Phenotypic and lipidomic characterization of primary human epidermal keratinocytes exposed to simulated solar UV radiation

Sunlight is composed of a continuous spectrum of electromagnetic radiation which has three main wavelength regions: ultraviolet (UV), visible and infrared. UV radiation comprises UVA (320 – 400 nm), UVB (280 – 320 nm) and UVC (200 - 280 nm). Whereas UVA radiation represents 95 % of the total solar UV that reaches the earth, UVC and most of the UVB radiation are absorbed by the stratospheric ozone layer [1–2]. Skin, the outermost tissue of the body, is exposed to various environmental aggressions, among which solar ultraviolet (UV) radiation is the most significant.