Molecular markers associated with potentially malignant oral lesions (Review)

xlomafota13 shared this article with you from Inoreader Molecular markers associated with potentially malignant oral lesions (Review) Via Experimental and therapeutic medicine Exp Ther Med. 2021 Aug;22(2):834. doi: 10.3892/etm.2021.10266. Epub 2021 Jun 4. ABSTRACT According to literature data, potentially premalignant oral lesions are the basis of over 85% of cell carcinomas. Despite multiple advances achieved during the last few decades in the diagnosis and treatment of oral squamous cell carcinomas, there has not been a significant change in the prognosis and 5-year survival rate. The prevention of malignant transformation of these tumors by diagnosis and targeted treatment would be the ideal scenario. These potentially premalignant oral lesions represent an important subject for either the clinical or the research field, due to the higher malignant transformation observed in the last few years at different ages. To date, histopathological examination based on TNM criteria is considered the 'golden standard'. However, this type of examination has its limitation due to staining procedures and photonic micro scope examination. Identification of cellular and molecular markers specific to these oral lesions with potentially malignant transformation could lead to early detection, accurate diagnosis, prevention of the development of oral squamous cell carcinoma (OSCC) and facilitate a targeted therapeutic approach. In this review, we focused on a series of molecules that are implicated in the malignant transformation of these lesions and considered potential biomarkers. PMID:34149880 | PMC:PMC8200803 | DOI:10.3892/etm.2021.10266 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.