Journal of Dermatological Treatment
2h
Mohs micrographic surgery versus wide local excision for head and neck melanoma-in-situ.
updated at 15:17 by Phan K, Onggo J, Loya A via Journal of Dermatological Treatment
Related Articles
Mohs micrographic surgery versus wide local excision for head and neck melanoma-in-situ.
J Dermatolog Treat. 2019 Jul 02;:1-15
Authors: Phan K, Onggo J, Loya A
Abstract
Background: Various surgical options can be used to remove melanoma in situ (MIS). These include wide local excision (WLE), staged excision, and Mohs micrographic surgery (MMS). For MIS lesions located in the head and neck regions, the WLE approach may not always be a technically feasible option if both cosmesis and anatomical function is to be preserved. Methods: We performed a retrospective analysis of the Surveillance, Epidemiology, and End Results (SEER) cancer registry. A total of 7933 cases of MIS in the head and neck region were included in this study, of which 5353 cases were treated by WLE and the remaining 2580 cases by MMS. Results: Comparing between the WLE and MMS group, cancer-specific survival rates at 5 (99% vs 99%) and 10 years (98% vs 98%) as well as the 5 year overall survival rate (85% vs 86%) were similar. After adjusting for confounders, there was no significant difference in cancer-specific survival (HR: 0.902, 95%CI: 0.539-1.511, p = 0.695) and overall-survival (HR: 0.943, 0.813-1.093, p = 0.435). Conclusions: For cosmetic and functional purposes, MMS is a valid and suitable alternative to WLE to treat MIS due to its tissue-preserving nature particularly in the head and neck region. Key points Our adjusted analysis demonstrates similar overall and cancer-specific survival for Mohs surgery vs wide local excision for head and neck melanoma-in-situ For cosmetic and functional purposes, MMS is a valid and suitable alternative to WLE to treat MIS This is due to its tissue-preserving nature particularly in the head and neck region.
PMID: 31264932 [PubMed - as supplied by publisher]
Add tags (Currently: PubMed)
Unread Email Website
2h
A revisit to the effects of zinc salt on skin burn wound healing to reflect the risks in current pharmaceutical care.
updated at 15:17 by Hakim Osman MA, Wong TW, Anuar NK via Journal of Dermatological Treatment
Related Articles
A revisit to the effects of zinc salt on skin burn wound healing to reflect the risks in current pharmaceutical care.
J Dermatolog Treat. 2019 Jul 02;:1-12
Authors: Hakim Osman MA, Wong TW, Anuar NK
Abstract
The lower limit of soluble zinc content that can possibly be applied onto a wounded skin as a healing promoter was not known. This study examined skin wound healing process of rats inflicted by partial thickness thermal burn wound as a function of applied soluble zinc contents (0.1 ml of zinc chloride solution 0.01% (w/w) or 5.0% (w/w)). The size, surface morphology and histological profiles of wound beds of untreated rats and those treated with zinc chloride solutions were characterized. A soluble zinc content as low as 10.5 μg/cm2 of skin negated skin wound healing when compared to the untreated rats. This was alarming as the commercial products currently in the market are formulated with a high level of zinc content. Albeit the zinc salt employed was water-insoluble, a minute fraction of soluble zinc might be available to the treatment sites. This could be partially responsible for the late adverse effects such as pruritis and inflammation reported with calamine/diphenhydramine lotion, medicated shampoo, Olay Complete defence moisturizing lotion and Zineryt® topical solution. The skin irritation was likely a resultant oxidative stress action of soluble zinc, where a small fraction could be adequate to negate the skin homeostasis. Key messages Zinc is essentially a cofactor for skin collagen formation. Soluble zinc content as low as 10.5 μg/cm2 of skin irritates skin and negates burn wound healing. Skin irritation of commercial products relates to minute soluble zinc content availability.
PMID: 31264929 [PubMed - as supplied by publisher]
Add tags (Currently: PubMed)
Unread Email Website
2h
Cannabinoids for the treatment of chronic refractory pruritus.
updated at 15:17 by Khanna R, Khanna R, Denny G, Kwatra SG via Journal of Dermatological Treatment
Related Articles
Cannabinoids for the treatment of chronic refractory pruritus.
