Tamai zone I fingertip replantation remains a challenging problem for surgeons. Tamai zone I fingertip replantation with venous anastomosis and without venous anastomosis is compared in this study. Though there is no difference in the survival rate between the two techniques, Tamai zone I fingertip replantantion with venous anastomosis had a better aesthetic results and fewer complications than that without venous anastomosis. Our results suggest that replantation with venous anastomosis should be...
Mon May 18, 2020 03:00
we congratulate with the authors for being so exhaustive in describing all the relevant issues the surgeon must face when approaching a columellar defect and reporting all of the reconstructive options, each one with its own advantages and limits.1
Mon May 18, 2020 03:00
No preoperative risk assessment tool is available to predict postoperative bulge formation after abdomen-based breast reconstruction. The authors evaluated the association between clinical variables and morphometric measurements on preoperative computed tomographic (CT) angiography and postoperative abdominal wall morbidity.
Mon May 18, 2020 03:00
We thank the authors for their interest in our work on digital models for anatomical education. As described, this was a student based subjective assessment of our 3D Anterolateral thigh model as a learning modality.1 Objective learning outcomes will be assessed in future studies with our newer Augmented Reality (AR) models and teaching packages which are in development. The current 3D ALT model together with our recently completed, highly anatomically accurate 3D model - the Definitive Human – are...
Mon May 18, 2020 03:00
Key PointsCD56pos NKG2Chigh NK cell individuals have lower frequencies of TEMRA CD8 T cells. Depletion of NKG2Cpos NK cells augments expansion of CMV-specific CD8 T cells. NKG2Cpos NK cells negatively regulate HLA-Ehigh CD8 T cells.
Mon May 18, 2020 23:00
Key PointsToxicity induced by a bsTCE was mediated by CD4+ T cells, CD8+ T cells, and myeloid cells. IFN- was required for modulation of T cell and myeloid populations and toxicity. Toxicity was reduced by perforin or GM-CSF deficiency and phagocyte depletion.
Mon May 18, 2020 23:00
Key PointsExpression of miR-1 is regulated by the JAK-STAT pathway. miR-1 inhibits the Dorsal/NF-B pathway by targeting MyD88. The STAT–miR-1–MyD88-Dorsal axis plays a regulatory role in immune responses.
Mon May 18, 2020 23:00
Key PointsTNF-α signals via NF-B to promote Panx1 expression. Panx1 channel signaling can regulate [Ca2+]i in HUVECs. Increased Panx1 regulates HUVEC IL-1β release and monocyte binding.
Mon May 18, 2020 23:00
Key PointsMaternal T cells drive VUE responses; fetal immune cells drive infectious etiology. Clonal overlap between VUE subjects is minimal but common in placental infection. Contrary to placental infection, VUE T cells do not recognize common viral epitopes.
Mon May 18, 2020 23:00
Key PointsZebrafish p65 is required for the antiviral response. Zebrafish p65 activates proinflammatory genes. Zebrafish p65 is involved in antiviral/IFN responses.
Mon May 18, 2020 23:00
Key PointsAnti-TNF maintains IL10 expression in CD4+ T cells at the transcriptional level. IKZF3 is enriched in IL-10+ CD4+ T cells; degrading IKZF3 disrupts IL-10 production. Overexpression of IKZF3 does not drive IL10 or activate local enhancers.
Mon May 18, 2020 23:00
Key PointsInulin enhanced susceptibility to Trichuris muris infection in C57BL/6 mice. The combination of inulin and infection caused colonic inflammation and dysbiosis. Neutralization of IFN- restored worm expulsion in inulin-fed mice.
Mon May 18, 2020 23:00
Key PointsMalat1 is suppressed during Th1 and Th2 differentiation. Malat1 loss suppresses IL-10 and Maf expression in effector Th cells. Malat1–/– mice mount enhanced immune responses in leishmaniasis and malaria models.
Mon May 18, 2020 23:00
Mon May 18, 2020 23:00
Maxillary hypoplasia is a common outcome in patients with cleft lip and palate after surgical and orthodontic interventions, and maxillary distraction osteogenesis has become a useful procedure for patients with extensive maxillary deformities. The aim of this study was to evaluate long term (two years) stability after maxillary advancement of more than 10mm by distraction osteogenesis in cleft patients using internal devices. We organised a retrospective study on 42 patients with cleft lip and palate...
Mon May 18, 2020 03:00
A recent publication by M.A. Al-Muharraqi recommends a COVID-19 testing protocol which involves both PCR and antibody testing for planned crucial head and neck surgical patients.1 Using the flowchart, surgery would proceed with the exception of where a positive PCR result is obtained in which case the patient would be allowed to recover from the illness and surgery postponed. We solely implemented a PCR testing strategy for all pre-operative elective surgical patients in our institution on 31st March.
