Abstract Objective To investigate outcomes after surgery for rare brain tumors using the Swedish Brain Tumor Registry (SBTR). Methods This is a nationwide study of patient in the SBTR, validated in the Surveillance, Epidemiology, and End Results (SEER) registries. We included all adults diagnosed 2009–2015 with a rare brain tumor entity (n = 216),...
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Abstract Introduction Sinonasal tumors that harbor neuroendocrine histologic features include olfactory neuroblastoma (previously known as esthesioneuroblastoma), sinonasal neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma. These tumors represent a diverse spectrum of clinical behavior and as such require histology-specific management. Herein, we review the management of these sinonasal tumors with neuroendocrine features...
Mon May 18, 2020 03:00
Abstract Introduction Cognitive impairment is frequent in patients with high-grade glioma and requires cognitive follow-up. Cognitive screening tools such as the Montreal Cognitive Assessment (MoCA) have been used to assess cognition in these patients. Here we assessed the sensitivity of the MoCA in screening for cognitive impairment in a cohort of 156 patients with newly-diagnosed high-grade glioma, after surgery and before radiochemotherapy....
Fri May 15, 2020 03:00
Abstract Introduction Stereotactic radiosurgery (SRS) has shown durable local control for the treatment of metastatic diseasespinal metastases. Multilevel disease or epidural or paraspinal involvement present challenges to achieving local control, and this study aims to analyze treatment outcomes for such lesions. Methods Patients treated at a single...
Fri May 15, 2020 03:00
Abstract The influence of non-thermal plasma (NTP) treatment on the prevention of antibiotic resistance of microbial biofilms was studied. Staphylococcus epidermidis and Escherichia coli bacteria and a yeast Candida albicans, grown on the surface of Ti-6Al-4V alloy used in the manufacture of prosthetic implants, were employed. Their biofilms were exposed to NTP produced by DC cometary discharge and subsequently treated with antibiotics commonly used for the treatment of infections...
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Abstract Microbial and enzymatic degradation of keratin waste is more preferred over various conventional approaches which are costly and not environmentally suitable. Diverse niches are auspicious for the discovery of new microorganisms. To discover novel keratinolytic bacteria, 60 isolates from different poultry dumping sites were initially screened, and among these found a potent keratinolytic isolate (NKSP-7) that displayed higher feather-degrading ability. The selected isolate...
Sat May 16, 2020 03:00
Abstract The aim of the study was to identify the optimum cultivation conditions for the microalgal growth and lipid production of the oleaginous microalga Chlorella pyrenoidosa Chick (IPPAS C2). Moreover, an appropriate NO3− concentration in the cultivation medium for maximized lipid accumulation was determined. The experimental design involved a biphasic cultivation strategy with an initial biomass accumulating phase under optimized light (400 μmol/m2 per s), temperature (25 °C),...
Fri May 15, 2020 03:00
Abstract Toxoplasma gondii is an obligate intracellular protozoan parasite with domestic or free-living members of family Felidae known as the only definitive hosts of the parasite. The study aimed to evaluate the seroprevalence of toxoplasmosis in selected population groups in Slovakia and to analyse the infection risk factors. Totally 1536 serum samples of voluntary respondents were examined by EIA Toxoplasma IgG (Test-Line Ltd., Clinical Diagnostics, Brno, Czech Republic)....
Fri May 15, 2020 03:00
Abstract Halophilic bacterias from saline soil from former Lake Texcoco were isolated, identified based on 16 rRNA and tested to produce glucolytic, nucleolytic, proteolytic and lipolytic exoenzymes. The Bacillus, Virgibacillus, Kocuria, Salinicoccus, Gracilibacillus, Halobacillus, Tenuibacillus and Nesterekonia genera where identified. Lipase/eserases and proteases from Nesterenkonia sp. and Nesterenkonia aethiopica showed halotolerant characteristics and were selected to synthesize...
