Genetic Polymorphism predicting Methotrexate efficacy in Chinese patients with psoriasis vulgaris

Psoriasis is an immune-mediated chronic, relapsing, inflammatory, polygene genetic disease characterized as erythrocyte plaque, hyperplasia of keratinocytes and infiltration of lymphocytes [1–4]. Currently, the clinical drugs for psoriasis is increasing, the traditional drugs included methotrexate, retinoids, and cyclosporine A, etc [5]. There are a lot of new biological agents included TNF-α inhibitors, anti-IL-17, anti-IL-23 antibodies in clinical or under clinical studies. Although the treatment of psoriasis has entered a new era of biological agents, traditional medicines still hold an important position in the treatment of psoriasis.