Construction of a risk model for the development of metachronous squamous cell carcinoma after endoscopic resection of esopahageal squamous cell carcinoma

Abstract

Background

Previously, we identified that rs1229984 in ADH1B, rs671 in ALDH2, and smoking status were independently associated with the risk of developing metachronous squamous cell carcinoma (SCC) after endoscopic resection (ER) for esophageal SCC (ESCC). However, this analysis included cases with short-term follow-up. In the present study, we investigated the environmental and genetic factors associated with developing metachronous SCC using long-term follow-up observation after ER for ESCC.

Methods

One hundred and thirty ESCC patients who underwent treatment with ER were followed up using endoscopy for ≥ 30 months. We investigated the incidence of, and genetic/environmental factors associated with, metachronous SCC development after ER for ESCC. We also analyzed the potential risk factors for multiple metachronous SCC development using Cox's proportional hazards model. Moreover, we constructed a risk model for the development of metachronous SCC after ER for ESCC.

Results

Male, rs1229984, rs671, alcohol consumption (> 20 g/day), smoking, and multiple Lugol-voiding lesions (LVLs) significantly affected the incidence of multiple metachronous SCCs. Multiple Cox proportional analysis revealed that rs1229984, rs671, alcohol consumption, smoking, and multiple LVLs were independently associated with the risk of developing metachronous SCC. Patients who had ≤ 2 risk factors did not develop metachronous SCC, and the risk of developing metachronous SCC in patients with ≥ 3 risk factors was significantly higher than in patients with ≤ 2 risk factors.

Conclusion

The risk model using these 5 genetic and environmental factors is useful as an indication for multiple metachronous development in ESCC patients.

Preparation and application of magnetic nitrogen-doped rGO for persulfate activation

Abstract

A heterogeneous catalyst (M-N-rGO) composed of stability enhanced magnetic iron oxide nanoparticles and nitrogen-doped reduced graphene oxide was synthesized and characterized by SEM, XRD, BET, and XPS. It showed excellent catalytic degradation properties in advanced oxidation technology. In the presence of 200 mg/L catalyst and 135 mg/L persulfate at pH 5, 95% of 10–20 mg/L methylene blue could be degraded in 90 min with the TOC removal efficiency of 50%. The rate constant based on pseudo-first-order kinetics ranged from 0.0227 to 0.0488/min in the temperature range of 15 to 32 °C, and the activation energy was 32.5 kJ/mol. Under the optimal operation conditions, 20 mg/L of 2,4-dichlorophneol (2,4-DCP) could be removed almost completely. EPR analysis showed that sulfate and hydroxyl radicals were responsible for degradation of pollutants, and radical quenching experiments indicated that nonradical pathway also played a role in pollutant removal. And a mechanism for M-N-rGO and persulfate system was elucidated. This catalyst was easy for preparation, low-cost, highly effective, convenient for separation, and could be used effectively for four times through 0.1 mol/L H₂SO₄ regeneration. It provided a choice for wastewater treatment in practice.

Orthogonal design-guided preparation of multi-level porous-activated carbon by pyrolysis of waste polyester textiles

Abstract

Multi-level porous amorphous-activated carbon with excellent adsorption performance was prepared by a ZnCl₂-assisted pyrolysis of waste polyester textiles. Experimental parameters were optimized by using orthogonal design. Result of orthogonal design revealed that pyrolysis temperature and pyrolysis time were the dominant individual factors. Samples prepared at the optimal condition were systematically characterized by Brunauer-Emmett-Teller (BET) porosity analyzer, FT-IR spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscope (SEM), and transmission electron microscope (TEM). Iodine (I₂), methylene blue (MB) and phenol (PhOH) were selected as target dyes to measure the adsorption performance. Experimental results showed that porous-activated carbon with multi-level pores could be obtained by optimizing experimental parameters. The specific surface area and total pore volume were calculated to be 846.37 m² g⁻¹ and 0.726 cm³ g⁻¹, respectively. Benefit from its multi-level rich porosity, the optimized sample possessed attractive adsorption performance toward different types of dyes. The corresponding adsorption capacity toward I₂, MB, and PhOH were calculated to be 980.48, 384.00, and 300.62 mg g⁻¹, respectively.

Palpebral cutaneous melanomas: a review of 17 cases from a tertiary center

International Journal of Dermatology, EarlyView.

Development of the International Severe Asthma Registry (ISAR): a modified Delphi study

Publication date: Available online 1 September 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Lakmini Bulathsinhala, Nevaashni Eleangovan, Liam G. Heaney, Andrew Menzies-Gow, Peter G. Gibson, Matthew Peters, Mark Hew, Job FM. van Boven, Lauri Lehtimäki, Eric van Ganse, Manon Belhassen, Erin Harvey, Luis Perez de Llano, Anke H. Maitland-van der Zee, Nikolaos Papadopoulos, J. Mark FitzGerald, Celeste Porsbjerg, G. Walter Canonica, Vibeke Backer, Chin Kook Rhee

Abstract

Background

The lack of centralised data on severe asthma has resulted in a scarcity of information about the disease and its management. The development of a common data collection tool for the International Severe Asthma Registry (ISAR) will enable standardised data collection, subsequently enabling data interoperability.

Objectives

To create a standardised list of variables for the first international registry for severe asthma via expert consensus.

Methods

A modified Delphi process was used to reach consensus on a minimum set of variables to capture in ISAR: the core variables. The Delphi panel brought together 27 international experts in the field of severe asthma research. The process consisted of three iterative rounds. In each round, all Delphi panel members were issued an electronic ISAR Delphi workbook to complete and return to the ISAR Delphi administrator. Workbooks and result summaries were anonymously distributed by the Delphi administrator to all panel members at subsequent rounds. Finalisation of the core variable list was facilitated by two face-to-face meetings.

Results

Of the initial 747 selected variables, the Delphi panel reached a consensus on 95. The chosen variables will allow severe asthma to be assessed against patient demographics and medical history, patient-reported outcomes, diagnostic information and clinical characteristics. Physician-reported outcomes such as non-adherence and information about treatment and management strategies will also be recorded.

Conclusion

This is the first global attempt to generate an international severe asthma registry using a common set of core variables to ensure that data collected across all participating countries are standardised.

