Severe bullous pemphigoid with flares triggered by pychosocial stressors

Introduction: Bullous pemphigoid is a rare life-long skin condition that is typically characterized by areas of large fluid-filled blisters and scattered urticarial papules and plaques on the trunk, arms, and legs. It can be induced by medications including furosemide, captopril, or penicillin. Often misdiagnosed as urticaria, the classic manifestations of tense vesicels and bullae which develop on an urticarial base do not develop until later in the course of the disease. It is an immunobullous disorder caused by autoantibodies against basement membrane protein.