Giant condyloma acuminatum of the vulva: Successful management with imiquimod

Giant condyloma acuminata (GCA) is a large condyloma of the anogenital region with a cauliflowerlike appearance. The tumor is extremely rare and is related to human papilloma virus (HPV) infection (HPV type 6 and 11 in 90% of cases).1 The definitive treatment is wide surgical excision, but topical medical treatment can be effective in selected cases.2,3 Here we report the first case, to our knowledge, of complete regression of vulvar GCA after treatment with topical imiquimod (5% cream) therapy, with no recurrence reported over a 3-year follow-up period.