Hymenoptera Venom Extracts in Clinical Practice

Publication date: Available online 1 September 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): James M. Tracy, David BK. Golden

Abstract

Venom immunotherapy is the only treatment for the prevention of anaphylaxis and remains the prototypical model for its diagnosis and management. Unlike other causes of anaphylaxis, such as foods and drugs, preventative treatment is highly effective and widely available. Hymenoptera venoms are also unique in that the primary allergens are directly measurable in terms of micrograms, rather than labeled based on potency. As such, venoms were the first truly standardized extracts. However, Hymenoptera venom presents unique challenges in collection, processing and stabilization of the venom extract product. Historically, there have been minor variations in insect composition in venom extract content. These differences were in part, based on variation of insect availability and venom collection and have created minor challenges. However, it is a recognized need that venom extracts contain an optimal and complete repertoire of relevant venoms so as to be assured of appropriate diagnosis and treatment. As such, insect availability and collection, as well as storage, stability and sterility of venom extracts have remained critical components to appropriate diagnosis and prevention of venom induced anaphylaxis. In recent years there has been concerns of adequate supplies of venom for appropriate diagnosis and treatment of venom allergy, but these concerns seem to have stabilized, with the movement to a single venom supplier. This movement to a single supplier may provide its own challenges.

Drug Rash Eosinophilia and Systemic Symptoms (DRESS) Syndrome Identified in the Electronic Health Record Allergy Module

Publication date: Available online 31 August 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Anna R. Wolfson, Li Zhou, Yu Li, Neelam A. Phadke, Ohn A. Chow, Kimberly G. Blumenthal

Abstract

Background

Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare but severe hypersensitivity reaction that remains poorly characterized in the US.

Objective

We aimed to identify and describe DRESS syndrome cases in an integrated healthcare system using electronic health record (EHR) allergy module free text searches.

Methods

We identified DRESS syndrome cases with rash, absolute eosinophil count ≥500/L, organ involvement, and RegiSCAR (European Registry of Severe Cutaneous Adverse Reactions [SCAR]) to Drugs and Collection of Biological Samples) score ≥2 by reviewing patients from 1980-2016 whose EHR allergic reaction matched DRESS-related keywords. Liver injury required alanine aminotransferase ≥100U/L and renal injury required creatinine increase by ≥0.5mg/dL or 50%. Patient and DRESS characteristics were described, resource use was determined, and cost was estimated.

Results

Among 3,162,562 patients with 3,319,387 million allergy entries, 538 reactions matched keywords, and 69 were DRESS cases (prevalence 2.18 in 100,000). DRESS patients had liver (42%) or renal (42%) injury; 11 (16%) had both liver and renal injury. Primary drug culprits were antibiotics (74%) (vancomycin [39%], beta-lactams [23%], fluoroquinolones [4%], tetracyclines [4%], and sulfonamides [3%]) and anticonvulsants (20%). Of 65 (94%) hospitalized DRESS patients, 43 (66%) were hospitalized for DRESS syndrome management with median length of stay 9 days [IQR, 6-17 days] and cost approximately $17,101 per patient.

Conclusions

Using free text search of the EHR allergy module identified a large US DRESS syndrome cohort. DRESS prevalence was 2.18 per 100,000 patients. Both liver and kidney injury were frequent, and vancomycin was the most common drug culprit. DRESS cases were morbid and resource-intensive.

Routine clinical utility of honeybee venom allergen components

Publication date: Available online 31 August 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Martina Vachová, Petr Panzner, Peter Kopac, Urska Bidovec Stojkovič, Peter Korošec

Adjuvant treatment for high-risk renal-cell carcinoma: the jury is still out

Larva migrans cutánea facial de origen autóctono en España

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): C. Durán-Vian, I. Vilanova-Udaniz, B. Castro-Gutierrez, M.A. González-López

Enfermedad de Kikuchi-Fujimoto con compromiso de cuero cabelludo

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): A. Combalia, X. Fustà-Novell, A. García-Herrera, J. Ferrando

Enfermedad de Rosai-Dorfman cutánea: una nueva presentación clínica

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): J.M. Conde, A.Y. Kim, R. de Miguel, C.H. Nousari

Melanocitosis dérmica agminada en el territorio del nevus de Ota

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): L. Diluvio, M. Mazzeo, L. Bianchi, E. Campione

Celulitis cervical odontógena

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): P. García-Montero, G. González-Pérez, N. Blázquez-Sánchez

Raro compromiso lingual de leishmaniasis mucocutánea por Leishmania perteneciente al subgénero Viannia

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): R. Bueno-Filho, S. Vernal, C.M. Gomes, A.M. Roselino

FR-Calidad de vida en cáncer cutáneo no melanoma

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): P. García-Montero, M.V. de Gálvez-Aranda, M. de Troya Martín

Máculas evanescentes en tronco y extremidades

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): M.Á. Flores-Terry, M. Franco-Muñóz, J.A. Garrido-Martín, N. Villasanti-Rivas

Lesión ulcerada en pene

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): E.R. Martínez Lorenzo, B. Moreno Torres, A.I. Sánchez Moya

Pitiriasis liquenoide y varioliforme aguda asociada al virus herpes humano tipo 7

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): M. Costa-Silva, A. Calistru, J. Sobrinho-Simões, C. Lisboa, F. Azevedo

Resumen

Tanto la pitiriasis liquenoide y varioliforme aguda como la pitiriasis liquenoide crónica representan 2 extremos de un espectro de enfermedad de etiología desconocida. En este trabajo se describen 2 casos de pitiriasis liquenoide y varioliforme aguda, en los que se detectó ADN de virus herpes humano tipo 7 en muestras de piel mediante la metodología de reacción en cadena de la polimerasa, una asociación no descrita previamente. Este manuscrito puede apoyar la participación de la infección viral en la etiopatogenia de esta enfermedad.

Abstract

Pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica represent 2 ends of a disease spectrum of unknown etiology. Herein we describe 2 cases of pityriasis lichenoides et varioliformis acuta, in which human herpesvirus 7 DNA was detected in skin samples by polymerase chain reaction methodology, an association not previously described. This report may support the involvement of viral infection in the etiopathogeny of this disease.

Granuloma aséptico facial idiopático: hallazgos clínicos y ecográficos de 3 casos

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): A.I. Rodríguez-Bandera, M. Feito-Rodríguez, R. Maseda-Pedrero, R. de Lucas-Laguna

Resumen

El granuloma aséptico facial idiopático es una entidad propia de la infancia que se caracteriza por la presencia de uno o varios nódulos asintomáticos en la mejilla. Aunque su patogenia no está clara, se ha sugerido que pueda pertenecer al espectro de la rosácea infantil. Resuelve espontáneamente pero puede plantear dudas diagnósticas con otras lesiones que sí requieren tratamiento.

