Mon May 18, 2020 23:00
Mon May 18, 2020 23:00
Key PointsGILT expression in thymic APCs enhances the negative selection of CD4+ T cells. GILT facilitates MHC class II–restricted presentation by thymic APCs. GILT expression in mTECs preferentially facilitates negative selection.
Mon May 18, 2020 23:00
Key PointsVAD causes overzealous T cell responses and tissue damage. Retinoic acid protects vitamin A–deficient mice in viral infection. Retinoic acid downregulates TCR-proximal signals.
Mon May 18, 2020 23:00
Key PointsCD137L deficiency in myeloid APCs suppresses type 1 diabetes. CD137L deficiency in pathogenic T cells enhances their diabetogenic activity. CD137 is important for the suppressive function of FOXP3+ regulatory CD4 T cells.
Mon May 18, 2020 23:00
Key PointsThere is an enhancer region within the first intron of the LILRB1 gene. The region is polymorphic and functions in NK cells. YY1 sites in the enhancer bring the enhancer into contact with the promoters.
Mon May 18, 2020 23:00
Key PointsThe TLR2 2029C/T SNP was more common in AAA patients than in healthy subjects. The homozygous recessive genotype of the TLR3 –7C/A SNP exhibited low expression. The wild-type genotype of the TLR3 –7C/A SNP was associated with hypertension.
Mon May 18, 2020 23:00
Key PointsCD56pos NKG2Chigh NK cell individuals have lower frequencies of TEMRA CD8 T cells. Depletion of NKG2Cpos NK cells augments expansion of CMV-specific CD8 T cells. NKG2Cpos NK cells negatively regulate HLA-Ehigh CD8 T cells.
Mon May 18, 2020 23:00
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