Combination therapies for vitiligo: 5-Fluorouracil laser–assisted drug delivery

Case report: A 35-year-old man with stable vitiligo on the hands with no response to previous treatments was submitted to three monthly sessions of fractional CO2 10,600 nm laser with drug delivery parameters (Sculptor CO2, Vydence; first 3 passes: tip 800, random mode, energy 30 mJ, density 150 mtz/cm2; fourth pass: tip 800, brush mode, energy 30 mJ, density 60 mtz/cm2). Immediately after, the drug delivery lotion with 5-FU 5% and alfa bisabolol 2% was applied. This lotion was applied at night for six days.