Sat May 16, 2020 03:00
Background: Several thyroid societies have endorsed ultrasound (US) malignancy risk stratification systems for thyroid nodules and the recently released European Thyroid Imaging Reporting and Data System (EU-TIRADS) needs large prospective studies for validation. Objective: The purpose of our study was to evaluate the performance of EU-TIRADS in identifying thyroid nodules for fine-needle aspiration biopsy (FNAB) and its ability to reduce the number of unnecessary biopsies. Methods: This was a single-center...
Mon May 18, 2020 18:04
Abstract Purpose The PECARN head trauma (HT) prediction rules have been developed to guide computed tomography–related decision-making for children with minor HT (mHT). There are currently limited data on the rate of unscheduled revisits to emergency departments (EDs), and initially missed intracranial injuries, in children with mHT initially assessed using the PECARN rules. This study aimed to fill this gap in knowledge. ...
Mon May 18, 2020 03:00
Abstract Purpose Postoperative analgesia after corrective surgery of pediatric craniosynostosis is crucial in terms of short- and long-term outcomes. The objective of this observational study was to evaluate the effectiveness of an analgesic technique based on the scalp block versus traditional pharmacological approach. Methods Thirteen patients, aged...
Sun May 17, 2020 03:00
Abstract Purpose Diffuse intrinsic pontine glioma (DIPG) remains the leading cause of death among pediatric brain tumor patients. Its pontine location and aggressive nature make developing effective treatment an ongoing challenge in pediatric oncology. Although studies have found that one of the hallmark features of glioma is immunosuppression, the immune status of DIPG patient is not clearly understood. ...
Sat May 16, 2020 03:00
Abstract Purpose Extradural haematoma (EDH) is a serious neurosurgical emergency in children, which confers significant morbidity and mortality rates. The objective of this study was to retrospectively evaluate the role of post-operative imaging in children with EDH who were managed surgically in a national paediatric neurosurgical unit over a 9-year period (January 2008 to December 2016). ...
Sat May 16, 2020 03:00
Leading hearing technology manufacturers have partnered with the United States Department of Veterans Affairs (VA) to improve the remote delivery of audiology care to U.S. veterans. With the VA recently expanding the approval of more telehealth solutions, this significant move contributes to the continuity of audiological care for veterans, many of whom are particularly vulnerable to the human coronavirus. These partnerships also help in ensuring access to proper communication among veterans with...
Fri May 15, 2020 14:52
As social distancing and self-quarantines have become the norm in the face of COVID-19, individuals with hearing loss may find it difficult to get the help they need. Responding to this reality, Signia recently introduced Remote Care, a new program enabling hearing care professionals (HCPs) to prescribe, fit, and fine-tune hearing aids remotely. It also includes Signia Assistant, a new virtual assistant built upon the latest artificial intelligence technology and provides 24/7 support in the form...
Fri May 15, 2020 14:32
By Alexis GuerraWhile some states begin to lift their stay-at-home COVID-19 restrictions, many audiology practices will need to consider how to reopen safely while following local or federal guidance. To aid in navigating these times of uncertainty, the Academy of Doctors of Audiology (ADA) hosted a webinar on May 6, outlining possible return-to-work guidelines as well as HR policies and procedures.Matthew Lockaby, founder, and managing partner of Lockaby PLLC and the event's key speaker, stressed...
Fri May 15, 2020 12:31
Leading hearing technology manufacturers have partnered with the United States Department of Veterans Affairs (VA) to improve the remote delivery of audiology care to U.S. veterans. With the VA recently expanding the approval of more telehealth solutions, this significant move contributes to the continuity of audiological care for veterans, many of whom are particularly vulnerable to the human coronavirus. These partnerships also help in ensuring access to proper communication among veterans with...
Fri May 15, 2020 14:52
As social distancing and self-quarantines have become the norm in the face of COVID-19, individuals with hearing loss may find it difficult to get the help they need. Responding to this reality, Signia recently introduced Remote Care, a new program enabling hearing care professionals (HCPs) to prescribe, fit, and fine-tune hearing aids remotely. It also includes Signia Assistant, a new virtual assistant built upon the latest artificial intelligence technology and provides 24/7 support in the form...
Fri May 15, 2020 14:32
By Alexis GuerraWhile some states begin to lift their stay-at-home COVID-19 restrictions, many audiology practices will need to consider how to reopen safely while following local or federal guidance. To aid in navigating these times of uncertainty, the Academy of Doctors of Audiology (ADA) hosted a webinar on May 6, outlining possible return-to-work guidelines as well as HR policies and procedures.Matthew Lockaby, founder, and managing partner of Lockaby PLLC and the event's key speaker, stressed...
