Antidepressants reduced risk of mortality in patients with diabetes mellitus: a population-based cohort study in Taiwan.

updated at 15:16 by Chen HM, Yang YH, Chen KJ, Lee Y, McIntyre RS, Lu ML, Lee YC, Hsieh MC, Chin-Hung Chen V via American Goiter Association

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Antidepressants reduced risk of mortality in patients with diabetes mellitus: a population-based cohort study in Taiwan.
J Clin Endocrinol Metab. 2019 Jul 02;:
Authors: Chen HM, Yang YH, Chen KJ, Lee Y, McIntyre RS, Lu ML, Lee YC, Hsieh MC, Chin-Hung Chen V
Abstract
CONTEXT: The effect of antidepressants (ATDs) use on mortality in patients with diabetes mellitus (DM) has not yet been sufficiently studied although co-morbid depression is common in this population.
OBJECTIVE: To explore the impact of ATDs on mortality among DM patients.
DESIGN: A retrospective cohort study in a national database.
SETTING: This population-based study used National Health Insurance Research Database in Taiwan. Since 2000, we identified 53,412 cases of newly diagnosed patients with DM and depression. Patient cases were followed for assessing mortality until 2013.
MAIN OUTCOME MEASURE: The association between mortality and ATDs use was explored adjusting for cumulative dosing.
RESULT: Using the time-dependent Cox regression model, ATDs use was associated with significantly reduced mortality among patients with DM (in the highest dose group, hazard ratio [HR]= 0.65, 95% confidence interval [CI]= 0.59-0.71). Further analysis showed that differences on mortality existed across ATD categories: selective serotonin reuptake inhibitors (HR=0.63, 95% CI= 0.56-0.71), serotonin-norepinephrine reuptake inhibitors (HR=0.58, 95% CI= 0.44-0.78), norepinephrine-dopamine reuptake inhibitors (HR=0.20,95% CI= 0.07-0.63), mirtazapine (HR=0.60, 95% CI= 0.45-0.82), tricyclic/tetracyclic antidepressants (HR=0.73, 95% CI= 0.54-0.97), trazodone (HR=0.52, 95% CI= 0.29-0.91). However, reversible inhibitor of monoamine oxidase A (RIMA) was found to be associated with an increase, rather than decrease, in total mortality. (HR=1.48, 95% CI= 1.09-1.99).
CONCLUSION: Most ATDs but not RIMA were associated with significantly reduced mortality among population with comorbid DM and depression.
PMID: 31265070 [PubMed - as supplied by publisher]