Related ArticlesEmerging Trends, Techniques, and Technologies in Facial Plastic and Reconstructive Surgery. Facial Plast Surg Clin North Am. 2019 Aug;27(3):xi Authors: Thomas JR PMID: 31280858 [PubMed - indexed for MEDLINE]
Sat May 16, 2020 15:45
Health-Related Quality of Life Changes Associated With Hearing Loss. JAMA Otolaryngol Head Neck Surg. 2020 May 14;: Authors: Dixon PR, Feeny D, Tomlinson G, Cushing S, Chen JM, Krahn MD Abstract Importance: Utility is a single-value, preference-based measure of health-related quality of life that represents the desirability of a health state relative to being dead or in perfect health. Clinical, funding, and policy decisions rely on measured changes...
Fri May 15, 2020 15:19
Overexpression of RPN2 suppresses radiosensitivity of glioma cells by activating STAT3 signal transduction. Mol Med. 2020 May 13;26(1):43 Authors: Li C, Ran H, Song S, Liu W, Zou W, Jiang B, Zhao H, Shao B Abstract BACKGROUND: Radiation therapy is the primary method of treatment for glioblastoma (GBM). Therefore, the suppression of radioresistance in GBM cells is of enormous significance. Ribophorin II (RPN2), a protein component of an N-oligosaccharyl...
Fri May 15, 2020 15:19
Related ArticlesThe Alberta Reconstructive Technique: An Occlusion-Driven and Digitally Based Jaw Reconstruction. Laryngoscope. 2019 12;129 Suppl 4:S1-S14 Authors: Seikaly H, Idris S, Chuka R, Jeffery C, Dzioba A, Makki F, Logan H, O'Connell DA, Harris J, Ansari K, Biron V, Cote D, Osswald M, Nayar S, Wolfaardt J Abstract OBJECTIVES/HYPOTHESIS: The free flap reconstructive protocols of the jaws have been refined over the years and presently are based...
Fri May 15, 2020 15:19
Related ArticlesAGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine. Br J Radiol. 2019 Jan;92(1093):20180365 Authors: Lux F, Tran VL, Thomas E, Dufort S, Rossetti F, Martini M, Truillet C, Doussineau T, Bort G, Denat F, Boschetti F, Angelovski G, Detappe A, Crémillieux Y, Mignet N, Doan BT, Larrat B, Meriaux S, Barbier E, Roux S, Fries P, Müller A, Abadjian MC, Anderson C, Canet-Soulas E, Bouziotis P,...
Fri May 15, 2020 15:19
Abstract Background Diagnosis of classic metaphyseal lesions (CMLs) in children suspected for child abuse can be challenging. Ultrasound (US) can potentially help diagnose CMLs. However, its accuracy is unknown. Objective To evaluate the accuracy of US in the diagnosis of CMLs using skeletal survey reports as the gold standard. ...
Mon May 18, 2020 03:00
Abstract Background One main challenge in pediatric imaging is to reduce motion artifacts by calming young patients. To that end, the Radiological Society of North America (RSNA) as early as 1997 stated the necessity of adults accompanying their child during the child’s examination. Nonetheless, current research lacks data regarding radiation dose to these chaperones. Objective...