Presentamos los hallazgos clínicos y ecográficos y la evolución, tanto clínica y ecográfica, de 3 nuevos casos. En 2 pacientes, la lesión se presentó en el contexto de una rosácea infantil. En ecografía, el granuloma aséptico facial idiopático mostró un patrón característico, con variaciones en función del momento evolutivo.

La ecografía de alta frecuencia puede facilitar el diagnóstico diferencial, evitando biopsias o extirpaciones innecesarias.

Abstract

Idiopathic facial aseptic granuloma is a typical childhood disease characterized by the presence of one or more asymptomatic nodules on the cheek. Although pathogenesis remains unclear, the disease is thought to be a type of childhood rosacea. It resolves spontaneously, yet it could be confused with other lesions that require treatment.

We present clinical and ultrasound findings and outcome from 3 new cases. In 2 cases, the lesion presented as childhood rosacea. Ultrasound revealed a characteristic pattern, with variations depending on the stage of development.

High-frequency ultrasound can facilitate the differential diagnosis and thus obviate unnecessary biopsy or excision.

Registro de linfomas cutáneos primarios de la AEDV: primer año de funcionamiento

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): Y. Peñate, O. Servitje, S. Machan, R. Fernández-de-Misa, M.T. Estrach, E. Acebo, J. Mitxelena, M.D. Ramón, A. Flórez, M. Blanes, M. Morillo, S. Medina, J. Bassas, A. Zayas, P. Espinosa, A. Pérez, N. Gónzalez-Romero, J.D. Domínguez, C. Muniesa, J. López Robles

Resumen

Antecedentes y objetivo

Los linfomas primarios cutáneos son enfermedades poco frecuentes. Este artículo describe el Registro de linfomas cutáneos primarios de la AEDV y sus primeros resultados.

Pacientes y métodos

Registro de enfermedad de pacientes con linfomas cutáneos primarios. Los centros participantes recogieron datos prospectivamente de todos los pacientes, incluyendo datos del diagnóstico, de los tratamientos, de las pruebas realizadas y del estado actual del paciente. Se realizó un análisis descriptivo.

Resultados

En diciembre del 2017 el registro tenía datos de 639 pacientes pertenecientes a 16 hospitales universitarios. Un 60% eran hombres y los diagnósticos, por orden de frecuencia, fueron: micosis fungoide/síndrome de Sézary (MF/SS) (348 casos; 55%), linfoma cutáneo primario de células B (LCCB) (184; 29%), trastorno linfoproliferativo de células T CD30+ (LTCD30+) (70; 11%) y otro tipo de linfoma T (OLT) (37; 5%). El número de casos incidentes recogidos durante el primer año fue de 105 (16,5%). En los pacientes con MF/SS, el diagnóstico más frecuente fue MF clásica (77,3%). La mitad de estos casos se diagnosticaron en estadio IA. La mayoría de los pacientes estaban en remisión parcial (32,5%) o enfermedad estable (33,1%). Los tratamientos más usados fueron los corticoides tópicos (90,8%) seguidos de fototerapia. En los pacientes con LCCB el diagnóstico más frecuente fue el linfoma de la zona marginal (50%). Casi todos los pacientes tuvieron afectación exclusivamente cutánea y casi la mitad fue T1a. La mayoría (76,1%) estaba en remisión completa. Los tratamientos más utilizados fueron la cirugía (55,4%) y la radioterapia (41,9%). En los pacientes con LTCD30+, el diagnóstico más frecuente fue la papulosis linfomatoide (68,6%). La mayoría fueron clasificados T3b (31,4%). La mitad de los casos estaban en remisión completa. Los tratamientos más frecuentes fueron los esteroides tópicos (68,6%), seguidos de la quimioterapia sistémica (32,9%).

Conclusión

Las características del paciente con linfoma cutáneo primario en España no difieren de otras series descritas en la literatura. El registro facilitará al grupo de linfomas de la AEDV realizar investigación clínica.

Abstract

Background and objective

Primary cutaneous lymphomas are uncommon. This article describes the Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV) and reports on the results from the first year.

Patients and methods

Disease registry for patients with primary cutaneous lymphoma. The participating hospitals prospectively recorded data on diagnosis, treatment, tests, and disease stage for all patients with primary cutaneous lymphoma. A descriptive analysis was performed.

Results

In December 2017, the registry contained data on 639 patients (60% male) from 16 university hospitals. The most common diagnoses, in order of frequency, were mycosis fungoides/Sézary syndrome (MF/SS) (348 cases, 55%), primary cutaneous B-cell lymphoma (CBCL) (184 cases, 29%), primary cutaneous CD30⁺ T-cell lymphoproliferative disorder (CD30⁺ CLPD) (70 cases, 11%), and other types of T-cell lymphoma (37 cases, 5%). In total, 105 (16.5%) of the cases recorded were incident cases. The most common diagnosis in the MF/SS group was classic MF (77.3%). Half of the patients with MF had stage IA disease when diagnosed, and the majority were either in partial remission (32.5%) or had stable disease (33.1%). The most widely used treatments were topical corticosteroids (90.8%) and phototherapy. The most common form of primary CBCL was marginal zone lymphoma (50%). Almost all of the patients had cutaneous involvement only and nearly half had stage T1a disease. Most (76.1%) were in complete remission. The main treatments were surgery (55.4%) and radiotherapy (41.9%). The most common diagnosis in patients with CD30⁺ CLPD was lymphomatoid papulosis (68.8%). Most of the patients (31.4%) had stage T3b disease and half were in complete remission. The most common treatments were topical corticosteroids (68.8%) and systemic chemotherapy (32.9%).

Conclusion

The characteristics of patients with primary cutaneous lymphoma in Spain do not differ from those described in other series in the literature. The registry will facilitate clinical research by the AEDV's lymphoma group.

Graphical abstract

Actualización en la dermatitis de contacto alérgica por parafenilendiamina

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): B. Encabo Durán, D. Romero-Pérez, J.F. Silvestre Salvador

Resumen

La parafenilendiamina (PPD) es una amina empleada en la actualidad principalmente como componente de tintes capilares y en tatuajes de henna. Se ha observado un incremento en la incidencia de la dermatitis alérgica de contacto por PPD, y en edades cada vez más tempranas. En el presente trabajo se realiza una revisión de las principales fuentes que contienen PPD, así como de las sustancias con las que puede interaccionar, y se propone un algoritmo de manejo diagnóstico y terapéutico desde un enfoque práctico, para los pacientes que presenten una clínica compatible con sospecha de alergia a PPD.

