Treatment of hydroxyurea-induced ulcers with topical timolol

Introduction: Hydroxyurea is an antimetabolite used to treat myeloproliferative disorders, solid tumors, and sickle cell anemia, which has been well documented to cause lower extremity ulcers. Discontinuing the medication may result in spontaneous ulcer resolution. However, hydroxyurea-induced skin ulcers often heal slowly over months to years, causing considerable morbidity.