Combination of imiquimod with cryotherapy in the treatment of penile intraepithelial neoplasia

Penile intraepithelial neoplasia (PIN) is a rare disease that can be associated with great morbidity and mortality. Historically, the term PIN has been used to refer to 3 premalignant penile lesions: Bowen disease (BD), erythroplasia of Queyrat (EQ), and Bowenoid papulosis (BP). Although these clinical variants share similar histopathologic features of squamous cell carcinoma in situ—namely, transepidermal keratinocyte atypia, numerous mitotic figures, and nuclear crowding—they vary in their clinical presentation.