Abstract

Paraphenylenediamine (PPD) is an amine that is mainly used as an ingredient in hair dyes and henna tattoos. The incidence of allergic contact dermatitis to PPD is increasing, particularly in younger patients. In this article, we review the main sources of PPD and the substances with which it can interact and present a practical algorithm for diagnosing and treating suspected cases of PPD allergy.

Graphical abstract

Papel de la ecografía doppler color en el diagnóstico de granuloma aséptico facial idiopático

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): X. Wortsman

Posturas ergonómicas para la exploración en dermatología

Publication date: September 2018

Source: Actas Dermo-Sifiliográficas, Volume 109, Issue 7

Author(s): I. Hernández Aragüés, A. Neyra Castañeda, E. Fernández Vilariño, G. Simal

Comprehensive Long‐Term Safety of Adalimumab from Eighteen Clinical Trials in Adult Patients With Moderate to Severe Plaque Psoriasis

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

Reconstruction mammaire par lambeau musculo-cutané de grand dorsal avec prothèse : la technique du soutien-gorge dorsal

Publication date: Available online 1 September 2018

Source: Annales de Chirurgie Plastique Esthétique

Author(s): C. Bruant-Rodier, L. Ruffenach, S. Hendriks, F. Bodin, C. Dissaux

Résumé

Malgré l'essor de la microchirurgie, la reconstruction mammaire par lambeau musculo-cutané de grand dorsal pédiculé reste une intervention très pratiquée. Elle est fiable, réalisable chez la quasi-totalité des patientes, sans contre-indication chez les fumeuses et est indiquée après radiothérapie. La variante technique qui combine le lambeau de grand dorsal et un implant, permet de reconstruire le volume mammaire désiré et favorise l'augmentation prothétique controlatérale si la patiente le souhaite. La palette dorsale augmente la poche cutanée, le muscle étoffe en profondeur la peau irradiée et protège la prothèse. Un positionnement précis de la palette cutanée en zone mammaire, soit dans la cicatrice de mastectomie, soit dans une contre-incision à part, permet un apport cutané dans le pôle inféro-externe du sein le plus galbé et permet au muscle d'englober la prothèse à la manière d'un soutien-gorge. Ces repères précis de positionnement du lambeau sont reproductibles et assurent un résultat d'emblée harmonieux et stable dans le temps.

Summary

Despite the development of microsurgical techniques, latissimus dorsi myocutaneous pedicle flap remains mainly used in breast reconstruction surgery. It is reliable and could be performed on almost all the patients, even if they smoke. It is also a good indication in case of irradiation. The technical alternative, which combines latissimus dorsi myocutaneous flap and an implant, allows the reconstruction of the expected volume and enables controlateral implant augmentation if the patient desires. The dorsal skin paddle increases the cutaneous pocket. The muscle in-depth enhances the irradiated skin and protects the implant. Positioning the skin paddle on the breast area is essential: it should be based on the mastectomy scar or on an added contraincision barring it. Thus it allows the muscle to embrace the implant as a bra. The precise reference points helping the placement of the flap could be reproduced and ensure pleasant and stable results over time.

Real‐world use of apremilast for patients with psoriasis in Japan

The Journal of Dermatology, EarlyView.

Atypical pemphigus developed in a patient with urothelial carcinoma treated with nivolumab

The Journal of Dermatology, EarlyView.

Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis

Journal of Cosmetic Dermatology, EarlyView.

Sweet's syndrome associated with Talaromyces marneffei and Mycobacterium abscessus infection due to anti-interferon-gamma autoantibodies

Hongyan Xu, Donghua Liu, Xiaoyue He, Dongyan Zheng, Yan Deng

Indian Journal of Dermatology 2018 63(5):428-430

Three sequential lymphomatous tumors in a patient

Ellie Choi, Sam Yang, Kong Bing Tan, Derrick Aw, Nisha Suyien Chandran

Indian Journal of Dermatology 2018 63(5):443-444

Estimation of zinc and iron levels in the serum and hair of women with androgenetic alopecia: Case–control study

Samer A Dhaher, Abdulla A Yacoub, Ausama Ayob Jacob

Indian Journal of Dermatology 2018 63(5):369-374

Background: Although female androgenetic alopecia (FAGA) occurs in genetically susceptible women, some trace elements may play an important role. Aim of the Study: This study aimed to evaluate serum and hair zinc and iron levels in patients with FAGA and to compare the findings with normal controls. Patients and Methods: A case–control study that was conducted at Dermatology Clinic in Basra General Hospital, Basra, Iraq. The participants were divided into two groups: The first group consisted of 27 women with FAGA and the second was age-matched 28 healthy women control group. The serum and hair zinc and iron assays were done for all participants. Results: Both hair and serum zinc levels in FAGA group were significantly lower than that in the control (103.4±25.5 ppm vs. 143.5±33.1 ppm for hair and 65.6±14.2 μg/dl vs. 128.4±41.4 μg/dl for serum). Hair iron level in FAGA was significantly lower than in control (17.9±3.8 ppm vs. 26.9±7.4 ppm, P>0.05). Serum iron level in FAGA group was lower than in the control, but it was not significant statistically (88.9±22.3 μg/dl vs. 100.9±18.9 μg/dl). Except for the hair iron, there was no significant correlation between zinc and iron concentrations in hair and serum with severity of alopecia. Conclusions: Zinc and iron levels in serum and hair were lower in FAGA compared to that of normal individuals indicating that trace elements might play an important role in the etiopathogenesis of FAGA.