Fri May 15, 2020 03:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00675K, PaperZhi Fang Wu, Hui Zhou, Qian Jin Han, Xuelian Lin, Dongxue Han, Xun LiThe efficient detection of illicit drugs such as cocaine continues to be important for the area of fight against drug trafficking. Herein, we report a one-step method for rapid and...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00647E, CommunicationShi-Shu Yang, Chen Wang, Jing Xiao, Xi-Zhong Yu, Wenbin Shang, David Da Yong Chen, Zhi-Yuan GuHighly efficient enrichment of target glycopeptides plays a crucial role in glycoproteome research. Owing to their large surface area and excellent hydrophilicity, 2-D Hf-BTB nanosheets showed effective and selective enrichment...The content of this RSS Feed (c) The Royal Society of Chemistry
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Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00492H, PaperShizhuang Weng, Hecai Yuan, Xueyan Zhang, Pan Li, Ling Zheng, Jinling Zhao, Linsheng HuangSurface-enhanced Raman spectroscopy (SERS) based on machine learning methods has been applied in material analysis, biological detection, food safety, and intelligent analysis. However, machine learning methods generally require extra preprocessing...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon May 18, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00707B, CommunicationJeon Woong Kang, Soo Yeong Lim, Luis H Galindo, Hongman Yoon, Ramachandra R Dasari, Peter So, Hyung Min KimSince the fat content of pork is a deciding factor in meat quality grading, the use of a noninvasive subcutaneous probe for real time in situ monitoring of the fat...The content of this RSS Feed (c) The Royal Society of Chemistry
Mon May 18, 2020 02:00
Analyst, 2020, Accepted ManuscriptDOI: 10.1039/D0AN00622J, PaperMagnus Restan, Frøydis Sved Skottvoll, Henrik Jensen, Stig Pedersen-BjergaardThis fundamental work investigated the removal of sodium dodecyl sulfate (SDS) from highly concentrated samples by electromembrane extraction (EME). SDS concentrations were in the range 0.1-1.0% w/v, covering both sub-...The content of this RSS Feed (c) The Royal Society of Chemistry
Sat May 16, 2020 02:00
Anopheles sinensis is a major malaria vector in Southeast Asia. Resistance to pyrethroid insecticides in this species has impeded malaria control in the region. Previous studies found that An. sinensis populations from Yunnan Province, China were highly resistant to deltamethrin and did not carry mutations in the voltage-gated sodium channel gene that cause knockdown resistance. In this study, we tested the hypothesis that other genomic variants are associated with the resistance phenotype. Using...
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Genetic background commonly modifies the effects of mutations. We discovered that worms mutant for the canonical rol-1 gene, identified by Brenner in 1974, do not roll in the genetic background of the wild strain CB4856. Using linkage mapping, association analysis and gene editing, we determined that N2 carries an insertion in the collagen gene col-182 that acts as a recessive enhancer of rol-1 rolling. From population and comparative genomics, we infer the insertion is derived in N2 and related...
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In Escherichia coli, endoribonuclease RNase E initiates degradation of many RNAs and represents a hub for post-transcriptional regulation. The tetrameric adaptor protein RapZ targets the small regulatory RNA GlmZ to degradation by RNase E. RapZ binds GlmZ through a domain located at the C-terminus and interacts with RNase E, promoting GlmZ cleavage in the base-pairing region. When necessary, cleavage of GlmZ is counteracted by the homologous small RNA GlmY, which sequesters RapZ through molecular...
Mon May 18, 2020 18:48
Polyriboadenylic (poly(rA)) strands of sufficient length form parallel double helices in acidic and/or ammonium-containing conditions. Poly(rA) duplexes in acidic conditions are held together by A+–A+ base-pairing also involving base interactions with the phosphate backbone. Traditional UV-melting studies of parallel poly(A) duplexes have typically examined homo-duplex formation of a single nucleic acid species in solution. We have adapted a technique utilizing a DNA nanoswitch that detects interaction...