J Dermatolog Treat. 2019 Jul 02;:1-7
Authors: Khanna R, Khanna R, Denny G, Kwatra SG
PMID: 31264498 [PubMed - as supplied by publisher]
Add tags (Currently: PubMed)
Unread Email Website
2h
Mohs micrographic surgery versus wide local excision for head and neck melanoma-in-situ.
updated at 15:17 by Phan K, Onggo J, Loya A via Journal of Dermatological Treatment
Related Articles
Mohs micrographic surgery versus wide local excision for head and neck melanoma-in-situ.
J Dermatolog Treat. 2019 Jul 02;:1-15
Authors: Phan K, Onggo J, Loya A
Abstract
Background: Various surgical options can be used to remove melanoma in situ (MIS). These include wide local excision (WLE), staged excision, and Mohs micrographic surgery (MMS). For MIS lesions located in the head and neck regions, the WLE approach may not always be a technically feasible option if both cosmesis and anatomical function is to be preserved. Methods: We performed a retrospective analysis of the Surveillance, Epidemiology, and End Results (SEER) cancer registry. A total of 7933 cases of MIS in the head and neck region were included in this study, of which 5353 cases were treated by WLE and the remaining 2580 cases by MMS. Results: Comparing between the WLE and MMS group, cancer-specific survival rates at 5 (99% vs 99%) and 10 years (98% vs 98%) as well as the 5 year overall survival rate (85% vs 86%) were similar. After adjusting for confounders, there was no significant difference in cancer-specific survival (HR: 0.902, 95%CI: 0.539-1.511, p = 0.695) and overall-survival (HR: 0.943, 0.813-1.093, p = 0.435). Conclusions: For cosmetic and functional purposes, MMS is a valid and suitable alternative to WLE to treat MIS due to its tissue-preserving nature particularly in the head and neck region. Key points Our adjusted analysis demonstrates similar overall and cancer-specific survival for Mohs surgery vs wide local excision for head and neck melanoma-in-situ For cosmetic and functional purposes, MMS is a valid and suitable alternative to WLE to treat MIS This is due to its tissue-preserving nature particularly in the head and neck region.
PMID: 31264932 [PubMed - as supplied by publisher]
Add tags (Currently: PubMed)
Unread Email Website
2h
A revisit to the effects of zinc salt on skin burn wound healing to reflect the risks in current pharmaceutical care.
updated at 15:17 by Hakim Osman MA, Wong TW, Anuar NK via Journal of Dermatological Treatment
Related Articles
A revisit to the effects of zinc salt on skin burn wound healing to reflect the risks in current pharmaceutical care.
J Dermatolog Treat. 2019 Jul 02;:1-12
Authors: Hakim Osman MA, Wong TW, Anuar NK
Abstract
The lower limit of soluble zinc content that can possibly be applied onto a wounded skin as a healing promoter was not known. This study examined skin wound healing process of rats inflicted by partial thickness thermal burn wound as a function of applied soluble zinc contents (0.1 ml of zinc chloride solution 0.01% (w/w) or 5.0% (w/w)). The size, surface morphology and histological profiles of wound beds of untreated rats and those treated with zinc chloride solutions were characterized. A soluble zinc content as low as 10.5 μg/cm2 of skin negated skin wound healing when compared to the untreated rats. This was alarming as the commercial products currently in the market are formulated with a high level of zinc content. Albeit the zinc salt employed was water-insoluble, a minute fraction of soluble zinc might be available to the treatment sites. This could be partially responsible for the late adverse effects such as pruritis and inflammation reported with calamine/diphenhydramine lotion, medicated shampoo, Olay Complete defence moisturizing lotion and Zineryt® topical solution. The skin irritation was likely a resultant oxidative stress action of soluble zinc, where a small fraction could be adequate to negate the skin homeostasis. Key messages Zinc is essentially a cofactor for skin collagen formation. Soluble zinc content as low as 10.5 μg/cm2 of skin irritates skin and negates burn wound healing. Skin irritation of commercial products relates to minute soluble zinc content availability.
PMID: 31264929 [PubMed - as supplied by publisher]
Add tags (Currently: PubMed)
Unread Email Website
2h
Cannabinoids for the treatment of chronic refractory pruritus.
updated at 15:17 by Khanna R, Khanna R, Denny G, Kwatra SG via Journal of Dermatological Treatment
Related Articles
Cannabinoids for the treatment of chronic refractory pruritus.
J Dermatolog Treat. 2019 Jul 02;:1-7
Authors: Khanna R, Khanna R, Denny G, Kwatra SG
PMID: 31264498 [PubMed - as supplied by publisher]
Add tags (Currently: PubMed)
Unread Email Website
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.