Use of an anal retractor device for excision in patients with perianal extramammary paget's disease

Yuichi Yoshida, Hiroyuki Goto, Reiko Tsutsumi, Osamu Yamamoto

Indian Journal of Dermatology 2018 63(5):435-437

Topical steroid damaged/dependent face (TSDF): A study from a tertiary care hospital in Eastern India

Dayamay Pal, Projna Biswas, Sudip Das, Abhishek De, Nidhi Sharma, Asad Ansari

Indian Journal of Dermatology 2018 63(5):375-379

Background: Awareness against abuse of topical corticosteroids (TC), especially over the face, has been going on for last 5 years in India. In spite of that we are getting lots of cases in our hospitals. Aims: The aims of this study were to ascertain the demographics, magnitude and clinical features of TC misuse on the face among the dermatology outpatient department (OPD) attendees and to analyze its causes. Methods: This study was conducted in a tertiary care medical center of eastern India. Patients with relevant facial dermatoses were asked about their current use of topical formulations and confirmed to be TSDF were included in the study. Results: A total of 748 patients with facial dermatoses were screened, of which 271 (36.22%) were using TC. Of them mostly young adults between 20 and 29 years (37.10%) were using TC. Average duration between starting of use of medication and the onset of symptoms was 5 months. Ninety-eight (36.16%) patients were using topical corticosteroid for the treatment of acne and 74 (27.30%) were using as depigmenting cream. About 108 (39.85%) patients bought medicine over the counter being recommended by pharmacist/shop owner. Rosacea like features with photosensitivity was the most common adverse effect found in 79 (29.15%) patients whereas comedonal acne/acne exacerbation were found in 68 (25.09%) patients. Most of them (227, 83.76%) were unaware about the side effects of steroids. Conclusions: TC misuse in patients with facial dermatoses is still quite common even after efforts to grow the awareness among population.

Metastatic dermatosis in breast carcinoma on adjuvant trastuzumab: Is skin a sanctuary site in human epidermal growth factor receptor-2-amplified disease?

Amit Sehrawat, Sumedha A Kotwal, KM Parthasarathy

Indian Journal of Dermatology 2018 63(5):424-426

Cutaneous metastasis (CM) from internal malignancies is commonly seen. Sometimes, skin metastases can be the first sign of advanced cancer or an indicator of cancer recurrence. Cases of breast cancer with cutaneous progression after or during trastuzumab therapy have been described in the past, frequently associated with systemic disease progression. However, CM during adjuvant trastuzumab therapy is very rare. It has been hypothesized that cancer cells located in the skin survive and take proliferative advantage by virtue of an immune-tolerance mechanism that hampers trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity. We describe a case of human epidermal growth factor receptor-2-overexpressing breast cancer presenting with diffuse CM during adjuvant trastuzumab therapy.

Comparison of efficacy of doxycycline and isotretinoin on cutaneous human beta-defensin-1 and -2 levels in acne vulgaris

Gulhan Aksoy, Esra Adisen, Ozlem Erdem, Ahmet Burhan Aksakal

Indian Journal of Dermatology 2018 63(5):380-385

Background: Recent studies have shown that human beta-defensin-1 (hBD-1) and (human beta-defensin-2 hBD-2), which are antimicrobial peptides produced by the skin, play a role in the pathogenesis of acne vulgaris (AV). Objective: The aim of this study was to determine the role of antimicrobial peptides in the pathogenesis of AV and enlighten the effects of doxycycline and isotretinoin in the expression of these defensins in AV. Materials and Methods: A total of 44 patients (22 patients in each group) with Grade 6 and 8 AV who were indicated doxycycline or isotretinoin for their treatment, and 20 healthy volunteers were included in this study. Pretreatment cutaneous samples were obtained from pustular lesions and uninvolved skin of AV patients and were repeated after the treatment. Only one biopsy was obtained from controls. Results: Cutaneous levels of hBD-1 and hBD-2 were significantly increased in AV patients when compared with healthy controls (P<0.05). Doxycycline therapy achieved a decrease in hBD-1 levels (P<0.05), whereas isotretinoin therapy achieved a reduction in hBD-2 levels when compared with pretreatment levels (P<0.05). Posttreatment hBD-1 and hBD-2 levels were not different between doxycycline and isotretinoin groups (P>0.05). Conclusion: In the light of these results, it was reasonable to assume the role of hBD-1 and hBD-2 in the pathogenesis of AV. Our results showing a significant reduction in hBD-1 staining with doxycycline treatment and in hBD-2 with isotretinoin suggested that some part of their anti-acne effect worked through these mechanisms.

Cyclosporine in generalized bullous-fixed drug eruption

Ranjana Beniwal, Lalit Kumar Gupta, Ashok Kumar Khare, Asit Mittal, Sharad Mehta, Manisha Balai

Indian Journal of Dermatology 2018 63(5):432-433

Pathogenic yeasts recovered from acne vulgaris: Molecular characterization and antifungal susceptibility pattern

Ayatollah Nasrollahi Omran, Alinaghi Ghiasi Mansori

Indian Journal of Dermatology 2018 63(5):386-390

Context: Acne vulgaris is a disorder showing persistent inflammation in the pilosebaceous follicles. It is one of the most prevalent dermatoses that millions of people suffer from globally. Aim: The aim of this study was to identify Candida species from patients with acne and to determine their drugs susceptibility. Subjects and Methods: A total of 70 cutaneous samples from acne vulgaris patients suspected to have Candida infections were collected. Macroscopic and microscopic morphology were recorded followed by polymerase chain reaction-sequencing of ITS regions, using universal primers. In vitro antifungal susceptibility was performed using Clinical and Laboratory Standards Institute method. Results: Overall, 11 Candida species including Candida parapsilosis 8 (72.73%), Candida krusei 1 (12.5%), Candida lusitaniae 1 (12.5%), Candida kefyr 1 (12.5%), and a Trichosporon asahi out of the collected clinical materials were isolated and identified. C. parapsilosis isolates susceptibility to diverse concentrations of the antifungal agents to isolate Cp1 study indicated that the isolated Cp8 and Cp5 with minimal inhibitory concentration (MIC) 50 = 32, 0.5, 0.25 and MIC 90 of <64, <1, <0.5 μg/ml fluconazole, itraconazole, and ketoconazole were resistant, respectively. Some of the isolates having relative strength, almost all other species of C. parapsilosis isolates were susceptible to these drugs. Conclusion: C. parapsilosis was the most prevalent Candida species in acne vulgaris samples which had higher in vitro susceptibility for antifungals.

Dermatofibrosarcoma protuberans secondary to a decorative tattoo: An Isotattootopic Response?

