Lipoxin A4 inhibits UV radiation-induced skin inflammation and oxidative stress in mice

The skin, as the outermost organ, is a physical barrier between the organism and the environmental deleterious factors such as ultraviolet (UV) radiation. UV radiation is one of the major risk factors for dermatologic diseases and chronic UV radiation exposure has been shown to cause skin cancer and premature skin aging [1]. Pathological levels of reactive oxygen species (ROS) are formed as a consequence of exposure to UV radiation and by recruited neutrophils expressing gp91phox, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) subunit that contributes to superoxide anion production during acute inflammation [2].