Exacerbation of mycosis fungoides leading to the diagnosis of chronic myelomonocytic leukemia

Patients with mycosis fungoides (MF) are at a greater risk (relative risk, 1.73; range, 1.32-2.4) to have secondary malignancies than healthy subjects, and co-occurrence of cutaneous T-cell lymphoma with other hematoproliferative diseases has been reported.1,2 Chronic myelomonocytic leukemia (CMML) is a rare myeloproliferative disease with features of myelodysplastic syndrome and myeloproliferative disorders leading to monocytosis in the peripheral blood.3 Cutaneous manifestations of CMML have been reported and seem to be associated with a poor prognosis and more likely progression to acute myeloid leukemia.