Irene Lastrucci, Susanna Gunnella, Alessandro Pileri, Vincenza Maio, Vieri Grandi

Indian Journal of Dermatology 2018 63(5):439-440

Sensitization to fungi in atopic dermatitis patients 14 year and older – Association with other atopic diseases and parameters

Jarmila Celakovska, Bukac Josef, Karel Ettler, Jaroslava Vaneckova, Kvetuse Ettlerova, Krejsek Jan

Indian Journal of Dermatology 2018 63(5):391-398

Background: Fungi as a source of allergen are still largely neglected in basic research as well as in clinical practice. This study aimed to highlight the impact of fungal allergens in a group of patients suffering from atopic dermatitis (AD). Aims and Objectives: The evaluation of the sensitization to fungi in AD patients aged 14 year and older and the evaluation of the relation of fungal sensitization to the occurrence of other atopic diseases and parameters. Materials and Methods: All patients satisfying inclusion criteria attending our hospital between 2008 and 2017 were included in the study. The complete dermatological and allergological examinations were performed in all included patients including examination of specific immunoglobulin E, skin prick test to mixture of fungi and inhalant allergens, evaluation of asthma bronchiale, rhinitis, onset of AD, family history about atopy, duration of eczematous lesions, severity of AD. Pairs of these categories were entered in the contingency tables and the Chi-square test for relationship of these variables was performed with the level of significance set below 5%. Results: Three hundred and thirty-one patients were included in the study; the average age was 26.8 years. The sensitization to fungi was recorded in 100 patients (30%). In these patients, the occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher than in patients without sensitization to fungi. We did not find any significant relation between the sensitization to fungi and the severity of AD, no relation was also found between the sensitization to fungi and sensitization to mites, animal dander, bird feather, and dust. Conclusion: The occurrence of asthma bronchiale, rhinitis, family history about atopy, sensitization to grass and trees was significantly higher in AD patients with sensitization to fungi. No relation was found between the severity of AD and the sensitization to fungi.

Antifungal resistance in dermatology

Varadraj Pai, Ajantha Ganavalli, Naveen Narayanshetty Kikkeri

Indian Journal of Dermatology 2018 63(5):361-368

Cutaneous fungal infections affect more than one-fourth of world's population. The pathogenesis and severity of fungal infection depend on various immunological and nonimmunological factors. The rampant use of antifungal therapy in immunocompromised individuals marked the onset of antifungal drug resistance. Fungal resistance can be microbiological or clinical. Microbiological resistance depends on various fungal factors which have established due to genetic alteration in the fungi. Clinical resistance is due to host- or drug-related factors. All these factors may cause fungal resistance individually or in tandem. In addition to standardized susceptibility testing and appropriate drug dosing, one of the ways to avoid resistance is the use of combinational antifungal therapy. Combination therapy also offers advantages in increased synergistic action with enhanced spectrum activity. Newer insights into mechanisms of drug resistance will help in the development of appropriate antifungal therapy.

Impact on quality of life in vitiligo patients treated with narrowband ultraviolet B phototherapy

Yatendra S Chahar, Pramod Kumar Singh, Vijay Kumar Sonkar, Inder Rajani, Mohammad Adil

Indian Journal of Dermatology 2018 63(5):399-402

Context: Vitiligo is a psychosocial problem which significantly affects quality of life in Indian scenario. Aims: The purpose of this study was to compare the changes in quality of life in patients of vitiligo before and after treatment with narrowband ultraviolet B (NBUVB) phototherapy. Subjects and Methods: A total of 54 patients had completed the study. The age ranged between 16 and 70 years with a mean age of 26.77±14.2 years. The initial dose of NBUVB was 300 mJ/cm2 in adults and 150 mJ/cm2 in children twice weekly with 20% dose increment on subsequent visits. It was given for a maximum period of 6 months and was followed up for another 6 months to determine stability of repigmentation. Results: The average number of exposure given to the patients was 45.63±12.74 while the mean irradiation cumulative dose was 39.8 J/cm2. Mean Dermatology Life Quality Index (DLQI) of the vitiligo patients was 8.64±4.32 while those patients with acrofacial vitiligo had a mean DLQI of 11.78±5.61. After treatment with NBUVB, mean DLQI of all vitiligo patients was significantly reduced to 5.86±2.15 (P<0.01). Conclusions: This study showed that phototherapy had a positive therapeutic outcome in vitiligo, especially in younger patients. Even a small, depigmented lesion in a child could be psychosocially devastating.

A case of bullous pemphigoid associated with lichen sclerosus et atrophicus

Asuka Yoshifuku, Aoi Okubo, Nozomi Jimura, Kazuyasu Fujii, Yuko Higashi, Takuro Kanekura

Indian Journal of Dermatology 2018 63(5):427-428

A comparative study of combined dermaroller and platelet-rich plasma versus dermaroller alone in acne scars and assessment of quality of life before and after treatment

Shefali Porwal, Yatendra Singh Chahar, Pramod Kumar Singh

Indian Journal of Dermatology 2018 63(5):403-408

Background: Scarring due to acne is a frequently encountered problem in dermatological outpatient department. Microneedling has been a well-accepted modality for the treatment of atrophic acne scars. Platelet-rich plasma (PRP) is a newer option to investigate. Aims: The aims of this study were (1) to compare the efficacy of combined dermaroller and PRP therapy with dermaroller alone in facial acne scars and (2) to assess the psychosocial impact due to acne scars and its treatment. Methods: A total of 55 patients were included in the study and randomly divided into two groups, Group A: 28 and Group B: 27. Proper counseling was done, and detailed clinical findings were recorded. Patients in Group A were treated with dermaroller alone while Group B patients underwent treatment with a combination of dermaroller and intradermal PRP injections. A total of three sitting were done at monthly interval. Final response was assessed at 1 month after the last sitting. Criteria of evaluation included Goodman and Baron's quantitative scale, visual analog score, and dermatology life quality index scores. Side effects were noted. Results were analyzed using Chi-square test and t-test. Results: Significant percentage improvement was noted in both the groups. However, Group B treated with both modalities had better results when compared with that in the Group A. Conclusion: A combination approach using dermaroller and PRP was a safe and better option than using dermaroller alone in atrophic acne scars for clinical improvement as well as for improvement in dermatology life quality index score.