Fri May 15, 2020 12:31
Gut dysbiosis induced by high-fat diet (HFD) may result in low-grade inflammation leading to diverse inflammatory diseases. The beneficial effects of probiotics and prebiotics on obesity have been reported previously. However, their benefits in promoting human health and the underlying mechanisms still need to be further characterized. This study is aimed at understanding how probiotic Bacillus licheniformis Zhengchangsheng® (BL) and prebiotic xylooligosaccharides (XOS) influence the health of a...
Mon May 18, 2020 20:50
Perimenopausal women are associated with increased risks of depression and anxiety, which may be potentially related to the lack of ovarian hormone with antidepression activity in the body. However, the precise mechanism remains unclear so far. This study first adopted the Sprague-Dawley (SD) female rats to construct the ovariectomy (OVX) combined with a chronic unpredictable stress (CUS) model. Then, a series of behavioral experimental results revealed that the ovariectomized rats receiving CUS...
Mon May 18, 2020 18:20
Background. Prostate adenocarcinoma (PRAD) is a common malignant tumor in elderly men. Our research uses The Cancer Gene Atlas (TCGA) database to find potential related genes for predicting the prognosis of patients with PRAD. Methods. We downloaded gene expression profiles and clinical sample information from TCGA for 490 patients with PRAD (patient age: 41-78 years). We calculated stromal and immune scores using the ESTIMATE algorithm to predict the level of stromal and immune cell infiltration....
Mon May 18, 2020 17:05
Mon May 18, 2020 17:05
Allergic asthma is an inflammatory disease involving the Th1/Th2 cell imbalance in the peripheral blood. Repeated herbal acupoint sticking (RHAS) has been used for hundreds of years in China to relieve the recurrence of allergic asthma, and it is still practiced today. Thus, we explored the effect on allergic asthma relapse and the underlying immunoregulatory mechanism in this study. Here, we enrolled 50 allergic asthma participants, and 38 of them completed the treatment and follow-up (the allergic...
Mon May 18, 2020 16:50
Purpose. To evaluate the performance of amide proton transfer-weighted (APTw) imaging against the reference standard of gadolinium-enhanced T1-weighted imaging (Gd-T1w) in children with intracranial infection. Materials and Methods. Twenty-eight pediatric patients (15 males and 13 females; age range 1-163 months) with intracranial infection were recruited in this study. 2D APTw imaging and conventional MR sequences were conducted using a 3 T MRI scanner. Kappa () statistics and the McNemar test were...
Mon May 18, 2020 10:05
Aim. Our study is aimed at investigating whether Lipopolysaccharide- (LPS-) treated podocytes could polarize naive CD4+ T cells into different subsets in vitro. Materials and Methods. Podocytes and mouse bone marrow-derived dendritic cells (BMDCs) were first cultured with 25 μg/ml LPS for 6 hours, respectively. Then, naive CD4+ T cells were cocultured with the LPS-treated podocytes or BMDCs at a ratio of 1 : 1 or 1 : 1 : 1. After 48 hours, we collected the suspended cells and supernatant from all...
Mon May 18, 2020 09:50
The latest WHO guideline of CNS tumor defined a RELA fusion-positive ependymoma type with extremely poor prognosis, and the expression of L1CAM was correlated well with the presence of RELA fusion. However, the L1CAM protein expression in large sample gliomas other than ependymoma, its relationship with the RELA gene and its prognostic significance remained unknown. We examined the expression of L1CAM in 565 glioma cases (WHO grade I-IV). The L1CAM IHC-positive cases were selected to test RELA fusion...
Mon May 18, 2020 09:50
Background. Due to long-hour outdoor working environment, policemen have been subjected to tremendous health risks including blood pressure (BP) and heart rate (HR). In tropical countries, the temperature is extremely harsh which may get peak at above 40 Celsius degrees or drops under 8 Celsius degrees. However, the existing data on the effects of weather variation on BP and HR among police task force has been scarce in Vietnam. Aims. This study aimed to describe the variation of 24-hour BP and HR...
Sat May 16, 2020 19:05
Synpolydactyly type 1 (SPD1, OMIM 186000) is inherited as autosomal dominant and is caused by HOXD13 mutations. The condition is rare and is known for its phenotypic heterogeneity. In the homozygous state, the phenotype is generally more severe and is characterized by three main features: a more severe degree of syndactyly, a more severe degree of brachydactyly, and the frequent loss of the normal tubular shape of the metacarpals/metatarsals. Due to the phenotypic heterogeneity and the phenotypic...
Sat May 16, 2020 09:35
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.