Publication date: July 2020Source: European Journal of Cancer, Volume 133Author(s): Petra Ketteler, Isabel Hülsenbeck, Mirjam Frank, Börge Schmidt, Karl-Heinz Jöckel, Dietmar R. Lohmann
Mon May 18, 2020 17:55
Publication date: July 2020Source: European Journal of Cancer, Volume 133Author(s): Koji Matsuo, Shinya Matsuzaki, David J. Nusbaum, Hiroko Machida, Yoshikazu Nagase, Brendan H. Grubbs, Lynda D. Roman, Jason D. Wright, Philipp Harter, Maximilian Klar
Mon May 18, 2020 17:55
Publication date: Available online 18 May 2020Source: European Journal of CancerAuthor(s): Michela Roberto, Fabio Basta, Federica Mazzuca, Giuseppe Curgliano, Paolo Marchetti
Mon May 18, 2020 17:55
Publication date: Available online 18 May 2020Source: European Journal of CancerAuthor(s): Rami Nassabein, Bertrand Routy, Normand Blais, Jean-pierre Ayoub, Mustapha Tehfé
Mon May 18, 2020 17:55
Publication date: Available online 16 May 2020Source: European Journal of CancerAuthor(s): Alberto Bongiovanni, Laura Mercatali, Valentina Fausti, Toni Ibrahim
Sun May 17, 2020 18:15
Publication date: July 2020Source: European Journal of Cancer, Volume 133Author(s): Yoko Tsukita, Eisaku Miyauchi, Masahide Fukudo, Takaaki Sasaki, Masakazu Ichinose
Sat May 16, 2020 14:41
Publication date: July 2020Source: European Journal of Cancer, Volume 133Author(s): Jason K. Sicklick, Shumei Kato, Ryosuke Okamura, Razelle Kurzrock
Sat May 16, 2020 14:41
Publication date: July 2020Source: European Journal of Cancer, Volume 133Author(s): Hans H.B. Wenzel, Ramon G.V. Smolders, Jogchum J. Beltman, Sandrina Lambrechts, Hans W. Trum, Refika Yigit, Petra L.M. Zusterzeel, Ronald P. Zweemer, Constantijne H. Mom, Ruud L.M. Bekkers, Valery E.P.P. Lemmens, Hans W. Nijman, Maaike A. Van der Aa
Sat May 16, 2020 14:41
Publication date: July 2020Source: European Journal of Cancer, Volume 133Author(s): Bryan V. Dieffenbach, Nan Li, Arin L. Madenci, Andrew J. Murphy, Dana Barnea, Todd M. Gibson, Emily S. Tonorezos, Wendy M. Leisenring, Rebecca M. Howell, Lisa R. Diller, Qi Liu, Eric J. Chow, Gregory T. Armstrong, Yutaka Yasui, Kevin C. Oeffinger, Christopher B. Weldon, Brent R. Weil
Sat May 16, 2020 14:41
Comparative sequence analyses have been used to discover numerous classes of structured noncoding RNAs, some of which are riboswitches that specifically recognize small-molecule or elemental ion ligands and influence expression of adjacent downstream genes. Determining the correct identity of the ligand for a riboswitch candidate typically is aided by an understanding of the genes under its regulatory control. Riboswitches whose ligands were straightforward to identify have largely been associated...
Mon May 18, 2020 16:30
Fragments of mature tRNAs have long been considered as mere degradation products without physiological function. However, recent reports show that tRNA-derived small RNAs (tsRNAs) play prominent roles in diverse cellular processes across a wide spectrum of species. Contrasting the situation in other small RNA pathways the mechanisms behind these effects appear more diverse, more complex, and are generally less well understood. In addition, surprisingly little is known about the expression profiles...
Mon May 18, 2020 16:30
N6-methyladenosine (m6A) is an abundant post-transcriptional modification that can impact RNA fate via interactions with m6A-specific RNA binding proteins. Despite accumulating evidence that m6A plays an important role in modulating pluripotency, the influence of m6A reader proteins in pluripotency is less clear. Here, we report that YTHDF2, an m6A reader associated with mRNA degradation, is highly expressed in induced pluripotent stem cells (iPSCs) and down-regulated during neural differentiation....