Fri May 15, 2020 22:42
DEAD-box proteins (DBPs) are RNA remodeling factors associated with RNA helicase activity that are found in nearly all organisms. Despite extensive studies on the mechanisms used by DBPs to regulate RNA function, very little is known about how DBPs themselves are regulated. In this work, we have analyzed the expression and regulation of DeaD/CsdA, the largest of the DBPs in Escherichia coli (E. coli). We show that deaD transcription initiates 838 nts upstream of the start of the coding region. We...
Fri May 15, 2020 20:15
Purpose: Several groups have reported a prevalence of human cytomegalovirus (CMV) in glioblastoma close to 100%. Previously, we reported that treatment with the antiviral drug valganciclovir as an add-on to standard therapy significantly prolonged survival in 50 glioblastoma patients. Here we present an updated retrospective analysis that includes an additional 52 patients. Experimental Design: From December 2006 to November 2019, 102 patients with newly diagnosed glioblastoma received valganciclovir...
Mon May 18, 2020 16:11
Purpose: The purpose of this study was to evaluate the rational combination of TORC 1/2 inhibitor TAK-228 and Aurora A kinase inhibitor alisertib in preclinical models of triple-negative breast cancer (TNBC), and to conduct a phase 1 dose escalation trial in patients with advanced solid tumors. Rxperimental Design: TNBC cell lines and patient derived xenograft (PDX) models were treated with alisertib, TAK-228 or the combination and evaluated for changes in proliferation, cell cycle, mTOR pathway...
Fri May 15, 2020 16:51
Purpose: The two most common molecular subtypes of endometrial cancers (EC), mismatch repair deficient (MMRd) and p53 wildtype (p53wt) comprise the majority of ECs and have intermediate prognoses where additional risk stratification biomarkers are needed. Isoform switching of fibroblast growth factor receptor 2 (FGFR2) from FGFR2b to FGFR2c (normally expressed in mesenchymal cells), has been reported in other solid carcinomas. The objective of this study was to investigate the role of FGFR2c in risk...
Fri May 15, 2020 16:51
Glaucoma is well-known clinical eye conditions that damage the optic nerve due to abnormal pressure conditions in eye. Hesperidin is well-known glycoside widely present in the citrus fruits, and its aglycone f...
Mon May 18, 2020 03:00
Characterization and antimicrobial activity of lectins purified from three Egyptian leguminous seeds
Lectins are carbohydrate-binding proteins that play vital roles in many biological processes. In this study, lectins from three Egyptian cultivars (fava bean, lentil, and pea) were isolated by precipitation wi...
Fri May 15, 2020 03:00
The current outbreak of the novel coronavirus disease 2019 (COVID-19) in more than 250 countries has become a serious threat to the health of people around the world. Human-to-human transmission of the Severe ...
Fri May 15, 2020 03:00
Recent cell culture media for mammalian cells can be abundantly formulated with nutrients supporting production, but such media can be limited to use in host cell culture, transfection, cell cloning, and cell ...
Fri May 15, 2020 03:00
Lactobacillus casei f1, L. paracasei f2 and L. paracasei f3 with lipolytic activity were isolated and identified from vinasses according to the morphological–physiological properties detection and 16S rDNA analys...
Fri May 15, 2020 03:00
Abstract Objectives To analyse the residual monomer (MMA) elution of polymethyl methacrylate (PMMA) in distilled water after diverse fabrication methods and aging procedures. Materials and methods PMMA specimens (N = 192, PalaXpress; Kulzer, Hanau, Germany) were manufactured (pouring, n = 96/injection, n = 96) and polymerized in water (55°C) without pressure...
Mon May 18, 2020 03:00
Abstract Objective The aim of this study was to compare the effects of AFG and i-PRF on palatal wound healing and postoperative discomfort. Materials and methods Thirty-six patients in need of FGG were divided into three groups. AFG (n = 12) or i-PRF (n = 12) was applied and compared with control group (n = 12). Wound healing with H2O2 test, VAS, MSS, and...
Mon May 18, 2020 03:00
Abstract Objectives To explore whether a computed tomography (CT) examination of the head and neck region induces biological damage and whether the damage was correlated with the radiation dose. Materials and methods Peripheral blood was taken from 33 individuals who received head and neck CT examinations. Blood samples were divided into three groups: the...
