Audiological Evaluation of Vestibular Schwannoma Patients with Normal Hearing.

updated at 15:21 by Salem N, Galal A, Mastronardi V, Talaat M, Sobhy O, Sanna M via Skull Base

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Audiological Evaluation of Vestibular Schwannoma Patients with Normal Hearing.
Audiol Neurootol. 2019 Jul 02;:1-10
Authors: Salem N, Galal A, Mastronardi V, Talaat M, Sobhy O, Sanna M
Abstract
OBJECTIVE: To evaluate the audiological aspects of vestibular schwannoma (VS) patients with normal hearing.
STUDY DESIGN: Retrospective study.
SETTING: Quaternary referral center for skull base pathologies.
PATIENTS: The records on 4,000 patients who had been diagnosed with VS between 1986 and December 2017 were retrospectively reviewed. The patients included in the study were the ones who complied with the strict audiological normality criteria, as follows: a pure tone hearing threshold (at the 6-octave-spaced frequencies from 250 to 8,000 Hz) ≤25 dBHL; a word recognition score >90%; and interaural differences ≤10 dB at each frequency.
INTERVENTIONS: Auditory brainstem response (ABR) testing and radiological imaging.
MAIN OUTCOME MEASURES: The incidence of normal objective hearing among VS patients, and the diagnostic utility of the ABR and the effect of tumor size and site on the response.
RESULTS: The incidence of normal hearing among VS patients was 4.2%. Tinnitus and vertigo were the most common symptoms across tumor grades; 5.6% of the tumors were large and giant tumors. The ABR yielded a sensitivity of 73.6%, with a false negative rate of 26.3% using a cutoff point of 0.2 ms for interaural latency differences.
CONCLUSIONS: The diagnosis of VS should not be based on audiometric thresholds alone. Alarming signs of VS should be clear to the physician in order not to miss or delay the diagnosis of the disease. The ABR is useful in the diagnosis of VS, but normal results do not exclude the occurrence of the disease in patients with normal hearing.
PMID: 31266017 [PubMed - as supplied by publisher]