BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation

B lymphocyte-induced maturation protein-1 (BLIMP1) encoded by the PRDM1 gene belongs to the PRDM family of transcription repressor. BLIMP1 lacks intrinsic histone methyltransferase activity and serves as a scaffold for numerous epigenetic regulators to modulate DNA binding, gene silencing and chromatin reorganization [1,2]. Beside the well-known master regulator of B lymphocyte differentiation, BLIMP1 controls the development of various immune cells [3–7]. Thus, BLIMP1 is critical in maintenance of immune homeostasis, and dysfunction of BLIMP1 may contribute to autoimmune disorders.