Mon May 18, 2020 16:30
Human immunodeficiency virus type 1 (HIV-1) transcripts have three fates: to serve as genomic RNAs, unspliced mRNAs, or spliced subgenomic mRNAs. Recent structural studies have shown that sequences near the 5' end of HIV-1 RNA can adopt at least two alternate three-dimensional conformations, and that these structures dictate genome versus unspliced mRNA fates. HIV-1's use of alternate transcription start sites (TSS) can influence which RNA conformer is generated, and this choice, in turn, dictates...
Mon May 18, 2020 16:30
DNA replication occurs on mammalian chromosomes in a cell-type distinctive temporal order known as the replication timing program. We previously found that disruption of the noncanonical lncRNA genes ASAR6 and ASAR15 results in delayed replication timing and delayed mitotic chromosome condensation of human chromosomes 6 and 15, respectively. ASAR6 and ASAR15 display random monoallelic expression and display asynchronous replication between alleles that is coordinated with other random monoallelic...
Mon May 18, 2020 16:30
Macrolides are one of the most successful and widely used classes of antibacterials, which kill or stop the growth of pathogenic bacteria by binding near the active site of the ribosome and interfering with protein synthesis. Dirithromycin is a derivative of the prototype macrolide erythromycin with additional hydrophobic side chain. In our recent study, we have discovered that the side chain of dirithromycin forms lone pair- stacking interaction with the aromatic imidazole ring of the His69 residue...
Mon May 18, 2020 16:30
The spontaneous emergence of long RNA molecules on the early Earth, a phenomenon central to the RNA World hypothesis, continues to remain an enigma in the field of origins of life. Few studies have looked at the nonenzymatic oligomerization of cyclic mononucleotides under neutral to alkaline conditions, albeit in fully dehydrated state. In this study, we systematically investigated the oligomerization of cyclic nucleotides under prebiotically relevant conditions, wherein starting reactants were subjected...
Mon May 18, 2020 16:30
Publication date: Available online 17 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Marta Revilla-León, Nadin Al-Haj Husain, Laura Ceballos, Mutlu Özcan
Mon May 18, 2020 17:21
Publication date: Available online 17 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): María Florencia Lezcano, Fernando José Dias, Priscila Chuhuaicura, Pablo Navarro, Ramón Fuentes
Mon May 18, 2020 17:21
Publication date: Available online 16 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Gabriel Felipe de Bragança, Júlia Dantas Mazão, Antheunis Versluis, Carlos José Soares
Sat May 16, 2020 16:53
Publication date: Available online 15 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Arindam Das, Byrasandra C. Muddugangadhar, Dipal P. Mawani, Arindam Mukhopadhyay
Sat May 16, 2020 16:53
Publication date: Available online 14 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Pravinkumar G. Patil, Smita Nimbalkar
Fri May 15, 2020 16:53
Publication date: Available online 14 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Richard O’Brien, Chandur P.K. Wadhwani, Paul S. Rosen, Kwok-Hung Chung
Fri May 15, 2020 16:53
Publication date: Available online 14 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Wenjun Wang, Jian Sun
Fri May 15, 2020 16:53
Publication date: Available online 14 May 2020Source: The Journal of Prosthetic DentistryAuthor(s): Abdullah H. Alnasser, Chandur P.K. Wadhwani, Todd R. Schoenbaum, Mathew T. Kattadiyil
Fri May 15, 2020 16:53
Abstract Fibrous dysplasia (FD) is a rare condition commonly involving the jaws. While FD has a typical clinical and histological presentation, considerable variation exists. Moreover, overlap of features with other disorders is possible. This study serves to characterize the features of a large case series of FD of the jaws. With IRB approval, the University of Florida Oral Pathology Biopsy Service archive was retrospectively searched from 1994 to 2015 for cases of FD. Epidemiological...
Mon May 18, 2020 17:16
Abstract Claudins are integral to the structure and function of tight junctions. Altered claudin expression has been shown to affect disease behavior and patient prognosis in various neoplasms. The objectives of this study were to analyze the claudin-1, -4 and -7 expression in odontogenic tumors and characterize their expression pattern in distinct tumor cell types in relation to the recurrence potential. Sixty-nine cases of odontogenic tumors, including 43 ameloblastomas (AM),...