Fri May 15, 2020 03:00
Related ArticlesIs noise-induced hearing loss still a public health problem after decades of legislation? Braz J Otorhinolaryngol. 2020 Apr 10;: Authors: Silva VARD, Mitre EI, Crespo AN PMID: 32417151 [PubMed - as supplied by publisher]
Mon May 18, 2020 15:36
Publication date: Available online 17 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Christopher X.W. Tan, Henk S. Brand, Sumaira Iqbal, Nanne K.H. De Boer, Tymour Forouzanfar, Jan G.A.M. de Visscher
Mon May 18, 2020 15:32
Publication date: Available online 17 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Asha Sude, Donald R. Nixdorf
Mon May 18, 2020 15:32
Publication date: Available online 17 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Allison Buchanan, Rachel Hancock, Sajitha Kalathingal
Sun May 17, 2020 15:12
Publication date: Available online 16 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Gabriell Bonifacio Borgato, Gabriel Alvares Borges, Ana Paula Souza, Cristiane H. Squarize, Rogerio M Castilho
Sat May 16, 2020 14:48
Publication date: Available online 15 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Henrique Timm Vieira, Mariana Boessio Vizzotto, Priscila Fernanda da Silveira, Nádia Assein Arús, Juliana Andréa Corrêa Travessas, Heraldo Luis Dias da Silveira
Sat May 16, 2020 14:48
Publication date: Available online 14 May 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Ahmad Al Ramil, Soulafa Almazrooa, Nada Binmadi, Hani Mawardi
Fri May 15, 2020 13:55
Publication date: Available online 18 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Dimitris Reissis, Nikita Joji, Ewan Campbell, Vikram P. Sharma, Robert M.T. Staruch, Benjamin G. Baker
Mon May 18, 2020 15:24
Publication date: Available online 17 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Timothy Shun Man Chu, Ka Siu Fan
Mon May 18, 2020 15:24
Publication date: Available online 17 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): M.E. McMahon, S.M. Bollard, S.M. Potter, R.P. Hanson
Mon May 18, 2020 15:24
Publication date: Available online 17 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Kavish Maheshwari, Sandip Hindocha, Ali Yousif
Sun May 17, 2020 15:16
Publication date: Available online 15 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Marco Pignatti, Valentina Pinto, Maria Elisa Lozano Miralles, Federico A. Giorgini, Riccardo Cipriani
Sat May 16, 2020 14:02
Publication date: Available online 15 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Rafael Denadai, Lun-Jou Lo
Sat May 16, 2020 14:02
Publication date: Available online 15 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Minlu Huang, Zuoliang Qi
Sat May 16, 2020 14:02
Publication date: Available online 15 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Dr. Davide Sallam, Dr. Marcello Carminati, Dr. Gabriele Mevio, Dr. Maurizio Verga, Dr. Denis Codazzi
Sat May 16, 2020 14:02
Publication date: Available online 14 May 2020Source: Journal of Plastic, Reconstructive & Aesthetic SurgeryAuthor(s): Aladdin H. Hassanein, Rachel Danforth, Will DeBrock, Brian A. Mailey, Mary Lester, Juan Socas
Fri May 15, 2020 12:35
Ultraconserved elements (UCEs) are stretches of hundreds of nucleotides with highly conserved cores flanked by variable regions. Although the selective forces responsible for the preservation of UCEs are unknown, they are nonetheless believed to contain phylogenetically meaningful information from deep to shallow divergence events. Phylogenetic applications of UCEs assume selection as being largely invariant across the entire locus, including its variable flanking regions. We present a Wright-Fisher...
Mon May 18, 2020 03:00
Cospeciation has been suggested to be the main force driving the evolution of herpesviruses, with viral species co-diverging with their hosts along more than 400 million years of evolutionary history. Recent studies, however, have been challenging this assumption, showing that other co-phylogenetic events, such as intrahost speciations and host switches play a central role on their evolution. Most of these studies, however, were performed with undated phylogenies, which may underestimate or overestimate...
Sun May 17, 2020 03:00
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic offers a unique opportunity to study the introduction and evolution of a pathogen into a completely naive human population. We identified and analysed the amino acid mutations that gained prominence worldwide in the early months of the pandemic. Eight mutations have been identified along the viral genome, mostly located in conserved segments of the structural proteins and showing low variability among coronavirus, which indicated...
Sun May 17, 2020 03:00
The explosion in population genomic data demands ever more complex modes of analysis, and increasingly these analyses depend on sophisticated simulations. Recent advances in population genetic simulation have made it possible to simulate large and complex models, but specifying such models for a particular simulation engine remains a difficult and error-prone task. Computational genetics researchers currently re-implement simulation models independently, leading to duplication of effort and the possibility...
Sun May 17, 2020 03:00
Reptiles have repeatedly invaded and thrived in aquatic environments throughout history, however fewer than 8% of the 6000 extant species are primarily aquatic. The Galapagos Marine Iguana (Amblyrhynchus cristatus), the world's only marine lizard, may have had one of the most unique and challenging transitions to aquatic life. Curiously, previous studies have identified relatively few physiological adaptations in Marine Iguanas, however, little is known about the extent of morphological specialisation...
Sat May 16, 2020 03:00
Hosts and viruses are constantly evolving in response to each other: as hosts attempt to suppress the virus, the virus attempts to evade and suppress the hosts immune system. This arms race results in the evolution of novel pathways in both the host and virus to gain the upper hand. Here we describe the coevolution between Drosophila species and a common and virulent DNA virus. We identify two distinct viral types that differ 100-fold in viral titer in infected individuals, with similar effects across...