Mon May 18, 2020 03:00
Abstract Objective To assess the potential of ultrasound examination (USE) as an adjunctive method to conventional radiology to evaluate the healing processes occurring after the treatment of bone lesions of the jaws. The research question was: what is the effectiveness of USE to evaluate the healing of intra-osseous bone lesions when compared to radiological or clinical examination? ...
Sat May 16, 2020 03:00
Abstract Objectives To compare the cleanliness and erosion of root canal walls after the use of a new HEDP (1-hydroxyethane-1,1-diphosphonic acid) -based irrigant with that achieved by irrigation with sodium hypochlorite followed by EDTA. Materials and methods Forty recently extracted single-rooted teeth were prepared with ProTaper Next files to size X3,...
Sat May 16, 2020 03:00
Abstract Objectives The aim of this study was to assess in a multi-modular manner the bone healing 1 year post root-end surgery (RES) with leukocyte- and platelet-rich fibrin (LPRF) and Bio-Gide® (BG; Geistlich Pharma North America, Inc., Princeton, USA) as an occlusive membrane. Materials and methods A randomized controlled clinical trial (RCT) of RES +/−...
Sat May 16, 2020 03:00
Abstract Objectives The aim of this study was to conduct a systematic review and meta-analysis on the efficacy of growth factors (GF) on clinical outcomes after treatment (surgical/non-surgical) of peri-implant diseases (peri-implant mucositis and peri-implantitis). Materials and methods A protocol was developed to answer the following focused question: Is...
Sat May 16, 2020 03:00
Abstract Objectives To assess complete blood count (CBC) dynamics following ligature removal and open flap debridement in experimental peri-implantitis in dogs. Materials and methods Seven male beagle dogs were included in the study. Four rough-surface implants were placed pair-wise in both sides of the mandible 14 weeks after tooth extraction. Second stage...
Sat May 16, 2020 03:00
Abstract Objectives To evaluate the effect of non-viral gene therapy on human dental pulp stem cells (DPSCs) in an in vitro and an ex vivo model. Materials and methods Nanoplexes comprising polyethyleneimine (PEI) and plasmid DNA (pDNA) encoding for fibroblast growth factor-2 (pFGF-2) and bone morphogenic protein-2 (pBMP-2) were cultured with DPSCs to evaluate...
Fri May 15, 2020 03:00
Ελληνική μελέτη που εντοπίζει σημαντική αλληλουχία στην πρωτεϊνη S («ακίδα») του νέου κορωνοϊού SARS-CoV-2, η οποία είναι ομόλογη με νευροτοξίνη φιδιού, είναι προς κρίση για δημοσίευση στο επιστημονικό περιοδικό FEBS Journal. Η μελέτη που τη Δευτέρα, στo preprints.com, υπό τον τίτλο «Nicotinic Cholinergic System and COVID-19: Identification of a Potentially Crucial Snake Toxin-Like Sequence in the SARS-CoV-2 Spike Glycoprotein«, έγινε από τους Κωνσταντίνο Φαρσαλινό, Ηλία Ηλιόπουλο,...
Mon May 18, 2020 21:45
Γράφει ο Αντώνης Δημητρακόπουλος, Παθολόγος, Διευθυντής του Γ’ Παθολογικού Τμήματος του Νοσοκομείου Ερρίκος Ντυνάν και ειδικός σύμβουλος παθολόγος του «Αιγινήτειου» Νοσοκομείου Ο ρόλος που παίζουν τα παιδιά στην εξάπλωση του κορωνοϊού αποτελεί έναν από τους σημαντικότερους αστάθμιστους παράγοντες από την αρχή της πανδημίας. Σήμερα, καθώς αρκετές χώρες ανοίγουν και πάλι τα σχολεία, οι επιστήμονες προσπαθούν να δώσουν απαντήσεις στα ερωτήματα σχετικά με το ποσοστό μετάδοσης της νόσου από τον πληθυσμό...
Mon May 18, 2020 17:19
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