Familiar manifestations of unfamiliar selenium toxicity

Banashree Majumdar, Nirmala Saini, Shweta Agrawal, Chiatra Prakash

Indian Journal of Dermatology 2018 63(5):430-431

Idiopathic eruptive macular pigmentation - uncommon presentation of an uncommon condition

Resham Jayvant Vasani

Indian Journal of Dermatology 2018 63(5):409-411

Idiopathic eruptive macular pigmentation (IEMP) is an asymptomatic condition with dark brown, nonconfluent lesions chiefly occurring in children and adolescents. The usual sites involved are face, trunk, extremities, and the lesions resolve over few months to years. We report an unusual presentation of this uncommon condition. A 22-year-old male presented with multiple dark-colored asymptomatic lesions on the scalp and forehead for the past 3 years. There was no history of preceding symptoms, drug, or applications, past or family history of such lesions. Examination revealed multiple hyperpigmented macules and barely elevated nonscaly plaques with a velvety feel akin to acanthosis nigricans (AN). Dermoscopy was similar to AN. Blood sugar, thyroid, and lipid profiles were normal. Histology showed "pigmented papillomatosis" concluding the final diagnosis of IEMP. Confluence of lesions is a rarely described phenomenon, with the scalp being a hitherto unreported site. The velvety feel of lesions, the dermoscopic, and histopathological findings further substantiate the hypothesis of this entity being an eruptive variant of AN.

Kaposi's varicelliform eruption in a patient with darier's disease

Irene Garcia-Morales, Sandra Case-Mérida, Jerónimo Escudero

Indian Journal of Dermatology 2018 63(5):434-435

A distinct clinicopathological presentation of cutaneous dermatophytosis mimicking autoimmune blistering disorder

Jignaben Krunal Padhiyar, Nayankumar Harshadkumar Patel, Trusha Gajjar, Bhagirath Patel, Aseem Chhibber, Mansi Buch

Indian Journal of Dermatology 2018 63(5):412-414

Infectious diseases can clinically present as vesiculobullous disorders. Direct immunofluorescence (DIF) study of skin biopsy helps distinguish true autoimmune blistering disorders from other conditions. In many situations, even DIF findings in infections disorders imitate autoimmune process. Here, we describe a case of 29-year-old female with extensive dermatophytosis having presentation mimicking bullous pemphigoid both clinically and histopathologically including DIF findings.

A bibliometric evaluation of global productivity of teledermatology publications between 1975 and 2017 with a 3-year update

Engin Senel, Emre Demir, Refika Ferda Artüz

Indian Journal of Dermatology 2018 63(5):437-439

BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation

B lymphocyte-induced maturation protein-1 (BLIMP1) encoded by the PRDM1 gene belongs to the PRDM family of transcription repressor. BLIMP1 lacks intrinsic histone methyltransferase activity and serves as a scaffold for numerous epigenetic regulators to modulate DNA binding, gene silencing and chromatin reorganization [1,2]. Beside the well-known master regulator of B lymphocyte differentiation, BLIMP1 controls the development of various immune cells [3–7]. Thus, BLIMP1 is critical in maintenance of immune homeostasis, and dysfunction of BLIMP1 may contribute to autoimmune disorders.

NEUTROPHILS CONTRIBUTE TO VASCULITIS BY INCREASED RELEASE OF NEUTROPHIL EXTRACELLULAR TRAPS IN BEHÇET’S DISEASE

Bechet's disease (BD) is an inflammatory multi-system disorder causing recurrent oral and genital ulcers, uveitis, and vasculitis, in addition to cutaneous, neurological, gastrointestinal, articular and pulmonary manifestations [1]. Mild cases are treated with Colchicine, an anti-inflammatory drug. Severe cases can be life threatening and require systemic steroids, anti-TNFα drugs and immunosuppressants. Its pathophysiology is poorly known. Genetic studies identified several susceptibility loci implicating MHC1 and innate immunity genes namely HLA-B51, ERAP1, IL10, IL23R-IL12RB2, and IL1 A-IL1B [2–4].

Low-dose UVB therapy is comparable with conventional UVB phototherapy for treatment of vitiligo: A pilot study

UVB phototherapy is currently considered as the treatment of choice for vitiligo [1]. UVB is also used for treating inflammatory conditions including psoriasis. Although the major goals for treating vitiligo and psoriasis are different: one aims to bio-stimulate while the other aims to immune modulate, respectively, the protocols of phototherapy are surprisingly similar. More specifically, for narrow-band UVB (NBUVB) treatment of vitiligo, lesion repigmentation is associated with melanocyte precursor cell activation [2].

Non‐healing herpes zoster ophthalmicus

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.

Dissecting folliculitis (dissecting cellulitis) of the scalp: a 66‐patient case series and proposal of classification

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.

Antibacterial Effectiveness of Rice Water (Starch) Capped Silver Nanoparticles Fabricated Rapidly in Presence of Sunlight

Photochemistry and Photobiology, Volume 0, Issue ja, -Not available-.

Assessment of endothelial function during the loading phase of infliximab in psoriasis: a potential predictor of its drug survival

International Journal of Dermatology, EarlyView.

Basal cell carcinoma treated with Mohs micrographic surgery in young Ibero‐American patients

International Journal of Dermatology, EarlyView.

Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review

International Journal of Dermatology, EarlyView.

Controversies in off‐label prescriptions in dermatology: the perspective of the patient, the physician, and the pharmaceutical companies

International Journal of Dermatology, EarlyView.

Specific foot health‐related quality‐of‐life impairment in patients with type II versus type I diabetes

International Wound Journal, EarlyView.

The first ever reported case of malignant fibrous histiocytoma of the scalp

International Wound Journal, EarlyView.

Secondary‐intention healing following Mohs micrographic surgery for squamous cell carcinoma of a finger

International Wound Journal, EarlyView.

Prevention of hypergranulation tissue after gastrostomy tube placement: A randomised controlled trial of hydrocolloid dressings

International Wound Journal, EarlyView.

Percutan nasal septal retraction technique for dorsal cartilagenous deviations

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.

The Effect of Ventilation Tube Insertion to the Health‐Related Quality of Life in a Group of Children in Southeast Anatolia

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.

Fluoroscopic Balloon Diameter Measurement at Different Pressures during Eustachian Balloon Dilation

Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.

Atopic Dermatitis and Cancer in Solid Organs: a Systematic Review and Meta‐Analysis

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Creation and pilot test results of the dermatology‐specific proxy instrument the Infants and Toddlers Dermatology Quality of Life

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Evaluation of a non‐ablative, fractional 1565 nm laser for the improvement of striae distensae albae

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Investigation of the Predisposing Factor of Pemphigus and its clinical subtype through a Genome‐wide association and next generation sequence analysis

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Chromoblastomycosis: an autochthonous case of a tropical disease

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Bier's spots

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

The impact of atopic dermatitis on sexual health

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Manipulating mindsets to improve patient outcomes: Is it ethical? Can it be avoided?