Mon May 18, 2020 17:16
Abstract A 19 year old otherwise healthy male presented with a history of acute onset left neck pain with subsequent swelling and development of a left neck mass that progressively enlarged over a two month period. Imaging studies revealed a solid heterogeneous mass with prominent calcifications displacing normal structures. The lesion was resected via transcervical approach and a diagnosis of calcifying fibrous tumor (CFT) was rendered. The clinical, radiographic, histologic...
Mon May 18, 2020 17:16
Abstract Orthokeratinized odontogenic cysts (OOC) are developmental odontogenic cysts characterised by an orthokeratinized stratified squamous epithelial lining. They were originally believed to be part of the spectrum of Odontogenic Keratocyst, but are now considered to be a distinct entity. They are rare, making up approximately 1% of all odontogenic cysts and they usually occur singly. In this paper we present two new cases of multiple OOCs, and compare them to previous case...
Mon May 18, 2020 17:16
Abstract The classification of sinonasal adenocarcinoma (SNAC) is complex. The high-grade, non-intestinal SNAC group is particularly heterogeneous, with tumors showing widely variable morphology. SMARCB1 (INI-1)-deficient sinonasal carcinoma is a newly described, aggressive tumor that usually resembles sinonasal undifferentiated carcinoma (SNUC) or non-keratinizing squamous cell carcinoma; however, glandular differentiation has been rarely reported and this feature may be under-recognized....
Mon May 18, 2020 17:16
Abstract Giant cell tumours (GCT) of the bone are uncommon primary bone neoplasms that occur mainly in the epiphysis of long bones. GCT of the skull is rarely encountered, particularly of the temporal bone. We report a rare case of giant cell tumour of the squamous portion of the temporal bone extending to the infratemporal fossa in a 38-year old male. The patient presented with progressive trismus, and swelling and pain in the right temporal region. The patient underwent excision...
Mon May 18, 2020 17:16
Abstract Sinonasal glomangiopericytoma (GPC) is an uncommon primary sinonasal neoplasm showing a perivascular myoid differentiation. Originally perceived as an intranasal counterpart to soft tissue hemangiopericytomas, initial immunohistochemical reports showed mostly negative to focal weak reactivity for CD34 as useful in separating GPC (almost always benign) from morphologic mimics, mainly solitary fibrous tumor (potentially aggressive). In anecdotally encountering cases of...
Mon May 18, 2020 17:16
Abstract Neurofibromas rarely occur within the oral cavity and infrequently involve the tongue. The majority of lingual neurofibromas arise in patients affected by neurofibromatosis type 1 (NF1). Neurofibromas of the tongue unassociated with this disorder are exceedingly uncommon. The clinical and pathologic features of 10 cases of sporadic lingual neurofibromas, unassociated with NF1, were evaluated. The patients included six females and four males ranging in age from 30 to...
Mon May 18, 2020 17:16
Publication date: Available online 18 May 2020Source: Medical HypothesesAuthor(s): Vishal Rao US, Shalini Thakur, Jyothsna Rao, Gururaj Arakeri, Peter A Brennan, Sachin Jadhav, Mufti Suhail Sayeed, Gururaj Rao
Mon May 18, 2020 17:11
Publication date: Available online 18 May 2020Source: Medical HypothesesAuthor(s): Anuruddha Abeygunasekera, Saroj Jayasinghe
Mon May 18, 2020 17:11
Publication date: Available online 18 May 2020Source: Medical HypothesesAuthor(s): Pankaj Chetia, Muhammed Khairujjaman Mazumder, Saurov Mahanta, Biplab De, Manabendra Dutta Choudhury
Mon May 18, 2020 17:11
Publication date: Available online 18 May 2020Source: Medical HypothesesAuthor(s): Yanlin Mo, Xiaodong Zhu, Xiaoying Lai, Ling Li
Mon May 18, 2020 17:11
Publication date: Available online 18 May 2020Source: Medical HypothesesAuthor(s): Delia Izaguirre-Torres, Raúl Siche
Mon May 18, 2020 17:11
Publication date: Available online 16 May 2020Source: Medical HypothesesAuthor(s): Farid Dabaghian, Mahnaz Khanavi, Mohammad M. Zarshenas
Sun May 17, 2020 17:02
Publication date: Available online 16 May 2020Source: Medical HypothesesAuthor(s): Parham Habibzadeh, Mohsen Moghadami, Kamran Bagheri Lankarani
Sun May 17, 2020 17:02
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