The angiotensin converting enzyme 2 (ACE2) system in the brain: possible involvement in Neuro-Covid

xlomafota13 shared this article with you from Inoreader The angiotensin converting enzyme 2 (ACE2) system in the brain: possible involvement in Neuro-Covid Via Cellular and Molecular Biology Histol Histopathol. 2021 Jun 18:18356. doi: 10.14670/HH-18-356. Online ahead of print. ABSTRACT The brain has its own intrinsic renin-angiotensin system (RAS) with all its components present in the central nervous system (CNS). Recent data demonstrate that also the main components of the angiotensin concerting enzyme 2 (ACE2) system (at least ACE2 itself, as well as the biologically active angiotensin (1-7) and its cognate receptor Mas) are expressed in the brain. Aside from these members, alamadine and MrgD are discussed as further members that have neuro-active roles in the CNS. Little is known about the possible functions of MrgD within the brain. Concerning angiotensin (1-7) acting through the Mas receptor, data were accumulating that this system is involved in numerous processes contributing to neuronal plasticity and even learning and memory. Malfunctions in the brain ACE2 system are associated with disturbances in neuronal plast icity. Since SARS-CoV-2 has a high affinity towards ACE2, Neuro-Covid may directly or indirectly depend on a disturbed balance in the ACE2 derived angiotensin system in the brain. Since the ACE2 system in the brain is far from being understood, a deeper understanding of e.g. the angiotensin (1-7) / Mas system is needed, especially with regard to the roles of angiotensin (1-7) in neuronal plasticity. PMID:34142714 | DOI:10.14670/HH-18-356 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.