Mycophenolate mofetil extravasation resulting in extensive local tissue necrosis

Chemotherapy extravasation is an important complication of intravenous (IV) medication administration and can cause severe, irreversible local tissue damage, potential disfigurement, and functional impairment. Mycophenolate mofetil (MM) is an antiproliferative immunosuppressant used for prevention of organ rejection in solid organ transplant. We report a case of a 58-year-old man with a recent history of cardiac transplantation, with postsurgical course complicated by allograft failure, who was being treated with IV MM for prevention of transplant rejection.