Sat May 16, 2020 03:00
Over time, populations of species can expand, contract, and become isolated, creating subpopulations that can adapt to local conditions. Understanding how species adapt following these changes is of great interest, especially as the current climate crisis has caused range shifts for many species. Here, we characterize how Drosophila innubila came to inhabit and adapt to its current range: mountain forests in southwestern USA separated by large expanses of desert. Using population genomic data from...
Sat May 16, 2020 03:00
Homing endonucleases (HE) are enzymes capable of cutting DNA at highly specific target sequences, the repair of the generated double-strand break resulting in the insertion of the HE-encoding gene ("homing" mechanism). HEs are present in all three domains of life and viruses; in eukaryotes, they are mostly found in the genomes of mitochondria and chloroplasts, as well as nuclear ribosomal RNAs. We here report the case of a HE that accidentally integrated into a telomeric region of the nuclear genome...
Sat May 16, 2020 03:00
Microorganisms mainly exist within complex networks of ecological interactions. Given that the growth and survival of community members frequently depend on an obligate exchange of essential metabolites, it is generally unclear how such communities can persist despite the destabilizing force of ecological disturbance. Here we address this issue using a population dynamics model. In contrast to previous work that suggests the potential for obligate interaction networks to evolve is limited, we find...
Sat May 16, 2020 03:00
In a likely coevolutionary arms race, insects evolved a variety of counter strategies to avoid capture by spider webs, while spiders evolved innovations web structure and especially their adhesive silks. For instance, insect cuticles employ a variety of potential anti-adhesion mechanisms such as the detachable scales of moths and surface waxes and superhydrophobic structures that might resist spreading of glues. In contrast, the viscid capture threads of most spider orb webs are covered with aggregate...
Sat May 16, 2020 03:00
In malaria and several other important infectious diseases, high prevalence occurs concomitantly with incomplete immunity. This apparent paradox poses major challenges to malaria elimination in highly endemic regions, where asymptomatic Plasmodium falciparum infections are present across all age classes creating a large reservoir that maintains transmission. This reservoir is in turn enabled by extreme antigenic diversity of the parasite and turnover of new variants. We present here the concept of...
Sat May 16, 2020 03:00
Background: Molecular clocks have become powerful tools given increasing sequencing and fossil resources. However, outcome of calibration analyses depend on choosing priors. Here we revisit a seminal dating study of the genus Carabus by Andujar et al. proposing that their prior choices need re-evaluation with the hypothesis that reflecting fossil evidence and the Gondwanan split properly rewinds the molecular clock significantly. We used the same dataset including five mitochondrial and four nuclear...
Sat May 16, 2020 03:00
The interferon-inducible transmembrane (IFITM) proteins belong to the Dispanin/CD225 family and inhibit diverse virus infections. IFITM3 reduces membrane fusion between cells and virions through a poorly characterized mechanism. We identified a GxxxG motif in many CD225 proteins, including IFITM3 and proline rich transmembrane protein 2 (PRRT2). Mutation of PRRT2, a regulator of neurotransmitter release, at glycine-305 was previously linked to paroxysmal neurological disorders in humans. Here, we...
Sat May 16, 2020 03:00
Genetic drift is an important evolutionary force of strength inversely proportional to Ne, the effective population size. The impact of drift on genome diversity and evolution is known to vary among species, but quantifying this effect is a difficult task. Here we assess the magnitude of variation in drift power among species of animals via its effect on the mutation load - which implies also inferring the distribution of fitness effects of deleterious mutations (DFE). To this aim, we analyze the...
Fri May 15, 2020 03:00
In water, transparency seems an ideal concealment strategy, as testified by the variety of transparent aquatic organisms. By contrast, transparency is nearly absent on land, with the exception of insect wings, and knowledge is scarce about its functions and evolution, with fragmentary studies and no comparative perspective. Lepidoptera (butterflies and moths) represent an outstanding group to investigate transparency on land, as species typically harbour opaque wings covered with coloured scales,...
Fri May 15, 2020 03:00
Rapid phenotypic adaptation is often observed in natural populations and selection experiments. However, detecting the genome-wide impact of this selection is difficult, since adaptation often proceeds from standing variation and selection on polygenic traits, both of which may leave faint genomic signals indistinguishable from a noisy background of genetic drift. One promising signal comes from the genome-wide covariance between allele frequency changes observable from temporal genomic data, e.g....
Fri May 15, 2020 03:00
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