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Does the Dermatology Life Quality Index (DLQI) underestimate the disease‐specific burden of psoriasis patients?

Journal of the European Academy of Dermatology and Venereology, Volume 0, Issue ja, -Not available-.

Terminal osseous dysplasia presenting with intracytoplasmic inclusion bodies in digital fibromas

Pediatric Dermatology, EarlyView.

Vancomycin‐induced red man syndrome presentation in a preterm infant

Pediatric Dermatology, EarlyView.

Sinecatechins ointment for the treatment of warts in children

Pediatric Dermatology, EarlyView.

The value of full‐body skin examination: Poland syndrome diagnosed as an incidental finding

Pediatric Dermatology, EarlyView.

An atypical presentation of herpes simplex virus infection in Harlequin ichthyosis

Pediatric Dermatology, EarlyView.

Remission of seizures with immunosuppressive therapy in Parry‐Romberg syndrome and en coup de sabre linear scleroderma: Case report and brief review of the literature

Pediatric Dermatology, EarlyView.

Localized infantile hemangiomas of the face and scalp: Predilection for the midline and periorbital and perioral skin

Pediatric Dermatology, EarlyView.

Ulcerated congenital plexiform fibrohistiocytic tumor: Case report and literature review

Pediatric Dermatology, EarlyView.

Chronic urticaria in infants as the first manifestation of autoinflammatory disease

Pediatric Dermatology, EarlyView.

Segmental Hailey‐Hailey disease of the vulva

Pediatric Dermatology, EarlyView.

Pediatric ocular lichen planus and lichen planopilaris: One new case and a review of the literature

Pediatric Dermatology, EarlyView.

Prolonged migraine aura: new insights from a prospective diary-aided study

There is limited literature on prolonged aura (PA - defined as an aura including at least one symptom for > 1 h and 

Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: a consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH)

We systematically reviewed data about the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age. Thereafter a consensus procedure among international experts was unde...

New CACNA1A deletions are associated to migraine phenotypes

Familial hemiplegic migraine type 1 (FHM1) is a form of migraine with aura caused by heterozygous mutations in 4 genes: CACNA1A, ATP1A2, SNC1A and PRRT2, but further heterogeneity is expected. Here have been desc...

Esophageal cancer practice guidelines 2017 edited by the Japan esophageal society: part 2

A Milroy case with FLT4/VEGFR3 mutation and an unusual skin biopsy

British Journal of Dermatology, Volume 0, Issue ja, -Not available-.

Fatigue and the wear‐off effect in adult patients with common variable immunodeficiency

Clinical &Experimental Immunology, Volume 0, Issue ja, -Not available-.

Perfused 3D angiogenic sprouting in a high-throughput in vitro platform

Abstract

Angiogenic sprouting, the growth of new blood vessels from pre-existing vessels, is orchestrated by cues from within the cellular microenvironment, such as biochemical gradients and perfusion. However, many of these cues are missing in current in vitro models of angiogenic sprouting. We here describe an in vitro platform that integrates both perfusion and the generation of stable biomolecular gradients and demonstrate its potential to study more physiologically relevant angiogenic sprouting and microvascular stabilization. The platform consists of an array of 40 individually addressable microfluidic units that enable the culture of perfused microvessels against a three-dimensional collagen-1 matrix. Upon the introduction of a gradient of pro-angiogenic factors, the endothelial cells differentiated into tip cells that invaded the matrix. Continuous exposure resulted in continuous migration and the formation of lumen by stalk cells. A combination of vascular endothelial growth factor-165 (VEGF-165), phorbol 12-myristate 13-acetate (PMA), and sphingosine-1-phosphate (S1P) was the most optimal cocktail to trigger robust, directional angiogenesis with S1P being crucial for guidance and repetitive sprout formation. Prolonged exposure forces the angiogenic sprouts to anastomose through the collagen to the other channel. This resulted in remodeling of the angiogenic sprouts within the collagen: angiogenic sprouts that anastomosed with the other perfusion channel remained stable, while those who did not retracted and degraded. Furthermore, perfusion with 150 kDa FITC-Dextran revealed that while the angiogenic sprouts were initially leaky, once they fully crossed the collagen lane they became leak tight. This demonstrates that once anastomosis occurred, the sprouts matured and suggests that perfusion can act as an important survival and stabilization factor for the angiogenic microvessels. The robustness of this platform in combination with the possibility to include a more physiological relevant three-dimensional microenvironment makes our platform uniquely suited to study angiogenesis in vitro.

Esophageal cancer practice guidelines 2017 edited by the Japan Esophageal Society: part 1

Removal of hexavalent chromium from water by modified sponge iron particles and insights into mechanism

Abstract

Sponge iron particles modified with expanded graphite and Cu were used to purify solutions contaminated with aqueous Cr(VI). A removal mechanism that involved physical adsorption and a redox reaction is proposed. The reaction, which consisted of rapid adsorption, a desorption stage, and an adsorption–desorption equilibrium stage, corresponded to a first-order kinetic model. The properties of the adsorption materials before and after use were investigated by X-ray diffraction, scanning electron microscopy–energy-dispersive spectroscopy, Fourier-transform infrared spectroscopy, energy-dispersive X-ray fluorescence spectroscopy, and surface area measurements. Changes in the surface properties, e.g., attachment of material to the surface and filling of pores with Cr, were clearly observed. The Langmuir model best described Cr(VI) adsorption on the sponge iron and its modified particles. Removal efficiencies of 98.7, 98.8, and 100% were achieved in 7 h at a Cr(VI) dosage of 10 mg/L. Sponge iron particles are therefore potential adsorbents and after modification give good removal of Cr(VI) ions from contaminated water.

Familial acanthosis nigricans with the FGFR3 mutation: Differences of pigmentation between male and female patients

The Journal of Dermatology, EarlyView.

Hinführung zum Thema – Schmerzen bei an Krebs erkrankten Menschen

Efficiency of methylene blue mediated photodynamic therapy versus intense pulsed light in the treatment of onychomycosis in the toenails

Photodermatology, Photoimmunology &Photomedicine, Volume 0, Issue ja, -Not available-.

Diagnostic ultrasonography in a child with eosinophilic fasciitis

Clinical and Experimental Dermatology, EarlyView.

Von der Schmerzäußerung zur Schmerzbehandlung